Information on EC 3.4.11.1 - leucyl aminopeptidase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
3.4.11.1
-
RECOMMENDED NAME
GeneOntology No.
leucyl aminopeptidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
release of an N-terminal amino acid, Xaa-/-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low
show the reaction diagram
release of an N-terminal amino acid, Xaa-/-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid mides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide hydrolysis
-
-
hydrolysis of peptide bond
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glutathione metabolism
-
-
Metabolic pathways
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9001-61-0
-
90119-07-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
69-V
-
-
Manually annotated by BRENDA team
cv. Hayward
-
-
Manually annotated by BRENDA team
hyperthermophilic bacterium contains a highly thermostable enzyme
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain NRRL 6270, other strains show low enzyme activity
-
-
Manually annotated by BRENDA team
strains NRRL 1988 and NRRL 6271, other strains show low enzyme activity
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
N2
-
-
Manually annotated by BRENDA team
N2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Pacific oyster, constitutive gene expression
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ixodid tick, parthenogenetic Okayama strain
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Morimus funereus
-
-
-
Manually annotated by BRENDA team
L. cvs. Malviya-36 and Pant-12
-
-
Manually annotated by BRENDA team
red sea bream
-
-
Manually annotated by BRENDA team
; with acute HCV infection
-
-
Manually annotated by BRENDA team
human body louse
-
-
Manually annotated by BRENDA team
kidney bean
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ATCC 12633
-
-
Manually annotated by BRENDA team
Wistar strain
-
-
Manually annotated by BRENDA team
serovar typhimurium
SwissProt
Manually annotated by BRENDA team
incomplete sequence missing 26 N-terminal amino acids
SwissProt
Manually annotated by BRENDA team
rabbitfish
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain RH
-
-
Manually annotated by BRENDA team
strain RH
-
-
Manually annotated by BRENDA team
trout
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
SA1
-
-
Manually annotated by BRENDA team
SA1
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
additional information
-
regulation of the tick molecules involved in nutrient metabolism for the reproduction, including blood digestion and vitellogenesis, would help in controlling the tick population and tick-borne pathogens
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-N-(6-(dimethylamino)pyridin-3-yl)-4-methylpentanamide + H2O
?
show the reaction diagram
-
-
-
-
?
4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl L-leucinate + H2O
L-leucine + 4-[(E)-2-(4-aminophenyl)ethenyl-3-cyano-5,5-dimethylfuran-2(5H)-ylidene]propanedinitrile
show the reaction diagram
-
-
-
-
?
Ala-4-methylcoumaryl-7-amide + H2O
Ala + 7-amino-4-methylcoumarin
show the reaction diagram
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
show the reaction diagram
Ala-4-nitroanilide + H2O
L-alanine + 4-nitroaniline
show the reaction diagram
-
18.7% of activity towards Leu-4-nitroanilide
-
-
?
Ala-Ala-Ala-Ala
?
show the reaction diagram
-
-
-
-
?
Ala-Gly + H2O
Ala + Gly
show the reaction diagram
Ala-Leu + H2O
Ala + Leu
show the reaction diagram
alaninehydrazine
?
show the reaction diagram
-
-
-
-
?
alanyl-7-amido-4-methylcoumarin + H2O
alanine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
amino acid amides + H2O
amino acid + NH3
show the reaction diagram
angiotensin II + H2O
angiotensin IV + ?
show the reaction diagram
-
-
through angiotensin III
?
angiotensin II + H2O
Asp + angiotensin III
show the reaction diagram
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
Arg-4-nitroanilide + H2O
L-arginine + 4-nitroaniline
show the reaction diagram
-
52.5% of activity towards Leu-4-nitroanilide
-
-
?
Arg-Ala + H2O
Arg + Ala
show the reaction diagram
Arg-Ala-Arg + H2O
Arg + Ala-Arg
show the reaction diagram
-
Ala-p-nitroanilide is used as substrate with very low turnover rate
in the assay hydrolysis of Ala-p-nitroanilide is monitored
-
?
Arg-Glu + H2O
Arg + Glu
show the reaction diagram
Arg-Gly + H2O
Arg + Gly
show the reaction diagram
Arg-Gly-Arg + H2O
Arg + Gly-Arg
show the reaction diagram
Arg-Gly-Asp + H2O
Arg + Gly-Asp
show the reaction diagram
Arg-Gly-Gly + H2O
Arg + Gly-Gly
show the reaction diagram
Arg-Gly-Leu + H2O
Arg + Gly-Leu
show the reaction diagram
Arg-Gly-Phe + H2O
Arg + Gly-Phe
show the reaction diagram
Arg-Gly-Ser + H2O
Arg + Gly-Ser
show the reaction diagram
Arg-Ile + H2O
Arg + Ile
show the reaction diagram
Arg-Leu + H2O
Arg + Leu
show the reaction diagram
Arg-Phe + H2O
Arg + Phe
show the reaction diagram
Arg-Ser-Arg + H2O
Arg + Ser-Arg
show the reaction diagram
-
Ala-p-nitroanilide is used as substrate with very low turnover rate
in the assay hydrolysis of Ala-p-nitroanilide is monitored
-
?
Arg-Val + H2O
Arg + Val
show the reaction diagram
Asn-Leu + H2O
Asn + Leu
show the reaction diagram
-
-
?
Asp-Gln + H2O
Asp + Gln
show the reaction diagram
-
-
?
Asp-His + H2O
Asp + His
show the reaction diagram
-
-
?
Asp-Ile-Gly-Gly + H2O
Asp + Ile-Gly-Gly
show the reaction diagram
-
-
?
Asp-Leu + H2O
Asp + Leu
show the reaction diagram
-
-
?
Asp-Leu-Gly + H2O
Asp + Leu-Gly
show the reaction diagram
-
-
?
Asp-Leu-Lys + H2O
Asp + Leu-Lys
show the reaction diagram
-
-
?
Asp-Phe + H2O
Asp + Phe
show the reaction diagram
-
-
?
Asp-Tyr + H2O
Asp + Tyr
show the reaction diagram
-
-
?
benzyl-L-cysteinamide + H2O
?
show the reaction diagram
bimane-S-cysteinylglycine + H2O
?
show the reaction diagram
-
-
-
?
Cys-Gly + H2O
Cys + Gly
show the reaction diagram
Cys-Leu + H2O
Cys + Leu
show the reaction diagram
-
-
?
cysteinyl-bis-glycine + H2O
cysteine + glycine
show the reaction diagram
-
-
-
?
cysteinylglycine + H2O
cysteine + glycine
show the reaction diagram
DL-alpha-amino-acid amide + H2O
D-alpha-amino acid amide + L-alpha-amino acid
show the reaction diagram
-
-
-
-
-
dynorphin A + H2O
?
show the reaction diagram
-
-
-
?
Gln-Leu + H2O
Gln + Leu
show the reaction diagram
-
-
?
Glu-Leu + H2O
Glu + Leu
show the reaction diagram
-
-
?
Gly-Leu + H2O
Gly + Leu
show the reaction diagram
Gly-Phe + H2O
Gly + Phe
show the reaction diagram
Gly-Trp + H2O
Gly + Trp
show the reaction diagram
Gly-Tyr + H2O
Gly + Tyr
show the reaction diagram
Gly-Val + H2O
Gly + Val
show the reaction diagram
-
low activity
-
?
glycine-4-methylcoumaryl-7-amide + H2O
glycine + 7-amino-4-methylcoumarin
show the reaction diagram
-
3.9% activity in comparison to L-leucine-4-methyl-coumaryl-7-amide
-
-
?
hArg-7-amido-4-methylcoumarin + H2O
hArg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
His-Gly + H2O
His + Gly
show the reaction diagram
His-Leu + H2O
His + Leu
show the reaction diagram
Ile-Leu + H2O
Ile + Leu
show the reaction diagram
-
-
?
kallidin + H2O
?
show the reaction diagram
-
-
-
-
?
kallidin + H2O
Leu + bradykinin
show the reaction diagram
-
i.e. LRPPGFSPFR
i.e. RPPGFSPFR
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
show the reaction diagram
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
L-Ala-7-amido-4-trifluoro-methylcoumarin + H2O
L-Ala + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Leu + H2O
L-Ala + L-Leu
show the reaction diagram
-
-
-
?
L-alanine 4-nitroanilide + H2O
L-alanine + 4-nitroaniline
show the reaction diagram
L-alanine-4-methylcoumarin-7-amide + H2O
L-alanine + 7-amino-4-methylcoumarin
show the reaction diagram
L-alanine-4-methylcoumaryl-7-amide + H2O
L-alanine + 7-amino-4-methylcoumarin
show the reaction diagram
L-alanine-4-methylcoumaryl-7-amide + H2O
L-alanine + 7-amino-4-methylcoumarine
show the reaction diagram
-
-
-
?
L-alanyl-4-nitroanilide + H2O
L-alanine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-alanyl-7-amido-4-methylcoumarin + H2O
L-alanine + 7-amino-4-methylcoumarin
show the reaction diagram
L-amino acid-peptide + H2O
amino acid + peptide
show the reaction diagram
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
show the reaction diagram
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
L-Arg-7-amido-4-trifluoro-methylcoumarin + H2O
L-Arg + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
L-arginine-4-methylcoumarin-7-amide + H2O
L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
L-arginine-4-methylcoumaryl-7-amide + H2O
L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
L-arginine-4-methylcoumaryl-7-amide + H2O
L-arginine + 7-amino-4-methylcoumarine
show the reaction diagram
L-arginine-4-nitroanilide + H2O
L-arginine + 4-nitroaniline
show the reaction diagram
-
16.5% activity in comparison to L-leucine-4-nitroanilide
-
-
?
L-arginyl-7-amido-4-methylcoumarin + H2O
L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
L-Cys-7-amido-4-methylcoumarin + H2O
L-Cys + 7-amino-4-methylcoumarin
show the reaction diagram
L-glutamate 4-nitroanilide + H2O
L-glutamate + 4-nitroaniline
show the reaction diagram
L-Gly-7-amido-4-methylcoumarin + H2O
L-Gly + 7-amino-4-methylcoumarin
show the reaction diagram
enzyme shows only weak activity with this substrate
-
-
?
L-His-L-Leu + H2O
L-His + L-Leu
show the reaction diagram
-
-
-
?
L-Ile-4-nitroanilide + H2O
L-Ile + 4-nitroaniline
show the reaction diagram
L-Ile-7-amido-4-methylcoumarin + H2O
L-Ile + 7-amino-4-methylcoumarin
show the reaction diagram
L-Iso-7-amido-4-methylcoumarin + H2O
L-Iso + 7-amino-4-methylcoumarin
show the reaction diagram
enzyme shows only weak activity with this substrate
-
-
?
L-isoleucine 4-nitroanilide + H2O
L-isoleucine + 4-nitroaniline
show the reaction diagram
L-Leu beta-naphthylamide + H2O
L-Leu + beta-naphthylamine
show the reaction diagram
-
-
-
?
L-Leu methyl ester
?
show the reaction diagram
-
-
-
-
?
L-Leu-4-(phenylazo)phenylamide + H2O
L-Leu + 4-(phenylazo)phenylamine
show the reaction diagram
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
show the reaction diagram
L-Leu-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Leu
show the reaction diagram
-
-
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Leu-7-amido-4-trifluoro-methylcoumarin + H2O
L-Leu + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Leu-benzyl ester + H2O
L-Leu + benzylalcohol
show the reaction diagram
-
-
-
-
?
L-Leu-Gly + H2O
L-Leu + Gly
show the reaction diagram
-
-
-
?
L-Leu-hydrazide
?
show the reaction diagram
-
-
-
-
?
L-Leu-L-Arg + H2O
L-Leu + L-Arg
show the reaction diagram
-
-
-
?
L-Leu-L-Asn + H2O
L-Leu + L-Asn
show the reaction diagram
-
-
-
?
L-Leu-L-Asp + H2O
L-Leu + L-Asp
show the reaction diagram
-
low activity
-
?
L-Leu-L-Leu + H2O
L-Leu + L-Leu
show the reaction diagram
-
-
-
?
L-Leu-L-Met + H2O
L-Leu + L-Met
show the reaction diagram
-
-
-
?
L-Leu-L-Phe + H2O
L-Leu + L-Phe
show the reaction diagram
-
-
-
?
L-Leu-L-Ser + H2O
L-Leu + L-Ser
show the reaction diagram
-
-
-
?
L-Leu-L-Tyr + H2O
L-Leu + L-Tyr
show the reaction diagram
-
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
L-Leu-p-nitroanilide + H2O
L-leucine + p-nitroaniline
show the reaction diagram
L-Leu-phenylazophenylamide
?
show the reaction diagram
-
-
-
-
?
L-leucine 4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
L-leucine 4-nitroanilide + H2O
leucine + 4-nitroaniline
show the reaction diagram
L-leucine amide + H2O
L-leucine + NH3
show the reaction diagram
L-leucine hydrazide + H2O
L-leucine + azide
show the reaction diagram
L-leucine-4-methylcoumarin-7-amide + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
L-leucine-4-methylcoumaryl-7-amide + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
L-leucine-4-methylcoumaryl-7-amide + H2O
L-leucine + 7-amino-4-methylcoumarine
show the reaction diagram
L-leucine-4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
L-leucine-7-amido-4-methylcoumarin + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
L-leucine-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-leucine-p-nitroanilide + H2O
L-leucine + p-nitroaniline
show the reaction diagram
L-leucinhydrazide + H2O
L-leucine + H2NNH2
show the reaction diagram
-
-
-
-
?
L-leucyl-2-naphthylamide + H2O
L-leucine + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-leucyl-4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-leucyl-7-amido-4-methylcoumarin + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
L-leucylamide + H2O
L-leucine + NH3
show the reaction diagram
-
-
-
-
?
L-leucylglycine + H2O
L-leucine + glycine
show the reaction diagram
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-lysine-4-methylcoumaryl-7-amide + H2O
L-lysine + 7-amino-4-methylcoumarin
show the reaction diagram
L-lysine-4-nitroanilide + H2O
L-lysine + 4-nitroaniline
show the reaction diagram
-
24.5% activity in comparison to L-leucine-4-nitroanilide
-
-
?
L-lysyl-4-nitroanilide + H2O
L-lysine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-lysyl-7-amido-4-methylcoumarin + H2O
L-lysine + 7-amino-4-methylcoumarin
show the reaction diagram
ERAP2 preferentially hydrolyzes Arg-aminomethylcoumarin and Lys-aminomethylcoumarin
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
show the reaction diagram
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
show the reaction diagram
L-Met-L-Leu + H2O
L-Met + L-Leu
show the reaction diagram
-
-
-
?
L-methionine 4-nitroanilide + H2O
L-methionine + 4-nitroaniline
show the reaction diagram
L-methionine-4-methylcoumaryl-7-amide + H2O
L-methionine + 7-amino-4-methylcoumarin
show the reaction diagram
L-methionine-4-nitroanilide + H2O
L-methionine + 4-nitroaniline
show the reaction diagram
-
29.6% activity in comparison to L-leucine-4-nitroanilide
-
-
?
L-methionyl-4-nitroanilide + H2O
L-methionine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
L-Phe-L-Leu + H2O
L-Phe + L-Leu
show the reaction diagram
-
-
-
?
L-phenylalanine-4-methylcoumarin-7-amide + H2O
L-phenylalanine + 7-amino-4-methylcoumarin
show the reaction diagram
L-phenylalanine-4-methylcoumaryl-7-amide + H2O
L-phenylalanine + 7-amino-4-methylcoumarin
show the reaction diagram
L-phenylalanine-4-methylcoumaryl-7-amide + H2O
L-phenylalanine + 7-amino-4-methylcoumarine
show the reaction diagram
-
-
-
?
L-phenylalanine-4-nitroanilide + H2O
L-phenylalanine + 4-nitroaniline
show the reaction diagram
-
38.8% activity in comparison to L-leucine-4-nitroanilide
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Pro-L-Leu + H2O
L-Pro + L-Leu
show the reaction diagram
-
-
-
?
L-proline-4-methylcoumarin-7-amide + H2O
L-proline + 7-amino-4-methylcoumarin
show the reaction diagram
L-proline-4-methylcoumaryl-7-amide + H2O
L-proline + 7-amino-4-methylcoumarin
show the reaction diagram
-
1.3% activity in comparison to L-leucine-4-methyl-coumaryl-7-amide
-
-
?
L-proline-4-methylcoumaryl-7-amide + H2O
L-proline + 7-amino-4-methylcoumarine
show the reaction diagram
-
-
-
?
L-prolyl-7-amido-4-methylcoumarin + H2O
L-proline + 7-amino-4-methylcoumarin
show the reaction diagram
L-Thr-4-nitroanilide + H2O
L-Thr + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Thr-L-Leu + H2O
L-Thr + L-Leu
show the reaction diagram
-
-
-
?
L-Trp-7-amido-4-methylcoumarin + H2O
L-Trp + 7-amino-4-methylcoumarin
show the reaction diagram
L-Trp-L-Leu + H2O
L-Trp + L-Leu
show the reaction diagram
-
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
6.4% activity compared to L-Leu-7-amido-4-methylcoumarin
-
-
?
L-Tyr-L-Leu + H2O
L-Tyr + L-Leu
show the reaction diagram
-
-
-
?
L-tyrosine-4-methylcoumaryl-7-amide + H2O
L-tyrosine + 7-amino-4-methylcoumarin
show the reaction diagram
-
8.5% activity in comparison to L-leucine-4-methyl-coumaryl-7-amide
-
-
?
L-tyrosine-4-methylcoumaryl-7-amide + H2O
L-tyrosine + 7-amino-4-methylcoumarine
show the reaction diagram
20% activity compared to L-leucyl-4-methylcoumaryl-7-amide
-
-
?
L-tyrosyl-7-amido-4-methylcoumarin + H2O
L-tyrosine + 7-amino-4-methylcoumarin
show the reaction diagram
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
show the reaction diagram
L-Val-7-amido-4-methylcoumarin + H2O
L-Val + 7-amino-4-methylcoumarin
show the reaction diagram
enzyme shows only weak activity with this substrate
-
-
?
L-Val-L-Leu + H2O
L-Val + L-Leu
show the reaction diagram
-
-
-
?
L-valine-4-methylcoumaryl-7-amide + H2O
L-valine + 7-amino-4-methylcoumarin
show the reaction diagram
-
2.3% activity in comparison to L-leucine-4-methyl-coumaryl-7-amide
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Leu-2-naphthylamide + H2O
leucine + 2-naphthylamine
show the reaction diagram
Leu-4-methylcoumaryl-7-amide + H2O
Leu + 7-amino-4-methyl-coumarin
show the reaction diagram
-
-
-
-
?
Leu-4-methylcoumaryl-7-amide + H2O
Leu + 7-amino-4-methylcoumarin
show the reaction diagram
Leu-4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
Leu-4-nitroanilide + H2O
Leu + 4-nitroaniline
show the reaction diagram
Leu-4-trifluoroomethylcoumarin-7-amide + H2O
Leu + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
Leu-7-amido-4-methylcoumarin + H2O
Leu + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Leu-7-amido-4-methylcoumarin + H2O
leucine + 7-amino-4-methylcoumarin
show the reaction diagram
Leu-Arg + H2O
Leu + Arg
show the reaction diagram
Leu-Arg-Pro-Gly + H2O
Leu + Arg-Pro-Gly
show the reaction diagram
-
-
-
-
?
Leu-Asn + H2O
Leu + Asn
show the reaction diagram
Leu-Asp + H2O
Leu + Asp
show the reaction diagram
Leu-enkephalin
?
show the reaction diagram
-
-
-
-
?
Leu-Gly
?
show the reaction diagram
-
-
-
-
?
Leu-Gly + H2O
Leu + Gly
show the reaction diagram
Leu-Gly-Arg-Ser-Gly-Gly-Asp-Ile-Ile-Lys-Lys-Met-Gln-Thr-Leu + H2O
Leu + Gly-Arg-Ser-Gly-Gly-Asp-Ile-Ile-Lys-Lys-Met-Gln-Thr-Leu
show the reaction diagram
-
-
-
-
?
Leu-Gly-Gly
?
show the reaction diagram
Leu-Gly-Gly + H2O
Leu + Gly-Gly
show the reaction diagram
Leu-Gly-Tyr-Leu + H2O
Leu + Gly + Tyr + Leu
show the reaction diagram
-
synthetic peptide substrate, successive release of terminal amino acids with descending activity
-
-
?
Leu-Leu + H2O
Leu + Leu
show the reaction diagram
Leu-Leu-Leu + H2O
Leu + Leu-Leu
show the reaction diagram
-
-
-
-
?
Leu-Met + H2O
Leu + Met
show the reaction diagram
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
show the reaction diagram
Leu-Phe + H2O
Leu + Phe
show the reaction diagram
Leu-Ser + H2O
Leu + Ser
show the reaction diagram
Leu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu + H2O
? + Ile-Asn-Phe-Glu-Lys-Leu
show the reaction diagram
-
-
-
-
?
Leu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu + H2O
? + Ile-Ile-Asn-Phe-Glu-Lys-Leu
show the reaction diagram
-
-
-
-
?
Leu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu + H2O
L-leucine + Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu
show the reaction diagram
-
trimming of further model epitope precursors to antigenic peptides are also tested
-
-
?
Leu-systemin + H2O
Leu + systemin
show the reaction diagram
-
LAP-A1, only in vitro
-
-
?
Leu-Trp + H2O
Leu + Trp
show the reaction diagram
Leu-Tyr + H2O
Leu + Tyr
show the reaction diagram
Leu-Val + H2O
Leu + Val
show the reaction diagram
leucyl-7-amido-4-methylcoumarin + H2O
leucine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
leukotriene D4 + H2O
?
show the reaction diagram
-
low activity
-
?
Lys-4-nitroanilide + H2O
L-lysine + 4-nitroaniline
show the reaction diagram
-
41.9% of activity towards Leu-4-nitroanilide
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
show the reaction diagram
Met-4-methylcoumaryl-7-amide + H2O
Met + 7-amino-4-methyl-coumarin
show the reaction diagram
-
-
-
-
?
Met-4-nitroanilide + H2O
Met + 4-nitroaniline
show the reaction diagram
Met-Gly + H2O
Met + Gly
show the reaction diagram
-
-
?
Met-Leu + H2O
Met + Leu
show the reaction diagram
N-(6-methoxy-2-methylpyridin-3-yl),(S)-2-amino-4-methylpentanamide + H2O
?
show the reaction diagram
-
-
-
-
?
N-(6-methoxy-2-methylpyridin-3-yl)-(S)-2-amino-4-methylpentanamide + H2O
?
show the reaction diagram
-
-
-
-
?
N-(6-methoxypyridin-3-yl)-(S)-2-amino-4-methylpentanamide + H2O
?
show the reaction diagram
-
-
-
-
?
N-(tert-butoxycarbonyl)-L-leucine + H2O
?
show the reaction diagram
-
-
-
-
?
N-succinyl-L-Leu-4-nitroanilide + H2O
N-succinyl-L-Leu + 4-nitroaniline
show the reaction diagram
Neurokinin A + H2O
?
show the reaction diagram
-
-
-
?
Neuromedin B + H2O
?
show the reaction diagram
-
-
-
?
Phe-4-methylcoumaryl-7-amide + H2O
Phe + 7-amino-4-methyl-coumarin
show the reaction diagram
-
-
-
-
?
Phe-4-methylcoumaryl-7-amide + H2O
Phe + 7-amino-4-methylcoumarin
show the reaction diagram
Phe-Gly + H2O
Phe + Gly
show the reaction diagram
Phe-Leu + H2O
Phe + Leu
show the reaction diagram
Phg-7-amido-4-methylcoumarin + H2O
Phg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
phosphatidylinositol-dependent kinase-1 + H2O
?
show the reaction diagram
Pro-4-methylcoumaryl-7-amide + H2O
Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Pro-4-nitroanilide + H2O
Pro + 4-nitroaniline
show the reaction diagram
-
30% of the activity with Leu-4-nitroanilide
-
-
?
Pro-Leu + H2O
Pro + Leu
show the reaction diagram
Proteins + H2O
?
show the reaction diagram
S-nitrosocysteinylglycine + H2O
S-nitrosocysteine + glycine
show the reaction diagram
-
-
-
?
Ser-Gly + H2O
Ser + Gly
show the reaction diagram
-
-
?
Ser-Leu + H2O
Ser + Leu
show the reaction diagram
-
-
?
Thr-Leu + H2O
Thr + Leu
show the reaction diagram
Trp-Leu + H2O
Trp + Leu
show the reaction diagram
Tyr-Gly + H2O
Tyr + Gly
show the reaction diagram
Tyr-Leu + H2O
Tyr + Leu
show the reaction diagram
Val-Gly + H2O
Val + Gly
show the reaction diagram
Val-Leu + H2O
Val + Leu
show the reaction diagram
additional information
?
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