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Literature summary for 1.14.14.18 extracted from

  • Lin, C.C.; Liu, X.M.; Peyton, K.; Wang, H.; Yang, W.C.; Lin, S.J.; Durante, W.
    Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1 (2008), Arterioscler. Thromb. Vasc. Biol., 28, 739-745.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information far infrared irradiation induces HO-1 protein, mRNA and promoter activity through heat stress which activates the antioxidant responsive element/NF-E2-related factor-2 complex, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
tin protoporphyrin IX
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens inhibition or selective knockdown of HO-1 has anti-inflammatory effects via bilirubin, overview biliverdin + Fe2+ + CO + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
Homo sapiens
-
HUVEC cell i.e. human umbilical vein endothelial cell Homo sapiens
-
umbilical vein
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 inhibition or selective knockdown of HO-1 has anti-inflammatory effects via bilirubin, overview Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Homo sapiens
HO-1
-
Homo sapiens