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Literature summary for 3.4.11.1 extracted from

  • Skinner-Adams, T.S.; Lowther, J.; Teuscher, F.; Stack, C.M.; Grembecka, J.; Mucha, A.; Kafarski, P.; Trenholme, K.R.; Dalton, J.P.; Gardiner, D.L.
    Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds (2007), J. Med. Chem., 50, 6024-6031.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum the enzyme functions in the terminal stages of hemoglobin digestion ?
-
 ?
additional information Plasmodium falciparum M17 the enzyme functions in the terminal stages of hemoglobin digestion ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-
Plasmodium falciparum M17
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme functions in the terminal stages of hemoglobin digestion Plasmodium falciparum ?
-
 ?
additional information the enzyme functions in the terminal stages of hemoglobin digestion Plasmodium falciparum M17 ?
-
 ?

Synonyms

Synonyms Comment Organism
PfLAP
-
 Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000025
-
 bestatin recombinant enzyme Plasmodium falciparum