EC Number   |
General Information |
Reference |
|---|
   1.1.1.146 | malfunction |
feto-placental deletion of isoform HSD2 results in a reduced birthweight and the development of anxiety- and depression-like behaviours in adult mice. Brain-specific HSD2 removal also generates adult phenotypes of depressive-like behaviour and memory deficits |
762011 |
| 1.1.1.146 | malfunction |
global deletion of isoform 11beta-HSD1 drives an enhanced inflammatory phenotype, characterized by florid synovitis, joint destruction and systemic bone loss. This is associated with increased pannus invasion into subchondral bone, a marked polarisation towards pro-inflammatory M1 macrophages at sites of inflammation and increased osteoclast numbers |
761361 |
| 1.1.1.146 | malfunction |
inhibition of isoform 11beta-HSD1 aggravates the development of atopic dermatitis and increases serum cytokine levels associated with atopic dermatitis. Mice with whole-body knockout of11beta-HSD1 develop significantly worse atopic dermatitis upon induction by oxazolone |
762406 |
| 1.1.1.146 | malfunction |
the inhibition of isoform 11beta-HSD1 attenuates the development of type 2 diabetes mellitus, insulin resistance, metabolic syndrome and other diseases mediated by excessive cortisol production |
761908 |
| 1.1.1.146 | metabolism |
11beta-hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice |
741017 |
| 1.1.1.146 | metabolism |
isoform 11beta-HSD1 controls retinoid-related orphan receptor gamma activity |
761665 |
| 1.1.1.146 | metabolism |
isoform 11beta-HSD2 controls retinoid-related orphan receptor gamma activity |
761665 |
| 1.1.1.146 | metabolism |
prereceptor glucocorticoid metabolism by 11beta-HSD1 is implicated in the pathogenesis of the metabolic syndrome |
761754 |
| 1.1.1.146 | physiological function |
isoform 11beta-HSD1 activity is closely related to osteoblast differentiation |
760900 |
| 1.1.1.146 | physiological function |
isoform 11beta-HSD1 is a major factor affecting atopic dermatitis pathophysiology via suppression of atopic inflammation due to the modulation of active glucocorticoid in the skin |
762406 |
