Application | Comment | Organism |
---|---|---|
medicine | myocardial enzyme activity is increased during ischemia, partially due to activation by nitric oxide, enzyme inhibition increases glycolysis and glucose oxidation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zopolrestat | inhibition of enzyme, increase in rates of glycolysis and glucose oxidation | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.19 | - |
DL-glyceraldehyde | pH 6.2, 25°C, enzyme from ischemic heart | Rattus norvegicus | |
0.2 | - |
DL-glyceraldehyde | pH 6.2, 25°C, enzyme from normal heart | Rattus norvegicus | |
28.9 | - |
D-xylose | pH 6.2, 25°C, enzyme from normal heart | Rattus norvegicus | |
29 | - |
D-xylose | pH 6.2, 25°C, enzyme from ischemic heart | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-xylose + NADPH | - |
Rattus norvegicus | ? | - |
? | |
DL-glyceraldehyde + NADPH | - |
Rattus norvegicus | glycerol + NADP+ | - |
? |