Crystallization (Comment) | Organism |
---|---|
single-crystal x-ray data, neutron Laue data analysis and quantum mechanical modeling of aldose reductase. Quantum model of catalysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
alditol + NAD(P)+ = aldose + NAD(P)H + H+ | after the hydride donation step, the positive charge in the nicotinamide head stabilizes the neutral bridge between residues D43 and L77, allowing the relaxation of the tyrosine geometry toward the substrate head and the subsequent proton donation. After this last step, Y48 recoils to a locked geometry where the D43-L77 salt bridge is formed again and completes a tight four-charge sandwich involving the D(-), L(+), Y(-), and nicotinamide(+) head | Homo sapiens |