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Literature summary for 1.1.1.146 extracted from

  • Oppermann, U.C.T.; Persson, B.; Jornvall, H.
    The 11beta-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action (1997), Eur. J. Biochem., 249, 355-360.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Mus musculus type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Homo sapiens type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Oryctolagus cuniculus type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Comamonas testosteroni type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Mus musculus i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Homo sapiens i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Oryctolagus cuniculus i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Comamonas testosteroni i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r

Organism

Organism UniProt Comment Textmining
Comamonas testosteroni
-
isoenzymes type 1 and type 2
-
Homo sapiens
-
isoenzymes type 1 and type 2
-
Mus musculus
-
isoenzymes type 1 and type 2
-
Oryctolagus cuniculus
-
rabbit
-
Oryctolagus cuniculus
-
isoenzymes type 1 and type 2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Mus musculus
glycoprotein
-
Homo sapiens
glycoprotein
-
Oryctolagus cuniculus
glycoprotein
-
Comamonas testosteroni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids Mus musculus 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids Homo sapiens 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids Oryctolagus cuniculus 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids Comamonas testosteroni 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone Mus musculus 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone Homo sapiens 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone Oryctolagus cuniculus 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone Comamonas testosteroni 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r

Synonyms

Synonyms Comment Organism
11beta-HSD 2 isoforms: 11beta-HSD1 and 11beta-HSD2 Mus musculus
11beta-HSD 2 isoforms: 11beta-HSD1 and 11beta-HSD2 Homo sapiens
11beta-HSD 2 isoforms: 11beta-HSD1 and 11beta-HSD2 Oryctolagus cuniculus
11beta-HSD NAD-specific 11beta-HSD isoform type 2 Homo sapiens
11beta-HSD NAD-specific 11beta-HSD isoform type 2 Comamonas testosteroni

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Mus musculus
NADP+
-
Homo sapiens
NADP+
-
Oryctolagus cuniculus
NADP+
-
Comamonas testosteroni
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Oryctolagus cuniculus
NADPH
-
Comamonas testosteroni