Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-methoxy-N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
8-methoxy-N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
8-methoxy-N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
additional information | design and synthesis of chiral 2H-chromene-N-imidazolo-imino acid conjugates as aldose reductase inhibitors, identification by NMR and mass spectrometry, in vitro inhibition screening, molecular docking study, overview | Homo sapiens | |
N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens | |
N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000031 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.000065 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.000071 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.000091 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.000114 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | |
0.000146 | - |
pH 6.2, 30°C | Homo sapiens | N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.00022 | - |
pH 6.2, 30°C | Homo sapiens | N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-2H-1-benzopyran-3-carboxamide | |
0.000222 | - |
pH 6.2, 30°C | Homo sapiens | N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | |
0.000275 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | |
0.000337 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-2H-1-benzopyran-3-carboxamide | |
0.00042 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | |
0.000731 | - |
pH 6.2, 30°C | Homo sapiens | 8-methoxy-N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide | |
0.000732 | - |
pH 6.2, 30°C | Homo sapiens | N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | |
0.000771 | - |
pH 6.2, 30°C | Homo sapiens | N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.000899 | - |
pH 6.2, 30°C | Homo sapiens | 8-methoxy-N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide | |
0.001 | - |
pH 6.2, 30°C | Homo sapiens | 8-methoxy-N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide | |
0.002122 | - |
pH 6.2, 30°C | Homo sapiens | N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide | |
0.003072 | - |
pH 6.2, 30°C | Homo sapiens | N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide | |
0.00367 | - |
pH 6.2, 30°C | Homo sapiens | N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide | |
0.00429 | - |
pH 6.2, 30°C | Homo sapiens | N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide |