Information on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

New: Word Map on EC 1.13.11.52
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Search Reference ID:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.13.11.52
-
RECOMMENDED NAME
GeneOntology No.
indoleamine 2,3-dioxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-tryptophan + O2 = N-formyl-D-kynurenine
show the reaction diagram
-
-
-
-
L-tryptophan + O2 = N-formyl-L-kynurenine
show the reaction diagram
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-hydroxy-4-methyl-anthranilate biosynthesis I
-
-
3-hydroxy-4-methyl-anthranilate biosynthesis II
-
-
L-tryptophan degradation I (via anthranilate)
-
-
L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
-
-
L-tryptophan degradation XI (mammalian, via kynurenine)
-
-
Metabolic pathways
-
-
tryptophan metabolism
-
-
Tryptophan metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].
CAS REGISTRY NUMBER
COMMENTARY hide
9014-51-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Mus musculus DBA/2J
DBA/2J
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-benzofuran-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 22% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
1-benzothiophene-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 19% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
1-methyl-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 7% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
1-methyl-L-tryptophan + O2
?
show the reaction diagram
-
-
-
-
?
2-bromo-L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 21% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
2-chloro-L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 33% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
2-hydroxy-L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 4% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
3-indoleethanol + O2-
?
show the reaction diagram
-
-
-
-
?
3-N-aminoethyl-tryptophan + O2
?
show the reaction diagram
-
1 mM, 32% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
4-methyl-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 33% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
5-benzyloxy-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 1% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
5-bromo-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 36% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
5-fluoro-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 46% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
5-fluoro-tryptophan + O2
4-(2-amino-5-fluorophenyl)-2-(formylamino)-4-oxobutanoic acid
show the reaction diagram
-
-
-
-
?
5-fluorotryptophan + O2
?
show the reaction diagram
-
-
-
-
?
5-hydroxy-L-tryptophan + O2
(2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
show the reaction diagram
5-hydroxy-L-tryptophan + O2
?
show the reaction diagram
5-hydroxy-L-tryptophan + O2
N-formyl-5-hydroxy-L-kynurenine
show the reaction diagram
5-hydroxy-tryptophan + O2
4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
show the reaction diagram
-
-
-
-
?
5-hydroxytryptamine + O2
?
show the reaction diagram
-
-
-
-
?
5-hydroxytryptophan + O2
?
show the reaction diagram
-
-
-
-
?
5-hydroxytryptophan + O2-
N-formyl-5-hydroxykynurenine
show the reaction diagram
-
-
-
-
?
5-methoxy-D,L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 70% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
5-methyl-D,L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 123% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
5-methyl-tryptophan + O2
4-(2-amino-5-methylphenyl)-2-(formylamino)-4-oxobutanoic acid
show the reaction diagram
-
-
-
-
?
5-methyltryptophan + O2
?
show the reaction diagram
-
-
-
-
?
6-fluoro-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 38% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
6-fluorotryptophan + O2
?
show the reaction diagram
-
-
-
-
?
6-methyl-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 72% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
6-nitro-L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 2% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
7-methyl-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 18% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
alpha-methyl-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 35% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
alpha-methyl-DL-tryptophan + O2-
?
show the reaction diagram
-
-
-
-
?
alpha-N-methyl-L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 21% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
beta-methyl-DL-tryptophan + O2
?
show the reaction diagram
-
1 mM, 32% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
D-Trp + O2
D-formylkynurenine
show the reaction diagram
D-tryptophan + O2
?
show the reaction diagram
-
-
-
-
?
D-tryptophan + O2
D-kynurenine
show the reaction diagram
-
-
-
-
?
D-tryptophan + O2
N-formyl-D-kynurenine
show the reaction diagram
D-tryptophan + O2-
N-formyl-D-kynurenine
show the reaction diagram
indole + O2-
?
show the reaction diagram
-
-
-
-
?
kynurenine
?
show the reaction diagram
-
-
-
-
?
L-Trp + O2
L-formylkynurenine
show the reaction diagram
L-tryptophan + O2
L-kynurenine
show the reaction diagram
-
-
-
-
?
L-tryptophan + O2
N-formyl-L-kynurenine
show the reaction diagram
L-tryptophan + O2
N-formylkynurenine
show the reaction diagram
L-tryptophan + O2-
N-formyl-L-kynurenine
show the reaction diagram
L-tryptophan ethyl ester + O2
?
show the reaction diagram
-
1 mM, 14% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
L-tryptophan methyl ester + O2
?
show the reaction diagram
-
1 mM, 15% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
N-acetyl-L-tryptophan + O2
?
show the reaction diagram
-
1 mM, 3% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
-
?
serotonin + O2
?
show the reaction diagram
serotonin + O2-
?
show the reaction diagram
-
-
-
-
?
Trp + O2
formylkynurenine
show the reaction diagram
-
-
-
-
?
tryptamine + O2
?
show the reaction diagram
tryptamine + O2-
?
show the reaction diagram
-
-
-
-
?
tryptophan + O2
N-formylkynurenine
show the reaction diagram
-
if the cellular environment protects indoleamine 2,3-dioxygenase from oxidation to the ferric form, no additional electron donor might by required for indolamine 2,3-dioxygenase activity in intact tissues
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5-hydroxy-L-tryptophan + O2
N-formyl-5-hydroxy-L-kynurenine
show the reaction diagram
D-tryptophan + O2
N-formyl-D-kynurenine
show the reaction diagram
L-tryptophan + O2
N-formyl-L-kynurenine
show the reaction diagram
L-tryptophan + O2-
N-formyl-L-kynurenine
show the reaction diagram
serotonin + O2
?
show the reaction diagram
tryptamine + O2
?
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
FMNH2
-
4-5-fold higher activity than acitivity with methylene blue as the electron donor
methylene blue
-
stimulates the formation of D-kynurenine
tetrahydrobiopterin
-
-
additional information
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CN-
-
enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity
F-
-
enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity
N3-
-
enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2,4-dichlorophenyl)methanethiol
-
-
(2-chlorophenyl)methanethiol
-
-
(3,4-dichlorophenyl)methanethiol
-
-
(3-hydroxyphenyl)(phenyl)methanone
-
-
(3R,4S and 3S,4R)-3-bromo-4-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3R,4S and 3S,4R)-3-hydroxy-2,2-dimethyl-4-morpholino-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3R,4S and 3S,4R)-3-hydroxy-4-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3R,4S and 3S,4R)-4-(allylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3R,4S and 3S,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3R,4S and 3S,4R)-4-(benzylthio)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3R,4S and 3S,4R)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S and 3R,4R)-3,4-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
alpha-lapachone
(3S,4S and 3R,4R)-3-hydroxy-2,2-dimethyl-4-morpholino-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S and 3R,4R)-3-hydroxy-4-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S and 3R,4R)-4-(allylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S and 3R,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S and 3R,4R)-4-(benzyloxy)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S and 3R,4R)-4-(benzylthio)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S)-4-(benzylamino)-3,9-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(3S,4S)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
(4-chlorophenyl)methanethiol
-
-
(4-chlorophenyl)methanol
-
-
(4-fluorophenyl)methanethiol
-
-
(4-methoxyphenyl)methanethiol
-
-
(4-methylphenyl)methanethiol
-
-
(4E,4'E)-4,4'-bis(isopropylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione
-
-
-
(4E,4'E)-4,4'-bis(pentan-3-ylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione
-
-
-
(E)-4-(isopropylimino)-2-methylnaphthalen-1(4H)-one
-
-
-
(R)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide
-
-
-
(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(1,4-dihydroxy-3-methylnaphthalen-2-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid
-
-
(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid
-
-
(S)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide
-
-
-
1,2-naphthoquinone
-
-
1,4-naphtho-quinone
-
-
1-(1,3-benzothiazol-2-ylsulfanyl)-N,N-dimethylmethanamine
-
-
1-(4-chlorobenzyl)urea
-
-
1-(4-chlorophenyl)methanamine
-
-
1-(4-chlorophenyl)thiourea
-
-
1-benzofuran-DL-tryptophan
-
1 mM, 43% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
1-benzothiophene-DL-tryptophan
-
1 mM, 16% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
1-benzyl-5-phenyl-1H-imidazole
-
-
1-methyl-D-tryptophan
1-methyl-DL-tryptophan
1-methyl-L-tryptophan
1-methyl-tryptophan
1-Methyltryptophan
1-[2-(4-chlorophenyl)ethyl]thiourea
-
-
1H-benzotriazole
-
-
2,2-dimethyl-1a,9b-dihydro-2H-benzo[g]oxireno[c]chromene-4,9-dione
-
-
2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
dehydro-alpha-lapachone
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
2,2-dimethyl-3,4-epoxy-2H-naphtho[2,3-b]pyran-5,10-dione
-
-
2,3-dichloro-1,4-naphthoquinone
-
-
2,4-dichlorobenzyl carbamimidothioate hydrobromide
-
-
2-(1H-imidazol-4-yl)benzene-1,3-diol
-
-
2-(1H-imidazol-4-yl)benzenethiol
-
-
2-(1H-imidazol-4-yl)phenol
-
-
2-(1H-pyrazol-3-yl)phenol
-
-
2-(2-chlorophenyl)ethyl carbamimidothioate hydrobromide
-
-
2-(3-chlorophenyl)ethyl carbamimidothioate hydrobromide
-
-
2-(4-chlorophenyl)ethanamine
-
-
2-(4-chlorophenyl)ethyl carbamimidothioate hydrobromide
-
-
2-([5-(3-methoxyphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide
F5H5G0, P14902
poor inhibitor; poor inhibitor
2-amino-3-hydroxy-N-(4-hydroxynaphthalen-1-yl)propanamide
-
-
2-amino-N-(4-hydroxynaphth-1-yl)acetamide
-
-
-
2-bromo-L-tryptophan
-
1 mM, 11% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
2-chloro-L-tryptophan
-
1 mM, 20% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
2-chlorobenzyl carbamimidothioate hydrochloride
-
-
2-Hydroxy-1,4-naphthoquinone
-
-
2-hydroxy-L-tryptophan
-
1 mM, 30% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
2-hydroxygarveatin E
-
-
2-hydroxygarvin A
-
-
2-mercaptobenzothiazole
-
-
2-methoxy-1,4-naphthoquinone
-
-
2-methyl-1,4-naphthoquinone
-
-
2-methylnaphthalene-1,4-dione
-
-
2-phenoxyaniline
-
-
-
3,4-dichlorobenzyl carbamimidothioate hydrochloride
-
-
3-(1H-1,2,3-triazol-5-yl)pyridine
-
-
3-(1H-imidazol-4-yl)benzaldehyde
-
-
3-(1H-imidazol-4-yl)benzenethiol
-
-
3-(1H-imidazol-4-yl)benzonitrile
-
-
3-(1H-imidazol-4-yl)phenol
-
-
3-(4H-imidazol-4-yl)benzenethiol
-
-
3-chlorobenzyl carbamimidothioate hydrochloride
-
-
3-hydroxy-2,2-dimethyl-4-(morpholin-4-yl)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
3-hydroxy-4-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
3-indoleethanol
-
lowers Km value for D-tryptophan by 25% at pH 7, enhances Vmax by 40-60%
3-N-aminoethyl-tryptophan
-
1 mM, 28% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
-
3-phenylpyridine
-
-
4-(1H-1,2,3-triazol-5-yl)pyridine
-
-
4-(1H-imidazol-4-yl)phenol
-
-
4-(2,6-dimethoxyphenyl)-1H-imidazole
-
-
4-(2-(diethylamino)ethylamino)-1-naphthol
-
-
-
4-(2-(methylthio)phenyl)-1H-imidazole
-
-
4-(2-fluorophenyl)-1H-imidazole
-
-
4-(2-hydroxyethoxy)-1-naphthol
-
-
-
4-(3-(methylthio)phenyl)-1H-imidazole
-
-
4-(3-fluorophenyl)-1H-imidazole
-
-
4-(4-(methylthio)phenyl)-1H-imidazole
-
-
4-(4-fluorophenyl)-1H-imidazole
-
-
4-(benzylamino)-1-naphthol
-
-
-
4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
4-(cyclohexylamino)-1-naphthol
-
-
-
4-(dimethylamino)naphthalen-1-ol
-
-
4-(ethylamino)-1-naphthol
-
-
-
4-(isobutylamino)-1-naphthol
-
-
-
4-(isopropylamino)-1-naphthol
-
-
-
4-(methylamino)naphthalen-1-ol
-
-
4-(pent-3-ylamino)-1-naphthol
-
-
-
4-(phenylcarbonyl)benzyl carbamimidothioate hydrobromide
-
-
4-(propan-2-yl)benzyl carbamimidothioate hydrobromide
-
-
4-(propylamino)-1-naphthol
-
-
-
4-(tert-butylamino)naphthalen-1-ol
-
-
4-(thiophen-2-yl)-1H-imidazole
-
-
4-(trifluoromethyl)benzyl carbamimidothioate hydrochloride
-
-
4-amino-1,2,3-oxadiazole-3-carboximidamide
-
-
-
4-amino-1,2,5-oxadiazole-3-carboximidamide
-
competitive
4-amino-1-naphthol
-
-
4-amino-N'-hydroxy-N-(3-isopropylphenyl)-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N'-hydroxy-N-(3-methoxyphenyl)-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N'-hydroxy-N-(3-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N'-hydroxy-N-phenyl-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(2-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-chlorophenyl)-1,2,5-oxadiazole-3-carbohydrazonamide
-
-
4-amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-ethylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(3-tert-butylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-(4-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-benzyl-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
-
4-bromo-5-(4-methylphenyl)-1H-1,2,3-triazole
-
-
4-bromobenzyl carbamimidothioate hydrobromide
-
-
4-chlorobenzenesulfonic acid
-
-
4-chlorobenzenethiol
-
-
4-chlorobenzyl carbamimidothioate hydrochloride
-
-
4-chlorobenzyl N,N'-dimethylcarbamimidothioate - 1-chlorotetraoxidane (1:1)
-
-
4-cyanobenzyl carbamimidothioate hydrobromide
-
-
4-ethylbenzyl carbamimidothioate hydrochloride
-
-
4-fluoro-2-(1H-pyrazol-3-yl)phenol
-
-
4-fluorobenzyl carbamimidothioate hydrochloride
-
-
4-hydroxycarbazole
-
-
-
4-iodo-5-phenyl-1H-1,2,3-triazole
-
-
4-methoxy-1-naphthylamine
-
-
4-methoxybenzyl carbamimidothioate hydrochloride
-
-
4-methyl-DL-tryptophan
-
1 mM, 26% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
4-methylbenzyl carbamimidothioate hydrochloride
-
-
4-nitro-5-(4-nitrophenyl)-1H-1,2,3-triazole
-
-
4-nitrobenzyl carbamimidothioate hydrochloride
-
-
4-phenyl-1,3-thiazol-2-amine
-
-
4-phenyl-1,3-thiazole-2-thiol
-
-
4-phenylimidazole
4-tert-butylbenzyl carbamimidothioate hydrobromide
-
-
4-[(carbamimidoylsulfanyl)methyl]benzoic acid hydrochloride
-
-
4-[2-(methylsulfanyl)phenyl]-1H-imidazole
-
-
4-[3-(methylsulfanyl)phenyl]-1H-imidazole
-
-
5-(2-bromophenyl)-1H-1,2,3-triazole
-
-
5-(2-chlorophenyl)-1H-1,2,3-triazole
-
-
5-(2-methoxyphenyl)-1H-1,2,3-triazole
-
-
5-(4-bromophenyl)-1H-1,2,3-triazole
-
-
5-(4-chlorophenyl)-1H-1,2,3-triazole
-
-
5-(4-fluorophenyl)-1H-1,2,3-triazole
-
-
5-(4-methoxyphenyl)-1H-1,2,3-triazole
-
-
5-(ethylamino)quinolin-8-ol
-
-
-
5-(isopropylamino)quinolin-8-ol
-
-
-
5-amino-8-hydroxyquinoline
-
-
-
5-benzyloxy-DL-tryptophan
-
1 mM, 2% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
5-bromo-DL-tryptophan
-
1 mM, 56% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
5-chloro-1,3-benzothiazole-2(3H)-thione
-
-
5-fluoro-DL-tryptophan
-
1 mM, 32% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
5-hydroxy-1,4-naphthoquinone
-
-
5-hydroxy-D-tryptophan
-
0.1 mM, 26% inhibition of cleavage of D-tryptophan, 29% inhibition of cleavage of L-tryptophan
5-hydroxy-L-tryptophan
5-methoxy-DL-tryptophan
-
1 mM, 35% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
5-methyl-DL-tryptophan
-
1 mM, 6% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
5-phenyl-1H-1,2,3-triazole
-
-
6-fluoro-DL-tryptophan
-
1 mM, 54% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
6-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
6-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
6-methyl-DL-tryptophan
-
1 mM, 20% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
6-nitro-D-tryptophan
-
1 mM, 7% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
6-nitro-L-tryptophan
-
1 mM, competitive inhibition, 52% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
7-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
7-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
7-methyl-DL-tryptophan
-
1 mM, 36% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
8-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
9-fluorenone
-
-
9-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
alpha-caryopterone
9-hydroxyfluorene
-
-
9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
-
-
alpha-methyl-DL-tryptophan
-
1 mM, 1% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
alpha-N-methyl-L-tryptophan
-
1 mM, 33% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
annulin A
-
-
baicalein
-
uncompetitive reversible potent IDO-1 inhibitor
benzophenone
-
-
benzyl carbamimidothioate hydrochloride
-
-
Berberine
-
uncompetitive reversible potent IDO-1 inhibitor
beta-carboline
-
-
beta-Methyl-DL-tryptophan
-
1 mM, 7% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
cyanide
D-tryptophan
-
-
dexamethasone
Dichlorophene
-
-
epigallocatechin gallate
-
-
ethyl 1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carboxylate
-
-
exiguamine A
exiguamine B
-
-
-
gamma-glutamyl-S-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)cysteinylglycine
-
-
garveatin A
-
-
garveatin C
-
-
garveatin E
-
-
hydroxylamine sulfate
-
0.1 mM causes 79% inhibition, 1 mM causes 94% inhibition
imidazole
-
negatively cooperative or competitive
imidodicarbonimidic diamide, N-methyl-N''-9-phenanthrenyl-, monohydrochloride
-
-
indole
-
lowers Km value for D-tryptophan by 60% at pH 7, lowers Vmax by 12-24%, at 1 mM lowers activity by 13%
indole-3-acetic acid
-
1 mM, 19% inhibition of cleavage of D-tryptophan, 27% inhibition of cleavage of L-tryptophan
indole-3-acrylic acid
-
competitive inhibitor
Indole-3-propionic acid
-
-
interleukin-4
-
-
-
iodoacetic acid
-
1 mM, 12% inhibition of cleavage of D-tryptophan, 7% inhibition of cleavage of L-tryptophan
Jatrorrhizine
-
irreversible potent IDO-1 inhibitor
L-tryptophan
L-tryptophan ethyl ester
-
1 mM, 7% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
L-tryptophan methyl ester
-
1 mM, 30% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
menadione
methyl 2-methyl-5,10-dioxo-5,10-dihydro-2H-benzo[g]chromene-2-carboxylate
-
-
methyl 4-[(carbamimidoylsulfanyl)methyl]benzenesulfinate hydrobromide
-
-
methyl N-(4-chlorophenyl)carbamimidothioate hydroiodide
-
-
methyl N-[2-(4-chlorophenyl)ethyl]carbamimidothioate hydroiodide
-
-
methyl thiohydantoin-Trp
F5H5G0, P14902
;
methyl-thiohydantoin tryptophan
-
-
methyl-thiohydantoin-L-tryptophan
-
competitive inhibitor
-
methyl-thiohydantoin-tryptophan
-
limited selectivity towards indoleamine 2,3-dioxygenase
methylene blue
-
addition of methylene blue (0-0.1 mM) to NADPH-cytochrome P450 reductase-supported D-Trp incubations (with or without cytochrome b5) leads to concentration-dependent inhibition of IDO activity, addition of methylene blue (0-0.03 mM) to NADPH-cytochrome P450 reductase-supported L-Trp oxidation reactions results in a switch from substrate inhibition kinetics to Michaelis-Menten with increasing methylene blue concentration decreasing the affinity of IDO for L-Trp
methylthiohydantoin-DL-tryptophan
-
-
mitomycin C
-
-
N,N-dimethyl-1-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]methanamine
-
-
N-(1,3-benzodioxol-5-yl)-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide
F5H5G0, P14902
a reversible inhibitor of IDO1. highly specific for IDO1 compared to IDO2, docking analysis with IDO1 and IDO2; a reversible inhibitor of IDO1. highly specific for IDO1 compared to IDO2, docking analysis with IDO1 and IDO2
N-(4-hydroxy-1-naphthyl)ethane-1,2-diaminium chloride
-
-
-
N-(4-hydroxy-1-naphthyl)propane-1,3-diaminium chloride
-
-
-
N-(4-hydroxynaphthalen-1-yl)pyrrolidine-2-carboxamide
-
-
N-acetyl-L-tryptophan
-
1 mM, 7% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
n-butyl isocyanide
-
heme ligand which binds tightly to the ferrous enzyme
N-carbamoyl-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide
F5H5G0, P14902
poor inhibitor; poor inhibitor
N-ethylmaleimide
-
1 mM, 58% inhibition of cleavage of D-tryptophan, 45% inhibition of cleavage of L-tryptophan
N-methyl-L-Trp
F5H5G0, P14902
;
N-phenyl-p-phenylenediamine
-
-
NaN3
-
10 mM, 33% inhibition of cleavage of D-tryptophan, 32% inhibition of cleavage of L-tryptophan
naphthalene-1,4-diol
-
-
naphthalene-1,4-dione
-
-
nitric oxide
-
nitric oxide can potentially inhibit isozyme IDO2 activity
norharman
NSC 401366
-
competitive with respect to tryptophan
Palmatine
-
irreversible potent IDO-1 inhibitor
phenylmethanethiol
-
-
primaquine
-
-
quinolin-8-ol
-
-
serotonin
-
1 mM, 36% inhibition of cleavage of D-tryptophan, 37% inhibition of cleavage of L-tryptophan
sodium 4-chlorobenzenesulfinate
-
-
Sodium azide
-
1 mM causes 20% inhibition
Superoxide dismutase
tenatoprazole
-
highly selective for IDO2 inhibition, no inhibition of IDO1 or tryptophan dioxygenase
transforming growth factor-beta
-
inhibits expression in skin and synovial fibroblasts
-
tryptamine
vitamin K3
-
menadione
[4-(1,4-dioxido-1,2,4-benzotriazin-3-yl)aminobutyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
[4-(1-oxido-1,2,4-benzotriazin-3-yl)aminobutyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
[5-(1,4-dioxido-1,2,4-benzotriazin-3-yl)aminopentyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
[5-(1-oxido-1,2,4-benzotriazin-3-yl)aminopentyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(1H-indol-3-yl)ethanol
-
effector
3-indoleethanol
-
1 mM, enhances activity by 87%
alpha-interferon
ascorbate
-
promotes IDO peroxidase turnover by reducing Compound II
ascorbic acid
-
-
bacterial lipopolysaccharide
-
-
-
beta-interferon
-
induces IDO expression in monocytes
-
cortisone
-
subcutaneously
cytochrome b5
D-tryptophan
-
2g subcutaneously
diethyldithiocarbamate
-
inhibits superoxide dismutase
gamma-interferon
hematine
-
-
hydrogen peroxide
-
activates the peroxidase function of IDO to induce protein oxidation and inhibit dioxygenase activity
hyperbaric oxygen
hyperoxia
-
induces IDO expression in the lung
-
Inosine
-
0.1 mM, increases activity 5fold
L-tryptophan
-
2g subcutaneously
lipopolysaccharide
methylene blue
NADPH-cytochrome P450 reductase
-
-
-
paraquat
-
induces IDO expression in the lung
tumor-necrosis-factor-alpha
-
costimulation with gamma-interferon
-
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.062
1-methyl-L-tryptophan
-
-
0.006
5-fluoro-tryptophan
-
-
0.1 - 0.68
5-hydroxy-L-tryptophan
0.017
5-hydroxy-tryptophan
-
-
0.113
5-methoxy-DL-tryptophan
-
50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
0.088
5-methyl-DL-tryptophan
-
50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
0.098
5-methyl-tryptophan
-
-
0.056
6-methyl-DL-tryptophan
-
50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
0.0019 - 7.3
D-tryptophan
0.00072 - 12
L-tryptophan
0.042
O2
-
-
2.8
oxygen
additional information
additional information
-
kinetics of IDO-catalyzed indole oxidation as supported by H2O2, overview. The rate of disappearance of indole as a function of [H2O2] in the IDOFe3+-catalyzed reaction exhibits Michaelis-Menten behavior, with Km of about 1.1 mM for peroxide [indole]
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.064
1-methyl-L-tryptophan
Homo sapiens
-
-
0.76
5-fluoro-tryptophan
Homo sapiens
-
-
0.025
5-hydroxy-tryptophan
Homo sapiens
-
-
3.78
5-methyl-tryptophan
Homo sapiens
-
-
0.082 - 5.9
D-tryptophan
0.0015 - 0.002
kynurenine
0.101 - 12
L-tryptophan
2.9
O2
Homo sapiens
-
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.5 - 1200
L-tryptophan
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000061
(3R,4S and 3S,4R)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
0.00007
(3S,4S and 3R,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
0.000066
(3S,4S)-4-(benzylamino)-3,9-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
-
-
0.1 - 11.3
1-methyl-D-tryptophan
0.068
1-methyl-DL-tryptophan
-
-
0.019 - 2.75
1-methyl-L-tryptophan
0.034 - 0.0532
1-Methyltryptophan
0.0089
2-(1H-imidazol-4-yl)phenol
-
-
0.0014
2-hydroxygarveatin E
-
25C, pH 6.5
0.0023
2-hydroxygarvin A
-
25C, pH 6.5
0.0053
3-(1H-imidazol-4-yl)benzenethiol
-
-
0.0048
3-(4H-imidazol-4-yl)benzenethiol
-
-
0.0015
4-amino-1,2,5-oxadiazole-3-carboximidamide
-
-
0.018
5-(2-bromophenyl)-1H-1,2,3-triazole
-
pH 6.5, 37C, recombinant enzyme
0.0145
5-(2-chlorophenyl)-1H-1,2,3-triazole
-
pH 6.5, 37C, recombinant enzyme
0.0225
5-phenyl-1H-1,2,3-triazole
-
pH 6.5, 37C, recombinant enzyme
0.18
6-nitro-L-tryptophan
-
1 mM, competitive inhibition, 52% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37C, 10 min
0.00014 - 0.00069
annulin A
0.00012
annulin B
0.215
baicalein
-
pH and temperature not specified in the publication
0.008
Berberine
-
pH and temperature not specified in the publication
0.05
D-tryptophan
-
0.1 M potassium phosphate buffer (pH 6-8), 0.025 mM methylene blue, 0.2 mg catalase, 10 mM ascorbic acid, 50 nM dioxygenase, 25C
0.00021
exiguamine A
-
-
0.0032
garveatin A
-
25C, pH 6.5
0.0012
garveatin C
-
25C, pH 6.5
0.0031
garveatin E
-
25C, pH 6.5
0.0015
imidodicarbonimidic diamide, N-methyl-N''-9-phenanthrenyl-, monohydrochloride
-
-
0.0045 - 0.0068
indole-3-acrylic acid
1.6
L-tryptophan
-
inhibition of IDO1, pH and temperature not specified in the publication
0.176 - 1.96
norharman
0.0018
tenatoprazole
-
IDO2, pH and temperature not specified in the publication
0.367
[4-(1,4-dioxido-1,2,4-benzotriazin-3-yl)aminobutyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
0.0871
[4-(1-oxido-1,2,4-benzotriazin-3-yl)aminobutyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
0.197
[5-(1,4-dioxido-1,2,4-benzotriazin-3-yl)aminopentyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
0.0763
[5-(1-oxido-1,2,4-benzotriazin-3-yl)aminopentyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
-
-
additional information
additional information
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0035
(2,4-dichlorophenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0012
(2-chlorophenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0001
(3,4-dichlorophenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.5
(3-hydroxyphenyl)(phenyl)methanone
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.000512
(3R,4S and 3S,4R)-3-bromo-4-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000361
(3R,4S and 3S,4R)-3-hydroxy-2,2-dimethyl-4-morpholino-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00396
(3R,4S and 3S,4R)-3-hydroxy-4-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000183
(3R,4S and 3S,4R)-4-(allylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000252
(3R,4S and 3S,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00345
(3R,4S and 3S,4R)-4-(benzylthio)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000082
(3R,4S and 3S,4R)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.0015
(3S,4S and 3R,4R)-3,4-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
alpha-lapachone
0.0011
(3S,4S and 3R,4R)-3-hydroxy-2,2-dimethyl-4-morpholino-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000976
(3S,4S and 3R,4R)-3-hydroxy-4-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000186
(3S,4S and 3R,4R)-4-(allylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.000055
(3S,4S and 3R,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00109
(3S,4S and 3R,4R)-4-(benzyloxy)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00212
(3S,4S and 3R,4R)-4-(benzylthio)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00013
(3S,4S)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.0032
(4-chlorophenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.1
(4-chlorophenyl)methanol
Homo sapiens
-
IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0018
(4-fluorophenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0014
(4-methoxyphenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0013
(4-methylphenyl)methanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.00045
(4E,4'E)-4,4'-bis(isopropylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.00052
(4E,4'E)-4,4'-bis(pentan-3-ylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.0002
(E)-4-(isopropylimino)-2-methylnaphthalen-1(4H)-one
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.09
(R)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.00034
(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(1,4-dihydroxy-3-methylnaphthalen-2-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid
Homo sapiens
-
-
0.00088
(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid
Homo sapiens
-
-
0.06
(S)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.0071
1,2-naphthoquinone
Homo sapiens
-
-
0.00099
1,4-naphtho-quinone
Homo sapiens
-
-
0.05
1-(1,3-benzothiazol-2-ylsulfanyl)-N,N-dimethylmethanamine
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.1
1-(4-chlorobenzyl)urea
0.032
1-benzyl-5-phenyl-1H-imidazole
Homo sapiens
-
-
0.1
1-[2-(4-chlorophenyl)ethyl]thiourea
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
2.57
1H-benzotriazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.00495
2,2-dimethyl-1a,9b-dihydro-2H-benzo[g]oxireno[c]chromene-4,9-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000214
2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
dehydro-alpha-lapachone
0.00434
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00495
2,2-dimethyl-3,4-epoxy-2H-naphtho[2,3-b]pyran-5,10-dione
Homo sapiens
-
-
0.00028
2,3-dichloro-1,4-naphthoquinone
Homo sapiens
-
-
0.0004
2,4-dichlorobenzyl carbamimidothioate hydrobromide
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0053
2-(1H-imidazol-4-yl)benzene-1,3-diol
Homo sapiens
-
-
0.025
2-(1H-imidazol-4-yl)benzenethiol
Homo sapiens
-
-
0.0048
2-(1H-imidazol-4-yl)phenol
Homo sapiens
-
-
0.035
2-(1H-pyrazol-3-yl)phenol
Homo sapiens
-
-
0.1
2-(2-chlorophenyl)ethyl carbamimidothioate hydrobromide
0.057
2-(4-chlorophenyl)ethyl carbamimidothioate hydrobromide
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.25
2-([5-(3-methoxyphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide
Homo sapiens
F5H5G0, P14902
above, pH 7.0, 22C, IDO1; above, pH 7.0, 22C, IDO2
0.4
2-amino-3-hydroxy-N-(4-hydroxynaphthalen-1-yl)propanamide
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.105
2-amino-N-(4-hydroxynaphth-1-yl)acetamide
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.01
2-chlorobenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.675
2-Hydroxy-1,4-naphthoquinone
Homo sapiens
-
-
0.05
2-mercaptobenzothiazole
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.00072
2-methoxy-1,4-naphthoquinone
Homo sapiens
-
-
0.0011
2-methyl-1,4-naphthoquinone
1
2-phenoxyaniline
Homo sapiens
-
IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.017
3,4-dichlorobenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.68 - 0.708
3-(1H-1,2,3-triazol-5-yl)pyridine
0.825
3-(1H-imidazol-4-yl)benzaldehyde
0.0076
3-(1H-imidazol-4-yl)benzenethiol
Homo sapiens
-
-
0.041
3-(1H-imidazol-4-yl)benzonitrile
Homo sapiens
-
-
0.365
3-(1H-imidazol-4-yl)phenol
Homo sapiens
-
-
0.0077
3-(4H-imidazol-4-yl)benzenethiol
Homo sapiens
-
-
0.0046
3-chlorobenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.00036
3-hydroxy-2,2-dimethyl-4-(morpholin-4-yl)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00396
3-hydroxy-4-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.161
3-phenylpyridine
Homo sapiens
-
-
0.005
4-(1H-1,2,3-triazol-5-yl)pyridine
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
1.2
4-(1H-imidazol-4-yl)phenol
Homo sapiens
-
-
0.734
4-(2,6-dimethoxyphenyl)-1H-imidazole
Homo sapiens
-
-
0.003
4-(2-(diethylamino)ethylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.038
4-(2-(methylthio)phenyl)-1H-imidazole
Homo sapiens
-
-
0.179
4-(2-fluorophenyl)-1H-imidazole
0.0125
4-(2-hydroxyethoxy)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.073
4-(3-(methylthio)phenyl)-1H-imidazole
Homo sapiens
-
-
0.06
4-(3-fluorophenyl)-1H-imidazole
Homo sapiens
-
-
0.209
4-(4-(methylthio)phenyl)-1H-imidazole
Homo sapiens
-
-
0.123
4-(4-fluorophenyl)-1H-imidazole
Homo sapiens
-
-
0.0025
4-(benzylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.000055 - 0.00025
4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
0.00013
4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.015
4-(cyclohexylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
1
4-(dimethylamino)naphthalen-1-ol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.016
4-(ethylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.025
4-(isobutylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.0025
4-(isopropylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.0125
4-(methylamino)naphthalen-1-ol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.0035
4-(pent-3-ylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.1
4-(phenylcarbonyl)benzyl carbamimidothioate hydrobromide
0.0045
4-(propylamino)-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.004
4-(tert-butylamino)naphthalen-1-ol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.422
4-(thiophen-2-yl)-1H-imidazole
0.0026
4-(trifluoromethyl)benzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.003
4-amino-1-naphthol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.0021
4-amino-N'-hydroxy-N-(3-isopropylphenyl)-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.0044
4-amino-N'-hydroxy-N-(3-methoxyphenyl)-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.00055
4-amino-N'-hydroxy-N-(3-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.0032
4-amino-N'-hydroxy-N-phenyl-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.0065
4-amino-N-(2-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.000059
4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.000073
4-amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.000067
4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.0014
4-amino-N-(3-chlorophenyl)-1,2,5-oxadiazole-3-carbohydrazonamide
Homo sapiens
-
-
0.000086
4-amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.00043
4-amino-N-(3-ethylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.0005
4-amino-N-(3-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.025
4-amino-N-(3-tert-butylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
0.006
4-amino-N-(4-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Homo sapiens
-
-
1.028
4-bromo-5-(4-methylphenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.0013
4-bromobenzyl carbamimidothioate hydrobromide
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.1
4-chlorobenzenesulfonic acid
Homo sapiens
-
IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0019
4-chlorobenzenethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0022
4-chlorobenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.021
4-chlorobenzyl N,N'-dimethylcarbamimidothioate - 1-chlorotetraoxidane (1:1)
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.019
4-cyanobenzyl carbamimidothioate hydrobromide
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.016
4-ethylbenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.026
4-fluoro-2-(1H-pyrazol-3-yl)phenol
0.013
4-fluorobenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.4
4-hydroxycarbazole
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
1.371
4-iodo-5-phenyl-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.0055
4-methoxy-1-naphthylamine
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.052
4-methoxybenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.03
4-methylbenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.533
4-nitro-5-(4-nitrophenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.011
4-nitrobenzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
1
4-phenyl-1,3-thiazol-2-amine
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.05
4-phenyl-1,3-thiazole-2-thiol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.048
4-phenylimidazole
Homo sapiens
-
-
0.1
4-tert-butylbenzyl carbamimidothioate hydrobromide
0.038
4-[2-(methylsulfanyl)phenyl]-1H-imidazole
Homo sapiens
-
pH and temperature not specified in the publication
0.073
4-[3-(methylsulfanyl)phenyl]-1H-imidazole
Homo sapiens
-
pH and temperature not specified in the publication
0.148
5-(2-bromophenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.086
5-(2-chlorophenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
1.028
5-(2-methoxyphenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
1.256
5-(4-bromophenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.817
5-(4-chlorophenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.58
5-(4-fluorophenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
6
5-(4-methoxyphenyl)-1H-1,2,3-triazole
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.04
5-(ethylamino)quinolin-8-ol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.015
5-(isopropylamino)quinolin-8-ol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.003
5-amino-8-hydroxyquinoline
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.05
5-chloro-1,3-benzothiazole-2(3H)-thione
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.001
5-hydroxy-1,4-naphthoquinone
Homo sapiens
-
-
0.06 - 0.143
5-phenyl-1H-1,2,3-triazole
0.00019
6-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
0.00213
6-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00552
7-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.00302
7-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.002 - 0.00205
8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
0.000933
8-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
-
0.2
9-fluorenone
Homo sapiens
-
IC50 above 0.2 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.000121
9-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
Homo sapiens
-
alpha-caryopterone
1
9-hydroxyfluorene
Homo sapiens
-
IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.00292
9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
1
benzophenone
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.061
benzyl carbamimidothioate hydrochloride
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.0093
Berberine
Homo sapiens
-
pH and temperature not specified in the publication
0.07
Dichlorophene
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
2
ethyl 1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carboxylate
Homo sapiens
-
pH 6.5, 37C, recombinant enzyme
0.00088
gamma-glutamyl-S-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)cysteinylglycine
Homo sapiens
-
pH and temperature not specified in the publication
0.00064
menadione
Homo sapiens
-
in PBS buffer (pH 7.4), at 37C
0.000247
methyl 2-methyl-5,10-dioxo-5,10-dihydro-2H-benzo[g]chromene-2-carboxylate
Homo sapiens
-
-
0.1
methyl 4-[(carbamimidoylsulfanyl)methyl]benzenesulfinate hydrobromide
0.0216 - 0.0826
methyl thiohydantoin-Trp
1
N,N-dimethyl-1-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]methanamine
Homo sapiens
-
IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.003 - 0.25
N-(1,3-benzodioxol-5-yl)-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide
0.044
N-(4-hydroxy-1-naphthyl)ethane-1,2-diaminium chloride
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.005
N-(4-hydroxy-1-naphthyl)propane-1,3-diaminium chloride
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
-
0.2
N-(4-hydroxynaphthalen-1-yl)pyrrolidine-2-carboxamide
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.25
N-carbamoyl-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide
Homo sapiens
F5H5G0, P14902
above, pH 7.0, 22C, IDO1; above, pH 7.0, 22C, IDO2
0.4
N-phenyl-p-phenylenediamine
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.0015
naphthalene-1,4-diol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.00099
naphthalene-1,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
phenylmethanethiol
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.05
primaquine
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.75
quinolin-8-ol
Homo sapiens
-
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37C
0.1
sodium 4-chlorobenzenesulfinate
Homo sapiens
-
IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37C
0.001
vitamin K3
Homo sapiens
-
-
additional information
additional information