Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Mus musculus | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Homo sapiens | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Oryctolagus cuniculus | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Comamonas testosteroni | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Mus musculus | i.e. cortisone | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Homo sapiens | i.e. cortisone | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Oryctolagus cuniculus | i.e. cortisone | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | Comamonas testosteroni | i.e. cortisone | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Comamonas testosteroni | - |
isoenzymes type 1 and type 2 | - |
Homo sapiens | - |
isoenzymes type 1 and type 2 | - |
Mus musculus | - |
isoenzymes type 1 and type 2 | - |
Oryctolagus cuniculus | - |
rabbit | - |
Oryctolagus cuniculus | - |
isoenzymes type 1 and type 2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Mus musculus |
glycoprotein | - |
Homo sapiens |
glycoprotein | - |
Oryctolagus cuniculus |
glycoprotein | - |
Comamonas testosteroni |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | Mus musculus | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | Homo sapiens | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | Oryctolagus cuniculus | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids | Comamonas testosteroni | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | i.e. cortisone | Mus musculus | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | i.e. cortisone | Homo sapiens | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | i.e. cortisone | Oryctolagus cuniculus | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH | i.e. cortisone | Comamonas testosteroni | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ | i.e. cortisol | r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD | 2 isoforms: 11beta-HSD1 and 11beta-HSD2 | Mus musculus |
11beta-HSD | 2 isoforms: 11beta-HSD1 and 11beta-HSD2 | Homo sapiens |
11beta-HSD | 2 isoforms: 11beta-HSD1 and 11beta-HSD2 | Oryctolagus cuniculus |
11beta-HSD | NAD-specific 11beta-HSD isoform type 2 | Homo sapiens |
11beta-HSD | NAD-specific 11beta-HSD isoform type 2 | Comamonas testosteroni |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus | |
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Oryctolagus cuniculus | |
NADP+ | - |
Comamonas testosteroni | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Oryctolagus cuniculus | |
NADPH | - |
Comamonas testosteroni |