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4.6.1.1: adenylate cyclase

This is an abbreviated version!
For detailed information about adenylate cyclase, go to the full flat file.

Word Map on EC 4.6.1.1

Reaction

ATP
=
3',5'-cyclic AMP
+
diphosphate

Synonyms

3',5'-cyclic AMP synthetase, AC, AC 1, AC 2, AC 3, AC 4, AC 5, AC 7, AC 8, AC 9, AC Rv1625c, AC toxin, AC-IV, AC-V, AC-VI, AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9, ACA, ACB, ACbeta, ACG, ACI, ACII, ACIII, ACT, ACTP10, ACV, ACVI, ADCY10, Adcy5, adenyl cyclase, adenylate cyclase, adenylate cyclase 1, adenylate cyclase 10, adenylate cyclase 5, adenylate cyclase 6, adenylate cyclase toxin, adenylate cyclase type 10, adenylate cyclase type 5, adenylate cyclase [ATP pyrophosphate-lyase (cyclizing)], Adenylate cyclase, olfactive type, adenylate cyclases I, adenylate cyclases IV, adenylate cyclases VI, adenylyl cyclase, adenylyl cyclase 1, adenylyl cyclase 2, adenylyl cyclase 5, adenylyl cyclase 6, adenylyl cyclase 8, adenylyl cyclase 9, adenylyl cyclase toxin, adenylyl cyclase type 1, Adenylyl cyclase type 10, adenylyl cyclase type 5, adenylyl cyclase type 6, adenylyl cyclase type 8, adenylyl cyclase type V, adenylyl cyclase type VI, adenylyl cyclase VI, adenylyl cyclase VII, adenylyl cyclase, type-V, adenylyl cyclase, type-VI, adenylyl cyclase-5, adenylyl cyclase-beta, adenylyl cyclase-V, adenylyl cyclases 1, adenylyl cyclases 8, adenylylcyclase, Amac3, ATP pyrophosphate-lyase, ATP-diphosphate-lyase cyclizing, ATP-pyrophosphate lyase cyclizing, bacterial photoactivated adenylyl cyclase, BGP_1043, bPAC, Ca(2+)-inhibitable adenylyl cyclase, Ca(2+)/calmodulin activated adenylyl cyclase, Ca(II)- and calmodulin-dependent adenylyl cyclase edema factor, Ca-stimulated type 8 adenylyl cyclase, Ca2+-calmodulin stimulated adenylyl cyclase type 8, Ca2+-dependent adenylyl cyclase, Ca2+/calmodulin-stimulated adenylyl cyclase 1, calcium-sensitive adenylyl cyclase, calcium-stimulated adenylyl cyclase, class I AC, class I adenylate cyclase, class II AC, class III AC, class III adenylate cyclase, class III adenylyl cyclase, class IIIb AC, class IV AC, class IV adenylyl cyclase, class IVadenylyl cyclase, class V AC, class VI AC, Cya, Cya1, CyaA, CyaA toxin, CyaB, cyaB1, CyaB1 adenylyl cyclase, CyaB2, cyaC, CyaG, cyclase, adenylate, Cyr1p, Edema factor, ExoY, G protein-regulated adenylyl cyclase, GRESAG 4.1, GRESAG 4.3, GRESAG4.1, group 1 adenylyl cyclase, IIC2, ion-channel adenylyl cyclase, Ma1120, mAC, MAP0426c, MAP1279c, MAP1318c, MAP1357, MAP2079, MAP2250c, MAP2440, MAP2507c, MAP2672, MAP2695c, MAP3844, MAP4266, membrane adenylyl cyclase, ML1399, MM0123, MM0157, MM0286, MM0666, MM0730, MM0935, MM1414, MM2428, MM2454, MM2550, MM2962, MM3042, MM3043, MM3257, MM3505, MM3522, MM3640, MM3755, MM3757, MM3795, MM4078, MM4079, MM4080, MM4120, MM4173, MM4340, MM4370, MM4438, MM5137, MM5254, MM5257, More, MSMEG0218, MSMEG0536, MSMEG3253, MSMEG3579, MSMEG3786, MSMEG4282, MSMEG4472, MSMEG4909, MSMEG5003, MSMEG6117, Oscil6304_3613, PAC, particulate adenylyl cyclase, PfACalpha, pituitary adenylate cyclase, PleD, Rutabaga protein, Rv0386, Rv0891c, Rv1120c, Rv1264, Rv1318c, Rv1319c, Rv1320c, Rv1358, Rv1359, Rv1625c, Rv1647, Rv1900c, Rv2212, Rv2435c, Rv2488c, Rv3645, Ry1625c, sAC, sACI/II, SACY, Slr1991 adenylyl cyclase, soluble AC, soluble adenylate cyclase, soluble adenylyl cyclase, TczAC, tmAC, transmembrane adenylyl cyclase, transmembrane adenylyl cyclase type 1, transmembrane adenylyl cyclase type 3, transmembrane adenylyl cyclase type 8, type 1 AC, type 1 adenylyl cyclase, type 1 Ca2+/calmodulin-stimulated adenylyl cyclase, type 3 adenylyl cyclase, type 5 adenylyl cyclase, type 6 adenylyl cyclase, type 8 AC, type 8 adenylyl cyclase, type I adenylate cyclase, type II AC, type III adenylyl cyclase, type V AC, type V adenylate cyclase, type V adenylyl cyclase, type VI adenylyl cyclase, type VIII adenylyl cyclase, VC1, xlAC

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.1 adenylate cyclase

IC50 Value

IC50 Value on EC 4.6.1.1 - adenylate cyclase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.005
1,2,3,4,5,6,7,8,13,13,14,14-dodecachloro-1,4,4a,4b,5,8,8a,12b-octahydro-11-sulfo-1,4:5,8-dimethanotriphenylene-10-carboxylic acid
Arthrospira platensis
-
0.2
1-(bromo(1-naphthyl)methyl)naphthalene
Arthrospira platensis
about
0.001
17beta-estra-1(10),2,4-triene-2,3,17-triol
Arthrospira platensis
-
0.03 - 2.18
2',3'-O-isopropylidene adenosine
0.000165
2',5'-dd-3'-ATP
Apis mellifera
-
in 10 mM Tris-HCl pH 7.5, at 30°C
0.00073
2',5'-dideoxy-3'-adenosine triphosphate
Mycobacterium avium
IC50 of about 730 nM
0.075 - 0.465
2',5'-dideoxyadenosine
0.05
2',5'-dideoxyadenosine 3'-monophosphate
Mycobacterium avium
-
-
0.00075
2',5'-dideoxyadenosine-3'-triphosphate
Mycobacterium avium
-
-
0.05
2'-deoxy-3'-adenosine monophosphate
Mycobacterium avium
IC50 of about 50 microM
0.07
2'-deoxyadenosine
Apis mellifera
-
in 10 mM Tris-HCl pH 7.5, at 30°C
0.1
2,3,6,23-tetrahydroxyurs-12-en-28-oic acid
Arthrospira platensis
about
0.1
2,3-dibromo-1-(4-(hydroxy(oxido)amino)phenyl)-3-(4-quinolinyl)-1-propanone
Arthrospira platensis
about
0.00578 - 1.31
2-amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
0.002 - 0.008
2-hydroxyestradiol
0.0302
3'-AMP
Apis mellifera
-
in 10 mM Tris-HCl pH 7.5, at 30°C
0.015
3,20-dioxopregn-4-en-21-yl 4-bromobenzenesulfonate
Arthrospira platensis
-
0.043
4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid
Homo sapiens
-
in 50 mM Tris-HCl (pH 8.0), 50 mM NaCl, 10 mM MgCl2, 10 mM CaCl2, at 37°C
0.1
4,5,6,7-tetrachloro-3,3-bis(6-hydroxy[1,1'-biphenyl]-3-yl)-2-benzofuran-1(3H)-one
Arthrospira platensis
about
0.07
5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman
Arthrospira platensis
about
0.274 - 0.812
9-tetrahydro-2'-furyladenine
0.095
adenosine
Apis mellifera
-
in 10 mM Tris-HCl pH 7.5, at 30°C
0.016 - 13.36
alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile
0.000022
arginine-vasopressin
Homo sapiens
-
-
0.207 - 0.825
Caffeine
0.329 - 0.885
cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine
0.000033
cyclic poly-phosphate 17
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.002
cyclic triphosphate
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.00021
diphosphate
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.005
KH7
Plasmodium falciparum
-
at pH 7.5 and 37°C
0.0000034
Oxytocin
Homo sapiens
-
-
11
phosphate
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.0001
poly-phosphate 16
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.000027
poly-phosphate 25
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.000018
poly-phosphate 30
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
-
0.000012
poly-phosphate 45, poly-phosphate 68
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
-
0.000011
poly-phosphate 75
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
-
0.00002
Triphosphate
Mycobacterium tuberculosis
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C
0.036 - 0.119
tyrphostin A25