Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-keto,27-hydroxycholesterol | potent inhibitor of the isoform 11beta-HSD1-dependent oxoreduction of cortisone | Homo sapiens | |
7beta,27-dihydroxycholesterol | potent inhibitor of the isoform 11beta-HSD2-dependent oxidation of cortisol | Homo sapiens | |
glycyrrhetinic acid | inhibitor of isoform 11beta-HSD2 | Homo sapiens | |
additional information | 7alpha,27-dihydroxycholesterol does not inhibit the enzyme isoform 11beta-HSD1 activity at concentrations up to 0.01 mM; 7alpha,27-dihydroxycholesterol does not inhibit the enzyme isoform 11beta-HSD2 activity at concentrations up to 0.01 mM | Homo sapiens | |
T0504 | inhibitor of 11beta-HSD1 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000039 | - |
7-keto,27-hydroxycholesterol | isoform 11beta-HSD1, at pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.000056 | - |
7beta,27-dihydroxycholesterol | isoform 11beta-HSD2, at pH 7.4, temperature not specified in the publication | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-keto,27-hydroxycholesterol + NADP+ | Homo sapiens | the reaction is catalyzed by isoform 11beta-HSD1 | 7beta,27-dihydroxycholesterol + NADPH + H+ | - |
r | |
7-oxo-cholesterol + NADP+ | Homo sapiens | - |
7beta-hydroxycholesterol + NADPH + H+ | - |
? | |
7beta,27-dihydroxycholesterol + NADH + H+ | Homo sapiens | the reaction is catalyzed by isoform 11beta-HSD2 | 7-keto,27-hydroxycholesterol + NAD+ | - |
r | |
cortisol + NAD+ | Homo sapiens | the reaction is catalyzed by isoform 11beta-HSD2 | cortisone + NADH + H+ | - |
? | |
cortisone + NADPH + H+ | Homo sapiens | the reaction is catalyzed by isoform 11beta-HSD1 | cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Homo sapiens | R4GN04 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-keto,27-hydroxycholesterol + NADP+ | the reaction is catalyzed by isoform 11beta-HSD1 | Homo sapiens | 7beta,27-dihydroxycholesterol + NADPH + H+ | - |
r | |
7-oxo-cholesterol + NADP+ | - |
Homo sapiens | 7beta-hydroxycholesterol + NADPH + H+ | - |
? | |
7beta,27-dihydroxycholesterol + NADH + H+ | the reaction is catalyzed by isoform 11beta-HSD2 | Homo sapiens | 7-keto,27-hydroxycholesterol + NAD+ | - |
r | |
cortisol + NAD+ | the reaction is catalyzed by isoform 11beta-HSD2 | Homo sapiens | cortisone + NADH + H+ | - |
? | |
cortisone + NADPH + H+ | the reaction is catalyzed by isoform 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? | |
additional information | neither 7alpha-hydroxycholesterol nor 7betha-hydroxycholesterol is oxidized by isoform 11beta-HSD1 | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000011 | - |
isoform 11beta-HSD2, at pH 7.4, temperature not specified in the publication | Homo sapiens | 7beta,27-dihydroxycholesterol | |
0.000015 | - |
isoform 11beta-HSD2, at pH 7.4, temperature not specified in the publication | Homo sapiens | 7-keto,27-hydroxycholesterol | |
0.000357 | - |
isoform 11beta-HSD1, at pH 7.4, temperature not specified in the publication | Homo sapiens | 7-keto,27-hydroxycholesterol | |
0.003 | - |
isoform 11beta-HSD1, at pH 7.4, temperature not specified in the publication | Homo sapiens | 7beta,27-dihydroxycholesterol |
General Information | Comment | Organism |
---|---|---|
metabolism | isoform 11beta-HSD1 controls retinoid-related orphan receptor gamma activity | Homo sapiens |
metabolism | isoform 11beta-HSD2 controls retinoid-related orphan receptor gamma activity | Homo sapiens |