Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6-[[(3-chloro-2-methylphenyl)sulfonyl]amino]pyridin-2-yl)acetic acid | - |
Homo sapiens | |
2-(6-[[(3-chloro-2-methylphenyl)sulfonyl]amino]pyridin-2-yl)-N,N-diethylacetamide | - |
Homo sapiens | |
3-chloro-2-methyl-N-(6-methylpyridin-2-yl)benzenesulfonamide | - |
Homo sapiens | |
3-chloro-2-methyl-N-[6-(2-morpholin-4-yl-2-oxoethyl)-pyridin-2-yl]-benzenesulfonamide | - |
Homo sapiens | |
3-chloro-2-methyl-N-[6-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyridin-2-yl]benzenesulfonamide | - |
Homo sapiens | |
3-chloro-2-methyl-N-[6-[2-oxo-2-(piperidin-1-yl)ethyl]pyridin-2-yl]benzenesulfonamide | - |
Homo sapiens | |
3-chloro-2-methyl-N-[6-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyridin-2-yl]benzenesulfonamide | - |
Homo sapiens | |
3-chloro-2-methyl-N-[6-[2-oxo-2-(thiomorpholin-4-yl)ethyl]pyridin-2-yl]benzenesulfonamide | - |
Homo sapiens | |
4'-chloro-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-cyano-N-(6-cyclopropylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-cyano-N-(6-ethylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-cyano-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-cyano-N-[6-(ethylamino)pyridin-2-yl]biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-cyano-N-[6-(methylamino)pyridin-2-yl]biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-cyano-N-[6-(propan-2-yl)pyridin-2-yl]biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-fluoro-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
4'-methyl-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
4-methoxy-N-(6-methylpyridin-2-yl)benzenesulfonamide | - |
Homo sapiens | |
4-tert-butyl-N-(6-methylpyridin-2-yl)benzenesulfonamide | - |
Homo sapiens | |
N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide | - |
Homo sapiens | |
N-(6-methylpyridin-2-yl)-2-(trifluoromethyl)benzenesulfonamide | - |
Homo sapiens | |
N-(6-methylpyridin-2-yl)-4-(trifluoromethyl)benzenesulfonamide | - |
Homo sapiens | |
N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
N-(6-methylpyridin-2-yl)naphthalene-1-sulfonamide | - |
Homo sapiens | |
N-(6-methylpyridin-2-yl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
N-[6-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]pyridin-2-yl]-3-chloro-2-methylbenzenesulfonamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide | Ki below 0.000001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000017 | - |
4'-cyano-N-[6-(propan-2-yl)pyridin-2-yl]biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000019 | - |
4'-cyano-N-(6-cyclopropylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000004 | - |
4'-cyano-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000048 | - |
4'-cyano-N-[6-(ethylamino)pyridin-2-yl]biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000058 | - |
4'-chloro-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000066 | - |
4'-cyano-N-(6-ethylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000098 | - |
4'-cyano-N-[6-(methylamino)pyridin-2-yl]biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00002 | - |
4'-fluoro-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000048 | - |
N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000062 | - |
4'-methyl-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000084 | - |
N-(6-methylpyridin-2-yl)naphthalene-2-sulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000108 | - |
N-(6-methylpyridin-2-yl)-4-(trifluoromethyl)benzenesulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000169 | - |
3-chloro-2-methyl-N-[6-[2-oxo-2-(piperidin-1-yl)ethyl]pyridin-2-yl]benzenesulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000169 | - |
3-chloro-2-methyl-N-(6-methylpyridin-2-yl)benzenesulfonamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000287 | - |
2-(6-[[(3-chloro-2-methylphenyl)sulfonyl]amino]pyridin-2-yl)-N,N-diethylacetamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
1% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-(6-methylpyridin-2-yl)-2-(trifluoromethyl)benzenesulfonamide | |
additional information | - |
10% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-(6-methylpyridin-2-yl)naphthalene-1-sulfonamide | |
additional information | - |
11% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-chloro-2-methyl-N-[6-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyridin-2-yl]benzenesulfonamide | |
additional information | - |
22% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-[6-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]pyridin-2-yl]-3-chloro-2-methylbenzenesulfonamide | |
additional information | - |
23% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-methoxy-N-(6-methylpyridin-2-yl)benzenesulfonamide | |
additional information | - |
25% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (6-[[(3-chloro-2-methylphenyl)sulfonyl]amino]pyridin-2-yl)acetic acid | |
additional information | - |
32% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-tert-butyl-N-(6-methylpyridin-2-yl)benzenesulfonamide | |
additional information | - |
39% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-chloro-2-methyl-N-[6-[2-oxo-2-(thiomorpholin-4-yl)ethyl]pyridin-2-yl]benzenesulfonamide | |
additional information | - |
6% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-chloro-2-methyl-N-[6-(2-morpholin-4-yl-2-oxoethyl)-pyridin-2-yl]-benzenesulfonamide | |
additional information | - |
8% inhibition at 0.0001 mM, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-chloro-2-methyl-N-[6-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyridin-2-yl]benzenesulfonamide |