Information on EC 1.1.1.21 - aldehyde reductase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.1.1.21
-
RECOMMENDED NAME
GeneOntology No.
aldehyde reductase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Fructose and mannose metabolism
-
galactose degradation IV
-
Galactose metabolism
-
Glycerolipid metabolism
-
L-arabinose degradation II
-
Metabolic pathways
-
Pentose and glucuronate interconversions
-
Pyruvate metabolism
-
SYSTEMATIC NAME
IUBMB Comments
alditol:NAD(P)+ 1-oxidoreductase
Has wide specificity.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
17betaHSD5
P42330
-
20-alpha-HSD
-
-
-
-
20-alpha-hydroxysteroid dehydrogenase
-
-
-
-
AKR1B1
P15121
-
AKR1B10
-
-
AKR1B10
O60218
-
AKR1B3
-
-
AKR1B3
P45376
-
AKR1C3
P42330
-
AKR4C7
A2T1W7
-
aldehyde reductase
-
-
-
-
aldehyde reductase
-
-
aldehyde reductase
-
-
aldehyde reductase
Rattus norvegicus Sprague-Dawley
-
-
-
alditol/NADP+ oxidoreductase
-
-
alditol: NADP+ 1-oxidoreductase
-
-
alditol:NAD(P)+1oxidoreductase
-
-
alditol:NADP 1-oxidoreductase
-
-
-
-
alditol:NADP oxidoreductase
-
-
-
-
aldo-keto reductase
-
-
aldo-keto reductase family 1 member B7
-
-
-
-
aldoketo reductase 1C3
P42330
-
aldose reductase
P15121
-
aldose reductase
-
-
aldose reductase
-
-
aldose reductase
-
-
aldose reductase
Rattus norvegicus Sprague-Dawley
-
-
-
aldose reductase
Rattus norvegicus Wistar
-
;
-
aldose reductase
-
-
aldose reductase
-
-
-
aldose reductase
Q5DD64
-
aldose reductase
-
-
aldose reductase
A2T1W7
-
aldose reductase 2
-
-
aldose reductase-like protein
O60218
-
aldose reductase-like protein
-
-
aldose xylose reductase
-
-
-
-
ALR1
-
-
ALR1
Rattus norvegicus Sprague-Dawley, Rattus norvegicus Wistar
-
-
-
ALR2
-
-
-
-
ALR2
P15121
-
ALR2
Rattus norvegicus Sprague-Dawley, Rattus norvegicus Wistar
-
-
-
ALR2
-
-
Fibroblast growth factor regulated protein
-
-
-
-
FR-1 protein
-
-
-
-
HRAR
-
-
MVDP
-
-
-
-
NADPH-aldopentose reductase
-
-
-
-
NADPH-aldose reductase
-
-
-
-
polyol dehydrogenase (NADP2)
-
-
-
-
TPN-polyol dehydrogenase
-
-
-
-
VAS deferens androgen-dependent protein
-
-
-
-
YqhD
-
YqhD contributes significantly to the isobutyraldehyde reductase activity in Escherichia coli
isobutyraldehyde reductase
-
-
additional information
-
aldose reductase, ALR2 or AKR1B1, and AKR1B10, an aldehyde reductase, belong to aldo-keto reductase, AKR, superfamily
additional information
-
the enzyme belongs to the NADPH-dependent aldo-keot reductase family
additional information
-
the enzyme is a member of the aldo-keto reductase family
CAS REGISTRY NUMBER
COMMENTARY
9028-31-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
2 enzymes AR I (ALR 1) and AR II (ALR 2)
-
-
Manually annotated by BRENDA team
2 enzymes AR I (ALR 1) and AR II (ALR 2); calf
-
-
Manually annotated by BRENDA team
ox, low-KM enzyme subtype
-
-
Manually annotated by BRENDA team
2 isoenzymes ALR 1 und ALR 2
-
-
Manually annotated by BRENDA team
strain Y-1632
-
-
Manually annotated by BRENDA team
Candida shehatae Y-1632
strain Y-1632
-
-
Manually annotated by BRENDA team
strain VGI-II
-
-
Manually annotated by BRENDA team
Candida silvanorum VGI-II
strain VGI-II
-
-
Manually annotated by BRENDA team
strain Y-456
-
-
Manually annotated by BRENDA team
Candida tropicalis Y-456
strain Y-456
-
-
Manually annotated by BRENDA team
Euonymus sp.
distribution in various species
-
-
Manually annotated by BRENDA team
ALR2
Swissprot
Manually annotated by BRENDA team
ALR2 and AKR1B10
Swissprot
Manually annotated by BRENDA team
expressed in transgenic mice
-
-
Manually annotated by BRENDA team
female and male
-
-
Manually annotated by BRENDA team
isoform ALR2
Swissprot
Manually annotated by BRENDA team
isoform hALR2
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
recombinant protein
-
-
Manually annotated by BRENDA team
strain Y-488
-
-
Manually annotated by BRENDA team
Kluyveromyces marxianus Y-488
strain Y-488
-
-
Manually annotated by BRENDA team
isolate 2001-S
-
-
Manually annotated by BRENDA team
growth in pretreated sugarcane bagasse hydrolysate
-
-
Manually annotated by BRENDA team
growth in sugar cane bagasse hydrolysare
-
-
Manually annotated by BRENDA team
strain Y-1017
-
-
Manually annotated by BRENDA team
Meyerozyma guilliermondii Y-1017
strain Y-1017
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
apolipoprotein E-null mice
-
-
Manually annotated by BRENDA team
8-week-old Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
; male sprague-dawley rats
-
-
Manually annotated by BRENDA team
diabetic rats
-
-
Manually annotated by BRENDA team
Fischer 344 rats
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats
Uniprot
Manually annotated by BRENDA team
Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
strain BY4741
-
-
Manually annotated by BRENDA team
Torulopsis molishiama
-
-
-
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4.8
4.9
-
isoelectric focusing
5.85
-
-
calculated from amino acid sequence
PDB
SCOP
CATH
ORGANISM
Giardia intestinalis (strain ATCC 50803 / WB clone C6)
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
35
-
after 48 h incubation activity decreases
50
-
-
10 min, inactivation
53
-
-
after 60 min 40-50% activity left
55
-
-
thermal aggregation and precipitation is prevented by specific, thermal stress induced complexing of alpha-crystallin, stable at least for 2 h at 55°C and for hours at room temperature, complexing can be hindered by Tris
62
-
-
total inactivation within 10 min