Information on EC 3.4.21.37 - leukocyte elastase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.4.21.37
-
RECOMMENDED NAME
GeneOntology No.
leukocyte elastase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins, including elastin. Preferential cleavage Val-/- > Ala-/-
show the reaction diagram
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
peptides
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CAS REGISTRY NUMBER
COMMENTARY hide
9004-06-2
eastase
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
-
Manually annotated by BRENDA team
C57BL/6 mice
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(VGVAPG)2V + H2O
VGVAPGVGV + APGV + VGVAPG + VGVAPGV
show the reaction diagram
-
human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent
-
-
?
(VGVAPG)3V + H2O
VGVAPGVGV + APGVGVAPGV + VGVAPGVGVAPGVGV + APGV + VGVAPG + VGVAPGVGVAPGV + GVAPGV
show the reaction diagram
-
human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent
-
-
?
2-(chloroacetyl)-3-naphthoic acid o-toluidide + H2O
?
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-APEEIMDQQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APEEI + MDQQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is 136times greater for neutrophil elastase than for proteinase 3
-
-
?
2-aminobenzoyl-APEEIMDRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APEEI + MDRQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is 47times greater for neutrophil elastase than for proteinase 3
-
-
?
2-aminobenzoyl-APEEIMDRYQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APEEI + MDRYQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is 30times greater for neutrophil elastase than for proteinase 3
-
-
?
2-aminobenzoyl-APEEIMDYQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APEEI + MDYQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is 114times greater for neutrophil elastase than for proteinase 3
-
-
?
2-aminobenzoyl-APEEIMPRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APEEI + MPRQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is over 11times greater for neutrophil elastase than for proteinase 3
-
-
?
2-aminobenzoyl-APEEIMRRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APEEI + MRRQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is over 500times greater for neutrophil elastase than for proteinase 3
-
-
?
4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-APEEIMDDQ-ethylene diamine 2,4 dinitrophenyl + H2O
2-aminobenzoyl-APEEI + MDDQ-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
kcat/Km is 45times greater for neutrophil elastase than for proteinase 3
-
-
?
Abz-QPMAVVQSVPQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
acetyl-Ala-Ala-Ala-p-nitroanilide + H2O
?
show the reaction diagram
acetyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
acetyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
acetyl-Ala-Ala-Pro-Val + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-L-Phe-2-naphthyl ester + H2O
acetyl-L-Phe + 2-naphthol
show the reaction diagram
-
-
-
-
?
alpha1-PI + H2O
?
show the reaction diagram
-
important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis
-
-
?
annexin 1 + H2O
?
show the reaction diagram
antithrombin + H2O
?
show the reaction diagram
Antithrombin III + H2O
?
show the reaction diagram
degradation
-
-
?
APG(VGVAPG)2 + H2O
APGVGV + APGVAPGV + APGVGVAPGVGV + APGVGVAPG + APGV + VGVAPGV
show the reaction diagram
-
human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent
-
-
?
azocasein + H2O
?
show the reaction diagram
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-
-
-
?
benzyloxycarbonyl-Ala-3-hydroxy-5-phenylpyrrole + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Ala-4-nitrophenol + H2O
benzyloxycarbonyl-Ala + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-Ala 2-naphthyl ester + H2O
benzyloxycarbonyl-Ala + 2-naphthol
show the reaction diagram
-
-
-
-
?
Bovine serum albumin + H2O
?
show the reaction diagram
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-
-
-
?
BP180/type XVII collagen + H2O
peptide p561 + peptide p506
show the reaction diagram
-
neutrophil elastase degrades recombinant mouse BP180 within the immunodominant extracellular domain at amino acid positions 506 and 561
-
-
?
Cartilage proteoglycan + H2O
?
show the reaction diagram
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-
-
-
?
CD2 + H2O
?
show the reaction diagram
-
CD2 on peripheral blood T lymphocytes
-
-
?
CD4 + H2O
?
show the reaction diagram
-
CD4 on peripheral blood T lymphocytes
-
-
?
CD8 + H2O
?
show the reaction diagram
-
CD8 on peripheral blood T lymphocytes
-
-
?
coagulation factor V + H2O
?
show the reaction diagram
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-
-
-
?
coagulation factor VIII + H2O
?
show the reaction diagram
-
-
-
-
?
coagulation factor XI + H2O
?
show the reaction diagram
-
-
-
-
?
coagulation factor XIII + H2O
?
show the reaction diagram
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-
-
-
?
Collagen + H2O
?
show the reaction diagram
Collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
collagenase + H2O
?
show the reaction diagram
-
-
-
-
?
complement factor C3 + H2O
?
show the reaction diagram
-
-
-
-
?
complement factor C5 + H2O
?
show the reaction diagram
-
-
-
-
?
complement receptor + H2O
?
show the reaction diagram
-
-
-
-
?
corticosteroid-binding globulin + H2O
?
show the reaction diagram
Cut homeobox 1 + H2O
?
show the reaction diagram
-
-
-
-
?
elafin + H2O
?
show the reaction diagram
Elastin + H2O
?
show the reaction diagram
EMILIN1 + H2O
?
show the reaction diagram
-
-
-
-
?
Factor VIIIa + H2O
?
show the reaction diagram
-
neutrophil elastase inactivates factor VIIIa. The enzyme proteolyses the heavy chain of factor VIIIa into two terminal products, A11-358 and A2375-708, by limited proteolysis at Val358, Val374, and Val708
-
-
?
Fibrin + H2O
?
show the reaction diagram
Fibrinogen + H2O
?
show the reaction diagram
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
G-CSF receptor + H2O
?
show the reaction diagram
Gelatinase + H2O
?
show the reaction diagram
-
-
-
-
?
gp120 protein + H2O
?
show the reaction diagram
-
-
-
-
?
GW475151 + H2O
?
show the reaction diagram
-
-
-
-
?
histone H1 + H2O
?
show the reaction diagram
-
-
-
-
?
histone H2A ending on Val114 + H2O
VTIAQGGVLPNIQAV + ?
show the reaction diagram
-
-
-
-
?
histone H4 + H2O
?
show the reaction diagram
-
-
-
-
?
human IgG3 + H2O
?
show the reaction diagram
-
-
-
-
?
human SP-D protein + H2O
SP-D protein peptide fragments
show the reaction diagram
IgA + H2O
?
show the reaction diagram
-
involved in the regulation of inflammation by a feedback mechanism, elastase treated IgA preparations are unable to induce oxidative burst of polymorphonuclear leukocytes
protein cleaved in the hinge region
-
?
IgG + H2O
?
show the reaction diagram
-
involved in the regulation of inflammation by a feedback mechanism, elastase treated IgG preparations are unable to induce oxidative burst of polymorphonuclear leukocytes
protein cleaved in the hinge region
-
?
immunoglobulin A + H2O
?
show the reaction diagram
-
-
-
-
?
immunoglobulin G + H2O
?
show the reaction diagram
-
-
-
-
?
immunoglobulin M + H2O
?
show the reaction diagram
-
-
-
-
?
insulin receptor substrate-1 + H2O
?
show the reaction diagram
-
-
-
-
?
intercellular adesion molecule-1 + H2O
?
show the reaction diagram
-
-
-
-
?
intercellular adhesion molecule-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-6 + H2O
?
show the reaction diagram
-
-
-
-
?
IpaB protein + H2O
?
show the reaction diagram
-
neutrophil elastase cleaves IpaB protein after alanine, valine, isoleucine, or threonine residues
-
-
?
kininogen + H2O
?
show the reaction diagram
-
-
-
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
laminin-332 + H2O
?
show the reaction diagram
-
neutrophil elastase shows the greatest activity toward the gamma2 chain of laminin-332, in addition, neutrophil elastase cleaves a synthetic peptide derived from the region of human laminin gamma2 containing the matrix metalloproteinase-2 cleavage site, suggesting that neutrophil elastase may generate laminin-332 fragments that are also promigratory
-
-
?
lung surfactant + H2O
?
show the reaction diagram
-
-
-
-
?
MAAPV-p-nitroanilide + H2O
MAAPV + p-nitroaniline
show the reaction diagram
-
-
-
-
?
major outer membrane protein F + H2O
?
show the reaction diagram
-
-
-
-
?
matrix metalloprotease 9 + H2O
matrix metalloprotease 9 peptide fragments
show the reaction diagram
-
i.e. MMP-9, neutrophil elastase cleaves and activates at two specific cleavage sites, between Val38 and Ala39, and between Ala 39 and Glu40
-
-
?
matrix metalloproteinase-7 + H2O
?
show the reaction diagram
-
human leukocyte elastase may be a natural inactivator of matrix metalloproteinase-7 which can counteract matrix metalloproteinase-7-induced apoptosis resistance
-
-
?
methoxysuccinyl-Ala-Ala-Pro-Ala-4-nitroanilide
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Ala-Pro-Ala-thiobenzyl ester
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Ala-Pro-Met-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Ala-Pro-Val-4-methylcoumarin 7-amide + H2O
methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
show the reaction diagram
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
?
show the reaction diagram
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
show the reaction diagram
methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin + H2O
methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Ala-Pro-Val-thiobenzyl ester
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Ile-Pro-Met-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Pro-Ala-4-nitroanilide
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Pro-Ala-thiobenzyl ester
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Pro-Val-4-nitroanilide
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Ala-Pro-Val-thiobenzyl ester
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Pro-Val-4-nitroanilide
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Pro-Val-thiobenzyl ester
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Val-4-nitroanilide
methoxysuccinyl-Val + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Val-thiobenzyl ester
?
show the reaction diagram
-
-
-
-
?
mucin + H2O
?
show the reaction diagram
N-(4-(4-morpholinylcarbonyl)benzoyl)-Val-Pro-Ile + H2O
?
show the reaction diagram
-
-
-
-
?
N-methoxy-succinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
N-methoxy-succinyl-Ala-Ala-Pro-Val + 4-nitroaniline
show the reaction diagram
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
show the reaction diagram
N-methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin + H2O
N-methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val-4-nitroanilide + H2O
N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val-7-amido-4-methylcoumarin + H2O
N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-succinyl-Ala-Ala-Ala 4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
show the reaction diagram
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-methoxysuccinyl-Ala-Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-Ala-Ala-Val 4-nitroanilide + H2O
N-succinyl-Ala-Ala-Val + 4-nitroaniline
show the reaction diagram
Nalpha-methoxysuccinyl-Nepsilon-2-picolinoyl-L-lysinyl-L-Ala-L-Pro-L-Val 4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
-
native type I collagen + H2O
3/4 length fragments similar in size to those produced by interstitial collagenase
show the reaction diagram
-
human, bovine and rat type I collagen, the enzyme can cleave native type I collagen in the helix
-
?
o-aminobenzoic acid-Ala-Pro-Glu-Glu-Ile-Met-Asp-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-Pro-Glu-Val-Lys-Phe-Asn-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Gly-Ile-Ala-Thr-Phe-Cys-Met-Leu-Met-Pro-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Ile-Val-Ser-Ala-Arg-Met-Ala-Pro-Glu-Glu-Ile-Ile-Met-Asp-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Met-Met-Arg-Cys-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Thr-Phe-Cys-Met-Leu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Val-Ala-Asp-Cys-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Val-Ala-Glu-Cys-Cys-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoic acid-Val-Ser-Ala-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
OMTKY3a + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized B chain of insulin + H2O
?
show the reaction diagram
oxytalan fibre + H2O
?
show the reaction diagram
-
the elastase degrades the interfibrillar substances in the periodontal ligament and exposed individual collagen fibrils but not the collagen fibers of the transverse sections of rat mandibular first molars
-
-
?
plasminogen + H2O
?
show the reaction diagram
-
-
-
-
?
plasminogen + H2O
miniplasminogen + ?
show the reaction diagram
-
-
-
-
?
plasminogen activator inhibitor type-1 + H2O
?
show the reaction diagram
-
-
-
-
?
platelet IIb/IIIa receptor + H2O
?
show the reaction diagram
-
-
-
-
?
procarboxypeptidase R + H2O
carboxypeptidase R + ?
show the reaction diagram
-
generation of activated carboxypeptidase R from procarboxypeptidase R by elastase from activated neutrophils at the site of inflammation should contribute to the suppression of excessive inflammation and any abnormality in this mechanism can induce serious hyper-inflammation such as seen in multiple organ failure
-
-
?
progranulin + H2O
?
show the reaction diagram
-
-
-
-
?
progranulin + H2O
granulin + ?
show the reaction diagram
-
-
-
-
?
Protein + H2O
?
show the reaction diagram
-
enzyme capable of degrading proteins of the lung extracellular matrix in vitro
-
-
?
protein C + H2O
small peptides
show the reaction diagram
proteinase-activated receptor 2 N-terminus + H2O
GPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSAS + VLTGKLTTVFLP
show the reaction diagram
-
-
-
-
?
Proteoglycan + H2O
?
show the reaction diagram
secretory leucoprotease inhibitor + H2O
?
show the reaction diagram
secretory leukocyte protease inhibitor + H2O
?
show the reaction diagram
-
-
-
-
?
SLPI + H2O
?
show the reaction diagram
-
important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis
-
-
?
SP-D protein + H2O
SP-D protein peptide fragments
show the reaction diagram
succinyl-Ala-Ala-Ala-p-nitroanilide + H2O
succinyl-Ala-Ala-Ala + p-nitroaniline
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-NH-4-nitroanilide + H2O
succinyl-Ala-Ala-NH2 + 4-nitroaniline
show the reaction diagram
succinyl-Tyr-Leu-Val-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
syndecan-1 + H2O
?
show the reaction diagram
-
the heparan sulfate moiety of shed syndecan-1 binds and restricts neutrophil elastase from inhibition by alpha-1-antitrypsin
-
-
?
tert-butyloxycarbonyl-Ala-2-naphthyl ester + H2O
tert-butyloxycarbonyl-Ala + 2-naphthol
show the reaction diagram
-
-
-
-
?
tert-butyloxycarbonyl-Ala-4-nitrophenyl ester + H2O
tert-butyloxycarbonyl-Ala + 4-nitrophenol
show the reaction diagram
tert-butyloxycarbonyl-Val-4-nitrophenyl ester + H2O
tert-butyloxycarbonyl-Val + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
thrombomodulin + H2O
?
show the reaction diagram
-
-
-
-
?
tissue inhibitor of metalloprotease + H2O
?
show the reaction diagram
-
-
-
-
?
tissue inhibitor of metalloprotease-1 + H2O
tissue inhibitor of metalloprotease-1 peptide fragments
show the reaction diagram
-
i.e. TIMP-1, neutrophil elastase degrades TIMP-1 and cleaves between Val69-Cys70
-
-
?
tissue necrosis factor alpha + H2O
?
show the reaction diagram
-
-
-
-
?
tosyl-Ala-3-hydroxy-5-phenylpyrrole + H2O
?
show the reaction diagram
-
-
-
-
?
tosyl-Ala-4-nitrophenol + H2O
tosyl-Ala + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
tropoelastin + H2O
?
show the reaction diagram
-
-
-
-
?
VAPGVGVAPGV + H2O
VAPGVGV + APGV + VAPGV + GVAPGV
show the reaction diagram
-
human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent
-
-
?
H2 heavy chain of inter-alpha-trypsin inhibitor + H2O
additional information
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha1-PI + H2O
?
show the reaction diagram
-
important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis
-
-
?
annexin 1 + H2O
?
show the reaction diagram
-
annexin 1 is externalized and truncated upon adhesion of polymorphonuclear leukocytes to endothelial cells, annexin 1 participates in regulating leukocyte emigration into inflamed tissue through N-terminal peptides generated at inflammatory sites, overview
-
-
?
Antithrombin III + H2O
?
show the reaction diagram
P08246
degradation
-
-
?
BP180/type XVII collagen + H2O
peptide p561 + peptide p506
show the reaction diagram
-
neutrophil elastase degrades recombinant mouse BP180 within the immunodominant extracellular domain at amino acid positions 506 and 561
-
-
?
coagulation factor V + H2O
?
show the reaction diagram
-
-
-
-
?
coagulation factor VIII + H2O
?
show the reaction diagram
-
-
-
-
?
coagulation factor XI + H2O
?
show the reaction diagram
-
-
-
-
?
coagulation factor XIII + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
Collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
collagenase + H2O
?
show the reaction diagram
-
-
-
-
?
complement factor C3 + H2O
?
show the reaction diagram
-
-
-
-
?
complement factor C5 + H2O
?
show the reaction diagram
-
-
-
-
?
complement receptor + H2O
?
show the reaction diagram
-
-
-
-
?
corticosteroid-binding globulin + H2O
?
show the reaction diagram
-
cleavage by neutrophil elastase destroys ligand binding capacity and supposedly liberates cortisol at sites of inflammation. Enzyme activity on wild-type and mutant CBG serpin recombinantly produced by 293-EBNA cells, overview. CBG mutant G335V is more sensitive for elastase cleavage, while CBG mutant T342A is more resistant to elastase cleavage
-
-
?
elafin + H2O
?
show the reaction diagram
Elastin + H2O
?
show the reaction diagram
EMILIN1 + H2O
?
show the reaction diagram
-
-
-
-
?
Factor VIIIa + H2O
?
show the reaction diagram
-
neutrophil elastase inactivates factor VIIIa. The enzyme proteolyses the heavy chain of factor VIIIa into two terminal products, A11-358 and A2375-708, by limited proteolysis at Val358, Val374, and Val708
-
-
?
Fibrin + H2O
?
show the reaction diagram
Fibrinogen + H2O
?
show the reaction diagram
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
G-CSF receptor + H2O
?
show the reaction diagram
-
neutrophil elastase proteolytically cleaves the G-CSF receptor, G-CSFR, a transmembrane protein, in its extracellular region on neutrophils and blocks G-CSFR-mediated granulopoiesis in vitro, and growth of neutrophils and monocytes, CFU-GM, overview
-
-
?
Gelatinase + H2O
?
show the reaction diagram
-
-
-
-
?
gp120 protein + H2O
?
show the reaction diagram
-
-
-
-
?
histone H1 + H2O
?
show the reaction diagram
-
-
-
-
?
histone H2A ending on Val114 + H2O
VTIAQGGVLPNIQAV + ?
show the reaction diagram
-
-
-
-
?
histone H4 + H2O
?
show the reaction diagram
-
-
-
-
?
human SP-D protein + H2O
SP-D protein peptide fragments
show the reaction diagram
-
cleavage in the lungs of the cystic fibrosis human host, but not in helathy human hosts
cleavage product identification by N-terminal sequencing, overview
-
?
IgA + H2O
?
show the reaction diagram
-
involved in the regulation of inflammation by a feedback mechanism, elastase treated IgA preparations are unable to induce oxidative burst of polymorphonuclear leukocytes
protein cleaved in the hinge region
-
?
IgG + H2O
?
show the reaction diagram
-
involved in the regulation of inflammation by a feedback mechanism, elastase treated IgG preparations are unable to induce oxidative burst of polymorphonuclear leukocytes
protein cleaved in the hinge region
-
?
immunoglobulin A + H2O
?
show the reaction diagram
-
-
-
-
?
immunoglobulin G + H2O
?
show the reaction diagram
-
-
-
-
?
immunoglobulin M + H2O
?
show the reaction diagram
-
-
-
-
?
insulin receptor substrate-1 + H2O
?
show the reaction diagram
-
-
-
-
?
intercellular adhesion molecule-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-6 + H2O
?
show the reaction diagram
-
-
-
-
?
IpaB protein + H2O
?
show the reaction diagram
-
neutrophil elastase cleaves IpaB protein after alanine, valine, isoleucine, or threonine residues
-
-
?
kininogen + H2O
?
show the reaction diagram
-
-
-
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
lung surfactant + H2O
?
show the reaction diagram
-
-
-
-
?
major outer membrane protein F + H2O
?
show the reaction diagram
-
-
-
-
?
mucin + H2O
?
show the reaction diagram
-
proteolysis of mucin is suggested to be involved in cell damaging processes during chronic infection and inflammation of the respiratory tract
-
-
?
oxytalan fibre + H2O
?
show the reaction diagram
-
the elastase degrades the interfibrillar substances in the periodontal ligament and exposed individual collagen fibrils but not the collagen fibers of the transverse sections of rat mandibular first molars
-
-
?
plasminogen + H2O
?
show the reaction diagram
-
-
-
-
?
plasminogen + H2O
miniplasminogen + ?
show the reaction diagram
-
-
-
-
?
plasminogen activator inhibitor type-1 + H2O
?
show the reaction diagram
-
-
-
-
?
platelet IIb/IIIa receptor + H2O
?
show the reaction diagram
-
-
-
-
?
procarboxypeptidase R + H2O
carboxypeptidase R + ?
show the reaction diagram
-
generation of activated carboxypeptidase R from procarboxypeptidase R by elastase from activated neutrophils at the site of inflammation should contribute to the suppression of excessive inflammation and any abnormality in this mechanism can induce serious hyper-inflammation such as seen in multiple organ failure
-
-
?
progranulin + H2O
?
show the reaction diagram
-
-
-
-
?
progranulin + H2O
granulin + ?
show the reaction diagram
-
-
-
-
?
protein C + H2O
small peptides
show the reaction diagram
-
the enzyme splits protein C in vitro and also in vivo degradation of protein C may take place
-
?
proteinase-activated receptor 2 N-terminus + H2O
GPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSAS + VLTGKLTTVFLP
show the reaction diagram
-
-
-
-
?
Proteoglycan + H2O
?
show the reaction diagram
secretory leucoprotease inhibitor + H2O
?
show the reaction diagram
-
i.e. SLPI, SLPI is cleaved and inactivated by neutrophil elastase in cystic fibrosis lungs
-
-
?
SLPI + H2O
?
show the reaction diagram
-
important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis
-
-
?
SP-D protein + H2O
SP-D protein peptide fragments
show the reaction diagram
-
no activity in healthy lungs, but in 50% of cystic fibrosis patient lungs
cleavage product identification by N-terminal sequencing, overview
-
?
thrombomodulin + H2O
?
show the reaction diagram
-
-
-
-
?
tissue inhibitor of metalloprotease + H2O
?
show the reaction diagram
-
-
-
-
?
tissue necrosis factor alpha + H2O
?
show the reaction diagram
-
-
-
-
?
tropoelastin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((6R,7S)-2-{[(2S)-2-(dihydroxymethyl)pyrrolidin-1-yl]carbonyl}-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl acetate
-
-
(-)-epigallocatechin-3-gallate
-
-
(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl 2,6-dichlorobenzoate
-
-
(1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-ethylcarbamoyl}-ethyl)-carbamic acid benzyl ester
-
-
(1-{2-[1-(4,5-Dihydro-oxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester
-
(
(1-{2-[1-(Benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester
-
-
(1-{2-[1-(Benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester
-
-
(1-{2-[2-(3,3-Difluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-carbamic acid benzyl ester
-
-
(1-{[1-(2-tert-Butoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-2-methyl-propyl)-phosphonic acid diphenyl ester
-
-
(2-(3,5-bis-trifluoromethyl-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(3,5-difluoro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-amino-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-chloro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-formylamino-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-methoxy-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-(4-nitro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-cyclohexyl-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(2-isopropyl-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(22E,24R)-ergosta-7,22-dien-2alpha,3alpha,9alpha-triol
-
-
(2S)-1-({(6R,7S)-3-[(acetyloxy)methyl]-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)pyrrolidine-2-carboxylic acid
-
-
(3-methylindazol-1-yl)-m-tolyl-methanone
-
-
(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide
-
-
(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide 3-O-beta-D-glucoside
-
-
(3R)-1-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-3-carboxylic acid
-
-
(3S)-1-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-3-carboxylic acid
-
-
(4-tert-butyl-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl 2,6-dichlorobenzoate
-
-
(5-Benzyloxycarbonylamino-1-{2-methyl-1-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-pentyl)-carbamic acid benzyl ester
-
-
(5E)-3-benzyl-5-but-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5E)-3-benzyl-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5E)-3-butyl-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5E)-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(5Z)-3-benzyl-5-prop-2-ynylidenedihydrofuran-2(3H)-one
-
-
(6-oxo-2-(4-fluorophenyl)-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-pyridin-3-yl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-thiophen-2-yl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6-oxo-2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
-
-
(6E)-3-benzyl-6-prop-2-ynylidenetetrahydro-2H-pyran-2-one
-
-
(6E)-6-(1-bromoethylidene)-3-isopropyltetrahydro-2H-pyran-2-one
-
-
(6E)-6-(bromomethylene)-3-isopropyltetrahydro-2H-pyran-2-one
-
-
(6R,7S)-3-[(acetyloxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5,5-dioxide
-
-
(6Z)-3-benzyl-6-prop-2-ynylidenetetrahydro-2H-pyran-2-one
-
-
(6Z)-6-(bromomethylene)-3-isopropyltetrahydro-2H-pyran-2-one
-
-
(E)-6-O-p-coumaroyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
(E)-6-O-p-feruloyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
(E)-6-O-p-methoxycinnamoyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant. Molecular docking simulation and structural model for the inhibition of human neutrophil elastase, overview
(R)-3-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl-methanesulfonylamino)-propionic acid methyl ester
-
-
(S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxamide
-
-
(S)-3-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl-methanesulfonylamino)-propionic acid methyl ester
-
-
(Z)-6-O-p-coumaroyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
(Z)-6-O-p-methoxycinnamoyl scandoside methyl ester
-
an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant
1(6H)-Pyrimidineacetamide, 2-(4-aminophenyl)-5-[(methylsulfonyl)amino]-6-oxo-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 2-(4-fluorophenyl)-5-(methylamino)-6-oxo-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 5-(ethylamino)-6-oxo-2-(2-thienyl)-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 5-(formylamino)-6-oxo-2-(2-thienyl)-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1(6H)-Pyrimidineacetamide, 5-amino-2-(4-fluorophenyl)-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-6-oxo-
-
-
1(6H)-Pyrimidineacetamide, 5-amino-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-6-oxo-2-(2-thienyl)-
-
-
1(6H)-Pyrimidineacetamide, 5-[[(cyclohexylamino)sulfonyl]amino]-2-(4-fluorophenyl)-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-6-oxo-
-
-
1(6H)-Pyrimidineacetamide, 6-oxo-2-phenyl-5-[(trifluoroacetyl)amino]-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
1,2,5-thiadiazolidin-3-one 1,1-dioxide
-
the inhibitor causes rapid, time-dependent, irreversible loss of enzymatic activity
1-(2-((1-methyl-1H-imidazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-((5-phenyl-1,3,4-oxadiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-((benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-((benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(2-Acetylamino-propionyl)-pyrrolidine-2-carboxylic acid (3-chloro-1-methyl-2-oxo-propyl)-amide
-
-
1-(2-methylbenzoyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid methyl ester
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid propyl ester
-
-
1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid methyl ester
-
-
1-(4-((5-phenyl-1,3,4-oxadiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-((benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-((benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-chlorophenyl)-3,3-diethylazetidine-2,4-dione
-
-
1-(4-chlorophenyl)-3,3-dimethylazetidine-2,4-dione
-
-
1-(4-cyanobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(6-((benzo[d]thiazol-2-ylthio)methyl)pyridin-3-yl)-3,3-diethylazetidine-2,4-dione
-
-
1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid methyl ester
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid phenylamide
-
-
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid propyl ester
-
-
1-benzoyl-1H-indazole-3-carboxylic acid methyl ester
-
-
1-benzoyl-1H-indazole-3-carboxylic acid phenylamide
-
-
1-benzyl-3,3-dimethylazetidine-2,4-dione
-
-
1-butyryl-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-cyclopentanecarbonyl-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-methyl-1H-tetrazole-5-thiol
-
-
1-propionyl-1H-indazole-3-carboxylic acid ethyl ester
-
-
1-[(3-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(3-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(3-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(3-nitrophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-cyanophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(4-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide
-
-
1-[(methylsulfonyl)oxy]pyrrolidine-2,5-dione
-
-
1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid (3-chloro-1-isopropyl-2-oxo-propyl)-amide
-
-
1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid (3-chloro-1-methyl-2-oxo-propyl)-amide
-
-
1-[2-(4-Benzenesulfonylaminocarbonyl-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid (3,3-difluoro-1-isopropyl-2-oxo-3-phenethylcarbamoyl-propyl)-amide
-
-
1-[2-(chloromethyl)phenyl]-3,3-difluoroazetidin-2-one
-
-
1-[3-(5-cyclobutyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-cyclopropyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-ethyl-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(5-methyl-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-(7-methoxy-4-oxo-5-propyl-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-[3-[7-methoxy-4-oxo-5-(propan-2-yl)-4H-3,1-benzoxazin-2-yl]pyridin-2-yl]piperidine-4-carboxylic acid
-
-
1-{2-[4-(4-Bromo-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide
-
-
1-{2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (1-isopropyl-2,3-dioxo-heptyl)-amide
-
-
1-{2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide
-
-
1-{3-Methyl-2-[(naphthalene-2-carbonyl)-amino]-butyryl}-pyrrolidine-2-carboxylic acid (1-isopropyl-2,3-dioxo-heptyl)-amide
-
-
1-{[({2-[3-(trifluoromethyl)phenyl]ethyl}amino)carbonyl]oxy}pyrrolidine-2,5-dione
-
-
14alpha-hydroxy-ergosta-4,7,9(11),22-tetraen-3,6-dione
-
-
1H-indazol-1-yl(3-methylphenyl)methanone
-
-
2,2,2-trifluoroethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
2,2,2-trifluoroethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
2,2-Dimethyl-propionic acid 4-[2-(2,2-dihydroxy-ethylcarbamoyl)-benzenesulfonylamino]-phenyl ester
-
-
2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-propionyloxy)-benzoyl]-phenyl ester
-
-
2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]5-benzofuranol
-
the synthetic inhibitor may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement
2-(2,4-dinitrophenyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-(2-ethylbutanoyl)-1,2-benzisothiazol-3(2H)-one
-
-
2-(2-furoyl)-1,2-benzisothiazol-3(2H)-one
-
-
2-(2-furoyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-(2-methoxypyridin-3-yl)-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
2-(2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]pyridin-3-yl)-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-(2-[[2-(dimethylamino)ethyl](methyl)amino]pyridin-3-yl)-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(2-[[2-(dimethylamino)ethyl]amino]pyridin-3-yl)-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(3,3,3-Trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester
-
-
2-(3-trifluoromethylphenylamino)-4H-thieno[2,3-d][1,3]oxazin-4-one
-
-
2-(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzylthio)benzo[d ]-oxazole-6-carboxylic acid
-
-
2-(4-Chloro-benzenesulfonylamino)-5,5-dihydroxy-pentanoic acid (2-isopropylamino-5-methyl-4-oxo-4H-benzo[d][1,3]oxazin-7-yl)-amide
-
-
2-(4-Dihydroxymethyl-phenoxy)-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid 4-methyl-benzylamide
-
-
2-(5-amino-6-oxo-2-thien-2-ylpyrimidin-1(6H)-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-(chloromethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-(thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide
-
reversible, slow-binding, fully competitive
2-(trifluoromethyl)-4H-3,1-benzoxazin-4-one
-
-
2-Acetylamino-N-(1-ethylcarbamoyl-ethyl)-propionamide
-
-
2-Acetylamino-N-[1-(3-chloro-1-methyl-2-oxo-propylcarbamoyl)-ethyl]-propionamide
-
-
2-Acetylamino-N-[2-(2-{2-[(2-chloro-acetyl)-isopropyl-amino]-acetyl}-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-propionamide
-
-
2-Acetylamino-N-{1-[1-(3-chloro-1-methyl-2-oxo-propylcarbamoyl)-ethylcarbamoyl]-ethyl}-propionamide
-
-
2-amino-4H-3,1-benzoxazin-4-one
-
-
2-amino-5-ethyl-4H-3,1-benzoxazin-4-one
-
-
2-benzoyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
-
-
2-CF3CF2C(O)NH-C6H4-SO2-F
-
-
2-CF3SNH-C6H4-SO2-F
-
-
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid
2-ethoxy-4H-3,1-benzoxazin-4-one
-
-
2-ethoxy-5-ethyl-4H-3,1-benzoxazin-4-one
-
-
2-hydroxyethyl (4R)-4-[4-cyanophenyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]]-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
-
2-methyl-4H-3,1-benzoxazin-4-one
-
-
2-nitrophenylboronic acid
-
-
2-[(Imidazole-1-carbonyl)-amino]-pentanoic acid methyl ester
-
-
2-[2-(1H-imidazol-1-yl)pyridin-3-yl]-5-methyl-4H-3,1-benzoxazin-4-one
-
-
2-[2-(4-butylpiperazin-1-yl)pyridin-3-yl]-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-[2-(4-cyclopentylpiperazin-1-yl)pyridin-3-yl]-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-[2-(4-fluorophenyl)-6-oxo-5-[(cyclohexylsulfamoyl)-amino]-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[2-[4-(cyclopropylmethyl)piperazin-1-yl]pyridin-3-yl]-5-ethyl-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
2-[4-(2,2-Dihydroxy-ethyl)-phenoxy]-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid (1-benzo[1,3]dioxol-5-yl-butyl)-amide
-
-
2-[4-(2,2-Dihydroxy-ethyl)-phenoxy]-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid (1-p-tolyl-butyl)-amide
-
-
2-[4-(2,2-Dihydroxy-ethyl)-phenoxy]-3,3-diethyl-4-oxo-azetidine-1-carboxylic acid 4-methyl-benzylamide
-
-
2-[5-amino-2-(3,5-difluorophenyl)-6-oxopyrimidin-1(6H)-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[5-amino-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[5-amino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]-N-[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]acetamide
-
-
2-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
-
-
2-[benzyloxycarbonyl-NHCH2-C(O)NH]-C6H4-SO2-F
-
-
3,3-diethyl-1-(4-((phenylthio)methyl)phenyl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(4-methoxyphenyl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(4-methylphenyl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(6-methylpyridin-3-yl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(naphthalen-1-yl)azetidine-2,4-dione
-
-
3,3-diethyl-1-(pyridin-3-yl)azetidine-2,4-dione
-
-
3,3-diethyl-1-o-tolylazetidine-2,4-dione
-
-
3,3-diethyl-1-phenylazetidine-2,4-dione
-
-
3,3-diethyl-1-[4-(naphthalen-2-yloxy)phenyl]azetidine-2,4-dione
-
-
3,3-dimethyl-1-phenylazetidine-2,4-dione
-
-
3,4-dichloro-1H-isochromen-1-one
-
-
3-acetoxymethyl-7-[S]-methoxy-8-oxo-5-thia-1-aza-6[R]-bicyclo[4.2.0]oct-2-ene-2-(2-(S)-carboxypyrrolidine-carboxamide)-5,5-dioxide
-
L-658,758, cephalosporin-based anti-elastase
3-benzyl-1-(sulfooxy)pyrrolidine-2,5-dione
-
-
3-benzyl-1-[(methylsulfonyl)oxy]pyrrolidine-2,5-dione
-
-
3-benzyl-1-{[(4-vinylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione
-
-
3-benzyl-3-ethyl-1-phenylazetidine-2,4-dione
-
-
3-benzyl-3-methyl-1-phenylazetidine-2,4-dione
-
-
3-CF3-C6H4-CO-Ala-Ala-4-nitroanilide
-
-
3-chloro-1H-isochromen-1-one
-
-
3-ethyl-3-isobutyl-1-phenylazetidine-2,4-dione
-
-
3-isopropyl-1-[(methylsulfonyl)oxy]pyrrolidine-2,5-dione
-
-
3-isopropyl-1-{[(4-vinylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione
-
-
3-isopropyl-6-methylenetetrahydro-2H-pyran-2-one
-
-
3-methoxy-1-oxo-1H-isochromen-7-yl nitrite
-
-
-
3-methoxy-7-nitro-1H-isochromen-1-one
-
-
3-tert-butyl-1-{[(4-vinylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione
-
-
3-[(1-{2-[2-(3-Methoxycarbonyl-propionylamino)-propionylamino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-4-methyl-2-oxo-pentanoic acid methyl ester
-
-
3-[2-(2-Benzyloxycarbonylamino-propionylamino)-propionylamino]-2-oxo-pentanoic acid benzyl ester
-
-
3-[4-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperazin-1-yl]propanenitrile
-
-
3-{[1-(2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-4-methyl-2-oxo-pentanoic acid ethyl ester
-
-
3beta,5alpha,9alpha-trihydroxy-ergosta-7,22-dien-6-one
-
-
3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene
-
-
3beta,5alpha-dihydroxy-ergosta-7,22-dien-6-one
-
-
3beta-hydroxy-ergosta-7,22-dien-6-one
-
-
4-((1-(((1-(R)-(5-benzofuranyl)butyl)amino)carbonyl)-3,3-diethyl-4-oxo-2-(S)-azetidinyl)oxy)benzene acetic acid
-
the synthetic inhibitor may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement
4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile
-
-
4-(4-bromophenylsulfonylcarbamoyl)benzoyl-L-valyl-L-proline 1 (RS)-(1-trifluoroacetyl-2-methylpropyl)amide
-
ICI 200,355, reversible, tight, and potent inhibitor, prevents the ongoing destruction of insoluble elastin by elastase, IC50: 16 nM, 4fold excess of inhibitor over enzyme causes 83% inhibition
4-CH3-C6H4-SO2-F
-
-
4-chloro-3-ethoxy-1H-isochromen-1-one
-
-
4-chloro-3-methoxy-1-oxo-1H-isochromen-7-yl nitrite
-
-
4-chloro-3-methoxy-7-nitro-1H-isochromen-1-one
-
-
4-[3-(5-ethyl-7-methoxy-4-oxo-4H-3,1-benzoxazin-2-yl)pyridin-2-yl]piperazine-1-carboxylic acid
-
-
4-{5-(Adamantane-1-sulfonylamino)-6-oxo-6-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-hexylcarbamoyl}-butyric acid methyl ester
-
-
5,6-dimethyl-2-(4-nitrophenylamino)-4H-thieno[2,3-d][1,3]thioxazin-4-one
-
-
5-(2-Chloro-benzyl)-2-(2,2-dimethyl-propionyloxy)-5-hydroxy-5,6-dihydro-thieno[3,2-c]pyridin-5-ium; chloride
-
-
5-(4-Chloro-benzenesulfonylamino)-5-(2-isopropylamino-5-methyl-4-oxo-4H-benzo[d][1,3]oxazin-7-ylcarbamoyl)-pentyl-ammonium; chloride
-
-
5-aminopyridin-6-one-containing trifluoromethyl ketones
-
-
-
5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
5-chloro-2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-cyclobutyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-cyclobutyl-7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-cyclopropyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-cyclopropyl-7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-(isopropylamino)-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-methyl-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-2-[2-[4-(2-hydroxyethyl)piperazin-1-yl]pyridin-3-yl]-7-methoxy-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-(2-[4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]pyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-[4-(2-methoxyethyl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-ethyl-7-methoxy-2-[2-[4-(2-methylpropyl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-methoxy-2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-methylpyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-phenoxy-pyridin-3-yl)-benzo[d][1,3]oxazin-4-one
-
development and synthesis, overview
5-methyl-2-(2-phenoxyphenyl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-phenoxypyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(2-[[2-(morpholin-4-yl)ethyl]amino]pyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(6-methylpyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(pyridin-3-yl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-(trifluoromethyl)-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-methyl-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5-tert-butyl-7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
5alpha,6alpha,8alpha,9alpha-diepoxy-ergost-22-en-3beta,7alpha-diol
-
-
5alpha,6alpha-epoxy-ergosta-8(14),22-diene-3beta,7alpha-diol
-
-
5alpha,6alpha-epoxy-ergosta-8(9),22-dien-7-one-3beta-ol
-
-
6-({1-[2-(2-Benzyloxycarbonylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-amino)-4,4-difluoro-5-oxo-heptanoic acid methyl ester
-
-
6-amino-2-(2,2,2-trifluoro-acetylamino)-hexanoic acid [1-(4-trifluoromethyl-phenylcarbamoyl)-ethyl]-amide
-
-
7-(4-chlorophenylsulfonyl-L-glutamyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one
7-(4-chlorophenylsulfonyl-L-lysyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one
7-(dimethylamino)-5-ethyl-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
7-(dimethylamino)-5-ethyl-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-4H-3,1-benzoxazin-4-one
-
-
7-amino-3-methoxy-1H-isochromen-1-one
-
-
7-amino-4-chloro-3-methoxy-1H-isochromen-1-one
-
-
7-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-5-(propan-2-yl)-4H-3,1-benzoxazin-4-one
-
-
7-methoxy-2-[2-(4-methylpiperazin-1-yl)pyridin-3-yl]-5-propyl-4H-3,1-benzoxazin-4-one
-
-
7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-5-(propan-2-yl)-4H-3,1-benzoxazin-4-one
-
-
7-methoxy-2-[2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]pyridin-3-yl]-5-propyl-4H-3,1-benzoxazin-4-one
-
-
8-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
8-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
-
Ac-Pro-Ala-Pro-NH2CH(CH3)CH2OH
-
-
Ac-Pro-Ala-Pro-NH2CH(CH3)CHO
-
-
Ac-Pro-Ala-Pro-NH2CH(CH3)CONH2
-
-
acetyl-Ala-Ala-Ala-Ala-CH2Cl
-
-
acetyl-Ala-Ala-Pro-Ala-CH2Cl
-
-
acetyl-Ala-Ala-Pro-Ile-CH2Cl
-
-
acetyl-Ala-Ala-Pro-Val-CH2Cl
-
-
Ala-Ala-Pro-Ala
-
-
Ala15-reactive site variant of aprotinin
-
good inhibitor for proteinase 2B and weak inhibitor of proteinase 2A
-
alginate
-
weak inhibition, elastase molecule interacts with 19 uronic acid units of alginate
alpha-1-antichymotrypsin
-
-
-
alpha-1-antitrypsin
-
alpha-1-protease inhibitor
-
also called alpha-1-antitrypsin
-
alpha-aminobutyric acid15-reactive site variant of aprotinin
-
good inhibitor for proteinase 2B and weak inhibitor of proteinase 2A
-
alpha-aminovaleric acid15-reactive site variant of aprotinin
-
good inhibitor for proteinase 2B and weak inhibitor of proteinase 2A
-
alpha-ketobenzoxazoles
-
-
-
Alpha1-antitrypsin
-
Alpha1-proteinase inhibitor
-
alpha2-Macroglobulin
-
-
-
antipain
-
-
Aprotinin
astragaloside IV
-
-
benzyl 3,3,3-trifluoro-1-isopropyl-2-oxopropylcarbamate
-
-
betulinic acid
-
-
bis(2,3,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(2,3-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(2-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3,4,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3,4-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis(4-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis[3-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis[4-(methylsulfanyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
Boc-Ala-Pro-isobutyl-boronic acid amide
-
-
Butyric acid 3-(3-bromomethylene-6-isopropyl-5-oxo-[1,4]dioxan-2-yl)-pyrrolidin-1-yl ester
-
-
Ca2+
-
inhibition of human SP-D protein cleavage at physiological concentrations
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-(2-thienyl)-5-pyrimidinyl]-, 1-methylethyl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-(2-thienyl)-5-pyrimidinyl]-, 2,2,2-trifluoroethyl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-(2-thienyl)-5-pyrimidinyl]-, methyl ester
-
-
Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, 2,2,2-trifluoroethyl ester
-
-
Carbamic acid, [2-(4-fluorophenyl)-1,6-dihydro-1-[2-[[2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]amino]-2-oxoethyl]-6-oxo-5-pyrimidinyl]-, (3,5-dimethyl-4-pyridinyl)methyl ester
-
-
Carbamic acid, [2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-5-pyrimidinyl]-, 2-pyridinylmethyl ester
-
-
Carbamic acid, [2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-5-pyrimidinyl]-, 4-pyridinylmethyl ester
-
-
Carbamothioic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, S-methyl ester
-
-
Carbamothioic acid, [2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]ethyl]-5-pyrimidinyl]-, S-methyl ester
-
-
CBZ-Ala-(isobutyl-difluoro-boron)amide
-
-
CBZ-Ala-isobutyl-boronic acid amide
-
-
ceftazidime
-
slight inhibition of purified elastase
cephalotin
-
IC50: 0.00025 mg/ml
CF3-CO-Ala-Ala-4-nitroanilide
-
-
CF3-CO-Ala-Ala-Ala-OH
-
-
chymostatin
-
-
clitocybin D
-
4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid, isolated from mycelia culture broth of Clitocybe aurantiaca, structure determination by NMR and mass spectroscopy
cucurbitacin B
-
-
difluoro-beta-ketoamides
-
-
-
difluoromethyleneamines
-
-
-
diisopropyl fluorophosphates
-
almost complete inhibition
diisopropyl phosphorofluoridate
-
-
dimethyl 3,3'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphoryl]bis(oxy)]dibenzenesulfinate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]-2-methylpropyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]butyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]pentyl)phosphoryl]bis(oxy)]dibenzoate
-
-
dimethyl 4,4'-[[(1-[[(benzyloxy)carbonyl]amino]propyl)phosphoryl]bis(oxy)]dibenzoate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]butyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]ethyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
-
diphenyl (1-[[(benzyloxy)carbonyl]amino]propyl)phosphonate
-
-
EDTA
-
slight inhibition
Eglin c
eglin-c
-
-
elafin
-
elastase inhibitor III
-
-
-
Elastatinal
-
-
EPI-hNE-4
-
EPI-hNE4 (depelstat)
-
-
-
epigallocatechin gallate
-
-
ergosta-4,7,22-trien-3,6-dione
-
-
ergosta-7,22-dien-2beta,3alpha,9alpha-triol
-
-
ergosta-7,22-dien-3beta,5alpha,6beta,9alpha-tetraol
-
-
ergosterol
-
-
erythromycin
-
acts as an alternate substrate neutrophil elastase inhibitor
ethyl (2S,3R)-2-[(2,2-dihydroxyethyl)sulfonyl]-3-ethyl-4-oxoazetidine-1-carboxylate
-
-
ethyl 1-(1,3-benzodioxol-5-ylcarbonyl)-1H-indazole-3-carboxylate
-
-
ethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate
-
-
ethyl 1-acetyl-1H-indazole-3-carboxylate
-
-
ethyl 1-[(2-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(3-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(3-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(4-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(4-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl 1-[(4-methylphenyl)carbonyl]-1H-indazole-3-carboxylate
-
-
ethyl [4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)phenyl]acetate
-
-
flurythromycin
-
inactivator of neutrophil elastase
Formic acid 2-(3-{1-[2-(N'-benzyloxycarbonyl-N'-propyl-hydrazinocarbonyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-ureido)-4-methyl-pentyl ester
-
-
Formic acid 4-methyl-2-(3-{2-methyl-1-[2-(N'-phenoxycarbonyl-N'-propyl-hydrazinocarbonyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-pentyl ester
-
-
gentamycin
-
slight inhibition of purified elastase
ginsenoside Re
-
-
glutaryl-Ala-Ala-Pro-NH-C3H7
-
-
glycyrrhetinic acid
-
-
glycyrrhizin
-
-
gold thiomalate
-
inhibition is abolished by 1.0 M KCl
greglin
-
fast-acting and tight-binding inhibitor of neutrophil elastase
-
guamerin
-
recombinant guamerin isolated from the leech Hirudo nipponia
-
GW311616
-
-
GW311616A
-
-
GW447631
-
i.e. (3S,3aS,6aR)-4-(5-cyclopropylaminomethyl-pyrazine-2-carbonyl)-3-isopropyl-1-methanesulfonyl-hexahydropyrrolo[3,2-b]pyrrol-2-one hydrochloride
GW469002
-
i.e. (3S,3aS,6R)-4-[1-(2,2-dimethyl-propyl)azetidine-3-carbonyl]-3-isopropyl-1-methanesulfonyl-hexahydro-pyrrolo-[3,2-b]pyrrol-2-one
GW475151
heparin
horse leukocyte elastase inhibitor
-
human monocyte/neutrophil elastase inhibitor
-
effective inhibition
-
human pancreatic secretory trypsin inhibitor
-
variants optimized with respect to the affinity and specificity for human leukocyte elastase relative to trypsin, and in particular chymotrypsin
-
ICI 200,355
-
-
ICI 219,680
-
-
insulapeptolide A
-
-
insulapeptolide B
-
-
insulapeptolide C
-
-
insulapeptolide D
-
-
insulapeptolide E
-
-
insulapeptolide F
-
-
insulapeptolide G
-
-
insulapeptolide H
-
-
Kunitz inhibitor
-
-
-
L-658758
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1R)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-pyridinylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-pyridinylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2-oxo-4-[(phenylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3-difluoro-4-(methylamino)-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-4-(benzoylamino)-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-4-amino-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-pyridinylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[(1S)-3,3-difluoro-4-(methylamino)-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[(1S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-(phenoxycarbonyl)-L-valyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3,3-difluoro-1-(1-methylethyl)-2-oxo-4-[(phenylmethyl)amino]butyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3,3-difluoro-4-(methylamino)-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-4-amino-3,3-difluoro-1-(1-methylethyl)-2,4-dioxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-4-amino-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-difluoro-1-(1-methylethyl)-2-oxobutyl]-
-
-
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
-
-
leukocyte elastase inhibitor
-
leupeptin
-
-
long-chain fatty acids
-
-
lupeol
-
-
m-CF3-C6H4-CO-Ala-Ala-4-nitroanilide
-
-
matrix metalloproteinase-7
-
human leukocyte elastase cleaves matrix metalloproteinase-7 resulting in loss of enzymatic activity
-
MCoTI-II K10A
-
a MCoTI-II exchange analogue
MCoTI-II K10F
-
a MCoTI-II exchange analogue
MCoTI-II K10V
-
a MCoTI-II exchange analogue
MDL101146
-
suicide inhibitor
MeO-Suc-Ala-Ala-Pro-Ala-CH2Cl
MeO-Suc-Ala-Ala-Pro-Val-CH2Cl
MeOSuc-Ala-Ala-Pro-Val-chloromethylketone
-
neutrophil elastase-specific inhibitor
methoxsuccinyl-Ala-Ala-Pro-Ile-boronic acid
-
-
methoxysuccinyl-Ala-Ala-Pro-(isobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)amide
-
-
methoxysuccinyl-Ala-Ala-Pro-isobutyl-boronic acid amide
-
-
methoxysuccinyl-Ala-Ala-Pro-phenylethylboronic acid
-
-
methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
-
specific inhibitor
methoxysuccinyl-Ala-Ala-Pro-Val-CH2Cl
-
-
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone
-
-
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone
monocyte/neutrophil elastase inhibitor
-
N'-{1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-N-methyl-hydrazinecarboxylic acid 1-benzylcarbamoyl-ethyl ester
-
-
N'-{1-[2-(2-Acetylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-N-methyl-hydrazinecarboxylic acid 1-carbamoyl-ethyl ester
-
-
N-(1-(1-[1-(4-benzoyl-phenylcarbamoyl)-2-methyl-propylcarbamoyl]-3-methyl-butylcarbamoyl)-2-(4-hydroxy-phenyl)-ethyl)-succinamic acid
-
-
N-(1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-ethylcarbamoyl}-ethyl)-succinamic acid methyl ester
-
-
N-(1-{2-[2-(3-Chloro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-succinamic acid methyl ester
-
-
N-(1-{2-[2-(4-Ethoxy-3,3-difluoro-1-isopropyl-2-oxo-butylcarbamoyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-succinamic acid methyl ester
-
-
N-(2,2-diphenyl-ethyl)-1-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl)-methanesulfonamide
-
-
N-(2-phenylethyl)-1H-imidazole-1-carboxamide
-
-
N-(5-(adamantane-1-sulfonylamino)-5-[1-(1-formyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentyl)-succinamic acid
-
-
N-(5-(adamantane-1-sulfonylamino)-5-[1-(1-formyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentyl)-terephthalamic acid
-
-
N-(5-benzyloxycarbonylamino-1-(1-[2-(1-formyl-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl)-pentyl)-succinamic acid
-
-
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(3R,S)1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(3S)-1-methoxy-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,4-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,5-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2,6-dioxotetrahydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2-oxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2-oxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(3R)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-2-oxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]-L-prolinamide
-
i.e. AE-3763, it effects in lipopolysaccharide-induced lung injury model of lung edema and leukocyte infiltration, overveiw
N-([3-(carboxymethyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([3-(carboxymethyl)-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
-
-
N-([4-(carboxymethoxy)phenoxy]acetyl)-L-valyl-N-[(benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
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N-([4-(carboxymethyl)-2,3-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
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N-([4-(carboxymethyl)-2,3-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
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N-([4-(carboxymethyl)-2,3-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(3S)-1-methoxy-4-methyl-1,2-dioxopentan-3-yl]-L-prolinamide
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N-([4-(carboxymethyl)-2,5-dioxopiperazin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
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N-([4-(carboxymethyl)-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
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N-([4-(carboxymethyl)-6-methyl-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
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N-([4-(carboxymethyl)piperazin-1-yl]acetyl)-L-valyl-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-L-prolinamide
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N-benzyl-1-(1,1,3-trioxo-1,3-dihydro-1lambda6-1,2-benzisothiazol-2-yl)-methanesulfonamide
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N-galloyl-4-alkyliden-beta-lactam
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a beta-lactam with an N-linked galloyl moiety, specific noncompetitive inhibition of the enzyme, but not affecting chemotactic response and viability of polymorphonuclear leukocytes, synthesis and structure, overview
N-methoxysuccinyl-Ala-Ala-Pro-Ala chloromethylketone
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irreversible inhibitor