Information on EC 3.1.4.11 - phosphoinositide phospholipase C

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.1.4.11
-
RECOMMENDED NAME
GeneOntology No.
phosphoinositide phospholipase C
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
-
-
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
mechanism
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
mechanism
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
biochemical relationship between PLC and heterotrimeric G proteins during NFs signaling in legumes
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
show the reaction diagram
kinetic and catalytic reaction mechanism, overview
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
-
D-myo-inositol-5-phosphate metabolism
-
Inositol phosphate metabolism
-
Metabolic pathways
-
phosphatidate metabolism, as a signaling molecule
-
phospholipases
-
SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1-phosphatidyl-D-myo-inositol 4,5-bisphosphate inositoltrisphosphohydrolase
-
-
-
-
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
-
-
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
-
-
-
-
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Q9Z1B3
-
AtPLC1
Q39032
shown in vitro phosphoinositide-specific phospholipase C activities
AtPLC2
Q39033
shown in vitro phosphoinositide-specific phospholipase C activities
AtPLC3
Q56W08
shown in vitro phosphoinositide-specific phospholipase C activities
AtPLC4
Q944C1
-
AtPLC4
Q944C1
shown in vitro phosphoinositide-specific phospholipase C activities
AtPLC5
Q944C2
shown in vitro phosphoinositide-specific phospholipase C activities
AtPLC6
Q8GV43
contain necessary domains for active phosphoinositide-specific phospholipase C and is most likely active
AtPLC7
Q9LY51
contain necessary domains for active phosphoinositide-specific phospholipase C and is most likely active
AtPLC8
Q9STZ3
is unlikely to be enzymatically active
AtPLC9
Q6NMA7
is unlikely to be enzymatically active
Ca2 +-dependent phosphatidylinositol phosphodiesterase
-
-
calcium-ion-dependent phosphatidylinositol phosphodiesterase
-
-
cyclic phosphodiesterase
P34024
-
DsPLC2
Q9FSW1
-
endogenous phospholipase C
-
-
GPI-PLC
-
-
GPI-specific phospholipase C
-
-
hPLC-eta
Q4KWH8
-
inositol phosphosphingolipid-phospholipase C
-
-
inositol phosphosphingolipid-phospholipase C
Cryptococcus neoformans H99
-
-
-
IPC-PLC
Cryptococcus neoformans H99
-
-
-
Isc1
Cryptococcus neoformans H99
-
-
-
low molecular weight PI-PLC
-
-
monophosphatidylinositol inositolphosphohydrolase
-
-
mPLC-eta
Q4KWH5
-
myocardial phospholipase C
-
type I, II, III, and IV
No receptor potential A protein
-
-
-
-
NorpA
-
Drosophila sp. PLC-beta homolog
PH-PLCdelta1
-
-
phosphatidylinosite-specific phospholipase C
Q9P212
-
phosphatidylinositide-specific phospholipase C
Q6SA76, Q6TM09, Q6TM10
-
phosphatidylinositol -phospholipase C
-
-
phosphatidylinositol 4,5 bisphosphate-phospholipase C
-
-
phosphatidylinositol 4,5-bisphosphate phosphodiesterase
-
-
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol phosphodiesterase
Mus musculus C57BL
-
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol phosphodiesterase
-
phospholipase C-type
phosphatidylinositol phosphodiesterase
Rattus norvegicus Sprague-Dawley
-
-
-
phosphatidylinositol phosphodiesterase
-
-
phosphatidylinositol phospholipase C
-
-
phosphatidylinositol specific phospholipase C
-
-
phosphatidylinositol-4,5-bisphosphate phosphodiesterase
-
-
-
-
phosphatidylinositol-4,5-bisphosphate phospholipase C
-
-
-
-
phosphatidylinositol-4,5-bisphosphate-specific phospholipase C
O24297
-
phosphatidylinositol-phosphodiesterase
-
-
phosphatidylinositol-phosphodiesterase
-
-
phosphatidylinositol-specific phospholipase
P34024
-
phosphatidylinositol-specific phospholipase C
-
-
phosphatidylinositol-specific phospholipase C
-
-
phosphatidylinositol-specific phospholipase C
B2LSE7
-
phosphatidylinositol-specific phospholipase C
B4XX94, B4XX95
-
phosphatidylinositol-specific phospholipase C
-
-
phosphatidylinositol-specific phospholipase C
Q766D4
-
phosphatidylinositol-specific phospholipase C
-
-
phosphatidylinositol-specific phospholipase C
-
-
phosphatidylinositol-specific phospholipase C
Q6QJ78
-
phosphatidylinositol-specific phospholipase C-beta
Q00722
-
phosphatidylinositol-specific phospholipase C1
Q2YGU0
-
phosphatidylinositol-specific phospholipase C2
Q2YGU1
-
phosphatidylinositol-specific phospholipase-C
-
-
phosphatidylinositol-specific phospholipases C
-
-
phosphodiesterase
P34024
-
phosphodiesterase
-
-
phosphodiesterase, triphosphoinositide
-
-
-
-
phosphoinositidase C
-
-
-
-
phosphoinositide phospholipase C
Q9Z1B3
-
phosphoinositide specific phospholipase C
-
-
phosphoinositide-phospholipase C
Q15147
-
phosphoinositide-phospholipase C beta1
P19174, Q9NQ66
-
phosphoinositide-specific phospholipase
-
-
phosphoinositide-specific phospholipase C
Q39032, Q39033, Q56W08, Q6NMA7, Q8GV43, Q944C1, Q944C2, Q9LY51, Q9STZ3
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
Q9Z1B3
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
P10687
-
phosphoinositide-specific phospholipase C
P32383
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C
-
-
phosphoinositide-specific phospholipase C beta1
Q9NQ66
-
phosphoinositide-specific phospholipase C beta1
Q9Z1B3
-
phosphoinositide-specific phospholipase C beta1
P10687
-
phosphoinositide-specific phospholipase C-zeta
-
-
phosphoinositide-specific phospholipase-Cgamma
-
-
phosphoinositide-specific phospholipases C
-
-
phospholipase C
-
-
-
-
phospholipase C
-
-
phospholipase C
-
type I, II, III, and IV
phospholipase C
-
-
phospholipase C
-
-
phospholipase C
-
-
phospholipase C
-
-
phospholipase C
P10686, P10687, P10688, Q99JE6
-
phospholipase C
P32383
-
phospholipase C 1
Q6QJ78
-
phospholipase C beta1
Q9NQ66
-
phospholipase C beta1
Q9Z1B3
-
phospholipase C beta1
-
-
phospholipase C beta3
Q01970
-
phospholipase C epsilon
Q9P212
-
phospholipase C epsilon
-
-
phospholipase C-beta 2
Q00722
-
phospholipase C-beta-1
Q9Z1B3
-
phospholipase C-beta1
-
-
phospholipase C-beta2
Q00722
-
phospholipase C-beta3
-
-
phospholipase C-delta-1
Q8R3B1
-
phospholipase C-delta1
P51178
-
phospholipase C-delta1
Q7T274
-
phospholipase C-epsilon
-
-
phospholipase C-epsilon
-
-
phospholipase C-eta1a
Q4KWH8
-
phospholipase C-eta1a
Q4KWH5
-
phospholipase C-eta1b
Q4KWH8
-
phospholipase C-eta1c
Q4KWH5
-
phospholipase C-gamma1
P19174
-
phospholipase C-gamma2
-
-
phospholipase C-gamma2
P16885
-
phospholipase C-gamma2
-
-
phospholipase C-gamma2
Q8CIH5
-
phospholipase C-like phosphodiesterase
-
-
phospholipase Cbeta1
P10687
-
phospholipase Cepsilon
-
-
phospholipase Cepsilon
Q8K4S1
-
phospholipase Cgamma1
-
-
phospholipase Cgamma1
-
-
phospholipase Cgamma2
-
-
phospholipase Cgamma2
Q8CIH5
-
phosphotidylinositol 4,5-bisphosphate-specific phospholipase C
-
-
-
-
PI-PLC
Q39032, Q39033, Q56W08, Q6NMA7, Q8GV43, Q944C1, Q944C2, Q9LY51, Q9STZ3
-
PI-PLC
B2LSE7
-
PI-PLC
-
-
PI-PLC
Q9NQ66
-
PI-PLC
Q9P212
-
PI-PLC
Q2YGU0, Q2YGU1
-
PI-PLC
P34024
-
PI-PLC
Q9Z1B3
-
PI-PLC
Q766D4
-
PI-PLC
-, Q6SA76, Q6TM09, Q6TM10
-
PI-PLC
Q6QJ78
-
PI-PLC beta 1
Q9Z1B3
-
PI-PLC beta 1
P10687
-
PI-PLC beta1
-
-
PI-PLC beta1
P10687
-
PI-PLC beta3
-
-
PI-PLC beta3
Q99JE6
-
PI-PLC beta4
-
-
PI-PLC beta4
Q9QW07
-
PI-PLC delta1
P10688
-
PI-PLC delta3
-
-
PI-PLC delta4
Q62711
-
PI-PLC epsilon
Q99P84
-
PI-PLC gamma1
-
-
PI-PLC gamma1
P10686
-
PI-PLC gamma2
-
-
PI-PLC-▀1
-
-
PI-PLCbeta
-
-
PI-PLCbeta1
Q9NQ66
-
PI-PLCbeta4
Q15147
-
PI-PLCc
-
-
PI-PLCgamma1
P19174
-
PI-PLCm
-
-
PI-specific phospholipase C
Q9NQ66
-
PI-specific phospholipase C
Q9Z1B3
-
PIC
-
-
-
-
PIP(2)-specific-phospholipase
-
-
PIP2 PDE
-
-
-
-
PIP2 phosphodiesterase
-
-
-
-
PIP2-phospholipase C
-
-
PIP2-PLC
-
-
PIP2-PLC
-
-
PIP2-PLC
O24297
-
PIP2-specific phospholipase C
O24297
-
PIPLC
-
-
-
-
PL-C
-
-
PLC
-
-
-
-
PLC beta1
-
-
PLC beta1
-
-
PLC beta1
P10687
-
PLC beta1b
-
-
PLC beta3
Q99JE6
-
PLC delta1
P10688
-
PLC epsilon
Q9P212
-
PLC epsilon1a
Q9P212
PLC epsilon splice variant
PLC epsilon1b
Q9P212
PLC epsilon splice variant
PLC gamma1
-
-
PLC gamma1
P10686
-
PLC-148
-
-
-
-
PLC-154
-
-
-
-
PLC-154
Q9Z1B3
-
PLC-21
-
Drosophila sp. PLC-beta homolog
PLC-85
-
-
-
-
PLC-beta
-
-
PLC-beta-1
Q9Z1B3
-
PLC-beta1b
-
-
PLC-beta2
-
-
PLC-beta2
Q00722
-
PLC-delta
-
-
PLC-delta-1
Q8R3B1
-
PLC-delta1
-
-
PLC-delta1
-
-
PLC-epsilon
-
-
PLC-epsilon
-
-
PLC-epsilon
-
-
PLC-eta
-
-
PLC-gamma
-
-
PLC-gamma
-
-
PLC-gamma1
P19174
phospho-nephrin-binding protein
PLC-gamma2
-, P16885
-
PLC-gamma2
-, Q8CIH5
-
PLC-I
-
-
PLC-I
Q9Z1B3
-
PLC-II
-
-
PLC-zeta
-
-
PLC-zeta
-
-
PLC-zeta
Q8K4D7
-
PLCbeta1
Q9NQ66
-
PLCbeta1
Q9Z1B3
-
PLCbeta1
-
-
PLCbeta1
P10687
-
PLCbeta1
P10687
two splice variants, PLCbeta1a and PLCbeta1b
PLCdelta1
-
-
PLCdelta1
Q8R3B1
-
PLCdelta1
-
-
PLCdeta1
-
-
PLCepsilon
-
splice variants PLCepsilon1a and PLCepsilon1b
PLCeta2
A2AP18
-
PLCgamma
-
-
PLCgamma
-
-
PLCgamma
-
-
PLCgamma1
-
-
PLCgamma1
-
-
PLCgamma1
-
-
PLCgamma1
-
-
PLCgamma2
-
-
PLCgamma2
Q8CIH5
-
PLCgamma2
Q8CIH5
mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis
pleckstrin homology-phospholipase C-delta1
-
-
polyphosphoinositide phospholipase C
-
-
-
-
PsPLC
O24297
-
PtdIns phosphodiesterase
-
-
PtdIns phosphodiesterase
Mus musculus C57BL
-
-
-
PtdIns phosphodiesterase
-
-
PtdIns phosphodiesterase
Rattus norvegicus Sprague-Dawley
-
-
-
PtdIns(4,5)P2-directed phospholipase C
-
-
-
-
PtdIns(4,5)P2-PLC
-
-
suPLCbeta
-
-
TcPI-PLC
-
-
TcPI-PLC
Q9TZN8
PI-PLC of Trypanosoma cruzi, similar to mamalian delta-type PI-PLCs
TgPI-PLC
Q3ZTU7
-
triphosphoinositide phosphodiesterase
-
-
-
-
Vr-PLC1
Q6TM09
-
Vr-PLC2
Q6SA76
-
Vr-PLC3
Q6TM10
-
Vr-PLC3 protein
-
-
ZmPLC1
Q6QJ78
transgenic maize
monophosphatidylinositol phosphodiesterase
-
-
additional information
-
four major types of PLC: beta, gamma, delta and epsilon
additional information
-
four PLC subfamilies: beta, gamma, delta and epsilon
additional information
-
ten mammalian isoenzymes, grouped into three families: PLCbeta, PLCgamma and PLCdelta
additional information
-
four major types of PLC: beta, gamma, delta and epsilon
additional information
Q99P84
four PLC classes: beta, gamma and delta, which are differentially regulated by heterotrimeric G-proteins, tyrosine kinases and calcium, and epsilon
additional information
Rattus norvegicus PLCepsilon
Q99P84
four PLC classes: beta, gamma and delta, which are differentially regulated by heterotrimeric G-proteins, tyrosine kinases and calcium, and epsilon
-
CAS REGISTRY NUMBER
COMMENTARY
37213-51-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
4 weeks old, AtPLC2
SwissProt
Manually annotated by BRENDA team
ATPLC1; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
AtPLC1S, AtPLC2, delta-related isotypes
-
-
Manually annotated by BRENDA team
ATPLC2; ecotype Columbia-0
SwissProt
Manually annotated by BRENDA team
ATPLC3; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
ATPLC4; ecotype Columbia-0
SWissProt
Manually annotated by BRENDA team
ATPLC5; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
ATPLC6; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
ATPLC7; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
ATPLC8; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
ATPLC9; ecotype Columbia-0
UniProt
Manually annotated by BRENDA team
Columbia ecotype
SWissProt
Manually annotated by BRENDA team
four PLC delta isoenzymes: PLC delta1-4
-
-
Manually annotated by BRENDA team
PLC-beta1
-
-
Manually annotated by BRENDA team
serotype C; var. gattii serotype B; var. grubii serotype A
-
-
Manually annotated by BRENDA team
Cryptococcus neoformans H99
serotype C; var. gattii serotype B; var. grubii serotype A
-
-
Manually annotated by BRENDA team
DdPLC, homolog to mammalian PLC-delta
-
-
Manually annotated by BRENDA team
DsPLC2, 6 weeks old
SwissProt
Manually annotated by BRENDA team
NorpA, PLC-21
-
-
Manually annotated by BRENDA team
adult
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
breast cancer patients
-
-
Manually annotated by BRENDA team
four PLC delta isoenzymes: PLC delta1-4
-
-
Manually annotated by BRENDA team
myelodysplastic syndromes (MDS) patients
UniProt
Manually annotated by BRENDA team
myelodysplastic syndromes (MDS) patients
SwissProt
Manually annotated by BRENDA team
PLC-epsilon
-
-
Manually annotated by BRENDA team
PLCbeta1a and PLCbeta1b
SwissProt
Manually annotated by BRENDA team
PLCbeta1a; two isoforms of PLCbeta1, a and b; PLCbeta1b; two isoforms of PLCbeta1, a and b
SwissProt
Manually annotated by BRENDA team
PLCgamma2
-
-
Manually annotated by BRENDA team
PLCgamma2
SwissProt
Manually annotated by BRENDA team
-
Q2YGU0, Q2YGU1
SwissProt
Manually annotated by BRENDA team
13 mammalian PLC isozymes have been identified
-
-
Manually annotated by BRENDA team
PLC-beta, -gamma, -delta and -epsilon
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SWissProt
Manually annotated by BRENDA team
; PLCzeta
SwissProt
Manually annotated by BRENDA team
C57BL strain
-
-
Manually annotated by BRENDA team
C57BL/6
-
-
Manually annotated by BRENDA team
C57BL/6J and CAST/Ei
UniProt
Manually annotated by BRENDA team
PLC-beta
-
-
Manually annotated by BRENDA team
PLCbeta1
-
-
Manually annotated by BRENDA team
PLCbeta1a and PLCbeta1b
SwissProt
Manually annotated by BRENDA team
PLCdelta
-
-
Manually annotated by BRENDA team
PLCdelta1
Q9Z1B4
SwissProt
Manually annotated by BRENDA team
PLCgamma2-deficient mice
UniProt
Manually annotated by BRENDA team
Mus musculus C57BL
C57BL strain
-
-
Manually annotated by BRENDA team
Mytilus galloprovincialis Lam
Lam
-
-
Manually annotated by BRENDA team
L. cv. Ningxia
SwissProt
Manually annotated by BRENDA team
PsPLC delta isoform
SwissProt
Manually annotated by BRENDA team
; male Wistar rats
-
-
Manually annotated by BRENDA team
expression in COS-7 cells
-
-
Manually annotated by BRENDA team
female Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
four PLC delta isoenzymes: PLC delta1-4
-
-
Manually annotated by BRENDA team
PH-PLCdelta1 residues 11-140
-
-
Manually annotated by BRENDA team
PLC-delta1
-
-
Manually annotated by BRENDA team
PLCbeta1a and PLCbeta1b
SwissProt
Manually annotated by BRENDA team
PLCepsilon
SwissProt
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats
SwissProt
Manually annotated by BRENDA team
Wistar rats, adult
-
-
Manually annotated by BRENDA team
Rattus norvegicus PLC-delta1
PLC-delta1
-
-
Manually annotated by BRENDA team
Rattus norvegicus PLCepsilon
PLCepsilon
SwissProt
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
CEP A stre, YC17, and TS141, the strains are isogenic to W303
UniProt
Manually annotated by BRENDA team
Saccharomyces cerevisiae PLC1p
PLC1p
-
-
Manually annotated by BRENDA team
several strains, 4 genes encoding 1 bacterial type PI-PLC and 3 eukaryotic type PI-PLCs
-
-
Manually annotated by BRENDA team
genes Pi-Plc1 and Pi-Plc2
-
-
Manually annotated by BRENDA team
L. elite inbred line Ye 7922
UniProt
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM