Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-N-hydroxyacetamide | - |
Homo sapiens | |
(Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide | 18% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide | 32% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-2-(5-naphthalen-2-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide | 3% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-2-[2,4-dioxo-5-(3-phenoxybenzylidene)thiazolidin-3-yl]acetamide | 8% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-2-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | 16% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-2-[5-(3-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | 10% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-2-[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]-N-hydroxyacetamide | - |
Homo sapiens | |
(Z)-2-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | - |
Homo sapiens | |
(Z)-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | 31% inhibition at 0.0125 mM | Homo sapiens | |
(Z)-N-hydroxy-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide | - |
Homo sapiens | |
(Z)-N-hydroxy-2-(5-naphthalen-2-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide | 39% inhibition at 0.025 mM | Homo sapiens | |
(Z)-N-hydroxy-2-[2,4-dioxo-5-(3-phenoxybenzylidene)-thiazolidin-3-yl]acetamide | - |
Homo sapiens | |
(Z)-N-hydroxy-2-[2,4-dioxo-5-(4-phenoxybenzylidene)-thiazolidin-3-yl]acetamide | - |
Homo sapiens | |
(Z)-N-hydroxy-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | - |
Homo sapiens | |
epalrestat | - |
Homo sapiens | |
fidarestat | - |
Homo sapiens | |
lidorestat | - |
Homo sapiens | |
additional information | not inhibited by (Z)-2-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3-yl]acetamide, (Z)-2-[5-(4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide, and (Z)-2-[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | Homo sapiens | |
sorbinil | - |
Homo sapiens | |
Tolrestat | - |
Homo sapiens | |
zopolrestat | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00141 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | sorbinil | |
0.00179 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-N-hydroxy-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | |
0.00367 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-N-hydroxy-2-[2,4-dioxo-5-(4-phenoxybenzylidene)-thiazolidin-3-yl]acetamide | |
0.0042 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-N-hydroxy-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide | |
0.00652 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-2-[5-(4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide | |
0.00734 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-2-[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]-N-hydroxyacetamide | |
0.0127 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-N-hydroxy-2-[2,4-dioxo-5-(3-phenoxybenzylidene)-thiazolidin-3-yl]acetamide | |
0.0203 | - |
in 0.25 M potassium phosphate buffer pH 6.8, at 37°C | Homo sapiens | (Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-N-hydroxyacetamide |