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4.6.1.1: adenylate cyclase

This is an abbreviated version!
For detailed information about adenylate cyclase, go to the full flat file.

Word Map on EC 4.6.1.1

Reaction

ATP
=
3',5'-cyclic AMP
+
diphosphate

Synonyms

3',5'-cyclic AMP synthetase, AC, AC 1, AC 2, AC 3, AC 4, AC 5, AC 7, AC 8, AC 9, AC Rv1625c, AC toxin, AC-IV, AC-V, AC-VI, AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9, ACA, ACB, ACbeta, ACG, ACI, ACII, ACIII, ACT, ACTP10, ACV, ACVI, ADCY10, Adcy5, adenyl cyclase, adenylate cyclase, adenylate cyclase 1, adenylate cyclase 10, adenylate cyclase 5, adenylate cyclase 6, adenylate cyclase toxin, adenylate cyclase type 10, adenylate cyclase type 5, adenylate cyclase [ATP pyrophosphate-lyase (cyclizing)], Adenylate cyclase, olfactive type, adenylate cyclases I, adenylate cyclases IV, adenylate cyclases VI, adenylyl cyclase, adenylyl cyclase 1, adenylyl cyclase 2, adenylyl cyclase 5, adenylyl cyclase 6, adenylyl cyclase 8, adenylyl cyclase 9, adenylyl cyclase toxin, adenylyl cyclase type 1, Adenylyl cyclase type 10, adenylyl cyclase type 5, adenylyl cyclase type 6, adenylyl cyclase type 8, adenylyl cyclase type V, adenylyl cyclase type VI, adenylyl cyclase VI, adenylyl cyclase VII, adenylyl cyclase, type-V, adenylyl cyclase, type-VI, adenylyl cyclase-5, adenylyl cyclase-beta, adenylyl cyclase-V, adenylyl cyclases 1, adenylyl cyclases 8, adenylylcyclase, Amac3, ATP pyrophosphate-lyase, ATP-diphosphate-lyase cyclizing, ATP-pyrophosphate lyase cyclizing, bacterial photoactivated adenylyl cyclase, BGP_1043, bPAC, Ca(2+)-inhibitable adenylyl cyclase, Ca(2+)/calmodulin activated adenylyl cyclase, Ca(II)- and calmodulin-dependent adenylyl cyclase edema factor, Ca-stimulated type 8 adenylyl cyclase, Ca2+-calmodulin stimulated adenylyl cyclase type 8, Ca2+-dependent adenylyl cyclase, Ca2+/calmodulin-stimulated adenylyl cyclase 1, calcium-sensitive adenylyl cyclase, calcium-stimulated adenylyl cyclase, class I AC, class I adenylate cyclase, class II AC, class III AC, class III adenylate cyclase, class III adenylyl cyclase, class IIIb AC, class IV AC, class IV adenylyl cyclase, class IVadenylyl cyclase, class V AC, class VI AC, Cya, Cya1, CyaA, CyaA toxin, CyaB, cyaB1, CyaB1 adenylyl cyclase, CyaB2, cyaC, CyaG, cyclase, adenylate, Cyr1p, Edema factor, ExoY, G protein-regulated adenylyl cyclase, GRESAG 4.1, GRESAG 4.3, GRESAG4.1, group 1 adenylyl cyclase, IIC2, ion-channel adenylyl cyclase, Ma1120, mAC, MAP0426c, MAP1279c, MAP1318c, MAP1357, MAP2079, MAP2250c, MAP2440, MAP2507c, MAP2672, MAP2695c, MAP3844, MAP4266, membrane adenylyl cyclase, ML1399, MM0123, MM0157, MM0286, MM0666, MM0730, MM0935, MM1414, MM2428, MM2454, MM2550, MM2962, MM3042, MM3043, MM3257, MM3505, MM3522, MM3640, MM3755, MM3757, MM3795, MM4078, MM4079, MM4080, MM4120, MM4173, MM4340, MM4370, MM4438, MM5137, MM5254, MM5257, More, MSMEG0218, MSMEG0536, MSMEG3253, MSMEG3579, MSMEG3786, MSMEG4282, MSMEG4472, MSMEG4909, MSMEG5003, MSMEG6117, Oscil6304_3613, PAC, particulate adenylyl cyclase, PfACalpha, pituitary adenylate cyclase, PleD, Rutabaga protein, Rv0386, Rv0891c, Rv1120c, Rv1264, Rv1318c, Rv1319c, Rv1320c, Rv1358, Rv1359, Rv1625c, Rv1647, Rv1900c, Rv2212, Rv2435c, Rv2488c, Rv3645, Ry1625c, sAC, sACI/II, SACY, Slr1991 adenylyl cyclase, soluble AC, soluble adenylate cyclase, soluble adenylyl cyclase, TczAC, tmAC, transmembrane adenylyl cyclase, transmembrane adenylyl cyclase type 1, transmembrane adenylyl cyclase type 3, transmembrane adenylyl cyclase type 8, type 1 AC, type 1 adenylyl cyclase, type 1 Ca2+/calmodulin-stimulated adenylyl cyclase, type 3 adenylyl cyclase, type 5 adenylyl cyclase, type 6 adenylyl cyclase, type 8 AC, type 8 adenylyl cyclase, type I adenylate cyclase, type II AC, type III adenylyl cyclase, type V AC, type V adenylate cyclase, type V adenylyl cyclase, type VI adenylyl cyclase, type VIII adenylyl cyclase, VC1, xlAC

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.1 adenylate cyclase

KI Value

KI Value on EC 4.6.1.1 - adenylate cyclase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000011 - 0.05
2'(3')-O-(N-methylanthraniloyl)-ATP
0.00006 - 0.000872
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS
0.000051 - 0.004141
2'(3')-O-(N-methylanthraniloyl)-CTP
0.000013 - 0.001249
2'(3')-O-(N-methylanthraniloyl)-GTP
0.000027 - 0.000666
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS
0.000006 - 0.00003
2'(3')-O-(N-methylanthraniloyl)-ITP
0.00001 - 0.00005
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS
0.000022 - 0.0015
2'(3')-O-(N-methylanthraniloyl)-UTP
0.0055
2',3'-bis[(2-(N-methylanthraniloyl)amino)ethyl-carbamoyl]-ATP
0.0067
2',3'-di[(2-(N-methylanthraniloyl)amino)ethyl-carbamoyl]-ATP
0.00014 - 0.002
2',3'-O-(2,4,6-trinitrophenyl)-ADP
0.0048 - 0.021
2',3'-O-(2,4,6-trinitrophenyl)-AMP
0.0000037 - 0.0001
2',3'-O-(2,4,6-trinitrophenyl)-ATP
0.000024 - 0.00031
2',3'-O-(2,4,6-trinitrophenyl)-CTP
0.00041 - 0.0094
2',3'-O-(2,4,6-trinitrophenyl)-GDP
0.000023 - 0.00043
2',3'-O-(2,4,6-trinitrophenyl)-GTP
0.0000071 - 0.000092
2',3'-O-(2,4,6-trinitrophenyl)-UTP
0.00064 - 0.0029
2',3'-O-(N-anthraniloyl)-ADP
0.00012 - 0.00064
2',3'-O-(N-anthraniloyl)-ATP
0.0043 - 0.0075
2',3'-O-(N-anthraniloyl)-IMP
0.00079 - 0.0029
2',3'-O-(N-methylanthraniloyl)-ADP
0.0001 - 0.00033
2',3'-O-(N-methylanthraniloyl)-ATP
0.00058 - 0.0037
2',3'-O-(N-methylanthraniloyl)-CDP
0.00015 - 0.00069
2',3'-O-(N-methylanthraniloyl)-CTP
0.000053 - 0.00061
2',3'-O-(N-methylanthraniloyl)-GTP
0.000034 - 0.00037
2',3'-O-(N-methylanthraniloyl)-GTPgammaS
0.000031 - 0.000086
2',3'-O-(N-methylanthraniloyl)-IDP
0.0044 - 0.0085
2',3'-O-(N-methylanthraniloyl)-IMP
0.0000012 - 0.000014
2',3'-O-(N-methylanthraniloyl)-ITP
0.000032 - 0.00012
2',3'-O-(N-methylanthraniloyl)-ITPgammaS
0.00034 - 0.0027
2',3'-O-(N-methylanthraniloyl)-UDP
0.000032 - 0.00046
2',3'-O-(N-methylanthraniloyl)-UTP
0.0011 - 0.003
2',3'-O-(N-methylanthraniloyl)-XTP
0.00028
2',3'-O-bis(5-acetamidoanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.000091
2',3'-O-bis(5-bromoanthraniloyl)-ADP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0000126
2',3'-O-bis(5-bromoanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00002
2',3'-O-bis(5-bromoanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.000016
2',3'-O-bis(5-chloroanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.000015
2',3'-O-bis(5-chloroanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0065
2',3'-O-bis(5-methylanthraniloyl)-ADP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00036
2',3'-O-bis(5-methylanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0025
2',3'-O-bis(5-methylanthraniloyl)-CTP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0066
2',3'-O-bis(5-methylanthraniloyl)-IDP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.02
2',3'-O-bis(5-methylanthraniloyl)-IMP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.003
2',3'-O-bis(5-methylanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0007
2',3'-O-bis(5-propylanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0021
2',3'-O-bis(5-propylanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.012
2',3'-O-bis-anthraniloyl-IMP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00032 - 0.0048
2'-deoxy-3'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate
0.00027 - 0.0013
2'-deoxy-3'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
0.0003 - 0.022
2'-methylanthraniloyl-3'-d-ATP
0.0065 - 0.11
2,4,6-trinitrophenyl-ATP
0.01 - 0.41
2,4,6-trinitrophenyl-CTP
0.02 - 0.32
2,4,6-trinitrophenyl-GTP
0.058 - 0.78
2,4,6-trinitrophenyl-UTP
0.104 - 0.146
3'-dATP
0.000065 - 0.00054
3'-deoxy-2'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate
0.0018 - 0.0087
3'-deoxy-2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
0.0002 - 0.032
3'-methylanthraniloyl-2'-d-ATP
0.00071
3'-O-(5-acetamidoanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0048
3'-O-(5-acetamidoanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0087
3'-O-(5-bromoanthraniloyl)-ADP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00033
3'-O-(5-bromoanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00092
3'-O-(5-bromoanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00035
3'-O-(5-chloroanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0007
3'-O-(5-chloroanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.00082
3'-O-(5-propylanthraniloyl)-ATP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0038
3'-O-(5-propylanthraniloyl)-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
0.0094 - 0.01
8-[(4-(N-methylanthraniloyl)amino)butyl]amino-ATP
0.058 - 0.1
8-[(6-(N-methylanthraniloyl)amino)hexyl]-amino-ATP
0.000001 - 0.000025
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate
0.011 - 0.1
anthraniloyl-ADP
0.0013 - 0.02
anthraniloyl-ATP
0.029 - 0.1
anthraniloyl-GTP
0.0075
bis-acetamido-anthraniloyl-ITP
-
in 75 mM HEPES/NaOH, pH 7.4, at 25°C
1.3 - 3.7
cAMP
0.035 - 2.9
CTP
0.033 - 0.071
cytidine 5'-(gamma-thio)triphosphate
0.02 - 0.037
di-methylanthraniloyl-IMP
0.06 - 1.2
diphosphate
0.027 - 1
GTP
2.4 - 3
guanosine 5'-(beta,gamma-imido)triphosphate
0.4 - 0.41
guanosine 5'-(gamma-thio)triphosphate
0.35 - 0.48
inosine 5'-(beta,gamma-imido)triphosphate
0.02 - 0.021
inosine 5'-(gamma-thio)triphosphate
0.1 - 1.1
ITP
0.077
ITPgammaS
-
in the presence of Mn2+
0.012 - 0.091
methylanthraniloyl-ADP
0.0043 - 0.051
methylanthraniloyl-ATP
0.0012 - 0.015
methylanthraniloyl-ATPgammaS
0.018 - 0.1
methylanthraniloyl-CDP
0.0011 - 0.036
methylanthraniloyl-CTP
0.06
methylanthraniloyl-GDP
-
in the presence of Mn2+
0.0059 - 0.016
methylanthraniloyl-GTP
0.0054 - 0.0074
methylanthraniloyl-GTPgammaS
0.011 - 0.1
methylanthraniloyl-IDP
0.1
methylanthraniloyl-IMP
0.0006 - 0.016
methylanthraniloyl-ITP
0.0018 - 0.031
methylanthraniloyl-ITPgammaS
0.043 - 0.1
methylanthraniloyl-UDP
0.0026 - 0.042
methylanthraniloyl-UTP
0.0094 - 0.011
N6-[6-((N-methylanthraniloyl)amino)hexyl]-ATP
2.5 - 2.8
uridine 5'-(beta,gamma-imido)triphosphate
0.015 - 0.051
uridine 5'-(gamma-thio)triphosphate
0.12 - 2.2
UTP
0.036
UTPgammaS
-
in the presence of Mn2+
10
xanthosine 5'-(beta,gamma-imido)triphosphate
0.02 - 0.025
xanthosine 5'-(gamma-thio)triphosphate
0.55 - 0.95
XTP
additional information
additional information
-
inhibition of forskolin-stimulated adenylyl cyclase by mu-opioid recptor agonists in cells expressing different forms of G proteins, overview
-