Literature summary for 1.4.3.13 extracted from

Rodriguez, C.; Alcudia, J.F.; Martinez-Gonzalez, J.; Raposo, B.; Navarro, M.A.; Badimon, L.
Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction (2008), Atherosclerosis, 196, 558-564.

Search for more literature for 1.4.3.13

Inhibitors

Inhibitors	Comment	Organism	Structure
TNFalpha	TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity	Bos taurus
TNFalpha	TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and decreases endothelial LOX enzymatic activity	Homo sapiens
TNFalpha	TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity	Rattus norvegicus
TNFalpha	TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	-	Rattus norvegicus	-
aortic endothelial cell	-	Sus scrofa	-
aortic endothelial cell	-	Bos taurus	-
BAEC cell	-	Bos taurus	-
HUVEC cell	-	Homo sapiens	-
porcine aortic endothelial cell	-	Sus scrofa	-
umbilical vein endothelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
peptidyl-L-lysyl-peptide + O2 + H2O	-	Homo sapiens	peptidyl-allysyl-peptide + NH3 + H2O2	-	?
peptidyl-L-lysyl-peptide + O2 + H2O	-	Rattus norvegicus	peptidyl-allysyl-peptide + NH3 + H2O2	-	?
peptidyl-L-lysyl-peptide + O2 + H2O	-	Sus scrofa	peptidyl-allysyl-peptide + NH3 + H2O2	-	?
peptidyl-L-lysyl-peptide + O2 + H2O	-	Bos taurus	peptidyl-allysyl-peptide + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
LOX	-	Homo sapiens
LOX	-	Rattus norvegicus
LOX	-	Sus scrofa
LOX	-	Bos taurus
lysyl oxidase	-	Homo sapiens
lysyl oxidase	-	Rattus norvegicus
lysyl oxidase	-	Sus scrofa
lysyl oxidase	-	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)