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analysis
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technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
analysis
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technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
analysis
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technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
analysis
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technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
analysis
the enzyme activity is useful as a marker for determination of G-protein-coupled receptor function mediating adenylyl cylcase activation by extracellular baculovirus particles, usage of this budded virus display system to detect G-protein-coupled receptor signaling, method development, overview
analysis
development of a fluorescence resonance energy transfer (FRET) sensor that functions both as a soluble cyclase and a reporter of complementation within the catalytic domain. There is a strong linear correlation between catalytic domain complementation and cyclase activity upon stimulation with forskolin and the Galphas subunit. The sensor is functional in live cells
analysis
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technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
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drug development
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CyaA substantially contributes to the pathogenesis of whooping cough, catalytic site of CyaA possesses substantial conformational freedom to accommodate structurally diverse ligands, certain ligands bind to CyaA even in the absence of calmodulin, facilitating future inhibitor design
drug development
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stable AC2-expressing CHODUKX cell line in which the generation of high expressing GPCR receptor/AC2 lines can retain their functional responsiveness and can provide pharmacological drug comparisons between the same host line for screening purposes and measurement of multiple cellular parameters
drug development
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AC1 is a potential drug target site to improve long-term remote memor
medicine
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induction of cardiac myocyte apoptosis by high beta-adrenergic receptor stimulation is effectively prevented by type 5 adenylyl cyclase inhibitors. Inhibition of adrenergic signaling at the level of the type 5 adenylyl cyclase isoform by P-site inhibitors may serve as an effective method to prevent cardiac myocyte apoptosis induced by excessive adrenergic stimulation without deleterious effect on cardiac myocyte contraction
medicine
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A2bR mediates signaling through AC-6 isoform, therapeutic implications for intestinal inflammation or diarrhea wherein A2bR is upregulated
medicine
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A2bR mediates signaling through AC-6 isoform, therapeutic implications for intestinal inflammation or diarrhea wherein A2bR is upregulated
medicine
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AC1 and AC8 involved in long-term memory and in N-methyl-D-aspartate-dependent long-term potentiation, AC1 and AC8 are not required for acute pain response. AC1 is the major Ca2+ sensor for N-methyl-D-aspartate receptor activation and excitotoxicity
medicine
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AC5 is the major AC isoform mediating acute beta-adrenergic stimulation, AC5 plays a major role in L-type Ca2+ currents activation
medicine
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AC6 improves function in Galphaq-hypertrophic pigs
medicine
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AC6, but not AC5, mRNA is decreased in rats with cardiac hypertrophy after myocardial infarction, overexpression of AC6 in cardiac fibroblasts impairs collagen synthesis in response to serum or other activators
medicine
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cumulus cells possess multiple active isoforms of adenylyl cyclase, each isoform may have a specific role at a specific time during oocyte growth and maturation
medicine
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involved in mediating opioid actions, AC5 is essential for micro, and to a lesser extent, delta, opioid receptor signaling in striatum
medicine
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overexpression of AC6 or drug-stimulated cAMP accumulation in WI-38 lung fibroblast attenuates fibrosis
medicine
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overexpression of AC6 prevents development of cardiac hypertrophy, restores normal cardiac function, improves mortality rate, and contractile function. Overexpression of AC5 also restores cAMP signaling and contractile deficits, but cardiac hypertrophy still develops. Decreased AC5 expression does not diminish cardiac funcition, may be beneficial in mice experiencing artificial pressure overload
medicine
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sAC and the vacuolar proton pumping ATPase have a close association, may be part of a protein complex that is involved in regulating renal distal proton secretion
medicine
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sAC and the vacuolar proton pumping ATPase have a close association, may be part of a protein complex that is involved in regulating renal distal proton secretion
medicine
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sAC plays a critical role in cAMP signaling in spermatozoa, defective cAMP production prevents engagement of multiple components of capacitation resulting in male infertility. sAC and cAMP coordinate cellular energy balance in wild-type sperm. sAC appears to be a promising target for the development of male contraceptives
medicine
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inhibition of adenylyl cyclase type 5 is a strategy to treat heart failure
medicine
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isoform ACbeta represents a potential target for development of safe and effective antimalarial therapeutics
medicine
isoform Adcy1 catalytic activity can be delicately adjusted by mediating calmodulin activation of Adcy1 by reversible Met oxidation in calmodulin
medicine
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involved in mediating opioid actions, AC5 is essential for micro, and to a lesser extent, delta, opioid receptor signaling in striatum
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medicine
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AC5 is the major AC isoform mediating acute beta-adrenergic stimulation, AC5 plays a major role in L-type Ca2+ currents activation
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molecular biology
the enzyme is a favorable optogenetic tools for non-invasive, cell-selective, and spatio-temporally precise modulation of cAMP/cGMP with light. The rhodopsin domain from Catenaria is more photostable than that from Blastocladiella, and the signaling state persists longer, both of which are highly desirable traits for optogenetic applications
molecular biology
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the enzyme is a favorable optogenetic tools for non-invasive, cell-selective, and spatio-temporally precise modulation of cAMP/cGMP with light. The rhodopsin domain from Catenaria is more photostable than that from Blastocladiella, and the signaling state persists longer, both of which are highly desirable traits for optogenetic applications
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pharmacology
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activation of cardiac adenylyl cyclase isozyme ACVI expression increases the function of the failing ischemic heart in mice, overview. Increased left ventricular ACVI content also markedly reduces mortality and increases left ventricular function after acute myocardial infarction in mice
pharmacology
pharmacological approaches do not allow cell specific manipulation of cyclic nucleotides in tissue and lack precision in space and time, limitations that can be overcome using the light-activated enzyme
pharmacology
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pharmacological approaches do not allow cell specific manipulation of cyclic nucleotides in tissue and lack precision in space and time, limitations that can be overcome using the light-activated enzyme
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additional information
15 putative AC genes present
additional information
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AC8 acts as a low-pass filter for high-frequency Ca2+ events, enhancing the regulatory options available to this signalling pathway
additional information
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ACA has the same architecture as mammalian membrane-bound ACs, is essential for reacting to and production of cAMP. ACG is essential for germination. ACB is required for terminal maturation of spores
additional information
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ACIII is a marker for primary cilia throughout many regions of the adult mouse brain
additional information
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ACT enhances the adhesive functions of filamentous haemagglutinin and modifies the performance of the filamentous haemagglutinin heparin-inhibitable carbohydrate binding site
additional information
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activation of the HCO3-/sAC transduction pathway enhances both cftr gene and CFTR protein expression and appears to be a physiological mechanism whereby the cell adapts to variations in extracellular HCO3- concentration
additional information
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both sAC and tmACs participate in the sperm acrosome reaction and sperm motility
additional information
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Ca2+-stimulated AC regulates If via cAMP, modulation of the If pacemaker current
additional information
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can function as a ion channel
additional information
Q7CH76
class IV AC fold is distinct from the previously described folds for class II and class III ACs
additional information
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class IV AC fold is distinct from the previously described folds for class II and class III ACs
additional information
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compartmentalization of cAMP signalling, cAMP levels change in discrete domains of the cell with discrete local consequences
additional information
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contains a GGDEF domain
additional information
CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB2 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB2 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB2 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaC consists of a receiver domain, two GAF domains, a histidine kinase domain, another receiver and a CHD
additional information
CyaC consists of a receiver domain, two GAF domains, a histidine kinase domain, another receiver and a CHD
additional information
CyaC consists of a receiver domain, two GAF domains, a histidine kinase domain, another receiver and a CHD
additional information
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endothelin-1 deficiency increases inner medullary collecting duct AC5/6 content, that may synergize with acute endothelin-1 inhibition of vasopressin-stimulated cAMP accumulation
additional information
Drosophila sp. (in: flies)
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essential role of Ca2+/calmodulin-regulated ACs in learning and memory
additional information
interaction between the N-terminus of AC5 and the guanine nucleotide exchange factor Ric8a provides a pathway to fine-tune AC5 activity via a Galphai mediated pathway
additional information
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involved in sensing high osmotic pressure
additional information
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is an exotoxin
additional information
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is an exotoxin
additional information
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is an exotoxin
additional information
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isoform-selective signaling complexes likely contribute to various functional consequences of cAMP elevation in vascular smooth muscle cells. AC1 isoform contributes to modulation of extracellular signal-regulated kinase signaling, proliferation, and control of cell division, whereas AC6, at least partly because of uncoupling of cAMP synthesis from cAMP breakdown, results in sustained cAMP accumulation, vasodilator-stimulated phosphoprotein phosphorylation, and control of cytoskeletal rearrangements that contribute to vascular arborization
additional information
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membrane transitions in cAMP strengthen the endothelial cell barrier, whereas the production of cAMP by soluble AC within the cytosol away from the membrane disrupts the endothelial cell barrier
additional information
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overexpression of AC1 in forebrain enhances long-term potentiation
additional information
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restores adenylate cyclase activity in Escherichia coli knockout mutants
additional information
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restores adenylate cyclase activity in Escherichia coli knockout mutants
additional information
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restores adenylate cyclase activity in Escherichia coli knockout mutants
additional information
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restores adenylate cyclase activity in Escherichia coli knockout mutants
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
Rv1120c is a pseudogene in Mycobacterium tuberculosis
additional information
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Rv1264 plays a role in mycobacterial survival in the acidic environment of the pahgolysosome
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1318c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1319c has a HAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1320c has aHAMP domain
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1625c has the highest sequence similarity with the mammalian enzymes
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
additional information
Rv2212 gene has a domain composition identical to that of the AC isoform Rv1264, limited similarity of the N-termini, N-terminal domain of Rv2212 is not autoinhibitory as in Rv1264
additional information
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Rv2212 gene has a domain composition identical to that of the AC isoform Rv1264, limited similarity of the N-termini, N-terminal domain of Rv2212 is not autoinhibitory as in Rv1264
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
Rv3645 has a HAMP domain
additional information
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sAC is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency in conditions of changing intracellular CO2/HCO3- via production of cAMP
additional information
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senses ional changes in the environment
additional information
shares high sequence similarity (approximately 62%) with the Drosophila AC39E, enzyme serves in biogenic amine signal transduction cascades and in higher brain functions that contribute to learning and memory of the bee
additional information
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shares high sequence similarity (approximately 62%) with the Drosophila AC39E, enzyme serves in biogenic amine signal transduction cascades and in higher brain functions that contribute to learning and memory of the bee
additional information
construction of a fusion between Deinococcus radiodurans bacteriophytochrome linked to Synechocystis sp. guanylate/adenylate cyclase. The construct shows low dark-state activity and high dynamic range that outperforms previous optogenetic tools in vitro
additional information
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ACT enhances the adhesive functions of filamentous haemagglutinin and modifies the performance of the filamentous haemagglutinin heparin-inhibitable carbohydrate binding site
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additional information
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Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
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additional information
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Rv2212 gene has a domain composition identical to that of the AC isoform Rv1264, limited similarity of the N-termini, N-terminal domain of Rv2212 is not autoinhibitory as in Rv1264
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additional information
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Rv1647 adenylyl cyclase has a cyclase domain that is more closely related to fungal and protist cyclases
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additional information
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Rv1320c has aHAMP domain
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additional information
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Rv1319c has a HAMP domain
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additional information
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Rv1318c has a HAMP domain
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additional information
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15 putative AC genes present
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additional information
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Rv1625c has the highest sequence similarity with the mammalian enzymes
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additional information
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ACIII is a marker for primary cilia throughout many regions of the adult mouse brain
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