4.6.1.1: adenylate cyclase
This is an abbreviated version!
For detailed information about adenylate cyclase, go to the full flat file.
Word Map on EC 4.6.1.1
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4.6.1.1
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camp
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agonist
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forskolin
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beta-adrenergic
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pertussis
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phosphodiesterase
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isoproterenol
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prostaglandin
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gtp
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dopamine
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monophosphate
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cholera
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subtypes
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guanine
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pka
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desensitization
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phospholipase
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forskolin-stimulated
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g-proteins
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camp-dependent
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epinephrine
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pacap
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catecholamine
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parathyroid
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norepinephrine
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adrenergic
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muscarinic
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vasoactive
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guanylate
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receptor-mediated
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beta-adrenoceptor
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protein-coupled
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glucagon
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bordetella
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vasopressin
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toxin-sensitive
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naf
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inotropic
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gtp-binding
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3',5'-monophosphate
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carbachol
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propranolol
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radioligands
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dibutyryl
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ibmx
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adp-ribosylation
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somatostatin
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isoprenaline
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medicine
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pharmacology
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drug development
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rolipram
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3-isobutyl-1-methylxanthine
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analysis
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molecular biology
- 4.6.1.1
- camp
- agonist
- forskolin
-
beta-adrenergic
- pertussis
- phosphodiesterase
- isoproterenol
- prostaglandin
- gtp
- dopamine
- monophosphate
- cholera
- subtypes
- guanine
- pka
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desensitization
- phospholipase
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forskolin-stimulated
- g-proteins
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camp-dependent
- epinephrine
-
pacap
- catecholamine
- parathyroid
- norepinephrine
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adrenergic
-
muscarinic
-
vasoactive
-
guanylate
-
receptor-mediated
-
beta-adrenoceptor
-
protein-coupled
- glucagon
- bordetella
- vasopressin
-
toxin-sensitive
- naf
-
inotropic
-
gtp-binding
- 3',5'-monophosphate
- carbachol
- propranolol
-
radioligands
-
dibutyryl
- ibmx
-
adp-ribosylation
- somatostatin
- isoprenaline
- medicine
- pharmacology
- drug development
- rolipram
- 3-isobutyl-1-methylxanthine
- analysis
- molecular biology
Reaction
Synonyms
3',5'-cyclic AMP synthetase, AC, AC 1, AC 2, AC 3, AC 4, AC 5, AC 7, AC 8, AC 9, AC Rv1625c, AC toxin, AC-IV, AC-V, AC-VI, AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9, ACA, ACB, ACbeta, ACG, ACI, ACII, ACIII, ACT, ACTP10, ACV, ACVI, ADCY10, Adcy5, adenyl cyclase, adenylate cyclase, adenylate cyclase 1, adenylate cyclase 10, adenylate cyclase 5, adenylate cyclase 6, adenylate cyclase toxin, adenylate cyclase type 10, adenylate cyclase type 5, adenylate cyclase [ATP pyrophosphate-lyase (cyclizing)], Adenylate cyclase, olfactive type, adenylate cyclases I, adenylate cyclases IV, adenylate cyclases VI, adenylyl cyclase, adenylyl cyclase 1, adenylyl cyclase 2, adenylyl cyclase 5, adenylyl cyclase 6, adenylyl cyclase 8, adenylyl cyclase 9, adenylyl cyclase toxin, adenylyl cyclase type 1, Adenylyl cyclase type 10, adenylyl cyclase type 5, adenylyl cyclase type 6, adenylyl cyclase type 8, adenylyl cyclase type V, adenylyl cyclase type VI, adenylyl cyclase VI, adenylyl cyclase VII, adenylyl cyclase, type-V, adenylyl cyclase, type-VI, adenylyl cyclase-5, adenylyl cyclase-beta, adenylyl cyclase-V, adenylyl cyclases 1, adenylyl cyclases 8, adenylylcyclase, Amac3, ATP pyrophosphate-lyase, ATP-diphosphate-lyase cyclizing, ATP-pyrophosphate lyase cyclizing, bacterial photoactivated adenylyl cyclase, BGP_1043, bPAC, Ca(2+)-inhibitable adenylyl cyclase, Ca(2+)/calmodulin activated adenylyl cyclase, Ca(II)- and calmodulin-dependent adenylyl cyclase edema factor, Ca-stimulated type 8 adenylyl cyclase, Ca2+-calmodulin stimulated adenylyl cyclase type 8, Ca2+-dependent adenylyl cyclase, Ca2+/calmodulin-stimulated adenylyl cyclase 1, calcium-sensitive adenylyl cyclase, calcium-stimulated adenylyl cyclase, class I AC, class I adenylate cyclase, class II AC, class III AC, class III adenylate cyclase, class III adenylyl cyclase, class IIIb AC, class IV AC, class IV adenylyl cyclase, class IVadenylyl cyclase, class V AC, class VI AC, Cya, Cya1, CyaA, CyaA toxin, CyaB, cyaB1, CyaB1 adenylyl cyclase, CyaB2, cyaC, CyaG, cyclase, adenylate, Cyr1p, Edema factor, ExoY, G protein-regulated adenylyl cyclase, GRESAG 4.1, GRESAG 4.3, GRESAG4.1, group 1 adenylyl cyclase, IIC2, ion-channel adenylyl cyclase, Ma1120, mAC, MAP0426c, MAP1279c, MAP1318c, MAP1357, MAP2079, MAP2250c, MAP2440, MAP2507c, MAP2672, MAP2695c, MAP3844, MAP4266, membrane adenylyl cyclase, ML1399, MM0123, MM0157, MM0286, MM0666, MM0730, MM0935, MM1414, MM2428, MM2454, MM2550, MM2962, MM3042, MM3043, MM3257, MM3505, MM3522, MM3640, MM3755, MM3757, MM3795, MM4078, MM4079, MM4080, MM4120, MM4173, MM4340, MM4370, MM4438, MM5137, MM5254, MM5257, More, MSMEG0218, MSMEG0536, MSMEG3253, MSMEG3579, MSMEG3786, MSMEG4282, MSMEG4472, MSMEG4909, MSMEG5003, MSMEG6117, Oscil6304_3613, PAC, particulate adenylyl cyclase, PfACalpha, pituitary adenylate cyclase, PleD, Rutabaga protein, Rv0386, Rv0891c, Rv1120c, Rv1264, Rv1318c, Rv1319c, Rv1320c, Rv1358, Rv1359, Rv1625c, Rv1647, Rv1900c, Rv2212, Rv2435c, Rv2488c, Rv3645, Ry1625c, sAC, sACI/II, SACY, Slr1991 adenylyl cyclase, soluble AC, soluble adenylate cyclase, soluble adenylyl cyclase, TczAC, tmAC, transmembrane adenylyl cyclase, transmembrane adenylyl cyclase type 1, transmembrane adenylyl cyclase type 3, transmembrane adenylyl cyclase type 8, type 1 AC, type 1 adenylyl cyclase, type 1 Ca2+/calmodulin-stimulated adenylyl cyclase, type 3 adenylyl cyclase, type 5 adenylyl cyclase, type 6 adenylyl cyclase, type 8 AC, type 8 adenylyl cyclase, type I adenylate cyclase, type II AC, type III adenylyl cyclase, type V AC, type V adenylate cyclase, type V adenylyl cyclase, type VI adenylyl cyclase, type VIII adenylyl cyclase, VC1, xlAC
ECTree
4.6.1.1 adenylate cyclaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 4.6.1.1 - adenylate cyclase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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glomeruli of the antennal lobes are specifically stained, whereas the core of the antennal lobes displays only weak labeling
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AC1 preferentially expressed in sino-atrial node cells, present as mRNA and as protein, AC5 present, AC8 absent
epithelial cells, both intercalated cells and principal cells
erythroleukemia cell line, high expression of isozyme AC7
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the insulin-secreting cells, derived from in vivo immortalized insulin-secreting pancreatic beta cells, are endogenously expressing Ca2+-sensitive AC isoforms
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isoform AC3 is evenly distributed in different sensory, central and motor neuropils
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pheromone detection in male mice depends on signaling through AC3
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isoform AC5 is the major adenylyl cyclase isoform in the cortex of the kidney
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in all intercalated cells, sAC and vacuolar proton pumping ATPase show considerable overlap under basal conditions, but sAC is also found in other cellular locations in the absence of vacuolar proton pumping ATPase. In type A-intercalated cells, both sAC and vacuolar proton pumping ATPase are apically and subapically located, whereas in type B-intercalated cells, significant basolateral colocalization of sAC and the vacuolar proton pumping ATPase is seen
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specific localization of the 50 kDa isoform to the axoneme of ciliated airway epithelial cells
additional information
isozyme AC1
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limbic system, induced and uninduced enzyme activity in different structures, overview
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post-mortem Brodmanns area 9 and cerebellum from the right hemisphere from normal controls and suicide subjects, demographic characteristics, overview
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isozymes AC8, AC6, AC1, AC3, and AC2, high expression level of isozyme AC8 in numerous brain regions, including the hippocampus, thalamus, habenula, cerebellar cortex and hypothalamic supraoptic and paraventricular nuclei
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dorsal striatum and nucleus accumbens show a high content of isozyme AC5
isozyme AC1 is abundantly expressed within limbic regions of the central nervous system
isozyme AC5 is abundantly expressed within limbic regions of the central nervous system
isozyme AC8 is abundantly expressed within limbic regions of the central nervous system
isozyme AC8, high expression level of isozyme AC8 in numerous brain regions, including the hippocampus, thalamus, habenula, cerebellar cortex and hypothalamic supraoptic and paraventricular nuclei
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limbic system, induced and uninduced enzyme activity in different structures, overview
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highest AC1 expression, present in molecular layer, weak AC8 expression at postnatal day 7 and decreases further by postnatal day 14
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highest AC1 expression, present in molecular layer, weak AC8 expression at postnatal day 7 and decreases further by postnatal day 14
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ACIII localizes to cilia in adults, throughout the cortex, including the subiculum, as well as the retrosplenial granular, visual, motor, and orbital cortices
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ACIII localizes to cilia in adults, throughout the cortex, including the subiculum, as well as the retrosplenial granular, visual, motor, and orbital cortices
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neonatal cardiac, isozyme AC2 is localized to the same structures in adult mice
neonatal cardiac, isozyme AC5 is localized to the same structures in adult mice
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ACIII localizes to cilia in adults, throughout nuclei of the deep forebrain, including the nucleus accumbens, caudate/putamen, thalamus, and hypothalamus
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synaptosome fractions from the adult brain show robust expression of AC1 in the postsynaptic density and extrasynaptic regions, while expression of AC8 is observed in the presynaptic active zone and extrasynaptic fractions
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synaptosome fractions from the adult brain show robust expression of AC1 in the postsynaptic density and extrasynaptic regions, while expression of AC8 is observed in the presynaptic active zone and extrasynaptic fractions
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expression of isozyme adenylyl cyclase VI, ACVI, at the left ventricular
isozyme AC2 is localized to the same structures in adult mice
isozyme AC5 is localized to the same structures in adult mice
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isoforms AC3, AC5, and AC7 are detected in heart, AC5 is an important adenylyl cyclase isoform in heart
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high activity in sinoatrial nodal cells, and less in ventricular myocytes
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HEK-hD1, HEK-293 cells transiently transfected with human D1 dopamine receptor
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lowest expression of AC1, protein increases in abundance in the neonatal hippocampus from postnatal days 714. By adulthood, abundant AC1 protein expression in the mossy fiber tract. AC8 protein levels are abundant during development, with diffuse and increasing expression in the hippocampus that intensify in the CA1/CA2 region by adulthood
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strong expression of AC1 in the dentate gyrus and CA2 regions, AC8 expression is restricted to the CA1 region
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lowest expression of AC1, protein increases in abundance in the neonatal hippocampus from postnatal days 714. By adulthood, abundant AC1 protein expression in the mossy fiber tract. AC8 protein levels are abundant during development, with diffuse and increasing expression in the hippocampus that intensify in the CA1/CA2 region by adulthood
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ventricular, isozyme AC2 is localized to the same structures in adult mice
ventricular, isozyme AC5 is localized to the same structures in adult mice
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ventricular, significantly less cAMP formation in response to adenylate cyclase stimulation in aged compared to younger cells
anterior cingulate cortex, ACC, neurons from a key region involved in high brain cognitive and executive functions
spinal commissural neuron cultures from embryonic day 14 from pregnant Sprague-Dawley rats
isozyme AC3, epithelium
isozyme AC8, epithelium
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cyclic AMP levels in photoreceptor cells are highest in darkness and reduced by light exposure
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cyclic AMP levels in photoreceptor cells are highest in darkness and reduced by light exposure
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AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina
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localization of isozyme ACVII in photoreceptorouter segments, the outer plexiform layer, the inner plexiform layer and the ganglion cell layer
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AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina
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isozyme AC2
isozyme AC6
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both tmAC and sAC present, presence of more than one tmAC isoform in sea urchin sperm
isozyme AC8, and a short 50 kDa splice variant sAC
additional information
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AC isoforms 1, 3, 4, 6, and 9 in cumulus cells. AC1, AC4 and AC6 predominate
additional information
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AC5 present and AC1 and AC8 absent in ventricular muscle, AC8 absent from cerebellum
additional information
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AC1 and AC8 present at the apical pool of airway epithelial cells, specifically in ciliated cells, AC3 mainly present on the basolateral aspect
additional information
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ubiquitous expression of isozymes AC9, AC7 and AC4, and of a short 50 kDa splice variant sAC
additional information
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predominance if not the exclusive presence of AC-V isoform in juxtaglomerular cells, AC-VI isoform not detectable
additional information
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primarily expresses AC3 mRNA in the inner medullary collecting duct, AC5 and AC6 also present
additional information
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ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
ubiquitous expression of a short 50 kDa splice variant sAC
additional information
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predominance if not the exclusive presence of AC-V isoform in juxtaglomerular cells, AC-VI isoform not detectable
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additional information
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C6 glioma cell primarly expresses AC6, cardiomycete, in cardiac fibroblast AC6 present, in striatal neurons AC5 and AC6 present
additional information
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tissue specific expression of cytosolic isozymes, overview
