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Literature summary for 1.1.1.146 extracted from
- Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes (2006), J. Immunol., 176, 7605-7611.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-dehydrocorticosterone + NADPH | Mus musculus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? |  |
| 11-dehydrocorticosterone + NADPH | Homo sapiens | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
| cortisone + NADPH + H+ | Mus musculus | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? | |
| cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? | |
| additional information | Mus musculus | local amplification of glucocorticoids by isozyme 11beta-HSD1 promotes macrophage phagocytosis of apoptotic leukocytes | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
11beta-HSD1 | - |
| Mus musculus | - |
male C75BL/6 mice, 11beta-HSD1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | activity occurs after differentiation of neutrophils to macrophages | Homo sapiens | - |
| macrophage | derived from bone-marrow, peritoneal macrophages, expression of isozyme 11beta-HSD1, not isozyme 11beta-HSD2 | Mus musculus | - |
| additional information | no activity in polymorphonuclear cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Mus musculus | corticosterone + NADP+ | - |
? | |
| 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Homo sapiens | corticosterone + NADP+ | - |
? | |
| cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Mus musculus | cortisol + NADP+ | - |
? | |
| cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? | |
| additional information | local amplification of glucocorticoids by isozyme 11beta-HSD1 promotes macrophage phagocytosis of apoptotic leukocytes | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11 beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
| 11 beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
| 11beta-HSD1 | - |
Mus musculus |
| 11beta-HSD1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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