Information on EC 3.4.24.86 - ADAM 17 endopeptidase

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The expected taxonomic range for this enzyme is: Eutheria

EC NUMBER
COMMENTARY
3.4.24.86
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RECOMMENDED NAME
GeneOntology No.
ADAM 17 endopeptidase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains
show the reaction diagram
proTNF-alpha + H2O = soluble TNF-alpha. Cleavage of the precursor of tumor necrosis factor proTNFalpha to the mature tumor necrosis factor TNF-alpha, Swiss-Prot Acesssion Numbers: P78536(human), Q77636(pig), Q9Z1K9(rat), Q9Z0F8(mouse), Q923X3(chinese hamster). In peptidase family M12. In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNFa, which induces inflammation.
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(TACE/ADAM17/CD156q)
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(TACE:ADAM17)
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a disintegrin and metalloprotease 17
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a disintegrin and metalloprotease 17
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ADAM-17
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ADAM17 proteinase
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ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme
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ADAMTS-2
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CD156
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H-TACE
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human TACE B
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metalloprotease TACE
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metalloprotease-disintegrin tumour necrosis factor alpha convertase
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metalloproteinase ADAM17
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pro tumor necrosis factor cleavage enzyme
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pro-tumor necrosis factor-alpha-processing enzyme
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proteinase, pro-tumor necrosis factor (9CI)
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sheddase
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TACE
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TACE proteinase
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TACE/ADAM17
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TACE/ADAM17
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TNF-alpha convertase
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TNF-alpha converting enzyme
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TNF-alpha converting enzyme
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TNF-alpha converting enzyme
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TNF-alpha converting enzyme
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TNF-alpha processing protease
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tumor necrosis factor alpha convertase
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tumor necrosis factor alpha converting enzyme
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tumor necrosis factor alpha converting enzyme
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tumor necrosis factor alpha-converting enzyme
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tumor necrosis factor alpha-converting enzyme
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tumor necrosis factor alpha-converting enzyme
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tumor necrosis factor-alpha converting enzyme
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tumor necrosis factor-alpha converting enzyme
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tumor necrosis factor-alpha converting enzyme
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tumor necrosis factor-alpha converting enzyme
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tumor necrosis factor-alpha converting enzyme
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tumor necrosis factor-alpha-converting enzyme
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tumor necrosis factor-alpha-converting enzyme
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tumour necrosis factor alpha-converting enzyme
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tumour necrosis factor alpha-converting enzyme
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CAS REGISTRY NUMBER
COMMENTARY
151769-16-3
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
african green monkey, COS-7, an SV40 transformed kidney cell line
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Manually annotated by BRENDA team
chinese hamster, fragment
SwissProt
Manually annotated by BRENDA team
tumor necrosis factor-alpha-converting enzyme
SwissProt
Manually annotated by BRENDA team
tumor necrosis factor-alpha-converting enzyme mutant variant M1
SwissProt
Manually annotated by BRENDA team
tumor necrosis factor-alpha-converting enzyme mutant variant M2a; tumor necrosis factor-alpha-converting enzyme mutant variant M2b
Q6W3F6
SwissProt
Manually annotated by BRENDA team
accession number for cytoplasmic domain coding sequence
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Manually annotated by BRENDA team
HEK293 cells
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Manually annotated by BRENDA team
HEK293 cells; human monocytic cell line THP-1; SH-SY5Y
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Manually annotated by BRENDA team
HeLa cells; human
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Manually annotated by BRENDA team
HeLa cells; human; human monocytic cell line THP-1
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Manually annotated by BRENDA team
human monocytic cell line THP-1
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Manually annotated by BRENDA team
human; human monocytic cell line THP-1
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Manually annotated by BRENDA team
human; MonoMac 6 cells
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Manually annotated by BRENDA team
HUVECs
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Manually annotated by BRENDA team
MonoMac 6 cells
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Manually annotated by BRENDA team
MonoMac 6 cells; Ntera2/cl.D1, human embryonal carcinoma cell line
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Manually annotated by BRENDA team
recombinant
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Manually annotated by BRENDA team
BAC-1.2F5 immortalized by transfection with replication-deficient SV40 DNA; Dexter-ras-myc cell line
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Manually annotated by BRENDA team
EC-2, clonal Ras/Myc-immortalized fibroblast cell line; mouse
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Manually annotated by BRENDA team
mouse; strain 129, strain C57Bl/6 chimaera/ly9.l-
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Manually annotated by BRENDA team
mouse; strain AC2/G3
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Manually annotated by BRENDA team
mouse; strain C3H/HEN
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Manually annotated by BRENDA team
mouse; wild-type EC-4
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Manually annotated by BRENDA team
Mus musculus AC2/G3
strain AC2/G3
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Manually annotated by BRENDA team
Mus musculus C3H/HEN
strain C3H/HEN
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Manually annotated by BRENDA team
Mus musculus EC-4
wild-type EC-4
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Manually annotated by BRENDA team
female, Lewis
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Manually annotated by BRENDA team
immature Sprague Dawley
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Manually annotated by BRENDA team
rat; strain Lewis
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Manually annotated by BRENDA team
Rattus norvegicus Lewis
strain Lewis
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team