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Literature summary for 1.1.1.21 extracted from

  • Kato, A.; Yasuko, H.; Goto, H.; Hollinshead, J.; Nash, R.; Adachi, I.
    Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity (2009), Phytomedicine, 16, 258-261.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one i.e. rhetsinine, from Evodia rutaecarpa hot water extract. Rhetsinine inhibits sorbitol accumulation by 79.3% at 0.1 mM in erythrocytes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-glyceraldehyde + NADPH + H+ Homo sapiens
-
DL-glycerol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
muscle
-
Homo sapiens
-
retina
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
Homo sapiens DL-glycerol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0241
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one

General Information

General Information Comment Organism
metabolism aldose reductase plays key roles in the polyol pathway Homo sapiens