Literature summary for 3.4.11.1 extracted from

Albrecht, S.; Defoin, A.; Salomon, E.; Tarnus, C.; Wetterholm, A.; Haeggstroem, J.Z.
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors (2006), Bioorg. Med. Chem., 14, 7241-7257.

Search for more literature for 3.4.11.1

Inhibitors

Inhibitors	Comment	Organism	Structure
2-amino-1,4-dihydro-2-isoquinolin-3-one	-	Bos taurus
3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid	-	Bos taurus
3-amino-2-tetralone	-	Bos taurus
bestatin	-	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Bos taurus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-leucine-p-nitroanilide + H2O	-	Bos taurus	L-Leu + p-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
LAPc	-	Bos taurus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.01	-	3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid	-	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000005	-	-	Bos taurus	bestatin
0.12	-	-	Bos taurus	3-amino-2-tetralone
1	-	-	Bos taurus	2-amino-1,4-dihydro-2-isoquinolin-3-one

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Release 2023.1 (January 2023)