Information on EC 3.4.19.12 - ubiquitinyl hydrolase 1

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.19.12
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RECOMMENDED NAME
GeneOntology No.
ubiquitinyl hydrolase 1
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY hide
189642-63-5
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86480-67-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
strain N2, Bristol
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
dolphin
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
strain Rafinesque, NWAC103, gene UCHL5
UniProt
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
; gene uchl1
UniProt
Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
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Manually annotated by BRENDA team
DBA/2 mice
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Manually annotated by BRENDA team
ICR mice
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
no activity in Escherichia coli
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
plant
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
shrimp
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
synthetic construct
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
toad
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Automatic Mining of ENzyme DAta
trout
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(His)8-Ub-CTAPIII + H2O
(His)8-Ub + CTAPII
show the reaction diagram
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Ub i.e ubiquitin, CTAPII i.e. connective tissue-activating peptide
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?
Ac-ALRGG-7-amido-4-trifluoromethylcoumarin
?
show the reaction diagram
Ac-LRGG-7-amido-4-trifluoromethylcoumarin
?
show the reaction diagram
Ac-RLRGG-7-amido-4-trifluoromethylcoumarin
?
show the reaction diagram
activity-based haemagglutinin-tagged ubiquitin + H2O
?
show the reaction diagram
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-
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?
alpha-Tubulin + H2O
?
show the reaction diagram
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?
beta-tubulin + H2O
?
show the reaction diagram
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?
branched di-ubiquitin + H2O
ubiquitin
show the reaction diagram
branched polyubiquitin + H2O
ubiquitin
show the reaction diagram
conjugate of histone H2A and ubiquitin + H2O
ubiquitin + histone H2A
show the reaction diagram
di-ubiquitin + H2O
ubiquitin
show the reaction diagram
EBV ribonucleotide reductase
?
show the reaction diagram
is deubiquitinated by BPLF1 1-246
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?
HCF-1 + H2O
?
show the reaction diagram
HCF-1 is the principal Bap1-interacting protein. It is K48- and K63-ubiquitinated. Endogenous HCF-1C is ubiquitinated at lysine-1807 and/or lysine-1808
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?
head-to-tail polyubiquitin + H2O
ubiquitin
show the reaction diagram
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recombinant substrate from expression in Escherichia coli
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?
hemagglutinin-tagged ubiquitin-vinyl methyl ester + H2O
?
show the reaction diagram
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?
inhibitor of kappa B-alpha + H2O
?
show the reaction diagram
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UCHL1 deubiquitinates, thereby resulting in nuclear factor-kappa B inactivation
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?
K48-linked tetraubiquitin + H2O
K48-linked diubiquitin + diubiquitin
show the reaction diagram
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-
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?
K63-linked polyubiquitin + H2O
K63-linked polyubiquitin + ubiquitin
show the reaction diagram
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?
linear ubiquitin-beta-galactosidase + H2O
ubiquitin + protein
show the reaction diagram
monoubiquitin + H2O
?
show the reaction diagram
N2-L-Asp-ubiquitin + H2O
ubiquitin + L-Asp
show the reaction diagram
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?
N2-Lys-ubiquitin + H2O
ubiquitin + Lys
show the reaction diagram
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ubiquitin amide of the alpha amino group of lysine
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?
N6-(N2-acetyl)Lys-ubiquitin + H2O
ubiquitin + N2-acetyl-Lys
show the reaction diagram
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ubiquitin amide of the alpha amino group of lysine
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?
N6-Lys-ubiquitin + H2O
ubiquitin + Lys
show the reaction diagram
Nalpha-(diubiquitin)-[L-Lys] + H2O
?
show the reaction diagram
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K48 linked diubiquitin
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?
Nalpha-ubiquitin-[MQIFVRPR] + H2O
ubiquitin + MQIFVRPR
show the reaction diagram
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?
Nedd-8 + H2O
?
show the reaction diagram
NEDD8-protein + H2O
NEDD8 + protein
show the reaction diagram
enzyme shows dual specificity for ubiquitin-conjugates and NEDD8-conjugates
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?
Nepsilon-(diubiquitin)-[Nalpha-actyl-L-Lys] + H2O
?
show the reaction diagram
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K48 linked diubiquitin
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?
poly-His tagged di-ubiquitin + H2O
ubiquitin + ?
show the reaction diagram
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?
polyubiquitin + H2O
ubiquitin
show the reaction diagram
Smad2 + H2O
?
show the reaction diagram
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weaker association
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?
Smad3 + H2O
?
show the reaction diagram
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weaker association
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?
Smad7 + H2O
?
show the reaction diagram
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association with Smad7, which can act as an adaptor able to recruit UCH37 to the type I TGF-beta receptor and reverses Smurf-mediated ubiquitination
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?
spermidine-ubiquitin + H2O
ubiquitine + spermidine
show the reaction diagram
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?
type I TGF-beta receptor + H2O
?
show the reaction diagram
ubiquitin + H2O
?
show the reaction diagram
ubiquitin + H2O
monoubiquitin
show the reaction diagram
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UCH-L1 removes and recycles ubiquitin molecules from degraded proteins
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?
ubiquitin 7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
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?
ubiquitin C-terminal amide + H2O
ubiquitin + NH3
show the reaction diagram
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?
ubiquitin C-terminal-4-methyl-7-amido-coumarin + H2O
ubiquitin + 4-methyl-7-amino-coumarin
show the reaction diagram
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UCHL3 is 200fold more active than UCHL1/PGP 9.5
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?
ubiquitin ethyl ester + H2O
ubiquitin + ethanol
show the reaction diagram
ubiquitin ethylester + H2O
ubiquitin + an alcohol
show the reaction diagram
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synthetic substrate
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?
ubiquitin fused to 60% of its N-terminus + H2O
ubiquitin + 60% of ubiquitin N-terminus
show the reaction diagram
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recombinant substrate, expressed in Escherichia coli
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?
ubiquitin glycine methyl ester + H2O
ubiquitin + methanol
show the reaction diagram
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?
ubiquitin metallothionein + H2O
?
show the reaction diagram
ubiquitin thiol ester of dithiothreitol + H2O
ubiquitin + dithiothreitol
show the reaction diagram
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?
ubiquitin-4-methylcoumarin 7-amide + H2O
ubiquitin + 7-amino-4-methylcoumarin
show the reaction diagram
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?
ubiquitin-4-methylcoumarine 7-amide + H2O
ubiquitin + 7-amino-4-methylcoumarine
show the reaction diagram
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?
ubiquitin-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
show the reaction diagram
ubiquitin-alcohol + H2O
ubiquitin + alcohol
show the reaction diagram
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ir
ubiquitin-alpha-NH-dihydrofolate reductase + H2O
ubiquitin + dihydrofolate reductase
show the reaction diagram
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?
ubiquitin-alpha-NH-MHISPPEPESEEEEHYC + H2O
ubiquitin + MHISPPEPESEEEEHYC
show the reaction diagram
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?
ubiquitin-alphaNH-MHISPPEPESEEEEHYC + H2O
ubiquitin + MHISPPEPESEEEEHYC
show the reaction diagram
ubiquitin-AMC
?
show the reaction diagram
BPLF1 1-246 expresses deubiquitinating activity, cleaves ubiquitin chains linked by K48 and K63
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?
ubiquitin-AMC + H2O
?
show the reaction diagram
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?
ubiquitin-AW + H2O
?
show the reaction diagram
ubiquitin-B domain of staphylococcal protein-A + H2O
ubiquitin + B domain of staphylococcal protein-A
show the reaction diagram
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and variants thereof, substrate is expressed as alpha-linked C-terminal fusion to ubiquitin
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?
ubiquitin-beta1 domain of streptococcal protein G + H2O
ubiquitin + beta1 domain of streptococcal protein G
show the reaction diagram
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and variants thereof, substrate is expressed as alpha-linked C-terminal fusion to ubiquitin
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?
ubiquitin-carboxyl extension protein + H2O
ubiquitin + ubiquitin-carboxyl extension protein
show the reaction diagram
ubiquitin-CEP52 + H2O
ubiquitin + CEP52
show the reaction diagram
ubiquitin-CEP80 + H2O
ubiquitin + CEP80
show the reaction diagram
ubiquitin-Cys + H2O
ubiquitin + Cys
show the reaction diagram
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-
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?
ubiquitin-Cys-Cys + H2O
ubiquitin + Cys-Cys
show the reaction diagram
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-
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?
ubiquitin-Fur4p-conjugate + H2O
ubiquitin + Fur4p
show the reaction diagram
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ubiquitin is bound to the Fur4p protein via its Lys63
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?
ubiquitin-human carboxyl extension protein fusion protein + H2O
ubiquitin + human carboxyl extension protein
show the reaction diagram
ubiquitin-magainin + H2O
magainin + ubiquitin
show the reaction diagram
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is efficiently cleaved at the carboxyl terminus of ubquitin, yielding recombinant magainin with high antimicrobial activity
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?
ubiquitin-peptide + H2O
?
show the reaction diagram
ubiquitin-piscidin 1 + H2O
ubiquitin + piscidin 1
show the reaction diagram
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?
ubiquitin-protein + H2O
ubiquitin + protein
show the reaction diagram
ubiquitin-rhodamine110-glycine + H2O
rhodamine110
show the reaction diagram
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?
ubiquitin-W + H2O
?
show the reaction diagram
ubiquitin-W-G75A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-H68A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-I44A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-K11A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-K48A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-K63A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-K6A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-L71A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-L73A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-R42A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-R72A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-R74A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-W-V70A + H2O
?
show the reaction diagram
synthetic construct
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?
ubiquitin-WA + H2O
?
show the reaction diagram
ubiquitinyl-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
show the reaction diagram
ubiquitinyl-peptide + H2O
ubiquitin + peptide
show the reaction diagram
ubiquitinyldihydrofolate reductase + H2O
ubiquitin + dihydrofolate reductase
show the reaction diagram
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UCH-1
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?
Z-Arg-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
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?
additional information
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