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Literature summary for 2.4.2.12 extracted from
- Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine (2016), Br. J. Pharmacol., 173, 2182-2194.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A244M | the mutation prevents inhibitor binding | Homo sapiens |
| D219A | inactive | Homo sapiens |
| D219S | the mutation leads to a switch in substrate affinity | Homo sapiens |
| G217R | the mutation prevents inhibitor binding | Homo sapiens |
| G384A | inactive | Homo sapiens |
| H191R | the mutation prevents inhibitor binding | Homo sapiens |
| H247A | inactive | Homo sapiens |
| H247E | the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization | Homo sapiens |
| K342R | inactive | Homo sapiens |
| Q388R | the mutation prevents dimerization | Homo sapiens |
| R311D | the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization | Homo sapiens |
| R392A | the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization | Homo sapiens |
| S199D | the mutation prevents dimerization and leads to loss of activity | Homo sapiens |
| S200D | the mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization. The mutation prevents dimerization | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FK866 | i.e. daporinad, (E)-N-[4-[1-(benzoyl)piperidin-4-yl]butyl]-3-pyridin-3-ylprop-2-enamide | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinamide D-ribonucleotide + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P43490 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Homo sapiens | - |
| adipocyte | - |
Homo sapiens | - |
| amniotic epithelial cell | - |
Homo sapiens | - |
| B-16 cell | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| BT-549 cell | - |
Homo sapiens | - |
| cardiomyocyte | - |
Homo sapiens | - |
| cervical cancer cell | - |
Homo sapiens | - |
| chronic lymphocytic leukemia cell | - |
Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| DU-145 cell | - |
Homo sapiens | - |
| fibroblast | - |
Homo sapiens | - |
| glial cell | - |
Homo sapiens | - |
| glioma cell | - |
Homo sapiens | - |
| HCT-116 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| hepatoma cell | - |
Homo sapiens | - |
| HIB-1B cell | - |
Homo sapiens | - |
| HMCB cell | - |
Homo sapiens | - |
| Huh-7 cell | - |
Homo sapiens | - |
| HUVEC cell | - |
Homo sapiens | - |
| LB-24_MEL cell | - |
Homo sapiens | - |
| leucocyte | - |
Homo sapiens | - |
| LS-180 cell | - |
Homo sapiens | - |
| macrophage | - |
Homo sapiens | - |
| MCF10A cell | - |
Homo sapiens | - |
| MCF7 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
| MDA-MB-468 cell | - |
Homo sapiens | - |
| melanocyte | - |
Homo sapiens | - |
| melanoma cell | - |
Homo sapiens | - |
| mesothelioma cell | - |
Homo sapiens | - |
| MeWo cell | - |
Homo sapiens | - |
| monocyte | - |
Homo sapiens | - |
| neuroblastoma cell | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
| pancreatic beta cell | - |
Homo sapiens | - |
| pancreatic islet cell | - |
Homo sapiens | - |
| PC-12 cell | - |
Homo sapiens | - |
| peripheral blood lymphocyte | - |
Homo sapiens | - |
| pre-B cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
| sebocyte | - |
Homo sapiens | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
| SK-N-BE cell | - |
Homo sapiens | - |
| SkMel-28 cell | - |
Homo sapiens | - |
| T-47D cell | - |
Homo sapiens | - |
| U-87 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinamide D-ribonucleotide + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| eNAMPT | - |
Homo sapiens |
| pre-B cell colony-enhancing factor | - |
Homo sapiens |
| Visfatin | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | enzyme expression is decreased by insulin, PI3K and AKT inhibitors, quercetin | down |
| Homo sapiens | enzyme expression is increased by Ox-LDL, CTRP3, glucose, rosiglitazone, adipocyte differentiation, ATP, LPS, CoCl2, ischaemia, OGD, anti-CD38 and differentiation in CCL, oxidative stress (H2O2), hypoxia, TNF-alpha, interleukin-1beta, starvation, and C-peptide | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in cancer | Homo sapiens |
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