Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nitric oxide | from NO donors S-nitroso-N-acetylpenicillamine or S-nitrosoglutathione in vivo and in vitro, leads to increased S-glutathiolation of the enzyme | Homo sapiens | |
nitric oxide | from NO donors S-nitroso-N-acetylpenicillamine or S-nitrosoglutathione in vivo and in vitro, leads to increased S-glutathiolation of the enzyme | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | Homo sapiens | first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | Rattus norvegicus | first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens, the activity in diabetic rat lens is increased due to reduced NO concentration, overview | alditol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | from lens | Homo sapiens | - |
HLE-B3 cell | lens epithelial cell line | Homo sapiens | - |
lens | cultured epithelial cells | Homo sapiens | - |
lens | cultured, healthy and diabetic lens | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.2 | - |
healthy lens | Rattus norvegicus |
13.6 | - |
lens epithelial cell extract | Homo sapiens |
19.2 | - |
diabetic lens | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | - |
Rattus norvegicus | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens | Homo sapiens | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens, the activity in diabetic rat lens is increased due to reduced NO concentration, overview | Rattus norvegicus | alditol + NADP+ | - |
? | |
glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? | |
glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
aldose reductase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |