Literature summary for 1.1.1.146 extracted from

Tagawa, N.; Yuda, R.; Kubota, S.; Wakabayashi, M.; Yamaguchi, Y.; Kiyonaga, D.; Mori, N.; Minamitani, E.; Masuzaki, H.; Kobayashi, Y.
17Beta-estradiol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes (2009), J. Endocrinol., 202, 131-139.

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Inhibitors

Inhibitors	Comment	Organism	Structure
17beta-estradiol	non-competitive	Mus musculus
17beta-estradiol	-	Rattus norvegicus
17beta-estradiol-3-acetate	-	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00025	-	11-Dehydrocorticosterone	pH 7.4, 37°C	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-
adipocyte	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
11-dehydrocorticosterone + NADPH + H+	-	Mus musculus	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH + H+	-	Rattus norvegicus	corticosterone + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
11-oxoreductase	-	Mus musculus
11-oxoreductase	-	Rattus norvegicus
11beta-hydroxysteroid dehydrogenase type 1	-	Mus musculus
11beta-hydroxysteroid dehydrogenase type 1	-	Rattus norvegicus

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Release 2023.1 (January 2023)