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Literature summary for 1.1.1.146 extracted from

  • Maser, E.; Wsol, V.; Martin, H.J.
    11beta-Hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics (2006), Mol. Cell. Endocrinol., 248, 34-37.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glycyrrhetinic acid inhibits both 11beta-hydroxysteroid dehydrogenase and carbonyl reductase activities of the enzyme potently Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information the glucocorticoid and xenobiotic reductase activities show cooperative kinetics Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
Homo sapiens 5789
-
microsome
-
Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
2 * 34000, SDS-PAGE Homo sapiens
67400
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH Homo sapiens i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+
-
r
cortisone + NADPH + H+ Homo sapiens isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 cortisol + NADP+
-
r
dehydrocorticosterone + NADPH Homo sapiens isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 corticosterone + NADP+
-
r
additional information Homo sapiens the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate ?
-
?
oracin + NADPH + H+ Homo sapiens a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug dihydrooracin + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from liver microsomes to homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184 Homo sapiens 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+
-
r
cortisone + NADPH + H+ isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 Homo sapiens cortisol + NADP+
-
r
dehydrocorticosterone + NADPH isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 Homo sapiens corticosterone + NADP+
-
r
additional information the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate Homo sapiens ?
-
?
additional information the enzyme shows pluripotent substrate specificity being active as 11beta-hydroxysteroid dehydrogenase, EC 1.1.1.146, and carbonyl reductase, EC 1.1.1.184 Homo sapiens ?
-
?
oracin + NADPH + H+ a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug Homo sapiens dihydrooracin + NADP+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 34000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens
More cf. EC 1.1.1.184 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens