Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.21 extracted from

  • Ryle, C.M.; Dowling, T.G.; Tipton, K.F.
    Purification and properties of low-KM aldehyde reductase from ox brain (1984), Biochim. Biophys. Acta, 791, 155-163.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Sodium phosphate at pH 5.0-5.8 and pH 7.2 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Cl- at high ionic strength Bos taurus
NaCl
-
Bos taurus
NaNO3
-
Bos taurus
p-Carboxybenzaldehyde substrate inhibition at higher concentration Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.285
-
Succinic semialdehyde
-
Bos taurus
1.58
-
D-glucuronate
-
Bos taurus
1.67
-
xylose
-
Bos taurus
113
-
D-glucose 6-phosphate
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
gel filtration Bos taurus
35100
-
1 * 35100, SDS-PAGE in presence of 2-mercaptoethanol Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Bos taurus
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
ox, low-KM enzyme subtype
-

Purification (Commentary)

Purification (Comment) Organism
ox Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain ox Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
333.3
-
purified enzyme, with NADH in sodium phosphate buffer 100 mM, pH 7.0 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Bos taurus aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Bos taurus alditol + NAD(P)+
-
r
D-glucose 6-phosphate + NADPH + H+
-
Bos taurus ?
-
r
D-glucuronate + NAD(P)H
-
Bos taurus ?
-
r
D-xylose + NAD(P)H
-
Bos taurus xylitol + NAD(P)+
-
r
pyridine-3-aldehyde + NAD(P)H low-KM enzyme subtype Bos taurus 3-hydroxypyridine + NAD(P)+
-
r
succinic semialdehyde + NADH + H+
-
Bos taurus 4-hydroxybutyrate + NAD+
-
?
xylitol + NAD(P)+
-
Bos taurus D-xylose + NAD(P)H + H+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 35100, SDS-PAGE in presence of 2-mercaptoethanol Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Bos taurus
NADP+
-
Bos taurus