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Disease on EC 4.6.1.1 - adenylate cyclase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acantholysis
Effects of trypsin on the cyclic AMP system of the pig skin.
Achlorhydria
Adenylate cyclase in gastric mucosal biopsies from patients with achlorhydria. Stimulation by PGE2, histamine and gastrointestinal hormones.
Acidosis
Candidate human genetic polymorphisms and severe malaria in a Tanzanian population.
Effect of acidosis on PTH-dependent renal adenylate cyclase in phosphorus deprivation: role of G proteins.
Effect of acute metabolic acidosis on vasopressin-dependent cyclic AMP in rat kidney.
Effect of metabolic acidosis on the PTH receptor-adenylate cyclase system of canine kidney.
Hypercapnia Accelerates Adipogenesis: A Novel Role of High CO2 in Exacerbating Obesity.
Modulation of glucagon effects by changes in extracellular pH and calcium.
The cardiac adrenergic system in ischaemia: differential role of acidosis and energy depletion.
Acquired Immunodeficiency Syndrome
The fine-structural distribution of G-protein receptor kinase 3, beta-arrestin-2, Ca2+/calmodulin-dependent protein kinase II and phosphodiesterase PDE1C2, and a Cl(-)-cotransporter in rodent olfactory epithelia.
Acromegaly
GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line.
Growth hormone releasing hormone-sensitive adenylate cyclase activity in growth hormone-producing pituitary adenoma: correlation to the response of plasma growth hormone to growth hormone releasing hormone in patients with acromegaly.
ACTH-Secreting Pituitary Adenoma
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas.
Type I receptors for PACAP (a neuropeptide even more important than VIP?).
VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas.
Acute Kidney Injury
Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats.
The effect of gentamicin on antidiuretic hormone-stimulated osmotic water flow in the toad urinary bladder.
Adenocarcinoma
Adenylate cyclase activity in human pancreatic adenocarcinoma cell lines.
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Inactivation of the G alpha i2 and G alpha o genes by homologous recombination.
Production, analysis and bioactivity of recombinant vasoactive intestinal peptide analogs.
[Receptors for vasoactic intestinal peptide (VIP) in human colonic adenocarcinoma membranes: specific binding and stimulation of adenylate cyclase]
Adenocarcinoma of Lung
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Adenoma
Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.
Activation of adenyl cyclase in a pancreatic islet cell adenoma by glucagon and tolbutamide.
Adenylate cyclase activity and cyclic adenosine monophosphate levels in colon cancer lines and dermal fibroblasts and the effects of cholera toxin and epidermal growth factor.
Biological characteristics of adenomatous nodules, adenomas, and hyperfunctioning nodules as defined by adenylate cyclase activity and TSH receptors.
Cellular abnormalities in pituitary tumors.
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer.
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Comparative study of cyclic AMP-generation system, steroid biosynthesis and lipid metabolism in vitro in ACTH responsive and unresponsive adrenal tumors.
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol.
Growth hormone-releasing hexapeptide (GHRP-6) increases intracellular calcium concentrations in cultured cells from human pituitary adenomas of different types.
Hepatic preneoplasia in hepatitis B virus transgenic mice.
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine.
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.
Resistance to bromocriptine in prolactinomas.
Resistance to somatostatin (SRIH) analog therapy in acromegaly. Re-evaluation of the correlation between the SRIH receptor status of the pituitary tumor and the in vivo inhibition of GH secretion in response to SRIH analog.
Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions.
Somatostatin receptors, adenylate cyclase activity, and growth hormone (GH) response to octreotide in GH-secreting adenomas.
The adenylate cyclase-cyclic AMP-phosphodiesterase system in pathological human thyroid.
Thyrotrophin-responsive adenylate cyclase activity in thyroid toxic adenoma.
Thyrotropin receptor-adenylate cyclase function in human thyroid neoplasms.
[Alterations in receptor status and signal transduction mechanisms in pituitary tumors]
Adenoma, Islet Cell
Activation of adenyl cyclase in a pancreatic islet cell adenoma by glucagon and tolbutamide.
Adenoma, Villous
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
adenosine deaminase deficiency
Lithium chloride induces partial responsiveness to LPS in nonresponder B cells.
adenylate cyclase deficiency
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
An enzymatic alteration secondary to adenylyl cyclase deficiency in the cr-1 (crisp) mutant of Neurospora crassa: nicotinamide adenine dinucleotide (phosphate) glycohydrolase overproduction.
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Enzymatic alterations secondary to adenyl cyclase deficiency in the cr-1 (crisp) mutant of Neurospora crassa: anomalies of the beta-glucosidase system.
Adrenal Cortex Neoplasms
Abnormal hormone responses of an adrenocortical cancer adenyl cyclase.
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer.
Adrenal Gland Neoplasms
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
Adrenocortical Adenoma
Adenylate cyclase of human aldosterone-producing adrenocortical adenoma.
Basis of false-positive glucagon tests for pheochromocytoma.
Adrenocortical Carcinoma
Dual regulation of adenylate cyclase and guanylate cyclase: alpha 2-adrenergic signal transduction in adrenocortical carcinoma cells.
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
Ectopic beta-adrenergic receptors coupled to adenylate cyclase in human adrenocortical carcinomas.
Evidence for decreased activity of guanine nucleotide binding protein in adenylate cyclase of cell membranes in human ACTH-unresponsive adrenocortical carcinoma.
Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator.
Metabolic regulation and adenyl cyclase activity of adrenocortical carcinoma cultured cells.
Multiple specific hormone receptors in the adenylate cyclase of an adrenocortical carcinoma.
Airway Obstruction
Respiratory syncytial virus induces ?2-adrenergic receptor dysfunction in human airway smooth muscle cells.
Albuminuria
cAMP Signaling Prevents Podocyte Apoptosis via Activation of Protein Kinase A and Mitochondrial Fusion.
Altitude Sickness
Exposure to intermittent high altitude induces different changes in adenylyl cyclase activity in hearts of young and adult Wistar rats.
[Effect of adaptation to high altitude hypoxia and cold on rat myocardial adenyl cyclase activity]
Alzheimer Disease
Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease.
Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected.
Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease.
Age related decline in aluminum-activated human platelet adenylate cyclase: post-receptor changes in cyclic AMP second messenger signal amplification in normal aging and dementia of the Alzheimer type.
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease.
Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain.
Basal and stimulated hippocampal adenylate cyclase activity in the experimentally lesioned rat entorhinal cortex.
Chronic but not acute intracerebroventricular administration of amyloid beta-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus.
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Decreased beta-adrenoceptor-stimulated adenylyl cyclase activity in lymphocytes from Alzheimer's disease patients.
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations.
Effects of single and continuous administration of amyloid beta-peptide (25-35) on adenylyl cyclase activity and the somatostatinergic system in the rat frontal and parietal cortex.
G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies.
Hippocampal level of neural specific adenylyl cyclase type I is decreased in Alzheimer's disease.
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Increased accumulation of cAMP in cerebral microvessels in Alzheimer's disease.
Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield.
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain.
Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease.
Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Recovery of deficient cholinergic calcium signaling by adenosine in cultured rat cortical astrocytes.
Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes.
Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain.
Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Somatostatin receptors and the modulation of adenylyl cyclase activity in Alzheimer's disease.
The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques.
Amnesia
[Action of PMA (phorbol myristate acetate), scopolamine, propranolol, and oxotremorine on memorization of an active or passive avoidance test]
Amyloidosis
Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis.
Anaphylaxis
Potentiated anaphylaxis in patients with drug-induced beta-adrenergic blockade.
[Changes in the cyclic nucleotide system in experimental anaphylaxis and approaches to their correction]
Anemia
Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.
Human red cell membrane adenylate cyclase in normal subjects and patients with hereditary spherocytosis, sickle cell disease and unidentified hemolytic anemias.
Maturation dependence of fluoride-sensitive adenylate cyclase in red blood cells.
The enzymes of the red blood cell plasma membrane.
Anemia, Sickle Cell
Adenylyl Cyclase 9 Polymorphisms Reveal Potential Link to HDL Function and Cardiovascular Events in Multiple Pathologies: Potential Implications in Sickle Cell Disease.
Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.
Human red cell membrane adenylate cyclase in normal subjects and patients with hereditary spherocytosis, sickle cell disease and unidentified hemolytic anemias.
Anosmia
Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.
Anthrax
A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins.
A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol.
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo.
A diverse set of single-domain antibodies (VHHs) against the anthrax toxin lethal and edema factors provides a basis for construction of a bispecific agent that protects against anthrax infection.
A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo.
A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model.
A kinetic analysis of protein transport through the anthrax toxin channel.
A model of anthrax toxin lethal factor bound to protective antigen.
A NEUTRALIZING MONOCLONAL ANTIBODY TO EDEMA TOXIN AND ITS EFFECT ON MURINE ANTHRAX.
A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor.
Accounting for ligand-bound metal ions in docking small molecules on adenylyl cyclase toxins.
Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin.
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.
Anthrax biosensor, protective antigen ion channel asymmetric blockade.
Anthrax edema factor potency depends on mode of cell entry.
Anthrax Edema Factor Toxicity Is Strongly Mediated by the N-end Rule.
Anthrax edema factor, voltage-dependent binding to the protective antigen ion channel and comparison to LF binding.
Anthrax Edema Factor: An Ion-Adaptive Mechanism of Catalysis with Increased Transition-State Conformational Flexibility.
Anthrax edema toxin impairs clearance in mice.
Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.
Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells.
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
Anthrax edema toxin requires influx of calcium for inducing cyclic AMP toxicity in target cells.
Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.
Anthrax Lethal Factor (LF) Mediated Block of the Anthrax Protective Antigen (PA) Ion Channel: Effect of Ionic Strength and Voltage.
Anthrax lethal factor and edema factor act on conserved targets in Drosophila.
Anthrax lethal factor inhibitors as potential countermeasure of the infection.
Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice.
Anthrax Pathogenesis.
Anthrax protective antigen forms oligomers during intoxication of mammalian cells.
Anthrax protective antigen: efficiency of translocation is independent of the number of ligands bound to the prepore.
Anthrax toxin blocks priming of neutrophils by lipopolysaccharide and by muramyl dipeptide.
Anthrax toxin channel: What we know based on over 30 years of research.
Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously.
Anthrax toxin components stimulate chemotaxis of human polymorphonuclear neutrophils.
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
Anthrax toxin entry into polarized epithelial cells.
Anthrax toxin induces hemolysis: an indirect effect through polymorphonuclear cells.
Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Anthrax toxin protective antigen--insights into molecular switching from prepore to pore.
Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis.
Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.
Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage.
Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo.
Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplex.
Anthrax toxin: a tripartite lethal combination.
Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers.
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.
Anthrax Vaccine Precipitated induces Edema Toxin-neutralizing, Edema Factor-specific antibodies in human recipients.
Anthrax--an overview.
Antibodies to anthrax toxin in humans and guinea pigs and their relevance to protective immunity.
Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
Asp 187 and Phe 190 residues in lethal factor are required for the expression of anthrax lethal toxin activity.
Assembly and disassembly kinetics of anthrax toxin complexes.
Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
ATP conformations and ion binding modes in the active site of anthrax edema factor: A computational analysis.
ATP Depletion Via Mitochondrial F1F0 Complex by Lethal Factor is an Early Event in B. Anthracis-Induced Sudden Cell Death.
Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells.
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice.
Bacillus anthracis edema toxin inhibits hypoxic pulmonary vasoconstriction via edema factor and cAMP-mediated mechanisms in isolated perfused rat lungs.
Bacillus anthracis protective antigen kinetics in inhalation spore-challenged untreated or levofloxacin/ raxibacumab-treated New Zealand white rabbits.
Bacillus anthracis-derived edema toxin (ET) counter-regulates movement of neutrophils and macromolecules through the endothelial paracellular pathway.
Binding of N-terminal fragments of anthrax edema factor (EF(N)) and lethal factor (LF(N)) to the protective antigen pore.
Calcium dependence of the interaction between calmodulin and anthrax edema factor.
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
Calmodulin in action: diversity in target recognition and activation mechanisms.
CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies.
Cell entry and cAMP imaging of anthrax edema toxin.
Characterization of Protein-Protein Interfaces through a Protein Contact Network Approach.
Cloning and expression of the Bacillus anthracis protective antigen gene in Bacillus subtilis.
Cloning and expression of the calmodulin-sensitive Bacillus anthracis adenylate cyclase in Escherichia coli.
Control of anthrax toxin gene expression by the transition state regulator abrB.
COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro.
Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin.
Cross-Reactivity of Anthrax and C2 Toxin: Protective Antigen Promotes the Uptake of Botulinum C2I Toxin into Human Endothelial Cells.
Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
Cys-Cys Cross-Linking Shows Contact between the N-Terminus of Lethal Factor and Phe427 of the Anthrax Toxin Pore.
Deletion mutants of protective antigen that inhibit anthrax toxin both in vitro and in vivo.
Delivery of nucleic acid into mammalian cells by anthrax toxin.
Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.
Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles.
Development of a novel multiepitope chimeric vaccine against anthrax.
Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor.
Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model.
Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin.
Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.
Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.
Effect of nasal immunization with protective antigen of Bacillus anthracis on protective immune response against anthrax toxin.
Effects by anthrax toxins on hematopoiesis: a key role for cytokines as mediators.
Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor.
Effects of anthrax toxin components on human neutrophils.
Electrostatic ratchet in the protective antigen channel promotes anthrax toxin translocation.
Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions.
Evaluation of immune response to recombinant Bacillus anthracis LFD1-PA4 chimeric protein.
EVB Simulations of the Chemical Mechanism of ATP to cAMP Conversion by Anthrax Edema Factor.
Expression and purification of anthrax toxin protective antigen from Escherichia coli.
Expression of anthrax lethal factor gene by osmolyte induction.
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax.
Femtomolar detection of the anthrax edema factor in human and animal plasma.
Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen.
Fusion protein of Delta 27LFn and EFn has the potential as a novel anthrax toxin inhibitor.
Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells.
Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis.
GcoGSA-BA: a global core genome SNP analysis for Bacillus anthracis.
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Hydrophobic residues Phe552, Phe554, Ile562, Leu566, and Ile574 are required for oligomerization of anthrax protective antigen.
Identification of a lead small-molecule inhibitor of anthrax lethal toxin by using fluorescence-based high-throughput screening.
Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin.
Identification of small molecule inhibitors of anthrax lethal factor.
Imaging the Cell Entry of the Anthrax Edema and Lethal toxins with Fluorescent Protein Chimeras.
Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin.
Induction of cytotoxic T lymphocyte response against Mycobacterial antigen using domain I of anthrax edema factor as antigen delivery system.
Inhibition of anthrax lethal factor by ssDNA aptamers.
Inhibition of anthrax protective antigen outside and inside the cell.
Inhibition of anthrax toxins with a bispecific monoclonal antibody that cross reacts with edema factor as well as lethal factor of Bacillus anthracis.
Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.
Inhibitors of Bacillus anthracis edema factor.
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling.
Internalization of a Bacillus anthracis protective antigen-c-Myc fusion protein mediated by cell surface anti-c-Myc antibodies.
Involvement of residues 147VYYEIGK153 in binding of lethal factor to protective antigen of Bacillus anthracis.
Ion Conductance of the Stem of the Anthrax Toxin Channel during Lethal Factor Translocation.
Ion selectivity of the anthrax toxin channel and its effect on protein translocation.
Large-scale structural changes accompany binding of lethal factor to anthrax protective antigen: a cryo-electron microscopic study.
Lethal factor is not required for Bacillus anthracis virulence in guinea pigs and rabbits.
Lethal factor of anthrax toxin binds monomeric form of protective antigen.
Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge.
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis.
Mapping the anthrax protective antigen binding site on the lethal and edema factors.
Mapping the epitopes of a neutralizing antibody fragment directed against the lethal factor of Bacillus anthracis and cross-reacting with the homologous edema factor.
Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen.
MD simulations of anthrax edema factor: calmodulin complexes with mutations in the edema factor "switch a" region and docking of 3'-deoxy ATP into the adenylyl cyclase active site of wild-type and mutant edema factor variants.
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process.
Mechanism of reactant and product dissociation from the anthrax edema factor: A locally enhanced sampling and steered molecular dynamics study.
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway.
Model of the toxic complex of anthrax: responsive conformational changes in both the lethal factor and the protective antigen heptamer.
Modulation of the Bacillus anthracis secretome by the immune inhibitor A1 protease.
Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.
Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.
Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR.
Mouse monoclonal antibodies to anthrax edema factor protect against infection.
Multicomponent anthrax toxin display and delivery using bacteriophage T4.
Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.
Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin.
N-fragment of edema factor as a candidate antigen for immunization against anthrax.
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.
Neutralizing activity of vaccine-induced antibodies to two Bacillus anthracis toxin components, lethal factor and edema factor.
Neutralizing antibodies and persistence of immunity following anthrax vaccination.
New insights into the pathogenesis and treatment of anthrax toxin-induced shock.
Non-canonical effects of anthrax toxins on hem atop oiesis: implications for vaccine development.
Novel inhibitors of anthrax edema factor.
PA63 channel of anthrax toxin: an extended beta-barrel.
Participation of residue F552 in domain III of the protective antigen in the biological activity of anthrax lethal toxin.
Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs.
Pathogenicity, population genetics and dissemination of Bacillus anthracis.
pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen.
Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor.
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
Poly-gamma-d-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus anthracis in guinea-pigs and rabbits.
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding.
Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.
Production and purification of Bacillus anthracis protective antigen from Escherichia coli.
Production of biologically active Bacillus anthracis edema factor in Escherichia coli.
Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus.
Protein translocation through anthrax toxin channels formed in planar lipid bilayers.
Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient.
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently.
Proteome analysis of mouse macrophages treated with anthrax lethal toxin.
Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin.
Purification of anthrax edema factor from Escherichia coli and identification of residues required for binding to anthrax protective antigen.
Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity.
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.
Rapid purification of recombinant anthrax-protective antigen under nondenaturing conditions.
Role of the ? Clamp in the Protein Translocation Mechanism of Anthrax Toxin.
Scalable purification of Bacillus anthracis protective antigen from Escherichia coli.
Secondary Structure Preferences of the Anthrax Toxin Protective Antigen Translocase.
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Small molecule inhibitors of anthrax edema factor.
Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection.
Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Structural basis of anthrax edema factor neutralization by a neutralizing antibody.
Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis.
Structure and function of anthrax toxin.
Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site.
Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry.
Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracis.
Synthesis and screening of small molecule inhibitors of anthrax edema factor.
Synthesis of ?-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
The 2beta(2)-2beta(3) loop of anthrax protective antigen contains a dominant neutralizing epitope.
The adenylyl cyclase activity of anthrax edema factor.
The anthrax protective antigen (PA63) bound conformation of a peptide inhibitor of the binding of lethal factor to PA63: as determined by trNOESY NMR and molecular modeling.
The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity.
The channel formed in planar lipid bilayers by the protective antigen component of anthrax toxin.
The CMG2 ELISA for evaluating inhibitors of the binding of anthrax toxin protective antigen to its receptor.
The early humoral immune response to Bacillus anthracis toxins in patients infected with cutaneous anthrax.
The effects of anthrax lethal toxin on host barrier function.
The HC fragment of tetanus toxin forms stable, concentration-dependent dimers via an intermolecular disulphide bond.
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen.
The Major Neutralizing Antibody Responses to Recombinant Anthrax Lethal Factor and Edema Factors Are Directed to Non-Cross-Reactive Epitopes.
The overlap of small molecule and protein binding sites within families of protein structures.
The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.
Toxicity of anthrax toxin is influenced by receptor expression.
Trapping a translocating protein within the anthrax toxin channel: implications for the secondary structure of permeating proteins.
Trp 346 and Leu 352 residues in protective antigen are required for the expression of anthrax lethal toxin activity.
Vaccine Delivery with a Detoxified Bacterial Toxin.
Whole-cell voltage clamp measurements of anthrax toxin pore current.
Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.
[Anthrax--the past, present and future]
[Effect of anthrax toxin on the chemiluminescence of human leukocytes]
[Efficient expression of anthrax edema factor in Escherichia coli and its single-step purification].
[Expression and analysis of biological activity of the recombination anthrax edema factor]
[Expression of ATR-Fc fusion protein in CHO cells]
[The isolation and purification of the protective antigen and the edema factor from the culture filtrate of Bacillus anthracis STI-1]
[Toxin-neutralizing monoclonal antibodies to the different domains of anthrax protective antigen]
Aortic Coarctation
[The status of the adenylate cyclase system in rat myocardium in dystrophic degeneration]
Aortic Valve Disease
Effects of the H2-receptor agonist impromidine in human myocardium from patients with heart failure due to mitral and aortic valve disease.
Aortic Valve Insufficiency
Myocardial sympathetic denervation prevents chamber-specific alteration of beta-adrenergic transmembrane signaling in rabbits with heart failure.
Aortic Valve Stenosis
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
[Beta-adrenergic receptivity and left ventricular hypertrophy caused by pressure overload in man]
Apraxias
Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease.
Arrhythmias, Cardiac
Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction.
Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice.
Arteriosclerosis
[Adenyl cyclase activity in the tissues and excretion of cyclic adenosine monophosphate in experimental arteriosclerosis]
Arthritis
Adenyl cyclase activity in lymphocytes stimulated with immunologically specific and nonspecific stimuli.
Asthenozoospermia
ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.
Biochemical correlates of asthenozoospermia: a lesion at the level of the sperm adenylyl cyclase.
Asthma
?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.
Adenosine receptors and asthma.
Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children.
Allergen challenge primes for IL-5 mRNA production and abrogates beta-adrenergic function in peripheral blood T lymphocytes from asthmatics.
Defect in potentiation of adenylyl cyclase correlates with bronchial hyperreactivity.
Desensitization of the adenylyl cyclase system in peripheral blood mononuclear cells from patients with asthma three hours after allergen challenge.
Effects of salmeterol on muscarinic inhibition of adenylyl cyclase in bovine trachealis cells.
Experiments on the role of virus infections in the pathogenesis of bronchial asthma. The role of innate or acquired insufficiency or ergotropic adaptation in the mechanism of genesis of bronchial asthma.
Hormone-sensitive adenylate cyclase system in lymphocytes from asthmatic patients: possible defects at the postreceptor sites.
Increased adenosine triphosphatase activity in platelets of asthmatic children.
Lack of coupling of muscarinic receptors to phosphoinositide metabolism and adenylyl cyclase in human lymphocytes and polymorphonuclear leukocytes: studies in healthy subjects and allergic asthmatic patients.
Leukocyte adenyl cyclase activity in human bronchial asthma.
Leukocyte adenyl cyclase and ATPase in asthma: effect of corticosteroid therapy.
Magnesium sulfate for severe acute asthma in children.
Mechanisms of hyperreactivity of airways in asthma.
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.
Muscarinic control of airway function.
Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice.
Peripheral blood T lymphocytes from asthmatic patients are primed for enhanced expression of interleukin (IL)-4 and IL-5 mRNA: associations with lung function and serum IgE.
Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma.
Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice.
Receptors in asthmatic airways.
Reduced adenylyl cyclase activation with no decrease in beta-adrenergic receptors in basenji greyhound leukocytes: relevance to beta-adrenergic responses in airway smooth muscle.
Reduced responsiveness of adenylate cyclase in alveolar macrophages from patients with asthma.
Regulation of beta 2-adrenergic receptors and the implications for bronchial asthma: an update.
Regulation of the beta-receptor-adenylate cyclase system in lymphocytes of allergic patients with asthma: possible role for protein kinase C in allergen-induced nonspecific refractoriness of adenylate cyclase.
Relationship between nonspecific bronchial responsiveness to methacholine and peripheral mononuclear leukocyte beta-adrenergic receptor function in young drug-naive subjects.
Response of leucocyte adenyl cyclase to isoprenaline and effect of alpha-blocking drugs in extrinsic bronchial asthma.
Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells.
Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor.
The beta-adrenergic system and allergic bronchial asthma: changes in lymphocyte beta-adrenergic receptor number and adenylate cyclase activity after an allergen-induced asthmatic attack.
The relationship of leucocyte adenyl cyclase activity and airways response to beta blockade and allergen challenge in extrinsic asthma.
The role of adenylyl cyclase isoform 6 in ?-adrenoceptor signalling in murine airways.
The role of phospholipase in reduced beta-adrenergic responsiveness in experimental asthma.
Treatment of asthma with theophylline and beta adrenergic agents.
[Adrenergic blockade theory on the bronchial asthma, especially emphasizing adenyl cyclase activity (author's transl)]
[Interrelation between changes of adenylate cyclase and levels of several hormones in children with bronchial asthma]
[Role of adenylate cyclase system in pathogenesis of various types of occupational bronchial asthma]
[The adenyl cyclase system in asthma patients]
Astrocytoma
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
Adaptive changes in the responsiveness of adenylate cyclase to catecholamines.
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
Adenosine inhibits histamine-induced phosphoinositide hydrolysis mediated via pertussis toxin-sensitive G protein in human astrocytoma cells.
Agonists and phorbol esters desensitize beta-adrenergic receptors by different mechanisms.
An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors.
Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase.
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.
Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase.
D-1 dopaminergic and beta-adrenergic stimulation of adenylate cyclase in a clone derived from the human astrocytoma cell line G-CCM.
Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase.
Differential expression of components of the adenylate cyclase system during growth of astrocytoma cells in culture.
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.
Endogenous GTP and the regulation of epinephrine stimulation of adenylate cyclase.
Expression of rat mRNA coding for hormone-stimulated adenylate cyclase in Xenopus oocytes.
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
G?(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.
Inhibition of beta(2)-adrenergic and muscarinic cholinergic receptor endocytosis after depletion of phosphatidylinositol bisphosphate.
Isolation of adenylate cyclase-enriched membranes from mammalian cells using concanavalin A.
Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.
Maintenance of whole cell isoproterenol and forskolin responsiveness in adenylate cyclase of permeabilized cells.
Mechanisms of alpha-Sialosyl cholesterol action to suppress both cyclic AMP production and DNA synthesis of rat glial cells.
Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.
Mepacrine treatment prevents immobilization-induced desensitization of beta-adrenergic receptors in rat hypothalamus and brain stem.
Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Phospholipid methylation: a possible mechanism of signal transduction across biomembranes.
Regulation of adenosine 3':5'-monophosphate content of human astrocytoma cells: desensitization to catecholamines and prostaglandins.
Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells.
Selective ?2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac.
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site.
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
Ataxia
Active-site structure of class IV adenylyl cyclase and transphyletic mechanism.
Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination.
Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP.
Rat striatal adenosinergic modulation of ethanol-induced motor impairment: possible role of striatal cyclic AMP.
Sustained antagonism of acute ethanol-induced ataxia following microinfusion of cyclic AMP and cpt-cAMP in the mouse cerebellum.
Atherosclerosis
Adenosine inhibitory effect on enhanced growth of aortic smooth muscle cells from streptozotocin-induced diabetic rats.
Adenylate Cyclase Type 9 (ADCY9) Inactivation Protects from Atherosclerosis Only in the Absence of Cholesteryl Ester Transfer Protein (CETP).
Effects of dietary fluoride and magnesium supplements on cyclic adenosine monophosphate (cAMP), calcium and magnesium levels in aorta of genetically hypercholesterolaemic RICO rats.
Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.
The Notch pathway attenuates interleukin 1? (IL1?)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.
[Cyclic adenosine monophosphate and atherogenic factors]
[Effect of cortisol on adenylate cyclase and 3',5'-AMP phosphodiesterase activity and 3',5'-AMP concentration in tissues and biological fluids in experimental atherosclerosis]
Azotemia
The effect of hemodialysis on levels of cyclic nucleotide-associated hormones in patients with chronic renal failure.
Bacterial Infections
Constitutive expression of protective antigen gene of Bacillus anthracis in Escherichia coli.
Bartter Syndrome
Defective leukocyte adenylate cyclase function in hypokalemia.
Blister
Cell surface antigens of Bordetella pertussis.
Bone Diseases
A Signature of Circulating miRNAs Associated With Fibrous Dysplasia of Bone: the mirDys Study.
Fibrous dysplasia of bone: craniofacial and dental implications.
Bone Diseases, Metabolic
The effect of monocyclic and bicyclic analogs of human parathyroid hormone (hPTH)-(1-31)NH2 on bone formation and mechanical strength in ovariectomized rats.
Bone Neoplasms
Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model.
Bone Resorption
A noncyclical analog of salmon calcitonin (N alpha-propionyl Di-Ala1,7,des-Leu19 sCT) retains full potency without inducing anorexia in rats.
Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Adenylate cyclase stimulating activity immunologically similar to parathyroid hormone-related peptide can be extracted from fetal rat long bones.
Alterations in serum and urine parameters reflecting bone turnover in uremic patients during treatment with 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.
Bone collagen synthesis in vitro: structure/activity relations among parathyroid hormone fragments and analogs.
Bone resorption induced by A23187 is abolished by indomethacin: implications for second messenger utilised by parathyroid hormone.
Calcitonin-like effects of forskolin and choleratoxin on surface area and motility of isolated rabbit osteoclasts.
Characterization of a K26Q site-directed mutant of human parathyroid hormone expressed in yeast.
Cholera toxin-stimulated bone resorption in cultured mouse calvarial bones not inhibited by calcitonin: a possible interaction at the stimulatory G protein.
Comparison of the effects of a potent synthetic analog of bovine parathyroid hormone with native bPTH-(1-84) and synthetic bPTH-(1-34) on bone resorption and collagen synthesis.
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Direct measurement of hormone-induced acidification in intact bone.
Effect of diphosphonates on adenosine 3':5'-cyclic monophosphate in mouse calvaria after stimulation by parathyroid hormone in vitro.
Effects of atrial natriuretic factor on cyclic nucleotides, bone resorption, collagen and deoxyribonucleic acid synthesis, and prostaglandin E2 production in fetal rat bone cultures.
Effects of cholera toxin on cyclic AMP accumulation and bone resorption in cultured mouse calvaria.
Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures.
Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.
Eicosanoids, inflammation, and anti-inflammatory drugs.
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy.
Forskolin has both stimulatory and inhibitory effects on bone resorption in fetal rat long bone cultures.
Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro.
Forskolin-induced bone resorption in neonatal mouse calvaria in vitro.
Leukotriene B4 increases intracellular calcium concentration and phosphoinositide metabolism in mouse osteoblasts via cyclic adenosine 3',5'-monophosphate-independent pathways.
Parathyroid hormone-induced calcium efflux from cultured bone is mediated by protein kinase C translocation.
Phosphorylation of the human calcitonin receptor by multiple kinases is localized to the C-terminus.
Role of phosphodiesterase in the parathormone-stimulated adenosine 3',5'-monophosphate response in bone cell populations enriched in osteoclasts and osteoblasts.
Selective anabolic effects of muteins of mid-region PTH fragments on skeletal tissues of prepubertal rats.
The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.
The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.
Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro.
Bordetella Infections
The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis.
Brachydactyly
Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy.
Bradycardia
Adjustments in cholinergic, adrenergic and purinergic control of cardiovascular function in snapping turtle embryos (Chelydra serpentina) incubated in chronic hypoxia.
Brain Death
Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death.
Beta-adrenergic receptor antagonism preserves myocardial function after brain death in a porcine model.
Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.
Mechanisms of transplant right ventricular dysfunction.
Role of the beta-adrenergic receptor kinase in myocardial dysfunction after brain death.
Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death.
Brain Diseases
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.
Brain Edema
Enzyme histochemistry of rat interfascicular oligodendroglia, with special reference to 5'-nucleotidase.
Histamine H2-receptors participate in the formation of brain edema induced by kainic acid in rat thalamus.
[Experimental study of pituitary adenylate cyclase activating polypeptide on relieving brain edema induced by ischemia in rats].
Brain Injuries
Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity.
Regulation of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: comparison with brain-derived neurotrophic factor and the induction of neuronal cell death.
Brain Injuries, Traumatic
Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury.
Effects of pituitary adenylate cyclase activating polypeptide on CD4(+)/CD8(+) T cell levels after traumatic brain injury in a rat model.
Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration.
Plasma pituitary adenylate cyclase-activating polypeptide concentrations and mortality after acute spontaneous basal ganglia hemorrhage.
Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats.
Regulation of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: comparison with brain-derived neurotrophic factor and the induction of neuronal cell death.
Brain Ischemia
Adenylate cyclase activity and motor behavior following cerebral ischemia in the unanesthetized gerbil.
Alteration of second messengers during acute cerebral ischemia - adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein.
Autoradiographic analysis on second-messenger systems and local cerebral blood flow in ischemic gerbil brain.
Enhanced maximal binding capacity (Bmax) of second messenger ligand in the acute phase of cerebral ischemia--direct visualization by digital image analysis.
Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration.
Impairment of adenylyl cyclase and of spatial memory function after microsphere embolism in rats.
Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects.
Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats.
Selective reduction in type I adenylyl cyclase after microsphere embolism in rat brain.
Spatial and temporal distribution of pituitary adenylate cyclase activating polypeptide in gerbil global cerebral ischemia.
[Adenylate cyclase activity and cyclic AMP content in brain tissue of dogs during clinical death and in the post-resuscitation period]
Brain Neoplasms
Cerebral tumours induced by ENU; changes of adenylate cyclase activity in the tumour latency time.
Cyclic AMP and adenyl cyclase in brain tumors.
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Identifying polymer-forming SAM domains.
Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.
Targeting brain tumor cAMP: the case for sex-specific therapeutics.
Breast Neoplasms
1,25 Dihydroxyvitamin D3 modulates adenylate cyclase activity of the human breast cancer cell line T47D through increased synthesis of Gs.
A new in vitro bioassay for human calcitonin: validation and comparison to the rat hypocalcemia bioassay.
Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells.
An adenylate cyclase of brain reflects propensity for breast cancer in mice.
Behaviour of adenyl cyclase in mammary gland of mice subsceptible and resistant to breast cancer.
Biological activities and receptor interactions of des-Leu16 salmon and des-Phe16 human calcitonin.
Breast cancer cell response to calcitonin: modulation by growth-regulating agents.
Calcitonin and 1,25-dihydroxyvitamin D3 receptors in human breast cancer cell lines.
Calcitonin binding and degradation by two cultured human breast cancer cell lines (MCF 7 and T 47D).
Calcitonin induction of a persistent activated state of adenylate cyclase in human breast cancer cells (T 47D).
Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca2+ Release and Cyclic AMP.
Characterization of a receptor subtype-selective lysophosphatidic acid mimetic.
Characterization of normal breast epithelial cells in primary cultures: differentiation and growth factor receptors studies.
Covalent cross-linking of a photoactive derivative of calcitonin to human breast cancer cell receptors.
Different effects of adenylyl cyclase activators and phosphodiesterases inhibitors on cervical cancer (HeLa) and breast cancer (MCF-7) cells proliferation.
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.
Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Estrogen signaling characteristics of Atlantic croaker G protein-coupled receptor 30 (GPR30) and evidence it is involved in maintenance of oocyte meiotic arrest.
Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells.
Growth inhibition of human breast cancer cells induced by calcitonin.
Hormonal modulation of plasminogen activator: an approach to prediction of human breast tumor responsiveness.
Interaction of adrenomedullin with calcitonin receptor in cultured human breast cancer cells, T 47D.
PACAP(6-38) is a PACAP receptor antagonist for breast cancer cells.
Potentiation of glycine responses by dideoxyforskolin and tamoxifen in rat spinal neurons.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation.
Bronchial Hyperreactivity
Defect in potentiation of adenylyl cyclase correlates with bronchial hyperreactivity.
Bronchial Spasm
Etiology of anaphylactoid responses. The promise of nonionics.
Membrane IgE and adenyl cyclase activity in the dynamics of bronchospasm. Ketotifen as a blocker of antigen action.
[Bronchial spasm or edema, factor in the asthmatic crisis.]
Bronchiolitis
Nonspecific refractoriness to adenylyl cyclase stimulation in alveolar macrophages from infants with recurrent bronchiolitis.
Bulbo-Spinal Atrophy, X-Linked
Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.
Byssinosis
Byssinosis: role of polymer length on the effect of tannin on the airway beta-adrenergic receptor.
Camurati-Engelmann Syndrome
The new bone biology: pathologic, molecular, and clinical correlates.
Carcinogenesis
Alterations in hormone responsiveness of hepatic adenylate cyclase during ontogenesis and oncogenesis.
Anticarcinogenic effect of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate on 7,12-dimethylbenz(a)anthracene mammary tumor induction in the rat and its relationship to cyclic adenosine 3':5'-monophosphate metabolism and protein kinase.
Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.
Methylation of Cervical Neoplastic Cells Infected With Human Papillomavirus 16.
The adenyl cyclase system and carcinogenesis: decreased responsiveness of mouse epidermis to isoproterenol after 3,4-benzpyrene treatment.
Tumorigenesis-related key genes in adolescents and young adults with HR(+)/HER2(-) breast cancer.
[Adenylate cyclase activity in capillary walls and in hairy cells during experimental carcinogenesis]
[Disordered regulation of cell membrane adenyl cyclase and guanyl cyclase activity as a possible factor in carcinogenesis]
[Interrelation between the phospholipid composition of rat liver plasma membranes and adenylate cyclase activity in the early stages of liver carcinogenesis induced by nitrosodiethylamine]
[Statement of the possible role of adenyl cyclase system and cyclic adenosine monophosphate in the carcinogenesis process]
Carcinoid Tumor
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Carcinoma
Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.
Adenylate cyclase activity of renal cortical carcinoma and its relation to histology and ultrastructure.
Adenylate cyclase and protein phosphokinase activities in human thyroid. Comparison of normal glands, hyperfunctional nodules and carcinomas.
Adenylate cyclase, cyclic adenosin 3':5'-monophosphate phosphodiesterase, and regression of Walker 256 mammary carcinoma.
Androgen-secreting adrenal tumors.
Characterization of beta-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16).
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.
Ectopic beta-adrenergic receptors coupled to adenylate cyclase in human adrenocortical carcinomas.
Effect of estradiol and progesterone on the adenylate cyclase activity in grafts of 3-methylcholanthrene induced carcinomas in the mouse uterine cervix.
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Effects of thyroid-stimulating hormone on human thyroid carcinoma and adjacent normal tissue.
Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gs alpha.
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system.
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Evidence for the presence of both D-1 and D-2 dopamine receptors in human esophagus.
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Forskolin increases the expression of the pancreatic tumor antigen, Nd2, and uptake of Nd2 antibody.
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine.
Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity.
Humoral hypercalcaemia in a patient with renal-cell carcinoma.
Induction of adenylate cyclase in a mammary carcinoma cell line by human corticosteroid-binding globulin.
Interaction of forskolin with the P-glycoprotein multidrug transporter.
Interaction of vasoactive intestinal peptide with a cell line (HeLa) derived from human carcinoma of the cervix: binding to specific sites and stimulation of adenylate cyclase.
Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene.
Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells.
Modulation of the beta-adrenergic receptor-coupled adenylate cyclase by chemical inducers of differentiation: effects on beta receptors and the inhibitory regulatory protein Gi.
PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.
PACAP stimulates transcription of c-Fos and c-Jun and activates the AP-1 transcription factor in rat pancreatic carcinoma cells.
PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.
Properties of adenylate cyclase of murine mammary carcinoma.
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Synergistic activation of non-rectifying small-conductance chloride channels by forskolin and phorbol esters in cell-attached patches of the human colon carcinoma cell line HT-29cl.19A.
The adenylate cyclase-cyclic AMP-phosphodiesterase system in pathological human thyroid.
Thyrotropin (TSH) receptor and adenylate cyclase activity in human thyroid tumors: absence of high affinity receptor and loss of TSH responsiveness in undifferentiated thyroid carcinoma.
Thyrotropin receptor-adenylate cyclase function in human thyroid neoplasms.
Thyrotropin receptor: a role for thyroid tumourigenesis?
Transformation of BALB/3T3 cells with EJ/T24/H-ras oncogene inhibits adenylate cyclase response to beta-adrenergic agonist while increases muscarinic receptor dependent hydrolysis of inositol lipids.
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells.
[Adenyl cyclase activity of Ehrlich ascitic carcinoma cells in vitro]
[Biochemical differences in the tumor cells of 5-fluorouracil-sensitive and -resistant strains of Ehrlich ascitic carcinoma]
[Effect of hypolipidemic preparations on basal and stimulated adenylate cyclase activity in tumor cells]
[Effects of thyroid-stimulating hormone on adenylate cyclase of well differentiated human carcinoma and adjacent normal tissues]
[Transmembrane controls in cultured human thyroid carcinoma]
Carcinoma, Bronchogenic
Calcitonin-responsive adenylate cyclase in a calcitonin-producing human cancer cell line.
Carcinoma, Ehrlich Tumor
Anti-microtubular agents as inhibitors of desensitization to catecholamine stimulation of adenylate cyclase in Ehrlich ascites tumor cells.
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Difference between magnesium and manganese ions in modification of effect of catecholamine on adenylate cyclase system in Ehrlich ascites tumor cells.
[adenylate cyclase system in Ehrlich ascites tumor cells sensitive and resistant to 5-fluorouracil]
Carcinoma, Embryonal
Adenylyl cyclase activity and gene expression during mesodermal differentiation of the P19 embryonal carcinoma cells.
Alterations in calcitonin and parathyroid hormone responsiveness of adenylate cyclase in F9 embryonal carcinoma cells treated with retinoic acid and dibutyryl cyclic AMP.
Altered activation by calcitonin and inhibition by somatostatin of human embryonal carcinoma cell adenylate cyclase with retinoic acid-induced differentiation.
Altered hormonal responses: markers for embryonal and embryonic carcinoma stem cells and their differentiated derivatives.
Calcitonin-responsive adenylate cyclase in cultured F9 embryonal carcinoma cells.
Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells.
Production of immunoreactive calcitonin and parathyroid hormone by embryonal carcinoma cells: alteration with retinoic acid-induced differentiation.
The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid.
Carcinoma, Hepatocellular
Adenyl cyclase activity in Morris hepatomas 7777, 7794A, and 9618A.
Adenylate cyclase activity in plasma membranes of chicken liver and of Mc-29 virus induced hepatoma.
Altered adrenergic response and specificity of the receptors in rat ascites hepatoma AH130.
Anomalous adenosine cyclic 3':5'-monophosphate responses to glucagon in patients with hepatocellular carcinoma.
Bisecting GlcNAc structures act as negative sorting signals for cell surface glycoproteins in forskolin-treated rat hepatoma cells.
Changes in alpha-1 and beta-2 adrenoceptor density in human hepatocellular carcinoma.
Changes of adenylate cyclase activity in AH-130 ascites hepatoma of Yoshida induced by enrichment with fatty acids.
Comparative adenylate cyclase activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc (h).
Comparison of the epinephrine-mediated activation of adenylate cyclase in plasma membranes from liver and ascites hepatomas of rats.
Coordinate regulation of adenylate cyclase, protein kinase, and specific enzyme synthesis by cholera toxin in hormonally unresponsive hepatoma cells.
Cyclic AMP signalling pathway and cellular proliferation: induction of CREM during liver regeneration.
Cytochemical localization of adenyl cyclase in isoproterenol stimulated hepatoma ascites cells.
Effect of mitomycin C on the activation of adenylate cyclase in rat ascites hepatoma AH130 cells.
Effect of prostaglandins on adenylate cyclase activities in membranes from liver and transplantable hepatomas.
Effect of sodium fluoride on the epinephrine response of liver and hepatoma adenyl cyclase.
Enzymatic, biophysical and ultrastructural changes of plasma membranes in chemical-induced rat hepatoma.
Forskolin inhibits the Gs-stimulated adenylate cyclase in rat ascites hepatoma AH66F cells.
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.
Glucagon and epinephrine activation of adenylate cyclase and glucagon binding in Morris hepatomas.
Glucagon and prostaglandin E1 stimulation of cyclic adenosine 3', 5'-monophosphate levels and adenylate cyclase activity in benign hyperplastic nodules and malignant hepatomas of ethionine-treated rats.
Hepatic preneoplasia in hepatitis B virus transgenic mice.
Increased guanylate cyclase activity and guanosine 3',5'-monophosphate content in ethionine-induced hepatomas.
Inositolphosphoglycans possibly mediate the effects of glucagon-like peptide-1(7-36)amide on rat liver and adipose tissue.
Lack of glucagon receptors in Morris hepatoma 7800.
Membrane receptor function and the loss of glucagon-stimulated adenylate cyclase activity in hepatomas.
Prostaglandin receptor-adenylate cyclase system in plasma membranes of rat liver and ascites hepatomas, and the effect of GTP upon it.
Regulation of adenyl cyclase in hepatomas of different growth rates.
Regulation of the adenylate cyclase system in transplantable hepatomas.
Sequential alterations in the hepatic content and metabolism of cyclic AMP and cyclic GMP induced by DL-ethionine: evidence for malignant transformation of liver with a sustained increase in cyclic AMP.
Soluble and membrane-bound adenylate cyclase activity in Yoshida ascites hepatoma.
Some enzyme and hormonal attributes of hepatoma cell membranes.
Stimulatory and inhibitory effects of forskolin on adenylate cyclase in rat normal hepatocytes and hepatoma cells.
Studies of cAMP metabolism in cultured hepatoma cells: presence of functional adenylate cyclase despite low cAMP content and lack of hormonal responsiveness.
Studies on plasma membranes. XIV. Adenyl cyclase in plasma membranes isolated from rat and mouse livers and hepatomas, and its hormone sensitivity.
Studies on responsiveness of hepatoma cells to catecholamines. I. Lack of beta-adrenergic responsiveness in rat ascites hepatoma AH13 cells.
Studies on responsiveness of hepatoma cells to catecholamines. VI. Characteristics of adrenoceptors and adenylate cyclase response in rat ascites hepatoma cells and human hepatoma cells.
Temperature effects on the modulation of adenylate cyclases from rat liver and Morris hepatomas.
The action of mitomycin C on the induction of cyclic AMP phosphodiesterase and the development of desensitization of adenylate cyclase by isoproterenol in rat ascites hepatoma AH130 cells.
The role of cAMP-MAPK signalling in the regulation of human hepatocellular carcinoma growth in vitro.
[Activation of adenylate cyclase of rat ascites hepatoma by catecholamines and antagonism of beta-adrenergic blocking agents (author's transl)]
[Concentration and metabolism of cyclic AMP during the early stages of hepatoma 22a growth]
[Concentration of cyclic nucleotides, activity of adenylate cyclase, 3',5'-AMP phosphodiesterase and guanylate cyclase in plasma membranes from liver and hepatomas of different degrees of malignancy]
[Effect of 10-hydroxycamptothecin on adenylate cyclase activity in murine hepatoma cells]
[Some features of cyclic adenosine monophosphate metabolism in mouse liver and hepatoma 22]
[The role of the components of the cyclic nucleotide system in N-nitrosodiethylamine-induced hepatic carcinogenesis in rats]
Carcinoma, Medullary
Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity.
Pituitary adenylate cyclase-activating polypeptide receptors of types I and II and glucagon-like peptide-I receptors are expressed in the rat medullary carcinoma of the thyroid cell line 6/23.
Carcinoma, Non-Small-Cell Lung
Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells.
The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3.
Carcinoma, Papillary
Cell kinetics, DNA content and TSH receptor-adenylate cyclase system in differentiated thyroid cancer.
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Carcinoma, Renal Cell
Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor.
Hormone receptors and cyclic nucleotide metabolism in cancer cells.
Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity.
Carcinoma, Small Cell
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
Carcinoma, Squamous Cell
Characterization of beta-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16).
Characterization of the beta 2-adrenoceptor-dependent adenylate cyclase of A431 epidermoid carcinoma cells.
Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines.
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.
Studies on cyclic AMP metabolism in human epidermoid carcinoma (HEp-2) cells.
Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor.
[The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)]
Carcinosarcoma
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Cardiomegaly
A different desensitization pattern of cardiac beta-adrenoceptor subtypes by prolonged in vivo infusion of isoprenaline.
Adenylate cyclase activity during development and reversal of cardiac hypertrophy.
Alterations in the inotropic responses to forskolin and Ca2+ and reduced gene expressions of Ca2+-signaling proteins induced by chronic volume overload in rabbits.
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Cardiac beta-adrenergic signaling pathway alteration in isoproterenol-induced cardiac hypertrophy in male Sprague-Dawley rats.
Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects.
Cardiomegaly induced by pressure overload in newborn rats is accompanied by altered expression of the long isoform of G(s)alpha protein and deranged signaling of adenylyl cyclase.
Catecholamine-induced cardiac hypertrophy uncouples beta-adrenoceptors from slow calcium channels.
Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy.
Cyclic AMP synthesis and hydrolysis in the normal and failing heart.
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Enhancement of the cardiac beta-adrenergic system at an early diabetic state in spontaneously diabetic Chinese hamsters.
Isoprenaline-induced increase in mRNA levels of inhibitory G-protein alpha-subunits in rat heart.
Isoproterenol-induced cardiac hypertrophy: modifications in characteristics of beta-adrenergic receptor, adenylate cyclase, and ventricular contraction.
Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts.
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Prospectives for angiotensin converting enzyme inhibition in heart diseases.
Regression of thyroid hormone induced cardiac hypertrophy: effect on cardiac beta receptors and adenyl cyclase activity.
Ribonucleic acid (RNA) polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
RNA polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.
Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload.
Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart.
Cardiomyopathies
Abnormalities in heart membranes and myofibrils during bacterial infective cardiomyopathy in the rabbit.
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.
Activity of receptors coupled to guanine nucleotide binding regulatory protein in doxorubicin induced cardiomyopathy.
Adenylate cyclase activity coupled to the stimulatory guanine nucleotide binding protein in patients having electrophysiologic studies and either structurally normal hearts or idiopathic myocardial disease.
Adenylyl cyclase 6 deletion increases mortality during sustained ?-adrenergic receptor stimulation.
Adenylyl cyclase increases survival in cardiomyopathy.
Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy.
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
Beta-adrenoceptor antibodies and genetics in dilated cardiomyopathy--an overview and review.
Bitransgenesis with beta(2)-Adrenergic Receptors or Adenylyl Cyclase Fails to Improve beta(1)-Adrenergic Receptor Cardiomyopathy.
Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy.
Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy.
Catecholamine-responsive adenylate cyclase activity in human endomyocardial biopsies. Individual sensitivity to isoproterenol stimulation and propranolol inhibition.
Characterization of Mouse Heart Adenylyl Cyclase.
Decreased bioactivity of the guanine nucleotide-binding protein that stimulates adenylate cyclase in hearts from cardiomyopathic Syrian hamsters.
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G{alpha}q protein-induced cardiomyopathy.
Disruption of type 5 adenylyl cyclase prevents ?-adrenergic receptor cardiomyopathy: a novel approach to ?-adrenergic receptor blockade.
Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.
Molecular mechanism of hypertrophied failing heart--abnormalities of the diastolic properties and contractility.
Myocardial beta-adrenergic adenylate cyclase complex in a canine model of chagasic cardiomyopathy.
Ribonucleic acid (RNA) polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
RNA polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats.
The activity of adenylate cyclase and phosphodiesterase in the isoproterenol-damaged cardiac muscle of spontaneously hypertensive rats.
Verapamil ameliorates clinical, pathologic and biochemical manifestations of experimental chagasic cardiomyopathy in mice.
Cardiomyopathy, Dilated
Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy.
Assessment of immune modulation of beta-adrenergic pathways in human dilated cardiomyopathy: influence of methodologic factors.
Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
Effects of chronic application of propranolol on beta-adrenergic signal transduction in heart ventricles from myopathic BIO TO2 and control hamsters.
Effects of forskolin on left ventricular function in dilated cardiomyopathy.
Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure.
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate.
Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathy.
Influence of forskolin on the force-frequency behavior in nonfailing and end-stage failing human myocardium.
Inhibition of endogenous nitric oxide synthase augments contractile response to adenylyl cyclase stimulation without altering mechanical efficiency in patients with idiopathic dilated cardiomyopathy.
PDE3 inhibition in dilated cardiomyopathy.
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy.
Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Effects of chronic infusion of norepinephrine on cardiac structure, function, and biochemistry: physiologic versus pathologic hypertrophy.
Hypertrophic cardiomyopathy characterised by beta-adrenoceptor density, relative amount of beta-adrenoceptor subtypes and adenylate cyclase activity.
Cardiovascular Abnormalities
Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment.
Cardiovascular Diseases
Modulation of Gi Proteins in Hypertension: Role of Angiotensin II and Oxidative Stress.
Neurally mediated cardiac effects of forskolin in conscious dogs.
Regulation of Gi? protein expression by vasoactive peptides in hypertension: molecular mechanisms.
Catalepsy
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells.
Cerebral Palsy
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Chagas Disease
Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease.
Myocardial adenylate cyclase activity in acute murine Chagas' disease.
Stimulation of Trypanosoma cruzi adenylyl cyclase by an alpha D-globin fragment from Triatoma hindgut: effect on differentiation of epimastigote to trypomastigote forms.
Verapamil ameliorates clinical, pathologic and biochemical manifestations of experimental chagasic cardiomyopathy in mice.
Cholangiocarcinoma
Adenosine Induces Autophagy in Cholangiocarcinoma Cells.
Alpha(1)-and beta(2)-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C.
Cholangitis
Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.
The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis.
Cholangitis, Sclerosing
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
Cholera
1,2-Diacylglycerols overcome cyclic AMP-mediated inhibition of phosphatidylcholine synthesis in GH3 pituitary cells.
12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.
3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.
5-hydroxytryptamine release into human jejunum by cholera toxin.
6,7-Dihydroxy-2-dimethylaminotetralin (TL-99) stimulates postjunctional D-1 and D-2 dopamine receptors.
7-oxa-13-prostynoic acid and polyphloretin phosphate as non-specific antagonists of the stimulatory effects of different agents on adenylate cyclase from various tissues.
A conjugate of the A1 peptide of cholera toxin and the lectin of Wisteria floribunda that activates the adenylate cyclase of intact cells.
A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production.
A human pituitary adenoma secreting thyrotropin and prolactin: immunohistochemical, biochemical, and cell culture studies.
A mu-opiate receptor in 7315c tumor tissue mediates inhibition of immunoreactive prolactin release and adenylate cyclase activity.
A new principle for resistance to cholera: desensitization to cyclic AMP-mediated diarrhea induced by cholera toxin in the mouse intestine.
A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels.
A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells.
A second guanyl nucleotide-binding site associated with adenylate cyclase. Distinct nucleotides activate adenylate cyclase and permit ADP-ribosylation by cholera toxin.
A variant of S49 mouse lymphoma cells with enhanced secretion of cyclic AMP.
A viral K-RAS protein increases the stimulability of adenylate cyclase by cholera toxin in NRK cells.
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera.
Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells.
Acetylcholine inhibits positive inotropic effect of cholera toxin in ventricular muscle.
Acetylcholine-induced biphasic effect on the maximum upstroke velocity of action potential in mouse right atria: interaction with beta-adrenergic signaling cascade.
ACh-induced rebound stimulation of L-type Ca(2+) current in guinea-pig ventricular myocytes, mediated by Gbetagamma-dependent activation of adenylyl cyclase.
Action of cholera toxin to stimulate adenyl cyclase.
Action site of the lethal Ay gene in the mouse embryo.
Activation by cholera toxin of adenylate cyclase solubilized from rat liver.
Activation of adenylate cyclase by alcohols requires the nucleotide-binding protein.
Activation of adenylate cyclase by cholera toxin in rat liver homogenates.
Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors.
Activation of cAMP-dependent pathways in human airway smooth muscle cells inhibits TNF-alpha-induced ICAM-1 and VCAM-1 expression and T lymphocyte adhesion.
Activation of Escherichia coli heat-labile enterotoxins by native and recombinant adenosine diphosphate-ribosylation factors, 20-kD guanine nucleotide-binding proteins.
Activation of FSH-responsive adenylate cyclase by staurosporine: role for protein phosphorylation in gonadotropin receptor desensitization.
Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an "excited" state of GTPase is a control component of the system.
Activation of human synovial cells by cholera enterotoxin: correlation of morphological responses with adenylate cyclase activities, and the reversing effects of hyaluronidase.
Activation of immobilized, biotinylated choleragen AI protein by a 19-kilodalton guanine nucleotide-binding protein.
Activation of intestinal mucosal adenylate cyclase by Shigella dysenteriae I enterotoxin.
Activation of pigeon erythrocyte adenylate cyclase by cholera toxin. Partial purification of an essential macromolecular factor from horse erythrocyte cytosol.
Activation of rat liver adenylate cyclase by cholera toxin requires toxin internalization and processing in endosomes.
Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase.
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.
Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways.
Activation of the nigrostriatal dopaminergic pathway by injection of cholera enterotoxin into the substantia nigra.
Activators of adenylate cyclase and cyclic AMP prolong calcium-dependent action potentials of mouse sensory neurons in culture by reducing a voltage-dependent potassium conductance.
Activity of covalently cross-linked cholera toxin with the adenylate cyclase of intact and lysed pigeon erythrocytes.
Acute variations in extracellular pH modulate transduction pathways of PTH in rat proximal tubule.
Adaptations of myocardial beta-adrenergic receptor complex in hibernating marmots.
Adaptive changes in the number of Gs- and Gi-proteins underlie adenylyl cyclase sensitization in morphine-treated rat striatal neurons.
Adenosine 3',5'-monophosphate suppresses metastatic spread in nude mice of steroidogenic rat granulosa cells transformed by simian virus-40 and Ha-ras oncogene.
Adenosine 3':5'-cyclic monophosphate inhibits in vitro angiogenesis induced by endothelial cell growth factor.
Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.
Adenosine diphosphate-ribosylation of adenylate cyclase catalyzed by heat-labile enterotoxin of Escherichia coli: comparison with cholera toxin.
Adenosine receptors on human inflammatory cells.
Adenosine reverses the stimulatory effect of angiotensin II on the renal Na+-ATPase activity through the A2 receptor.
Adenylate cyclase activation by cholera toxin in pig epidermis: an obligatory role of the GTP-regulatory protein.
Adenylate cyclase activators and inhibitors, cyclic nucleotide analogs, and phosphatidylinositol: effects on interrenal function of coho salmon (Oncorhynchus kisutch) in vitro.
Adenylate cyclase activity and cyclic adenosine monophosphate levels in colon cancer lines and dermal fibroblasts and the effects of cholera toxin and epidermal growth factor.
Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells.
Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate.
Adenylate cyclase from rabbit small intestine: activation by cholera toxin and interaction with calcium.
Adenylate cyclase in human cytotrophoblasts: characterization and its role in modulating human chorionic gonadotropin secretion.
Adenylate cyclase in intestinal crypt and villus cells: stimulation by cholera enterotoxin and prostaglandin E1.
Adenylate cyclase in Xenopus laevis oocytes: characterization of the progesterone-sensitive, membrane-bound form.
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
Adenylate cyclase system in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes.
Adenylyl cyclase 6 expression is essential for cholera toxin-induced diarrhea.
Adenylyl cyclase and G-proteins in Phytomonas.
Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes.
Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.
ADP-ribosylation by cholera toxin of membranes derived from brain modifies the interaction of adenylate cyclase with guanine nucleotides and NaF.
ADP-ribosylation factor is functionally and physically associated with the Golgi complex.
ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.
ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits.
ADP-ribosylation of membrane proteins and activation of adenylate cyclase by cholera toxin in fat cell ghosts from euthyroid and hypothyroid rats.
ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.
ADP-ribosylation of membrane proteins in cholinergic nerve terminals.
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Adrenal cortex adenylate cyclase. In vitro modification of the enzyme by cholera toxin.
Age-associated decrease in vasopressin-induced renal water transport: a role for adenylate cyclase and G protein malfunction.
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Agents affecting adenylate cyclase activity modulate the stimulatory action of 1,25-dihydroxyvitamin D3 on the production of osteocalcin by human bone cells.
Agonist-induced subsensitivity of adenylate cyclase coupled with a dopamine receptor in slices from rat corpus striatum.
Alkaline phosphatases and adenylate cyclase in the normal and desensitized rat small intestine after acute cholera toxin challenge: a histochemical study.
Alpha 2-adrenergic regulation of arylalkylamine N-acetyltransferase in organ-cultured chick pineal gland: characterization with agonists and modulation of experimentally stimulated enzyme activity.
Alpha 2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats.
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Alteration by v-Ki-ras in NaF, cholera toxin and forskolin-induced adenylate cyclase activation in NIH/3T3 fibroblast cells.
Alterations in cardiac membrane beta-adrenoceptors and adenylyl cyclase due to hypochlorous acid.
Alterations in g-protein-linked signal transduction in vascular smooth muscle in diabetes.
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Alterations of adenylyl cyclase-linked G proteins in rat liver during aging.
Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.
Amiodarone compared with iodine exhibits a potent and persistent inhibitory effect on TSH-stimulated cAMP production in vitro: a possible mechanism to explain amiodarone-induced hypothyroidism.
An elusive adenylate cyclase complicit in cholera is exposed.
An increase in adenylate cyclase activity precedes DNA synthesis in cultured vascular smooth muscle cells.
An investigation of the role of possible neural mechanisms in cholera toxin-induced secretion in rabbit ileal mucosa in vitro.
An Mr = 52,000 peptide can mediate effects on cholera toxin on adenylate cyclase in intact cells.
Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells).
Angiotensin II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells.
Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal.
Antagonistic effects of thyrotropin and epidermal growth factor on thyroglobulin mRNA level in cultured thyroid cells.
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes.
Anticholeraic effect of methylated casein in rat jejunum.
Antigonadotropic and antisteroidogenic actions of peroxide in rat granulosa cells.
Antisecretory effects of berberine in rat ileum.
ARH1 in Health and Disease.
Artificial low-molecular-mass substrates of cholera toxin.
Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.
Bacterial toxins: potential weapons against HIV infection.
Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins.
beta-Adrenergic receptor activation increases acetylcholine receptor number in cultured skeletal muscle myotubes.
beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.
Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.
Biochemistry of Vibrio cholerae virulence: purification of cholera enterotoxin by preparative disc electrophoresis.
Biphasic action of forskolin on growth hormone and prolactin secretion by rat anterior pituitary cells in vitro.
Biphasic alterations in cardiac beta-adrenoceptor signal transduction mechanism due to oxyradicals.
Biphasic effect of sodium fluoride and guanyl nucleotides on binding to prostaglandin E2 receptors in rat epididymal adipocyte membranes.
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Both cholera toxin-induced adenylate cyclase activation and cholera toxin biological activity are inhibited by antibodies against related synthetic peptides.
Botulinum C2 toxin ADP-ribosylates actin.
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action.
Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.
Calcitonin gene-related peptide receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+ signaling pathways.
Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells.
Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes.
Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in Manduca sexta fat body.
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
cAMP elevating agents suppress secretory phospholipase A(2)-induced matrix metalloproteinase-2 activation.
cAMP in ovine oocytes: localization of synthesis and its action on protein synthesis, phosphorylation, and meiosis.
cAMP synthesis in the rat oocyte.
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Catecholamine-induced heterologous desensitization of rabbit luteal adenylyl cyclase: loss of luteinizing hormone responsiveness is associated with impaired G-protein function.
Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP.
Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay.
Cell junction and cycle AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type.
Cell type and receptor identity regulate cholera toxin subunit B (CTB) internalization.
Cell-cell interactions in the development of Dictyostelium.
Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase.
Cerebrospinal fluid production: stimulation by cholera toxin.
Characterization of the homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase.
Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase.
Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells.
Chloroquine inhibition of cholera toxin.
Chlorpromazine inhibits cholera toxin-induced intestinal hypersecretion.
Chlorpromazine reduces fluid-loss in cholera.
Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins.
Cholera toxin action on rabbit corpus luteum membranes: effects on adenylyl cyclase activity and adenosine diphospho-ribosylation of the stimulatory guanine nucleotide-binding regulatory component.
Cholera toxin activation of adenylate cyclase in cancer cell membrane fragments.
Cholera toxin activation of adenylate cyclase. Roles of nucleoside triphosphates and a macromolecular factor in the ADP ribosylation of the GTP-dependent regulatory component.
Cholera toxin activation of neuroblastoma adenylate cyclase.
Cholera toxin ADP-ribosylates the islet-activating protein substrate in adipocyte membranes and alters its function.
Cholera toxin and adenylate cyclase: properties of the activated enzyme in liver plasma membranes.
Cholera toxin and membrane gangliosides: binding and adenylate cyclase activation in normal and transformed cells.
Cholera toxin and the adenylate cyclase-activating signal.
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
Cholera toxin augmented epinephrine response to adenylate cyclase not decreased after prolonged in vitro incubation of isolated fat cells.
Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase.
Cholera toxin can recouple hormone receptors that are uncoupled from adenylate cyclase.
Cholera toxin covalently linked with horseradish peroxidase does not activate the adenylate cyclase of neuroblastoma cells.
Cholera toxin differentially decreases membrane levels of alpha and beta subunits of G proteins in NG108-15 cells.
Cholera toxin does not impair hormonal inhibition of adenylate cyclase and concomitant stimulation of a GTPase in adipocyte membranes.
Cholera toxin effects on body temperature changes induced by morphine.
Cholera toxin effects on fluid secretion, adenylate cyclase, and cyclic AMP in porcine small intestine.
Cholera toxin enhances adenylate cyclase-dependent transport in toad urinary bladder.
Cholera toxin facilitates calcium transport in jejunal brush border vesicles.
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Cholera toxin induces cAMP-independent degradation of Gs.
Cholera toxin induces changes in the ion permeability of intestinal brush border membranes.
Cholera toxin inhibits HIV-1 replication in human colorectal epithelial HT-29 cells through adenylate cyclase activation.
Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes.
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes.
Cholera toxin resistance associated with deficient adenylate-cyclase activity in a subclone of the rat promyelocytic leukemia (BNML).
Cholera toxin stimulates adenosine 3',5'-monophosphate synthesis and epithelial wound closure in the rabbit cornea.
Cholera toxin treatment increases in vivo growth and development of the mouse mammary gland.
Cholera toxin, cyclic AMP, and the firefly flash.
Cholera toxin, ganglioside receptors and the immune response.
Cholera toxin- and forskolin-induced cyclic AMP accumulations of pig skin (epidermis). Modulation by chemicals which reveal the beta-adrenergic augmentation effect.
Cholera toxin-catalysed ADP-ribosylation of erythrocyte proteins: general properties.
Cholera toxin-mediated inhibition of signalling in Jurkat cells is followed by, but not due to a loss of T cell receptor complex.
Cholera toxin-stimulated bone resorption in cultured mouse calvarial bones not inhibited by calcitonin: a possible interaction at the stimulatory G protein.
Cholera.
Cholera: something old, something new.
Cholinergic inhibition of catecholamine-stimulable cyclic AMP accumulation in murine atria.
Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins.
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Chronic nonocclusive coronary artery constriction in rats. Beta-adrenoceptor signal transduction and ventricular failure.
Cloning of genes that encode a new heat-labile enterotoxin of Escherichia coli.
Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription.
Comments on 'The activation of adenylate cyclase from small intestinal epithelium by cholera toxin'.
Comparison of the interaction of mono- and oligovalent ligands with cholera toxin. Demonstration of aggregate formation at low ligand concentrations.
Complete response to vasopressin requires epithelial organization in A6 cells in culture.
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP.
Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3',5'-cyclic monophosphate-independent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis.
Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs.
Contact-dependent cell interactions determine hormone responsiveness and desensitization in rat granulosa cells.
Control of growth in cultured rat thyroid cells.
Control of plasminogen activator activity in the thecal layer of the largest preovulatory follicle in the hen ovary.
Coordinate regulation of adenylate cyclase, protein kinase, and specific enzyme synthesis by cholera toxin in hormonally unresponsive hepatoma cells.
Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.
Cyclic adenosine-3',5'-monophosphate stimulates the acute release of placental lactogen from human trophoblast cells.
Cyclic AMP and calcium as potential mediators of stimulation of cultured Schwann cell proliferation by axolemma-enriched and myelin-enriched membrane fractions.
Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae.
Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes.
Cyclic AMP increasing agents rapidly stimulate vimentin phosphorylation in quiescent cultures of Swiss 3T3 cells.
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells.
Cyclic AMP modulates interleukin-1 action in a cytotoxic T-cell hybridoma.
Cyclic AMP regulation of Gs protein. Thyrotropin and forskolin increase the quantity of stimulatory guanine nucleotide-binding proteins in cultured thyroid follicles.
Cyclic AMP stimulation of Na-K pump activity in quiescent swiss 3T3 cells.
Cyclic AMP-dependent modulation of vesicular monoamine transport in pheochromocytoma cells.
Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils.
Cytidylate cyclase activity is stimulated via activation of a guanine nucleotide-binding protein.
Cytochemistry of adenylate cyclase: action of cholera toxin on the adenylate cyclase of pigeon erythrocytes.
D-2 dopamine receptor-mediated inhibition of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland requires guanosine 5'-triphosphate.
Decrease in cAMP levels promoted by CD48-CD2 interaction correlates with inhibition of apoptosis in B cells.
Decrease in coupling of Gs in v-src-transformed NIH-3T3 fibroblasts: possible involvement of tyrosine phosphorylation of Gs by pp60v-src.
Decreased adenylate cyclase responsiveness of transformed cells correlates with the presence of a viral transforming protein.
Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I.
Dehydroepiandrosterone sulfate (DHEA-S) and 3', 5'-cyclic adenosine monophosphate (cAMP) production in a cultured human adrenocortical carcinoma cell line (SW-13).
Depletion of protein kinase C-alpha by antisense oligonucleotides alters beta-adrenergic function and reverses the phorbol ester-induced reduction of isoproterenol-induced adenosine 3'-5'-cyclic monophosphate accumulation in murine Swiss 3T3 fibroblasts.
Depression of cell-mediated immunity in cholera.
Desensitization of beta-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog.
Desensitization of the cAMP system in mouse Leydig cells by hCG, cholera toxin, dibutyryl cAMP and cAMP: localization of the 'lesion' to the guanine nucleotide regulatory protein-adenylate cyclase complex.
Desensitization of the thyroid cyclic AMP response to thyroid stimulating immunoglobulin: comparison with TSH.
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Determination of the turn-off reaction for the epinephrine-inhibited human platelet adenylate cyclase.
Development of activatable adenylate cyclase in the preimplantation mouse embryo and a role for cyclic AMP in blastocoel formation.
Development of intestinal adenyl cyclase and its response to cholera enterotoxin.
Development of intestinal host defense: an increased sensitivity in the adenylate cyclase response to cholera toxin in suckling rats.
Development of physiological responsiveness to glucagon during embryogenesis of avian heart.
Developmental alterations in guanine nucleotide regulation of the beta-adrenergic receptor-adenylate cyclase system of skeletal muscle.
Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine.
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
Dibutyryl cyclic adenosine 3',5'-monophosphate: its role in regulation of cat brain extracellular fluid.
Dichlorodiphenyltrichloroethane impairs follicle-stimulating hormone receptor-mediated signaling in rat Sertoli cells.
Different inhibitory effect of adrenaline on platelet adenylate cyclase in the presence of GTP plus cholera toxin and of stable GTP analogues.
Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro.
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes.
Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
Differential effects of tumor promoters on cAMP production: inhibition of receptor-mediated and potentiation of cholera toxin-mediated stimulation.
Differential regulation of hCG and progesterone secretion by cholera toxin and phorbol ester in human cytotrophoblasts.
Differential regulation of P2Y(11) receptor-mediated signalling to phospholipase C and adenylyl cyclase by protein kinase C in HL-60 promyelocytes.
Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.
Differential roles of high and low affinity guanosine 5'-triphosphate binding sites in the regulation of follicle-stimulating hormone binding to receptor and signal transduction in bovine calf testis membranes.
Differential susceptibility to GTP formed from added GDP via membrane-associated nucleoside diphosphate kinase of GTP-sensitive adenylate cyclases achieved by hormone and cholera toxin.
Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters.
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.
Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by follicle-stimulating hormone or activators of adenylate cyclase.
Discovery of G protein signaling.
Discrepancy between effects of cholera toxin on net fluid movement and cAMP levels in rat jejunum, ileum, and colon.
Dissociation by cooling of hormone and cholera toxin activation of adenylate cyclase in intact cells.
Distinct effects of the C-terminal octapeptide of cholecystokinin and of a cholera toxin pretreatment of the kinetics of rat pancreatic adenylate cyclase activity.
Does enteropathogenic Escherichia coli produce heat-labile enterotoxin, heat-stable enterotoxins a or b, or cholera toxin A subunits?
Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium.
Down-regulation of protein kinase C by parathyroid hormone and mezerein differentially modulates cAMP production and phosphate transport in opossum kidney cells.
Dual bradykinin B2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a GS-mediated stimulation of the cyclic AMP pathway.
Dual regulation of ?2-adrenoceptor messenger RNA expression in human lung fibroblasts by ?2-cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression.
Early effect of progesterone on levels of cyclic adenosine 3':5'-monophosphate in Xenopus oocytes.
Effect of ageing on adenylate cyclase activity and G-proteins in rat submandibular salivary glands.
Effect of calcitonin gene-related peptide on skeletal muscle via specific binding site and G protein.
Effect of cholera enterotoxin on pacemaker rate and cyclic adenosine 3':5'-monophosphate in isolated rabbit sinoatrial node.
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Effect of cholera toxin on the activation of adenylate cyclase by calmodulin in bovine striatum.
Effect of glucocorticoid on prostaglandin E1 mediated cyclic AMP formation by vascular smooth muscle cells.
Effect of prostaglandin E2 and other intracellular cyclic AMP elevating agents on the mitogen induced mouse splenocyte proliferation in a serum free culture condition.
Effect of thyrotropin-induced desensitization of bovine thyroid adenylate cyclase on the nucleotide regulatory protein.
Effects of adenosine 3',5'-cyclic monophosphate, forskolin, and cholera toxin on hormone production in human term placental cells.
Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells.
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase.
Effects of cholera enterotoxin, glucagon, and dibutyryl cyclic AMP on rat liver alkaline phosphatase, bile flow, and bile composition.
Effects of cholera toxin and 5'-guanylylimidodiphosphate on human spermatozoal adenylate cyclase activity.
Effects of cholera toxin and guanosine 5'-[betagamma-imido]triphosphate on beta-adrenergic-receptor affinity.
Effects of cholera toxin on adenylate cyclase. Studies with guanylylimidodiphosphate.
Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops.
Effects of cholera toxin on cyclic adenosine 3',5'-monophosphate concentration and secretory processes in the exocrine pancreas.
Effects of cholera toxin on cyclic AMP accumulation and bone resorption in cultured mouse calvaria.
Effects of cyclic adenosine 3':5'-monophosphate upon glycoprotein and carcinoembryonic antigen synthesis and release by human colon cancer cells.
Effects of intravitreal cholera toxin on adenosine 3',5'-monophosphate, intraocular pressure, and outflow facility in rabbits.
Effects of long-term alcohol intake on ADP ribosylation in rat liver plasma membranes.
Effects of modulators of adenylyl cyclase on interleukin-2 production, cytosolic Ca2+ elevation, and K+ channel activity in Jurkat T cells.
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.
Effects of phospholipid and GTP on recombinant ADP-ribosylation factors (ARFs). Molecular basis for differences in requirements for activity of mammalian ARFs.
Effects of prostaglandin E2, forskolin and cholera toxin on cAMP production and in vitro LH-RH release from the rat hypothalamus.
Effects of proteolytic enzymes and protease inhibitors on bovine thyroid adenylate cyclase activity.
Effects of temperature on ADP-ribosylation factor stimulation of cholera toxin activity.
Effects of thyrotropin and cholera toxin on the thyroidal adenylate cyclase-adenosine 3',5'-monophosphate system.
Effects of Vibrio cholerae enterotoxin peptide on glomerular filtration rate and renal proximal tubular sodium transport.
Electrophysiologic and molecular properties of cultured enteric glia.
Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.
Endothelins inhibit adenylate cyclase in brain capillary endothelial cells.
Enhanced degradation of stimulatory G-protein (Gs alpha) by cholera toxin is mediated by ADP-ribosylation of Gs alpha protein but not by increased cyclic AMP levels.
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.
Enzymatic and immunological detection of G protein alpha-subunits in the pathogenic fungus Candida albicans.
Epidermal adenylate cyclase system is regulated by diacylglycerol-protein kinase C signal, but not by calcium signal.
Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein.
Epidermal growth factor but not insulin-like growth factor-I potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Epidermal growth factor stimulates formation of inositol phosphates in BALB/c/3T3 cells pretreated with cholera toxin and isobutylmethylxanthine.
Essential role of GTP in the expression of adenylate cyclase activity after cholera toxin treatment.
Establishment of gonadotropin-responsive murine leydig tumor cell line.
Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis.
Estrogen and progesterone augment growth responsiveness of mammary tissue to cholera toxin.
Estrogen and uterine sensitization for the decidual cell reaction in the rat: role of prostaglandin E2 and adenosine 3':5'-cyclic monophosphate.
Ethanol-induced desensitization of adenylate cyclase: role of the adenosine receptor and GTP-binding proteins.
Evidence for a rabbit luteal ADP-ribosyltransferase activity which appears to be capable of activating adenylyl cyclase.
Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin.
Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.
Evidence that cyclic nucleotides are not mediators of fever in rabbits.
Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin.
Evidence that the cAMP pathway controls emergence of both primary and appressorial germ tubes of barley powdery mildew.
Evidence that the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland is associated with an inhibitory guanyl nucleotide component.
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP.
Extra-long G?s variant XL?s protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling.
Fasting increases fat cell adenylate cyclase sensitivity to stimulatory agonists through enhanced ability of the stimulatory regulatory component Ns to dissociate.
Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts.
Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains.
Fine structural studies of ciliary processes after treatment with cholera toxin or its B subunit.
Follicle-stimulating hormone (FSH) increases FSH receptor messenger ribonucleic acid while decreasing FSH binding in cultured porcine granulosa cells.
Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase.
Formation and biological action of inositol 1,4,5-trisphosphate.
Forskolin but not cholera toxin bypasses flufenamate-induced inhibition of cAMP production in anterior pituitaries.
Forskolin potentiation of cholera toxin-stimulated cyclic AMP accumulation in intact C6-2B cells. Evidence for enhanced Gs-C coupling.
Forskolin-resistant Y1 mutants harbor defects associated with the guanyl nucleotide-binding regulatory protein, Gs.
From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones.
Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis.
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.
Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin.
Functional properties of polyclonal antibodies raised against the N-terminus region (residues 9-30) of the follicle-stimulating hormone (FSH) receptor: significance of this receptor region in FSH recognition and signal transduction.
Further characterization of the iodide inhibitory effect on the cyclic AMP system in dog thyroid slices.
Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site mediating intracellular Ca2+ mobilization and cell retraction.
G protein alterations in hypertension and aging.
G protein and cAMP-dependent protein kinase mediate amyloid beta-peptide inhibition of neuronal glucose uptake.
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
G proteins in rat liver proliferation during cholestasis.
G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions.
Ganglioside GM1 binding toxins and human neuropathy-associated IgM antibodies differentially promote neuritogenesis in a PC12 assay.
Gangliosides modulate sodium transport in cultured toad kidney epithelia.
Gastrin in the perinatal rat pancreas and gastric antrum: immunofluorescence localization of pancreatic gastrin cells and gastrin secretion in monolayer cell cultures.
GDP does not support activation of adenylate cyclase nor ADP-ribosylation of a guanine nucleotide binding protein by cholera toxin.
Generation of cell surface neoganglioproteins. GM1-neoganglioproteins are non-functional receptors for cholera toxin.
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.
Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor.
Glucocorticoids and dopamine-1 receptors on vascular smooth muscle cells.
Glucose modifies the cross-talk between insulin and the beta-adrenergic signalling system in vascular smooth muscle cells.
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
GM1 ganglioside modulates prostaglandin E1 stimulated adenylyl cyclase in neuro-2A cells.
Gonadotropic effects of cholera enterotoxin in the rat testis slices: stimulation of adenylate cyclase activity and testosterone synthesis from cholesterol.
Gonadotropin and cAMP modulation of IGE binding protein production in ovarian granulosa cells.
GTP-activated GTP binding protein(Gs) in membranes achieved by hormone plus GDP does not serve as a substrate for ADP-ribosylation by cholera toxin.
GTP-binding proteins and adenylate cyclase activity in v-Ki-ras transformed NIH/3T3 fibroblast cells.
GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica.
GTP-binding proteins associated with the human placental syncytiotrophoblast plasma membrane.
Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts.
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Guanine nucleotide binding proteins in the dual regulation of lacrimal function.
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.
Guanine nucleotide dependent formation of a complex between choleragen (cholera toxin) a subunit and bovine brain ADP-ribosylation factor.
Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.
Guanine nucleotide-binding proteins (G proteins) in activation of adenylyl cyclase: lessons learned from cholera and "travelers' diarrhea".
Guanosine 5'-O-(2-thiodiphosphate) as a competitive inhibitor of GTP in hormone or cholera toxin-stimulated pancreatic adenylate cyclase.
Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases.
Guanyl nucleotides participate in the beta-adrenergic stimulation of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland.
HeLa cells express cAMP-inhibitable sodium-dependent phosphate uptake.
Hemocyte-hemocyte adhesion and nodulation reactions of the greater wax moth, Galleria mellonella are influenced by cholera toxin and its B-subunit.
Hepatic adenylate cyclase. Development-dependent coupling to the beta-adrenergic receptor in the neonate.
Hepatocyte beta-adrenergic responsiveness and guanine nucleotide-binding regulatory proteins.
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Heterologous regulations of cAMP responses in pregnant rat myometrium. Evolution from a stimulatory to an inhibitory prostaglandin E2 and prostacyclin effect.
Hormone-independent activation of adenylate cyclase in large steroidogenic ovine luteal cells does not result in increased progesterone secretion.
Host response to Escherichia coli heat-labile enterotoxin via two microvillus membrane receptors in the rat intestine.
Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
Human gonadotropin-releasing hormone receptor gene transcription: up-regulation by 3',5'-cyclic adenosine monophosphate/protein kinase A pathway.
Human immunoglobulin preparation for intravenous use induces elevation of cellular cyclic adenosine 3':5'-monophosphate levels, resulting in suppression of tumour necrosis factor alpha and interleukin-1 production.
Human monocyte killing of Staphylococcus aureus: modulation by agonists of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate.
Human platelets are defective in processing of cholera toxin.
Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4.
Hypertrophy of pheochromocytoma cells treated with nerve growth factor and activators of adenylate cyclase.
Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells.
Identification of a functional Gs protein in Euglena gracilis.
Identification of receptor regulatory proteins, membrane glycoproteins, and functional characteristics of adenylate cyclase in vesicles derived from the human neutrophil.
Identification of the predominant substrate for ADP-ribosylation by islet activating protein.
Immunological probes into the mechanism of cholera toxin action.
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain.
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Increase in stimulatory G protein and glucagon-responsive adenylate cyclase activity in rat liver following partial hepatectomy.
Increased adenylate cyclase activity and rapid weight loss following intraseptal injection of cholera toxin.
Increased cholera toxin-, and forskolin-induced cyclic AMP accumulations in psoriatic involved versus uninvolved or normal human epidermis.
Increased number of beta-adrenoceptors in hepatocytes from rats treated with 2-acetylaminofluorene.
Indapamide alters the cyclic AMP signal transduction pathway in cardiomyocytes in culture.
Independent regulation of beta-adrenergic receptor and nucleotide binding proteins of adenylate cyclase. Developmental and denervation-dependent responses in rat parotid.
Induction of oligodendrocyte differentiation by activators of adenylate cyclase.
Induction of refractoriness to isoproterenol by prior treatment of C6-2B rat astrocytoma cells with cholera toxin.
Influence of cholera toxin (an adenylate cyclase activator) on deoxyribonucleic acid synthesis of bovine mammary tissue in vitro and in athymic nude mice.
Influence of cholera toxin on the regulation of adenylate cyclase by GTP.
Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland.
Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody.
Inhibition by cholera toxin of rat polymorphonuclear leukocyte chemotaxis demonstrated in vitro and in vivo.
Inhibition by forskolin of insulin-stimulated glucose transport in L6 muscle cells.
Inhibition of acetylcholine release from guinea pig myenteric neurons by neuropeptide Y: GTP-binding protein mediation.
Inhibition of adenylate cyclase by p-bromophenacyl bromide.
Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor.
Inhibition of ADP-ribosyltransferase activity of cholera toxin by MDL 12330A and chlorpromazine.
Inhibition of cholera toxin activation of the adenylate cyclase system in intact HeLa cells.
Inhibition of cholera toxin-stimulated intestinal epithelial cell adenylate cyclase by adenosine analogs.
Inhibition of cyclic AMP formation by iodide in suspension cultures of porcine thyroid follicle cells.
Inhibition of denuded mouse oocyte meiotic maturation by forskolin, an activator of adenylate cyclase.
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Inhibition of gonadotropin-induced granulosa cell differentiation by activation of protein kinase C.
Inhibition of heat-labile cholera and Escherichia coli enterotoxins by brefeldin A.
Inhibition of hepatic adenylate cyclase by NADH.
Inhibition of intestinal secretion in rats by colchicine and vinblastine.
Inhibition of murine lymphocyte proliferation by the B subunit of cholera toxin.
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
Inhibition of protein phosphatases by okadaic acid and calyculin-A differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT-20 corticotrophs: effect of pituitary adenylate activating polypeptide and corticotropin-releasing factor.
Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway.
Inhibition of the proliferation of Nb2 cells by femtomolar concentrations of cholera toxin and partial reversal of the effect by 12-O-tetradecanoyl-phorbol-13-acetate.
Inhibitory effect of cholera toxin on human natural cell-mediated cytotoxicity and its augmentation by interferon.
Inhibitory effect of guanyl nucleotides toward adenylate cyclase activity of Chinese hamster ovary cell membranes activated in vitro by cholera toxin.
Inhibitory effects of pentacaine and some related local anaesthetics on rat hepatic adenylate cyclase.
Inhibitory regulation of adenylyl cyclases. Evidence inconsistent with beta gamma-complexes of Gi proteins mediating hormonal effects by interfering with activation of Gs.
Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes.
Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C.
Interaction between prostacyclin and cortisol in fetal lung cells: effects on cAMP production.
Interaction between the calcium and adenylate cyclase messenger systems in dispersed chief cells from guinea pig stomach. Possible cellular mechanism for potentiation of pepsinogen secretion.
Interaction of GTP-binding regulatory proteins with chemosensory receptors.
Interaction of guanine nucleotides with adenylate cyclase in normal and spontaneously transformed RL-RP-C cloned rat hepatocytes.
Interactions of cholera toxin with isolated hepatocytes. Effects of low pH, chloroquine and monensin on toxin internalization, processing and action.
Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes.
Interleukin 2 counteracts the inhibition of cytotoxic T lymphocytes by cholera toxin in vitro and in vivo.
Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase.
Intestinal resistance to cholera toxin in mouse. Antitoxic antibodies and desensitization of adenylate cyclase.
Intestinal villus and crypt cell responses to cholera toxin.
Intraocular pressure and aqueous flow are decreased by cholera toxin.
Intrathecally administered cholera toxin blocks allodynia and hyperalgesia in persistent pain models.
Involvement of a high-affinity GTPase in the inhibitory coupling of striatal muscarinic receptors to adenylate cyclase.
Involvement of cAMP in initiating maturation of the brittle-star Amphipholis kochii oocytes: induction of oocyte maturation by inhibitors of cyclic nucleotide phosphodiesterase and activators of adenylate cyclase.
Involvement of cAMP signaling in elicitor-induced phytoalexin accumulation in Cupressus lusitanica cell cultures.
Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro.
Involvement of second messenger systems in stimulation of angiotensin converting enzyme of bovine endothelial cells.
Involvement of the cAMP messenger system and extracellular Ca(2+) during hyposmotically-induced prolactin release in the Mozambique tilapia.
Iron inhibits D-1 dopamine receptor coupled adenylate cyclase via G-proteins in the caudate nucleus of the rat.
Is dopamine-sensitive adenylate cyclase involved in regulating the activity of striatal cholinergic neurons?
Is the receptor-mediated endocytosis of cholera toxin A pre-requisite for its activation of adenylate cyclase in intact rat hepatocytes?
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.
Isolation and partial characterization of adenylate cyclase-enriched membranes from human platelets.
Isolation of a mutant LLC-PK1 cell line defective in hormonal responsiveness. A pleiotropic lesion in receptor function.
Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling.
Isoproterenol is a positive regulator of the suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes.
Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein.
Ketoconazole inhibits corticotropic cell function in vitro.
Kinetics of activation of ADP-ribosylation and adenylate cyclase by cholera toxin in cloned differentiated hepatocytes.
Labeling of a GTP-binding regulatory protein of rat brain adenylate cyclase system by cholera toxin-catalyzed ADP-ribosylation.
LH release is facilitated by agents that alter cyclic AMP-generating system.
Ligand-induced redistribution of lymphocyte membrane ganglioside GM1.
Limulus ventral photoreceptors contain a homologue of the alpha-subunit of mammalian Ns.
Lindane decreases forskolin-stimulated cyclic AMP accumulation but does not modify Gs in rat enterocytes.
Localization of the action of cholera toxin on adenyl cyclase in mucosal epithelial cells of rabbit intestine.
Localization of the GM1 ganglioside in the vestibular system using cholera toxin.
Loperamide: studies on its mechanism of action.
Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system.
MaxiK channel mediates beta2-adrenoceptor-activated relaxation to isoprenaline through cAMP-dependent and -independent mechanisms in guinea-pig tracheal smooth muscle.
MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms.
Mechanism of action of cholera toxin and the mobile receptor theory of hormone receptor-adenylate cyclase interactions.
Mechanism of action of cholera toxin on intact cells. Generation of A1 peptide and activation of adenylate cyclase.
Mechanism of action of cholera toxin. Specific inhibition of toxin-induced activation of adenylate cyclase.
Mechanism of action of cholera toxin: effect of receptor density and multivalent binding on activation of adenylate cyclase.
Mechanism of action of Vibrio cholerae enterotoxin. Effects on adenylate cyclase of toad and rat erythrocyte plasma membranes.
Mechanism of activation of adenylate cyclase by cholera toxin.
Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin.
Mechanism of activation of cholera toxin by ADP-ribosylation factor (ARF): both low- and high-affinity interactions of ARF with guanine nucleotides promote toxin activation.
Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site.
Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic.
Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.
Mechanism of cholera toxin activation by a guanine nucleotide-dependent 19 kDa protein.
Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.
Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes.
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX.
Mechanism of molybdate activation of adenylate cyclase.
Mechanisms of action of cholera and Escherichia coli enterotoxins.
Mesocestoides lineatus: trypsin induced development to adult mediated by Ca2+ and protein kinase C.
Methylation in bovine luteal cells as a regulator of luteinizing hormone action.
Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes.
Mn2+-uncoupling of the catecholamine-sensitive adenylate cyclase system of rat reticulocytes. Parallel effects on cholera toxin-catalyzed ADP-ribosylation of the system.
Mobility of cholera toxin receptors on rat lymphocyte membranes.
Mode of action of cholera toxin: stabilization of catecholamine-sensitive adenylate cyclase in turkey erythrocytes.
Mode of action of the cholera-coli family of enterotoxins.
Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.
Modification of cardiac beta-adrenoceptor mechanisms by H2O2.
Modification of the adenylate cyclase activity of bovine thyroid plasma membranes by manipulating the ganglioside composition with a nonspecific lipid transfer protein.
Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation.
Modification of TSH-stimulated adenylate cyclase activity of bovine thyroid by manipulation of membrane phospholipid composition with a nonspecific lipid transfer protein.
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
Modulation of adenylate cyclase in human keratinocytes by protein kinase C.
Modulation of enterotoxin binding and function in vitro and in vivo.
Modulation of Gs activity by phorbol myristate acetate in rat hepatocytes.
Modulation of in vitro erythropoiesis: enhancement of erythroid colony growth by cyclic nucleotides.
Modulation of intracellular cyclic adenosine monophosphate levels and the differentiation response of human neuroblastoma cells.
Modulation of lipoprotein lipase in the intact rat by cholera toxin--an irreversible agonist of cyclic AMP.
Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with b2-adrenergic agonist.
Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I.
Molecular cloning, sequence analysis and mRNA expression of human ADP-ribosylation factor.
Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways.
Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.
Multiple effects of ethanol on cardiac adenylate cyclase.
Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.
Multiple signalling pathways involved in beta(2)-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.
Multiple sites of action of ethanol on adenylate cyclase.
Muscarinic cholinergic induced secretin subsensitivity in rat isolated pancreatic acini. Effects on amylase release, cyclic adenosine monophosphate and inositol phosphate formation.
Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics.
Muscarinic receptor-stimulated phosphoinositide turnover in human SK-N-SH neuroblastoma cells: differential inhibition by agents that elevate cyclic AMP.
Mutagenesis of the amino-terminal glycine to alanine in Gs alpha subunit alters beta gamma-dependent properties and decreases adenylylcyclase activation.
Mutant alpha subunit of Gz transforms Swiss 3T3 cells.
N-Chloroacetylhydrazone of oxo-GTP irreversibly inhibits the activating function of GTP-binding protein coupled with adenylate cyclase.
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase.
Negative regulation of adipose-expressed galectin-12 by isoproterenol, tumor necrosis factor alpha, insulin and dexamethasone.
Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro.
Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+ -dependent adenylyl cyclase(s).
Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling.
Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme.
Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture.
Norepinephrine infusions increase adenylate cyclase responsiveness in brown adipose tissue.
Nucleotide binding and cofactor activities of purified bovine brain and bacterially expressed ADP-ribosylation factor.
Olfactory GTP-binding protein: signal-transducing polypeptide of vertebrate chemosensory neurons.
Ontogeny of insulin and glucagon receptors and the adenylate cyclase system in guinea pig liver.
Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase.
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Opposing regulatory effects of protein kinase C on the cAMP cascade in human HL-60 promyelocytic leukemia cells.
Orientation of cholera toxin bound to target cells.
p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase is involved in prostaglandin E1-induced vascular endothelial growth factor synthesis in osteoblasts.
Parathyroid hormone/adenylate cyclase coupling in vascular smooth muscle cells.
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.
Partial characterization of human spermatozoal phosphodiesterase and adenylate cyclase and the effect of steroids on their activities.
Partial purification of a water-soluble liver protein that regulates adenylate cyclase activity (basal, hormone- and cholera-toxin-activated) and cholera-toxin-catalyzed ADP-ribosylation of the membrane G protein.
Partial reversal of doxorubicin resistance by forskolin and 1,9-dideoxyforskolin in murine sarcoma S180 variants.
Participation of a guanine nucleotide-binding protein cascade in cholera toxin activation of adenylate cyclase.
Pathogenesis of Salmonella-mediated intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin.
Peptide mapping of adenylate cyclase regulatory proteins that are cholera toxin substrates.
Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus.
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
Pertussis toxin prevents homologous desensitization of adenylate cyclase in cultured renal epithelial cells.
Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase.
Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
PGE2, forskolin, and cholera toxin interactions in rabbit cortical collecting tubule.
Pharmacological analysis of ovarial patency in Heliothis virescens.
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction.
Pharmacological modulation of CRH-stimulated ACTH secretion by ketoconazole.
Pharmacological regulation in vitro of meiotic resumption in oocytes of Xenopus laevis.
Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.
Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells).
Phorbol esters inhibit adenylate cyclase activity in cultured collecting tubular cells.
Phosphorylation of the active, A1 component of cholera toxin by protein kinase.
Placental glycogen metabolism in diabetic pregnancy.
Plasma hyperosmolality increases G protein and 3',5'-cyclic adenosine monophosphate synthesis in the paraventricular and supraoptic nuclei.
Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways.
Plasma membrane-associated component(s) that confer(s) cholera toxin sensitivity to adenylate cyclase.
Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.
Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.
Possible involvement of inhibitory GTP binding regulatory protein in alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase activity in cerebral cortical membranes of rats.
Postnatal development of jejunal sucrase: independence from cyclic AMP.
Potentiating effect of bile on enterotoxin-induced diarrhea.
Preactivation as a determinant for the size of thyroid adenylate cyclase.
Pregnancy-related modifications of rat myometrial Gs proteins: ADP ribosylation, immunoreactivity and gene expression studies.
Progestin signaling through an olfactory G protein and membrane progestin receptor-alpha in Atlantic croaker sperm: potential role in induction of sperm hypermotility.
Prolactin and MA-10 Leydig cell steroidogenesis: biphasic effects of prolactin and signal transduction.
Prolonged stimulation of adenylate cyclase activity and testosterone production by cholera enterotoxin with suppression of gonadotropin release in rats.
Properties of adenyl cyclase from human jejunal mucosa during naturally acquired cholera and convalescence.
Properties of adenylate cyclase in mucosal cells of the rabbit ileum and the effect of cholera toxin.
Properties of cholera toxin- and NaF-stimulated adenylate cyclase from mouse thymocytes.
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Properties of protein kinase and adenylate cyclase-deficient variants of a macrophage-like cell line.
Properties of rat erythrocyte membrane cytoskeletal structures produced by digitonin extraction: digitonin-insoluble beta-adrenergic receptor, adenylate cyclase, and cholera toxin substrate.
Prostaglandin E in cholera toxin-induced intestinal secretion. Lack of an intermediary role.
Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase. Consequences on the guanyl nucleotide regulatory complex.
Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia.
Prostaglandin E2 is an inhibitor of adenylate cyclase in rabbit proximal tubule.
Prostaglandin E2 receptor heterogeneity and dysfunction in mammary tumor cells.
Prostaglandin E2, adenosine 3':5'-cyclic monophosphate and changes in endometrial vascular permeability in rat uteri sensitized for the decidual cell reaction.
Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes.
Protection against experimental cholera in the rat. A study on the formation of antibodies against cholera toxin and desensitization of adenylate cyclase after immunization with cholera toxin.
Protein kinase A activity modulates natriuretic peptide-dependent cGMP accumulation in renal cells.
Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.
Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.
Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium.
Protein kinase C-dependent modulation of stimulatory guanine nucleotide binding protein of fetal rat skin keratinocytes.
Protein synthesis is required for cholera toxin-induced stimulation of arachidonic acid metabolism.
Protein toxins produced by pathogenic vibrios.
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.
Raised cyclic-AMP and a small applied electric field influence differentiation, shape, and orientation of single myoblasts.
Rat kidney cells in primary culture: hormone-mediated desensitization of the adenosine 3',5'-monophosphate response to parathyroid hormone and calcitonin.
Rat pancreas adenylate cyclase. III. Its role in pancreatic secretion assessed by means of choleara toxin.
Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice.
Receptor-independent activation of cardiac adenylyl cyclase by GDP and membrane-associated nucleoside diphosphate kinase. A new cardiotonic mechanism?
Receptors for N-acetylated sugars may stimulate adenylate cyclase to sensitize and tune mechanoreceptors involved in triggering nematocyst discharge.
Recombinant nontoxinogenic Vibrio cholerae strains as attenuated cholera vaccine candidates.
Reconstitution of a hormone-sensitive adenylate cyclase with membrane extracts from Neurospora and avian erythrocytes.
Reconstitution of cholera toxin-activated adenylate cyclase.
Redox modulation of Gi protein expression and adenylyl cyclase signaling: role of nitric oxide.
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells. Long-term down-regulation of Gs alpha subunits by cholera toxin treatment.
Regulation by butyrate of the cAMP response to cholera toxin and forskolin in pituitary GH1 cells.
Regulation by forskolin of octopamine-stimulated adenylate cyclase from brain of the dipterous Ceratitis capitata.
Regulation of acetylcholine receptor by cyclic AMP.
Regulation of adenosine 3':5'-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins.
Regulation of adenylyl cyclase isoforms by N-alkanols.
Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium.
Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
Regulation of differentiation of the BC3H1 muscle cell line through cAMP-dependent and -independent pathways.
Regulation of dome formation in differentiated epithelial cell cultures.
Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.
Regulation of I(Cl,swell) in neuroblastoma cells by G protein signaling pathways.
Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate.
Regulation of insulin-like growth factor-binding protein-1 production in human granulosa-luteal cells.
Regulation of interleukin 2 synthesis by cAMP in human T cells.
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Regulation of oocyte maturation in the rainbow trout,Salmo gairdneri: role of cyclic AMP in the mechanism of action of the maturation inducing steroid (MIS), 17?-hydroxy, 20?-dihydroprogesterone.
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Regulation of S49 lymphoma cell growth by cyclic adenosine 3':5'-monophosphate.
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Regulation of the in vitro early anamnestic antibody response by exogenous cholera enterotoxin and cyclic AMP.
Regulation of the ovalbumin gene: effects of insulin, adenosine 3',5'-monophosphate, and estrogen.
Regulation of the transmodulated epidermal growth factor receptor by cholera toxin and the protein phosphatase inhibitor okadaic acid.
Regulation of thrombin-induced endothelial cell activation by bacterial toxins.
Regulatory states of adenylate cyclase in RL-PR-C cloned rat hepatocytes.
Relationship between the self-incompatibility and cAMP level in Lilium longiflorum.
Release of phospholipase A2 activity from rat vascular smooth muscle cells mediated by cAMP.
Requirement for guanosine triphosphate for cholera-toxin-catalysed incorporation of adenosine diphosphate ribose into rat liver plasma membranes and for activation of adenylate cyclase.
Requirement for guanosine triphosphate in the activation of adenylate cyclase by cholera toxin.
Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.
Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase.
Restoration of glucagon responsiveness in spontaneously transformed rat hepatocytes (RL-PR-C) by fusion with normal progenitor cells and rat liver plasma membranes.
Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK).
Reticulocyte cytosol activator protein: its actions upon the beta adrenergic receptor and the N-proteins of adenylate cyclase.
Robust sensitization to amphetamine following intra-VTA cholera toxin administration.
Role of adenylate cyclase in human T-lymphocyte surface antigen capping.
Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility.
Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties.
Role of cyclic nucleotides in the inhibition of growth-hormone secretion by somatostatin.
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle.
Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye.
Role of guanine nucleotides in the stimulation of thyroid adenylate cyclase by prostaglandin E1 and cholera toxin.
Role of membrane gangliosides in the binding and action of bacterial toxins.
Role of phosphodiesterases in the regulation of endothelial permeability in vitro.
Selective amplification of luteinizing hormone by adenosine in rat luteal cells.
Selective effects of cholera toxin on the adrenaline responsive component of hepatic adenyl cyclase.
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP.
Self-incompatibility involved in the level of acetylcholine and cAMP.
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Separation and properties of a regulatory GTPase activity associated with the adenylate cyclase system in rat brain synaptic plasma membranes.
Separation and reconstitution of regulatory and catalytic components of heart adenylate cyclase.
Sequence of events in the activation of adenylate cyclase by cholera toxin.
Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.
Shapes of cells spreading on fibronectin: measurement of the stellation of BHK21 cells induced by raising cyclic AMP, and of its reversal by serum and lysophosphatidic acid.
Short communications. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes.
Short term neonatal starvation altered cholera toxin binding in rabbits.
Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine.
Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
Signal transduction events in in vitro megakaryocytopoiesis.
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Signs of endolymphatic hydrops after perilymphatic perfusion of the guinea pig cochlea with cholera toxin; a pharmacological model of acute endolymphatic hydrops.
Similarities and differences in phorbol ester- and luteinizing-hormone-induced desensitization of rat tumour Leydig-cell adenylate cyclase.
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Site-directed mutagenic alteration of potential active-site residues of the A subunit of Escherichia coli heat-labile enterotoxin. Evidence for a catalytic role for glutamic acid 112.
Small fragments from the A subunit of cholera toxin capable of activating adenylate cyclase.
Soluble guanine nucleotide-dependent ADP-ribosylation factors in activation of adenylyl cyclase by cholera toxin.
Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP.
Somatostatin inhibits cAMP-mediated cholinergic transmission in the myenteric plexus.
Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.
Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat.
Some comparative properties and localization of porcine jejunal adenylate cyclase.
Specificity of cytochemical demonstration of adenylate cyclase in liver using adenylate-(beta, gamma-methylene) diphosphate as substrate.
Spin-labeled stearates as probes for microenvironment of murine thymocyte adenylate cyclase-cyclic adenosine 3':5'-monophosphate system.
Spontaneous Intracellular Calcium Oscillations and G(s) ? Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells.
Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Stimulation by cholera toxin of ADP-ribosylation of membrane proteins, adenylate cyclase and insulin release in pancreatic islets.
Stimulation of adenylate cyclase by Vibrio cholerae toxin and its active subunit.
Stimulation of adenylate cyclase in washed pigeon erythrocyte membrane with cholera toxin and its subunits.
Stimulation of calcium influx and calcium cascade by cyclic AMP in cultured carrot cells.
Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol: effect of cholera toxin.
Stimulation of intestinal adenyl cyclase by cholera toxin.
Stimulation of intestinal adenylate cyclase by cholera toxin in malnourished rats.
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.
Stimulation of slow action potentials in guinea pig papillary muscle cells by intracellular injection of cAMP, Gpp(NH)p, and cholera toxin.
Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium.
Stimulatory and inhibitory effects of forskolin on adenylate cyclase in rat normal hepatocytes and hepatoma cells.
Stimulatory and inhibitory effects of sodium salts on adenylate cyclase of rat liver. Implications for salt modulation of guanine nucleotide-binding regulatory component function.
Stimulatory guanine nucleotide binding protein in pig epidermis: transient increase of the 45KDA cholera toxin substrate (Gs alpha) in the tape stripping-induced hyperproliferative state.
Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle.
Structure of brain adenylate cyclase: proteolysis-dependent modifications.
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.
Studies of cAMP metabolism in cultured hepatoma cells: presence of functional adenylate cyclase despite low cAMP content and lack of hormonal responsiveness.
Studies on the function of pancreatic islet cell membranes.
Studies on the mechanism of the decreased guanine nucleotide stimulatory effects on adenylate cyclase after adrenalectomy in rat adipocytes.
Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets.
Studies on the mode of action of cholera toxin. Effects on solubilized adenylate cyclase.
Studies on the time course and rate-limiting steps in the activation of adenylate cyclase in rat liver by cholera toxin.
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Suppression of aquaporin adipose gene expression by isoproterenol, TNFalpha, and dexamethasone.
Synthesis and screening of small molecule inhibitors of anthrax edema factor.
Synthesis of a photoreactive, radiolabelled derivative of the oligosaccharide of GM1 ganglioside.
Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.
Synthetic peptides corresponding to human follicle-stimulating hormone (hFSH)-beta-(1-15) and hFSH-beta-(51-65) induce uptake of 45Ca++ by liposomes: evidence for calcium-conducting transmembrane channel formation.
Synthetic peptides with antigenic specificity for bacterial toxins.
Systematic shut-off of the hormone receptors in intraspecific adrenal x Leydig cell hybrids.
Tannin inhibits adenylate cyclase in airway epithelial cells.
The 5'-flanking region of the human P-450(SCC) gene shows responsiveness to cAMP-dependent regulation in a transient gene-expression system of Y-1 adrenal tumor cells.
The activation of adenylate cyclase by cholera toxin: possible interaction with the nucleotide regulatory site.
The activation of adenylate cyclase from small intestinal epithelium by cholera toxin.
The activation of rabbit intestinal adenylate cyclase by cholera toxin.
The adenylate cyclase system and calcitonin secretion from perfused dog thyroid lobes.
The B subunit of cholera toxin enhances DNA synthesis in rat hepatocytes induced by insulin and epidermal growth factor.
The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin.
The catalytic unit of ram sperm adenylate cyclase can be activated through the guanine nucleotide regulatory component and prostaglandin receptors of human erythrocyte.
The cox-2-specific inhibitor celecoxib inhibits adenylyl cyclase.
The differential detergent solubilization of adenylate cyclase and polypeptides ADP-ribosylated with cholera toxin suggests an excess of G/F protein relative to adenylate cyclase in rat pancreatic plasma membranes.
The effect of cholera toxin on choroid plexus carbonic anhydrase activity in vitro.
The effect of cholera toxin on intestinal adenyl cyclase.
The effect of streptozotocin diabetes on the vasoactive intestinal peptide receptor/effector system in membranes from rat ventral prostate.
The effects of hormones, cholera toxin, and N alpha-tosyl-L-lysine chloromethyl ketone on adenylate cyclase in viable granulosa cells.
The effects of retinoic acid on the in vitro and in vivo growth of neuroblastoma cells.
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
The immunologic control mechanism against cholera toxin. II. Stimulation of adenylate cyclase without fluid secretion.
The influence of EDTA on adenylate cyclase activity in membranes from rat and mouse myocardium.
The mechanism of action of cholera toxin in pigeon erythrocyte lysates.
The nature and action of cholera toxin.
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.
The regulation of steroidogenesis is different in the two types of ovine luteal cells.
The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase.
The role of calmodulin in the responses to adrenocorticotropin of plasma membranes from adrenal cells.
The role of G-proteins in the mitogenesis of rat lactogen-dependent and lactogen-independent Nb2 lymphoma cells.
The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.
The site of alpha-chymotryptic activation of pigeon erythrocyte adenylate cyclase.
The sites on the regulatory component of adenylate cyclase which are ADP-ribosylated by cholera toxin.
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.
The stimulatory guanine-nucleotide regulatory unit of adenylate cyclase from bovine cerebral cortex. ADP-ribosylation and purification.
The synaptic structure of PACAP immunoreactive axons in the intermediolateral nucleus of the rat.
Thermodependence of guanine nucleotide-activated rat cardiac adenylate cyclase activity. Effect of cholera toxin pretreatment.
Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.
Thyroid membrane ADP ribosyltransferase activity. Stimulation by thyrotropin and activity in functioning and nonfunctioning rat thyroid cells in culture.
Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
Thyrotropin stimulation of the ADP-ribosyltransferase activity of bovine thyroid membranes.
Tissue and species distribution of mRNA encoding two ADP-ribosylation factors, 20-kDa guanine nucleotide binding proteins.
Toxins which activate adenylate cyclase.
Transducin and the cyclic GMP phosphodiesterase: amplifier proteins in vision.
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Transforming growth factor-beta modulates receptor binding of calciotropic hormones and G protein-mediated adenylate cyclase responses in osteoblast-like cells.
Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.
Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.
Transmembrane signalling systems.
Transport of bacterial toxins into target cells: pathways followed by cholera toxin and botulinum progenitor toxin.
Treatment of cardiac myocytes with 8-(4-chlorophenylthio)-adenosine 3',5'-cyclic monophosphate, forskolin or cholera toxin does not stimulate cellular or heparin-releasable lipoprotein lipase activities.
Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms.
Triiodothyronine modulates interleukin-6 synthesis in osteoblasts: inhibitions in protein kinase A and C pathways.
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Type II heat-labile enterotoxins from 50 diverse Escherichia coli isolates belong almost exclusively to the LT-IIc family and may be prophage encoded.
Uncoupling of alpha-adrenoceptor-mediated inhibition of human platelet adenylate cyclase by N-ethylmaleimide.
Unique properties of the follicle-stimulating hormone- and cholera toxin-sensitive adenylyl cyclase of immature granulosa cells.
Unusual antagonistic actions of mixtures of vasoactive intestinal peptide, thyroid-stimulating antibodies, and cholera toxin on adenosine 3',5'-monophosphate accumulation in normal human thyroid cell cultures.
Up-regulation of beta 2-adrenergic receptors in previously transplanted, denervated nonfailing human hearts.
Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride.
Vibrio cholerae Infection of Drosophilamelanogaster Mimics the Human Disease Cholera.
Vibrio cholerae: Cholera toxin.
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
VIP receptor/effector system in liver membranes from cholestatic rats.
Voltage-sensitive adenylyl cyclase activity in cultured neurons. A calcium-independent phenomenon.
[Adenylate cyclase system responsive to thyroid stimulating hormone (TSH) of porcine thyroid cells in primary monolayer cultures. Potential effect of forskolin on TSH-mediated adenylate cyclase stimulation]
[Decrease in the lipid content of human atherosclerotic aorta cells as affected by compounds increasing the intracellular level of cyclic AMP]
[Effect of genotype and social stress on cAMP- and substrate-dependent mechanisms of regulating hormonal function of testis in mice]
[Electron microscopic demonstration of adenylate cyclase in rabbit small intestine enterocytes doubly stimulated by cholera toxin and sodium fluoride]
[G-proteins and endocrine tumors. The example of acromegaly]
[Involvement of protein kinase C in the acid secretion of gastric parietal cells]
[Mechanisms of diabetes-induced impairements of serotonin release from rat brain synaptosomes: effect of nicotinamide]
[Possible trophic role on the neuromuscular junction of a neuropeptide co-existing with acetylcholine in motor neurons of the spinal cord]
[Regulation of aromatase in human choriocarcinoma cells]
[Response of the IRD intestinal epithelial cell line to Clostridium difficile toxins A and B in rats. Effect of Saccharomyces boulardii]
[Response to cholera toxin of 2 epithelial intestinal cell lines. Effect of Saccharomyces boulardii]
[Sodium 2,3-dithiopropanesulfate blockade of the effect of cholera enterotoxin on adenylate cyclase and the concentration of cyclic 3',5'-adenosine monophosphate in the small intestine mucosa of the rabbit]
[Stimulatory effects of follicular stimulating hormone on the proliferation of ovarian cancer cell line in vitro and in vivo]
[Study of molecular mechanisms of the relaxin action on adenylyl cyclase signaling system using synthetic peptides derived from the relaxin receptor LGR7]
[The cAMP system and bacterial toxins]
[The effect of sodium and ouabain on the activation of beta 2-adrenoreceptor-dependent adenylate cyclase in human lymphocytes]
[The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria]
[The measurement of N-protein activity in plasma membranes: the comparison of assay methods by reconstitution of cyc- membranes and cholera toxin-catalyzed ADP ribosylation]
[The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)]
[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]
[Ultrastructural changes in rat colon epitheliocytes after treatment with cholera toxin]
Cholestasis
G proteins in rat liver proliferation during cholestasis.
VIP receptor/effector system in liver membranes from cholestatic rats.
Chondrocalcinosis
The new bone biology: pathologic, molecular, and clinical correlates.
Chorea
A de novo ADCY5 mutation causes early-onset autosomal dominant chorea and dystonia.
ADCY5 identified as a novel cause of benign hereditary chorea.
ADCY5 Mutations and Benign Hereditary Chorea.
ADCY5 mutations are another cause of benign hereditary chorea.
ADCY5-Related Dyskinesia: Improving Clinical Detection of an Evolving Disorder.
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Chorea.
Methylphenidate Can Improve Chorea in NKX2.1 and ADCY5 Mutation-positive Patients-A Report of Two Children.
Phenotypic insights into ADCY5-associated disease.
Recent advances in genetics of chorea.
Recurrent ADCY5 Mutation in Mosaic Form with Nocturnal Paroxysmal Dyskinesias and Video Electroencephalography Documentation of Dramatic Response to Caffeine Treatment.
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Choriocarcinoma
12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Effect of human parathyroid hormone on the cAMP production and the endocrine functions of trophoblast cells from first trimester placenta.
Effects of pituitary adenylate cyclase activating polypeptide on the survival and signal transduction pathways in human choriocarcinoma cells.
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line.
Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I.
PACAP-38 positively regulates glycoprotein hormone alpha-gene expression in placental cells.
Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin.
[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]
Classical Lissencephalies and Subcortical Band Heterotopias
Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.
Cleft Palate
Developmental pattern of cAMP, adenyl cyclase, and cAMP phosphodiesterase in the palate, lung, and liver of the fetal mouse: alterations resulting from exposure to methylmercury at levels inhibiting palate closure.
In vitro activation of adenylate cyclase by parathyroid hormone and calcitonin during normal and hydrocortisone-induced cleft palate development in the golden hamster.
Cleidocranial Dysplasia
The new bone biology: pathologic, molecular, and clinical correlates.
Coinfection
Inhibition of microtubule formation by metabotropic glutamate receptors.
Lethal infection by Bordetella pertussis mutants in the infant mouse model.
Colitis
Adenylyl cyclase 6 is involved in the hyposecretory status of experimental colitis.
Defective stimulation of cyclic AMP by prostaglandin E2 in colonic epithelial cells in colitis.
Inactivation of the G alpha i2 and G alpha o genes by homologous recombination.
Colitis, Ulcerative
Inactivation of the G alpha i2 and G alpha o genes by homologous recombination.
Increased colonic adenylate cyclase activity in active ulcerative colitis.
Colonic Neoplasms
Adenylate cyclase activity and cyclic adenosine monophosphate levels in colon cancer lines and dermal fibroblasts and the effects of cholera toxin and epidermal growth factor.
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Development of vasoactive intestinal peptide-responsive adenylate cyclase during enterocytic differentiation of Caco-2 cells in culture. Evidence for an increased receptor level.
Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells.
Elevated Adenylyl Cyclase 9 Expression Is a Potential Prognostic Biomarker for Patients with Colon Cancer.
Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer via the upregulation of ADCY1 by regulating microRNA-127-3p.
Colorectal Neoplasms
Hormonal regulation of adenylate cyclase activity in circulating lymphocytes and its interrelationship with hormone sensitivity of tumor tissue in colorectal cancer patients.
[Characteristics of the hormonal metabolic status of patients with colonic and rectal cancer]
[The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine]
Congenital Hypothyroidism
Comparative study of collecting tubules and vasopressin binding capacity in the renal medulla of developing hypothyroid rat.
Use of FRTL-5 for the study of thyroid antibodies involved in goitrogenesis.
Contracture
cAMP-dependent reduction in membrane fluxes during relaxation of arterial smooth muscle.
Effects of adenylate cyclase activators on porcine skeletal muscle in malignant hyperpyrexia.
Effects of cAMP and forskolin on caffeine-induced contractures and myofilament Ca-sensitivity in saponin-treated rat ventricular trabeculae.
Corneal Injuries
The PACAP-derived peptide MPAPO facilitates corneal wound healing by promoting corneal epithelial cell proliferation and trigeminal ganglion cell axon regeneration.
Coronary Artery Disease
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
Coronary Disease
Effects of beta blocking agents on the density of beta adrenoceptors and adenylate cyclase response in human myocardium: intrinsic sympathomimetic activity favours receptor upregulation.
Effects of beta-adrenergic stimulating and blocking agents on the adrenaline response and adenyl cyclase activity of leukocyte in monkey and human being.
Coronary Occlusion
Forskolin potentiates myocardial reactive hyperaemia in the open chest dog: the contribution of adenylate cyclase.
Coronary Stenosis
Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes.
Cough
BspR/BtrA, an Anti-? Factor, Regulates the Ability of Bordetella bronchiseptica To Cause Cough in Rats.
Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
Craniosynostoses
The new bone biology: pathologic, molecular, and clinical correlates.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain.
Cryptorchidism
Changes in germ cell adenylate cyclase and protein carboxyl methylase activities in rat testicular tissue during bilateral cryptorchidism and after orchidopexy.
Changes in isoproterenol-stimulated adenylate cyclase activity in rat testicular tissue during cryptorchidism and after orchidopexy.
Changes in rat testicular adenylate cyclase activities and gonadotrophin binding during unilateral experimental cryptorchidism.
Germ cell adenylyl cyclase activity in the human undescended testis and the effect of HCG-treatment.
Less calcium in cremaster muscles of boys with undescended testis supports a deficiency in sympathetic innervation.
Cushing Syndrome
cAMP pathway alterations from the cell surface to the nucleus in adrenocortical tumors.
Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumors.
Cystic Fibrosis
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera.
Adenylate cyclase in leukocytes from patients with cystic fibrosis.
An elusive adenylate cyclase complicit in cholera is exposed.
Are lymphocyte beta-adrenoceptors altered in patients with cystic fibrosis?
Combinatorial effects of genistein and sex-steroids on the level of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC) and cAMP in the cervix of ovariectomised rats.
Corrigendum to "Testosterone regulates levels of cystic fibrosis transmembrane regulator, adenylate cyclase and cAMP in the seminal vesicles of orchidectomized rats" [Theriogenology 85(2) (2016) 238-246].
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation.
Detection of adenylate cyclase-coupled receptors in Xenopus oocytes by coexpression with cystic fibrosis transmembrane conductance regulator.
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.
Estrogen and progesterone differentially regulate the levels of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC), and cyclic adenosine mono-phosphate (cAMP) in the rat cervix.
Extracts from peppermint leaves, lemon balm leaves and in particular angelica roots mimic the pro-secretory action of the herbal preparation STW 5 in the human intestine.
GABA induces thee differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium.
Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung.
Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.
Isoproterenol-induced desensitization of mucin release in isolated rat submandibular acini.
Lymphocyte and granulocyte phosphatidylethanolamine N-methyltransferase: properties and activity in cystic fibrosis.
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
NO inhibits signal transduction pathway for ATP release from erythrocytes via its action on heterotrimeric G protein Gi.
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.
Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi.
Regulation of cholangiocyte secretion.
Spermine and spermidine, modulators of the cell surface enzyme adenylate cyclase.
Testosterone regulates levels of cystic fibrosis transmembrane regulator, adenylate cyclase, and cAMP in the seminal vesicles of orchidectomized rats.
The multi-herbal drug STW 5 (Iberogast(R)) has prosecretory action in the human intestine.
THE SHARK RECTAL GLAND MODEL: A CHAMPION OF RECEPTOR MEDIATED CHLORIDE SECRETION THROUGH CFTR.
Cystitis
Cyclophosphamide cystitis as a model of visceral pain in rats: a c-fos and Krox-24 study at telencephalic levels, with a note on pituitary adenylate cyclase activating polypeptide (PACAP).
Cysts
Adenylate cyclase activity during growth and encystment of Acanthamoeba castellanii.
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.
Changes in the cellular phenotype and extracellular matrix during progression of estrogen-induced mesenchymal kidney tumors in Syrian hamsters.
Identification of a forskolin-like molecule in human renal cysts.
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
Mechanisms of fluid secretion by polycystic epithelia.
The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease.
The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease.
Tolvaptan plus Pasireotide Shows Enhanced Efficacy in a PKD1 Model.
Darier Disease
Human skin epidermal adenylate cyclase systems: defective beta-adrenergic responsiveness in the involved epidermis of Darier's disease.
Dehydration
A novel role for endogenous pituitary adenylate cyclase activating polypeptide in the magnocellular neuroendocrine system.
Protein toxins produced by pathogenic vibrios.
Dementia
Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected.
Age related decline in aluminum-activated human platelet adenylate cyclase: post-receptor changes in cyclic AMP second messenger signal amplification in normal aging and dementia of the Alzheimer type.
Ca2+/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain: possible relation to type I adenylyl cyclase.
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Reduced immunoreactivity of adenylyl cyclase in dementia of the Alzheimer type.
VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by Alzheimer's disease/senile dementia of the Alzheimer type.
Dementia, Vascular
[The changes of cAMP and adenylyl cyclase mRNA level in hippocampus of mice with ischemia/reperfusion].
Demyelinating Diseases
In vivo and in vitro models of demyelinating disease: activation of the adenylate cyclase system influences JHM virus expression in explanted rat oligodendrocytes.
Dermatitis
The adenyl cyclase of skin. II. Adenyl cyclase levels in atopic dermatitis.
Dermatitis, Atopic
Adenylate cyclase activity in mononuclear leucocytes from patients with atopic dermatitis.
Adrenergic mechanisms and the adenyl cyclase system in atopic dermatitis.
Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis.
Impaired lymphocyte cyclic adenosine monophosphate responses in atopic eczema.
Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis.
Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic dermatitis.
Relationship between increased cyclic AMP-phosphodiesterase activity and abnormal adenylyl cyclase regulation in leukocytes from patients with atopic dermatitis.
The adenyl cyclase of skin. II. Adenyl cyclase levels in atopic dermatitis.
Diabetes Insipidus
Alterations in Cyclic AMP Concentration and Adenylate Cyclase Activity in Specific Brain Areas of Rats with Inherited Hypothalamic Diabetes Insipidus (Brattleboro Rats).
Influence of chronic ADH treatment on adenylate cyclase and ATPase activity in distal nephron segments of diabetes insipidus Brattleboro rats.
Renal medullary adenylate cyclase in rats with hypothalamic diabetes insipidus.
Stability of the vasopressin V2 receptor-adenylyl cyclase system in rat kidney.
Diabetes Insipidus, Nephrogenic
"Lithium" A Versatile Tool to Understand Renal Physiology"
Cyclic AMP responses to parathyroid hormone and glucagon during lithium treatment.
Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.
Impairment of cyclic AMP response to bovine parathyroid hormone in patients on chronic lithium therapy with diminished renal urine-concentrating ability.
Interactions between angiotensin II and arginine vasopressin in water homeostasis.
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase.
Renal medullary adenylate cyclase in drug-induced nephrogenic diabetes insipidus.
Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.
The effect of gentamicin on antidiuretic hormone-stimulated osmotic water flow in the toad urinary bladder.
Thyroid function and urine-concentrating ability during lithium treatment.
Diabetes Mellitus
Beta-adrenergic receptor activity of cerebral microvessels in experimental diabetes mellitus.
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Changes in renal phospholipid fatty acids in diabetes mellitus: correlation with changes in adenylate cyclase activity.
Common genetic variants in ADCY5 and gestational glycemic traits.
Decrease in functional activity of G-proteins hormone-sensitive adenylate cyclase signaling system, during experimental type II diabetes mellitus.
Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus.
Effect of diabetes mellitus on responses of the rat basilar artery to activation of beta-adrenergic receptors.
Effect of long-term and short-term diabetes on the parathyroid hormone sensitive rat renal adenylate cyclase: correlation with vitamin D metabolism.
Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia.
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.
Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.
Streptozotocin-induced diabetes produces alterations in adenylate cyclase in rat cerebrum, cerebral microvessels and retina.
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects.
The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus.
The influence of bromocryptine treatment on activity of the adenylyl cyclase system in the brain of rats with type 2 diabetes mellitus induced by high-fat diet.
[A change of hormonal regulation of adenylyl cyclase in the epididymal adipose tissue of rats with experimental models of diabetes mellitus].
[Attenuation of inhibitory influence of hormones on adenylyl cyclase systems in the myocardium and brain of rats with obesity and type 2 diabetes mellitus and effect of intranasal insulin on it].
[BETA-ADRENERGIC REGULATION OF THE ADENYLYL CYCLASE SIGNALING SYSTEM IN MYOCARDIUM AND BRAIN OF RATS WITH OBESITY AND TYPES 2 DIABETES MELLITUS AND THE EFFECT OF LONG-TERM INTRANASAL INSULIN TREATMENT].
[Effects of intranasal insulin and serotonin on functional activity of the adenylyl cyclase system in the myocardium, ovaries, and uterus of rats with prolonged neonatal model of diabetes mellitus].
[Streptozocin model of diabetes mellitus in the mollusc Anodonta cygnea: functional state of the adenylyl cyclase mechanisms of action of peptides of the insulin superfamily and their effect on carbohydrate metabolism enzymes]
[THE CHANGES OF NOCICEPTIVE THRESHOLD AND ACTIVITY OF THE ADENYLYL CYCLASE SYSTEM IN THE SKELETAL MUSCLES OF RATS WITH ACUTE AND MILD TYPE 1 DIABETES MELLITUS ].
[The influence of long-term diabetes mellitus induced by streptozotocin treatment of six-week rats on the functional activity of adenylyl cyclase system].
[Urocanic acid content of the epidermis of diabetics]
Diabetes Mellitus, Experimental
Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes.
Diabetes alters the responses of glucagon secreting cells and vascular bed to isoprenaline and forskolin in vitro in rat pancreas.
Diabetes reduces right atrial beta-adrenergic signaling but not agonist stimulation of heart rate in swine.
[Adenine nucleotide metabolism in the testicular tissue of alloxan diabetic rats]
[Molecular causes of changes in sensitivity of adenylyl cyclase signaling system to biogenic amines in the heart muscle during experimental streptozotocin diabetes]
Diabetes Mellitus, Type 1
Beta-adrenoceptor regulation in insulin-dependent diabetes mellitus.
Mononuclear leukocyte beta 2-adrenergic receptors and adenylate cyclase sensitivity in insulin-dependent diabetes mellitus.
Relaxin adenylyl cyclase system of pregnant women with diabetes: functional defects in insulin and relaxin adenylyl cyclase signaling systems in myometrium of pregnant women with type 1 diabetes.
[Functional state of adenylyl cyclase signaling system in reproductive tissues of rats with experimental type 1 diabetes]
[THE CHANGES OF NOCICEPTIVE THRESHOLD AND ACTIVITY OF THE ADENYLYL CYCLASE SYSTEM IN THE SKELETAL MUSCLES OF RATS WITH ACUTE AND MILD TYPE 1 DIABETES MELLITUS ].
Diabetes Mellitus, Type 2
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.
ADCY5 couples glucose to insulin secretion in human islets.
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Altered action of glucagon on human liver in type 2 (non-insulin-dependent) diabetes mellitus.
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Characteristic features of insulin secretion in the streptozotocin-induced NIDDM rat model.
Common genetic variants in ADCY5 and gestational glycemic traits.
Decreased glucagon-stimulated cyclic AMP production by isolated liver cells of rats with type 2 diabetes.
Development of PACAP38 Analogue with Improved Stability: Physicochemical and In Vitro/In Vivo Pharmacological Characterization.
Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes.
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
G-proteins in essential hypertension: a study of human platelet plasma membranes.
Genetic origins of low birth weight.
Genetic variants in GCKR, GIPR, ADCY5 and VPS13C and the risk of severe sulfonylurea-induced hypoglycaemia in patients with type 2 diabetes.
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.
Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes.
Glucose enhances adenylyl cyclase responses in normal but not diabetic GK rat islets.
Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis.
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat.
Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study.
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.
Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes.
Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.
The influence of bromocryptine treatment on activity of the adenylyl cyclase system in the brain of rats with type 2 diabetes mellitus induced by high-fat diet.
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
[A decrease of sensitivity of adenylyl cyclase and heterotrimeric G-proteins to chorionic gonadotropin and peptide hormones action in the tissues of reproductive system of the rats in the condition of experimental type 2 diabetes].
[Adenylyl cyclase signaling mechanisms of the insulin superfamily peptide action and their impairment in myometrium of pregnant women with type 2 diabetes]
[Attenuation of inhibitory influence of hormones on adenylyl cyclase systems in the myocardium and brain of rats with obesity and type 2 diabetes mellitus and effect of intranasal insulin on it].
[BETA-ADRENERGIC REGULATION OF THE ADENYLYL CYCLASE SIGNALING SYSTEM IN MYOCARDIUM AND BRAIN OF RATS WITH OBESITY AND TYPES 2 DIABETES MELLITUS AND THE EFFECT OF LONG-TERM INTRANASAL INSULIN TREATMENT].
[Study of hormone responsiveness of the adenylyl cyclase signaling system in erythrocyte membranes of patients with type 2 diabetes mellitus].
[The influence of two-month treatment with bromocryptine on activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes mellitus].
Diabetes, Gestational
ADCY5, CAPN10 and JAZF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.
Diabetic Angiopathies
Platelet aggregation, platelet cAMP levels and thromboxane B2 synthesis in patients with diabetes mellitus.
Diabetic Cardiomyopathies
Adrenergic desensitization in left ventricle from streptozotocin diabetic swine.
Alterations in adenylate cyclase activity due to streptozotocin-induced diabetic cardiomyopathy.
beta-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in the diabetic rat.
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.
Selective alteration of secretin-stimulated cardiac adenylate cyclase activity in streptozotocin-diabetic rats.
Diabetic Nephropathies
Role of adenylyl cyclase activator in controlling experimental diabetic nephropathy in rats.
Diabetic Neuropathies
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Diabetic Retinopathy
Effects of PACAP on Intracellular Signaling Pathways in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress.
PACAP Application Improves Functional Outcome of Chronic Retinal Ischemic Injury in Rats-Evidence From Electroretinographic Measurements.
PACAP promotes neuron survival in early experimental diabetic retinopathy.
Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.
Diphtheria
A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol.
Bacteria and their toxins tamed for immunotherapy.
Bordetella pertussis adenylate cyclase. Penetration into host cells.
Botulinum C2 toxin ADP-ribosylates actin.
Characterization of membrane translocation by anthrax protective antigen.
Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor.
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.
Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase.
IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells.
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process.
Diverticulitis
Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms.
Donohue Syndrome
Decreased cyclic guanosine 3',5' monophosphate and guanylate cyclase activity in leprechaunism: evidence for a postreceptor defect.
Down Syndrome
The adrenergic responsiveness of Down syndrome cells.
The alpha adrenergic response of Down's syndrome platelets.
Ductus Arteriosus, Patent
Role of cyclic nucleotides in relaxation of fetal lamb ductus arteriosus.
Duodenal Ulcer
[Adenyl cyclase activity of gastric mucosa in patients with duodenal ulcer before and after treatment]
[Adenylate cyclase activity of the gastric mucosa and the morphological changes in the gastrointestinal tract in the experimental reproduction of duodenal ulcers with subsequent truncal vagotomy]
Dwarfism, Pituitary
Decreased epinephrine response of adenylate cyclase activity of lymphoid cells from immunodeficient pituitary dwarf mice.
Dysentery, Bacillary
Increased colonic adenylate cyclase activity in active ulcerative colitis.
[Prostaglandins and cyclic nucleotides in the gastrointestinal form of yersiniosis]
Dyskinesias
ADCY5 mutation carriers display pleiotropic paroxysmal day and nighttime dyskinesias.
ADCY5 mutations are another cause of benign hereditary chorea.
ADCY5-related dyskinesia presenting as familial myoclonus-dystonia.
ADCY5-related dyskinesia: Broader spectrum and genotype-phenotype correlations.
An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
Caffeine and the Dyskinesia Related to Mutations in the ADCY5 Gene.
Depression and psychosis in ADCY5-related dyskinesia-part of the phenotypic spectrum?
Emerging Monogenic Complex Hyperkinetic Disorders.
Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats.
Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia.
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.
Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease.
l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease.
Phenotypic insights into ADCY5-associated disease.
Teaching Video NeuroImage: Paroxysmal Nocturnal Dyskinesias: A Characteristic Feature of ADCY5 Mutation.
[ADCY5-associated dyskinesia in young children: a case report of a family and an updated review].
[Familial dyskinesia and facial myokymia in a patient with ADCY5 gene mutation].
Dystonia
4-phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.
A de novo ADCY5 mutation causes early-onset autosomal dominant chorea and dystonia.
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Child Neurology: Spastic paraparesis and dystonia with a novel ADCY5 mutation.
Emerging Monogenic Complex Hyperkinetic Disorders.
Phenotypic insights into ADCY5-associated disease.
Embolism
Impairment of adenylyl cyclase and of spatial memory function after microsphere embolism in rats.
Selective reduction in type I adenylyl cyclase after microsphere embolism in rat brain.
Endolymphatic Hydrops
Adenylate cyclase modulation of ion permeability in the guinea pig cochlea: a possible mechanism for the formation of endolymphatic hydrops.
Signs of endolymphatic hydrops after perilymphatic perfusion of the guinea pig cochlea with cholera toxin; a pharmacological model of acute endolymphatic hydrops.
Endometrial Neoplasms
Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines.
Endometriosis
Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model.
Endotoxemia
Comparison of terbutaline and dobutamine in rats with endotoxemia.
Endotoxin-exposed atria exhibit G protein-based deficits in inotropic regulation.
Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo.
Uncoupling of coronary microvascular beta 2-adrenoceptors by Escherichia coli endotoxemia.
Enterocolitis, Pseudomembranous
Purified Clostridium difficile cytotoxin stimulates guanylate cyclase activity and inhibits adenylate cyclase activity.
Eosinophilia
Beta 2-adrenergic receptors on eosinophils. Binding and functional studies.
Epilepsy
Anticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor?
Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression.
Lateral difference in responsiveness of norepinephrine-sensitive cyclic AMP-generating systems of rat cerebral cortex with iron-induced epileptic activity.
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Up-regulation of type II adenylyl cyclase mRNA in kindling model of epilepsy in rats.
Epilepsy, Generalized
Novel vistas of calcium-mediated signalling in the thalamus.
Epilepsy, Temporal Lobe
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Epstein-Barr Virus Infections
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase.
Erectile Dysfunction
Pathogen-host jujitsu: phagocyte impotence caused by internalized bacterial adenylate cyclase.
Phagocyte impotence caused by an invasive bacterial adenylate cyclase.
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2).
[New features of pharmacologic treatment of erectile dysfunction]
Erythema
Prevention of cerebral vasospasm by vasodilatory peptide maxadilan following subarachnoid hemorrhage in rabbits.
Ultraviolet radiation augments epidermal beta-adrenergic adenylate cyclase response.
Essential Hypertension
Adrenoceptors, calcium, and vasoconstriction in normal and hypertensive humans.
Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension.
[Association between single nucleotide polymorphism of adenylyl cyclase 3 and essential hypertension].
[Effect of Visken therapy on the lymphocyte beta2-adrenoceptor-dependent adenylate cyclase system in essential hypertension]
Euthyroid Sick Syndromes
Stimulation of thyroid adenylate cyclase activity by sera from patients with non-thyroidal illness.
Exanthema
Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes.
Exophthalmos
Structure of an exophthalmos-producing factor derived from thyrotropin by partial pepsin digestion.
Eye Diseases
Forskolin lowers intraocular pressure in rabbits, monkeys, and man.
Facial Nerve Diseases
ADCY5 mutations are another cause of benign hereditary chorea.
Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
Facial twitches in ADCY5-associated disease - Myokymia or myoclonus? An electromyography study.
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Phenotypic insights into ADCY5-associated disease.
[Familial dyskinesia and facial myokymia in a patient with ADCY5 gene mutation].
Familial Hypophosphatemic Rickets
In vivo Response of X-linked hypophosphatemic mice to calcitonin.
Familial Primary Pulmonary Hypertension
The cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in monocrotaline-treated rats.
Fanconi Syndrome
Renal refractoriness to PTH in experimental Fanconi syndrome: evidence for intact adenylate cyclase activation.
Fetal Alcohol Spectrum Disorders
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder.
Fetal Growth Retardation
Polymorphic variants of bovine ADCY5 gene identified in GWAS analysis were significantly associated with ovarian morphological related traits.
Fibrous Dysplasia of Bone
Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression.
Fibrous Dysplasia, Monostotic
Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
Clinical implications of genetic defects in G proteins: oncogenic mutations in G alpha s as the molecular basis for the McCune-Albright syndrome.
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.
The new bone biology: pathologic, molecular, and clinical correlates.
Urinary cyclic adenosine 3',5'-monophosphate response in McCune-Albright syndrome: clinical evidence for altered renal adenylate cyclase activity.
Ganglion Cysts
Sensitivity of Adenylyl Cyclase Signaling System of the Mollusk Anodonta cygnea Ganglions to Serotonin and Adrenergic Agonists.
Ganglioneuroblastoma
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in ganglioneuroblastoma and neuroblastoma.
Gangliosidoses, GM2
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Gastrinoma
Characterization of the in vivo and in vitro inhibition of gastrin secretion from gastrinoma by a somatostatin analogue (SMS 201-995).
Failure of secretin to stimulate gastrin release and adenylate cyclase activity in gastrinoma in vitro.
Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome.
Gastroenteritis
Jejunal adenylate cyclase activity in human subjects during viral gastroenteritis.
Genetic Diseases, Inborn
An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification.
The new bone biology: pathologic, molecular, and clinical correlates.
Glaucoma
Expression of adenylate cyclase subtypes II and IV in the human outflow pathway.
Role of cyclic AMP in the eye with glaucoma.
Glioblastoma
Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action.
Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist.
Somatostatin and somatostatin receptors in the diagnosis and treatment of gliomas.
VIP and pituitary adenylate cyclase activating polypeptide (PACAP) have an antiproliferative effect on the T98G human glioblastoma cell line through interaction with VIP2 receptor.
Glioma
2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12.
A hormone-independent rise of adenosine 3',5'-monophosphate desensitizes coupling of beta-adrenergic receptors to adenylate cyclase in rat glioma C6-cells.
A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Adenovirus-mediated expression of an olfactory cyclic nucleotide-gated channel regulates the endogenous Ca2+-inhibitable adenylyl cyclase in C6-2B glioma cells.
Adenylyl cyclase supersensitivity in opioid-withdrawn NG108-15 hybrid cells requires Gs but is not mediated by the Gsalpha subunit.
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.
ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity.
Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor.
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Alpha 2-adrenergic receptors in neuroblastoma x glioma hybrid cells. Characterization with agonist and antagonist radioligands and relationship to adenylate cyclase.
Attenuation of enkephalin activity in neuroblastoma X glioma NG108-15 hybrid cells by phospholipases.
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation.
Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells.
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2+ entry regulates Ca(2+)-inhibitable adenylyl cyclase in non-excitable cells.
Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.
Cell cycle changes in the adenylate cyclase of C6 glioma cells.
Cell-free desensitization of opioid inhibition of adenylate cyclase in neuroblastoma X glioma NG108-15 hybrid cell membranes.
Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase.
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase.
Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines.
Concanavalin A prevents phorbol-mediated redistribution of protein kinase C and beta-adrenergic receptors in rat glioma C6 cells.
Control of opiate receptor-adenylate cyclase interactions by calcium ions and guanosine-5'-triphosphate.
Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion.
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Delta9-tetrahydrocannabinol stimulates glucose utilization in C6 glioma cells.
Dependence of the Ca2+-inhibitable adenylyl cyclase of C6-2B glioma cells on capacitative Ca2+ entry.
Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis.
Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function.
Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and beta 2-adrenoceptor-expressing NG108-15 cells.
Developmental neurotoxicity of chlorpyrifos: targeting glial cells.
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.
Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells.
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
Docosahexaenoic acid alters Gs? localization in lipid raft and potentiates adenylate cyclase.
Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.
Down-regulation of protein kinase C in rat glioma C6 cells: effects on the beta-adrenergic receptor-coupled adenylate cyclase.
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells.
Effect of phospholipases on chronic opiate action in neuroblastoma X glioma NG108-15 hybrid cells.
Effects of protein kinase A activation on endothelin- and ATP-induced signal transduction.
Effects of valproic acid on beta-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells.
Efficacy of inverse agonists in cells overexpressing a constitutively active beta2-adrenoceptor and type II adenylyl cyclase.
Endogenous expression of adenosine A1, A2 and A3 receptors in rat C6 glioma cells.
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium.
Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.
Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells.
Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells.
Exfoliation of the beta-adrenergic receptor and the regulatory components of adenylate cyclase by cultured rat glioma C6 cells.
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in human glial cell tumors.
Expression of somatostatin receptor subtypes in cultured astrocytes and gliomas.
Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C.
Forskolin induction of S-100 protein in glioma and hybrid cells.
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells.
G?(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.
Generation of cell surface neoganglioproteins. GM1-neoganglioproteins are non-functional receptors for cholera toxin.
Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate.
Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.
Guanine nucleotide activation of adenylate cyclase in saponin permeabilized glioma cells.
Guanine nucleotide-independent inhibition of adenylate cyclase by a stimulatory hormone.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Guanosine-5'-O-thiodiphosphate functions as a partial agonist for the receptor-independent stimulation of neural adenylate cyclase.
Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas.
Immunochemical visualization and quantitation of cyclic AMP in single cells.
Inhibition by lithium of PGE1-sensitive adenylate cyclase in neuroblastoma X glioma hybrid cells: approach to the attenuation of the opiate withdrawal syndrome.
Inhibition by methylmercuric chloride of prostaglandin E1-sensitive adenylate cyclase activity in glioma but not in neuroblastoma cells in culture.
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Inhibition of adenylyl cyclase by neuronal P2Y receptors.
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins.
Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.
Lipid requirement for long-lived morphine-dependent activations of adenylate cyclase of neuroblastoma X glioma hybrid cells.
Mechanisms of downregulation of beta-adrenergic receptors: perspective on the role of beta-adrenergic receptors in congestive heart failure.
Modification of neuroblastoma x glioma hybrid NG108-15 adenylate cyclase by vanadium ions.
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
Modulation of adenylate cyclase activity by a cytosolic factor following chronic opiate exposure in neuroblastoma x glioma NG108-15 hybrid cells.
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Molecular cloning and functional analysis of a novel P2 nucleotide receptor.
Morphine receptors as regulators of adenylate cyclase activity.
Mu and delta opiate receptors coupled negatively to adenylate cyclase on embryonic neurons from the mouse striatum in primary cultures.
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation.
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Neuroblastoma X glioma NG108-15 hybrid cells cultured in a serum-free chemically defined medium: effects on acute and chronic opiate regulation of adenylate cyclase activity.
Ni-coupled receptors in cultured neural hybrid cells: cell specificity for dibutyryl cyclic AMP-induced down-regulation but not morphological differentiation.
Opiate-dependent modulation of adenylate cyclase.
Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.
Opioid activities and structures of alpha-casein-derived exorphins.
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms.
Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor.
Potent Gi-mediated inhibition of adenylyl cyclase by a phosphonate analog of monooleylphosphatidate.
Pre-steady state study of beta-adrenergic and purinergic receptor interaction in C6 cell membranes: undelayed balance between positive and negative coupling to adenylyl cyclase.
Predominant expression of type-VI adenylate cyclase in C6-2B rat glioma cells may account for inhibition of cyclic AMP accumulation by calcium.
Presence of calcitonin gene-related peptide receptors coupled to adenylate cyclase in human gliomas.
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Receptor-associated changes of the catecholamine-sensitive adenylate cyclase in glioma cells doubly transformed with Moloney sarcoma virus.
Regulation of adenosine 3':5'-monophosphate efflux from animal cells.
Regulation of adenylate cyclase from cultured human cell lines by adenosine.
Regulation of adenylate cyclase from glial tumor cells by calcium and a calcium-binding protein.
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. II. Long lived increase of adenylate cyclase activity mediated by alpha receptors.
Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.
Regulation of stimulatory adenylyl cyclase signaling during forskolin-induced differentiation of mouse neuroblastoma x rat glioma (NG108-15) cells.
Regulation of the Ca2+-inhibitable adenylyl cyclase type VI by capacitative Ca2+ entry requires localization in cholesterol-rich domains.
Relationship between desensitization and sequestration of muscarinic cholinergic receptors in two neuronal cell lines.
Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.
RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.
Role of receptor regulation in opioid tolerance mechanisms.
Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas.
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.
Specificity of interactions of receptors and effectors with GTP-binding proteins in native membranes.
Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?
Studies on synapse formation and opiate dependence.
Synaptic membrane G proteins are complexed with tubulin in situ.
The 5HT5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes.
The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein.
The beta-adrenergic receptor system in human glioma-derived cell lines: the mode of phosphodiesterase induction and the macromolecules phosphorylated by cyclic AMP-dependent protein kinase.
The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline.
The C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptor.
The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
The effects of exposure to unsaturated fatty acids on opiate receptors, prostaglandin E1 receptors, and adenylate cyclase activity of neuroblastoma x glioma hybrid cells.
The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase.
The role and specificity of guanine nucleotide binding proteins in receptor-effector coupling.
Tolerance and dependence evoked by an endogenous opiate peptide.
Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion.
Treatment of C6 glioma cells and rats with antidepressant drugs increases the detergent extraction of G(s alpha) from plasma membrane.
Tubulin stimulates adenylyl cyclase activity in C6 glioma cells by bypassing the beta-adrenergic receptor: a potential mechanism of G protein activation.
Turn on and turn off reactions of beta-adrenergic-sensitive adenylate cyclase in control and desensitized C6 glioma cells.
Up-regulation of a constitutively active form of the beta2-adrenoceptor by sustained treatment with inverse agonists but not antagonists.
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas.
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
Glucose Intolerance
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Goiter
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Influence of thyroglobulin on basal and stimulated human thyroid adenylate cyclase activity.
Localization of adenylate cyclase and 5'-nucleotidase activities in human thyroid follicular cells.
Serum thyroid-stimulating antibody, thyroglobulin levels, and thyroid suppressibility measurement as predictors of the outcome of combined methimazole and triiodothyronine therapy in Graves' disease.
Subgroups of Graves' patients identified on the basis of the biochemical activities of their immunoglobulins.
Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.
[Transgenic models of human thyroid pathologies: hyperfunctional adenoma, anaplastic cancer, differentiated cancer, hypothyroidism]
Goiter, Endemic
Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter.
Use of FRTL-5 for the study of thyroid antibodies involved in goitrogenesis.
Goiter, Nodular
Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.
Gout
P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages.
Granuloma
Alteration of granuloma formation by PGE1: effects of an adenylate cyclase inhibitor and splenectomy.
Granulomas in murine schistosomiasis mansoni contain vasoactive intestinal peptide-responsive lymphocytes.
Macrophages as targets of inhibitory effects of E-type prostaglandins in immune-related inflammation.
Graves Disease
A sensitive method for assaying thyroid stimulating immunoglobulins of Graves' disease: use of the guanyl nucleotide-amplified thyroid adenylate cyclase assay.
Abnormal adenylate cyclase activity and altered membrane gangliosides in thyroid cells from patients with Graves' disease.
Acute effects of corticosteroids on thyroid activity in Graves' disease.
Adenylate cyclase activity in thyroid tissue from patients with untreated Graves' disease.
Cyclooxygenase-dependent thyroid cell proliferation induced by immunoglobulins from patients with Graves' disease.
Detection of thyroid-stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor.
Detection of tsh binding inhibiting antibodies (TBI-ab) and thyroid adenylate cyclase stimulating antibodies (TS-ab) in sera of patients with Graves' disease.
Differences between changes in serum thyrotropin-binding inhibitory antibodies and thyroid-stimulating antibodies in the course of antithyroid drug therapy for Graves' disease.
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Evidence for normal thyroidal adenyl cyclase, cyclic AMP-binding and protein-kinase activities in Graves' disease.
Evidence of a correlation between thyrotrophin receptor binding inhibition and thyroid adenylate cyclase activation by immunoglobulins in Graves' disease before and during long-term antithyroid treatment.
Evidence supporting the identity in Graves' disease of thyroid-stimulating antibody and thyroid growth-promoting immunoglobulin G as assayed in FRTL5 cells.
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Human thyroid adenyl cyclase-stimulating activity in immunoglobulin G of patients with Graves' disease.
Human thyroid cells transfected with SV40 DNA retain the TSH receptor.
Hyperthyroidism following hypothyroidism.
In vitro lymphocyte proliferation in response to polyclonal activators and microbial antigens, and production of immunoglobulins stimulating thyroid adenylate cyclase in Graves' disease.
Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody.
Inhibition of adenylate cyclase activity of human thyroid membranes by gangliosides.
Interactions between TSH binding inhibiting--and adenylate cyclase stimulating--antibodies in Graves' disease.
Micromethod of human thyrocyte cultures for detection of thyroid-stimulating antibodies and thyrotrophin.
Serum thyroid-stimulating antibody, thyroglobulin levels, and thyroid suppressibility measurement as predictors of the outcome of combined methimazole and triiodothyronine therapy in Graves' disease.
The prognostic value of parallel measurements of thyrotropin binding inhibiting immunoglobulins (TBII) and thyroid adenylate cyclase stimulating antibodies (TSAb) in Graves' disease after longterm antithyroid treatment.
The use of the amplifiable high-expression vector pEE14 to study the interactions of autoantibodies with recombinant human thyrotrophin receptor.
Thyroid blocking antibodies in thyroiditis.
TSH and thyroid stimulating antibodies (TSAb) activate thyroid adenylate cyclase through different pathways.
TSH binding by globulins from patients with Graves' disease.
TSH-responsive adenylate cyclase activity in thyroid tissue from patients with Graves' disease.
Unlike thyrotropin, thyroid-stimulating antibodies do not activate phospholipase C in human thyroid slices.
[A comparison of various indicators of murine thyroid stimulation by LATS (author's transl)]
[Proceedings: Thyroid stimulating substances in man. (1). New findings concerning autoregulation of the thyroid gland of man: increases of adenyl cyclase caused by TSH administration and their inhibition by T3 and T4 in the thyroid of normal individuals and patients with Basedow's disease]
Growth Hormone-Secreting Pituitary Adenoma
Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
cAMP pathway and pituitary tumorigenesis.
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas.
GNAS imprinting and pituitary tumors.
Growth factors and the anterior pituitary.
Mutations in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) in human GH-secreting pituitary adenomas. Biochemical, clinical, and morphological aspects.
Presence of an adenylate cyclase dually regulated by somatostatin and human pancreatic growth hormone (GH)-releasing factor in GH-secreting cells.
Hashimoto Disease
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Hearing Loss
Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.
Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.
Heart Arrest
The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse.
The effect of cardiac arrest on the permeability of the mouse blood-brain and blood-spinal cord barrier to pituitary adenylate cyclase activating polypeptide (PACAP).
Uncoupling of human cardiac beta-adrenoceptors during cardiopulmonary bypass with cardioplegic cardiac arrest.
Heart Defects, Congenital
A post-receptor defect of adenylyl cyclase in severely failing myocardium from children with congenital heart disease.
Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.
Differences in response to activation of adenylyl cyclase by various stimulants in human myocardium.
Distribution of myocardial beta-adrenoceptor subtypes and coupling to the adenylate cyclase in children with congenital heart disease and implications for treatment.
Uncoupling of human cardiac beta-adrenoceptors during cardiopulmonary bypass with cardioplegic cardiac arrest.
Heart Diseases
Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging.
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: effects of targeted disruption of the type 5 adenylyl cyclase gene.
Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia.
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP.
Heart Failure
A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure.
A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology.
A mechanism of catecholamine tolerance in congestive heart failure--alterations in the hormone sensitive adenylyl cyclase system of the heart.
A post-receptor defect of adenylyl cyclase in severely failing myocardium from children with congenital heart disease.
AAV-mediated gene therapy for heart failure: enhancing contractility and calcium handling.
Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice.
Activity of receptors coupled to guanine nucleotide binding regulatory protein in doxorubicin induced cardiomyopathy.
Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction.
Adenylyl cyclase and G protein receptor kinase expression during development of heart failure.
Adenylyl cyclase gene transfer in heart failure.
Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats.
Adenylyl cyclase: a new target for heart failure therapeutics.
Adenylylcyclase gene transfer increases function of the failing heart.
Adrenergic signaling and oxidative stress: a role for sirtuins?
Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium.
Alterations in cardiac beta-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs.
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Alterations of adenylyl cyclase and G proteins in aortocaval shunt-induced heart failure.
Alterations of beta-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure.
Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril.
Augmentation of cardiac contractility with no change in L-type Ca2+ current in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8).
Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
Beta-adrenergic blockers for chronic heart failure.
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
Beta-adrenoceptor and adenylate cyclase function in the infarct model of rat heart failure.
Beta-adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Beta-adrenoceptors and adenylate cyclase activity in hypertrophied and failing rabbit left ventricle.
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Catecholamine refractoriness and their mechanisms in cardiocirculatory shock and chronic heart failure.
Changes in cardiac signal transduction systems in chronic ethanol treatment preceding the development of alcoholic cardiomyopathy.
Changes in the receptor-G protein-adenylyl cyclase system in heart failure from various types of heart muscle disease.
Characterization of lymphocyte beta-adrenergic receptors at rest and during exercise in ambulatory patients with chronic congestive heart failure.
Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure.
Comparison of heart sarcolemmal enzyme activities in normal and cardiomyopathic (UM-X7.1) hamsters.
Compartmentalization of beta-adrenergic signals in cardiomyocytes.
Coupling of ?1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Decreased type VI adenylyl cyclase mRNA concentration and Mg(2+)-dependent adenylyl cyclase activities and unchanged type V adenylyl cyclase mRNA concentration and Mn(2+)-dependent adenylyl cyclase activities in the left ventricle of rats with myocardial infarction and longstanding heart failure.
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Desensitization of the pulmonary adenylyl cyclase system: a cause of airway hyperresponsiveness in congestive heart failure?
Design of a Phase 3 trial of intracoronary administration of human adenovirus 5 encoding human adenylyl cyclase type 6 (RT-100) gene transfer in patients with heart failure with reduced left ventricular ejection fraction: The FLOURISH Clinical Trial.
Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure.
Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction.
Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.
Does Vidarabine Mediate Cardioprotection via Inhibition of AC5?
Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.
Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure.
Drug therapy aimed at adenylyl cyclase to regulate cyclic nucleotide signaling.
Effects of beta-blockade on beta-adrenergic receptors and signal transduction.
Effects of chronic heart failure on the capacity of glucagon to enhance contractility and adenyl cyclase activity of human papillary muscles.
Effects of experimental heart failure on the capacity of glucagon to augment myocardial contractility and activate adenyl cyclase.
Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes.
Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure.
Fine Tuning Adenylyl Cyclase as a (Gene) Therapy for Heart Failure.
Homologous vs. heterologous desensitization of the adenylate cyclase system in heart cells.
Hypersensitivity of Gi protein mediated muscarinic receptor adenylyl cyclase in chronic ischaemic heart failure in the rat.
Impaired cardiac muscarinic receptor function in dogs with heart failure.
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Increased myocardial muscarinic receptor density in idiopathic dilated cardiomyopathy: an in vivo PET study.
Inhibition of endogenous nitric oxide synthase augments contractile response to adenylyl cyclase stimulation without altering mechanical efficiency in patients with idiopathic dilated cardiomyopathy.
Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure.
Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial.
Intraventricular changes in the beta-adrenoceptor-adenylate cyclase system of the rat heart with the progress of monocrotaline-induced right ventricular hypertrophy.
L-type calcium currents of human myocytes from ventricle of non-failing and failing hearts and from atrium.
Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.
Measurement of adenylate cyclase activity in the right ventricular endomyocardial biopsy samples from patients with chronic congestive heart failure.
Mechanisms of downregulation of beta-adrenergic receptors: perspective on the role of beta-adrenergic receptors in congestive heart failure.
Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts.
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
Molecular mechanism of contractile dysfunction in cardiac allograft rejection.
Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.
Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.
Myocardial dysfunction following cardiopulmonary bypass: recovery patterns, predictors of inotropic need, theoretical concepts of inotropic administration.
Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.
New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.
Noradrenaline-induced desensitization in cultured heart cells as a model for the defects of the adenylate cyclase system in severe heart failure.
Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure.
Positive inotropic stimulation in the normal and insufficient human myocardium.
Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Reduced lymphocyte stimulatory guanine nucleotide regulatory protein and beta-adrenergic receptors in congestive heart failure and reversal with angiotensin converting enzyme inhibitor therapy.
Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium.
Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium.
Regulation of cyclic adenosine monophosphate release by selective ?(2)-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support.
Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes.
Restoration of myocardial beta-adrenergic receptor signaling after left ventricular assist device support.
Reversible contractile dysfunction in reversible experimental cardiac allograft rejection: alterations in the beta-receptor-stimulated adenylylcyclase pathway.
Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.
Role of HSF1-upregulated AC6 in ameliorating heart failure in mice.
Role of sarcolemmal changes in cardiac pathophysiology.
Signalling pathways in cardiac failure.
Skeletal muscle beta-receptors and isoproterenol-stimulated vasodilation in canine heart failure.
Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.
The cardiac beta-adrenoceptor-mediated signaling pathway and its alterations in hypertensive heart disease.
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
The glucagon receptor and adenylate cyclase.
Transregulation of adenylyl-cyclase-coupled inhibitory receptors in heart failure enhances anti-adrenergic effects on adult rat cardiomyocytes.
Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice.
Urocortin-2 induces vasorelaxation of coronary arteries isolated from patients with heart failure.
Vidarabine is neither a potent nor a selective AC5 inhibitor.
[Beta adrenergic signal transduction and heart adenyl cyclase]
[Beta-adrenergic receptors of the normal heart and in heart failure]
[Control mechanisms of renal functions: effects of cardiovascular drugs on vasoconstrictive and antinatriuretic stimuli in the in vivo kidney]
[Positive inotropic substances--therapeutic perspectives]
Hematologic Diseases
[Adenyl cyclase activity of human blood platelets in various blood diseases]
Hematologic Neoplasms
Molecular pathways: Beta-adrenergic signaling in cancer.
Hematoma, Subdural, Acute
Early changes in second messenger but not receptor binding sites after acute subdural hematoma: an in vitro autoradiographic study.
Hemiplegia
Alternating Hemiplegia of Childhood as a New Presentation of Adenylate Cyclase 5-Mutation-Associated Disease: A Report of Two Cases.
Hepatic Encephalopathy
Lack of evidence for impaired dopamine receptor function in experimental hepatic coma in the rabbit.
Hepatitis
Genetic polymorphisms of regulatory T cell-related genes modulate systemic inflammation induced by viral hepatitis.
[Changes in the adenylate cyclase system of rat liver cells in acute experimental hepatitis and ways of correcting them]
Hepatitis B, Chronic
Plasma pituitary adenylate cyclase activating polypeptide (PACAP) levels in chronic hepatitis B patients under lamivudine treatment.
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Hereditary Sensory and Motor Neuropathy
Charcot?Marie?Tooth type 1A drug therapies: role of adenylyl cyclase activity and G?protein coupled receptors in disease pathomechanism.
Herpes Simplex
Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.
The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.
Herpes Zoster
Alpha-melanocyte-stimulating hormone-induced inhibition of angiotensin II receptor-mediated events in the rat adrenal zona glomerulosa.
Angiotensin stimulates adenylate cyclase activity via prostaglandins in the adrenal glomerulosa membrane.
Autoradiographic localization of neuroleptic and dopamine receptors in the caudate-putamen and substantia nigra: effects of lesions.
Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current.
Dopamine-sensitive adenylate cyclase occurs in a region of substantia nigra containing dopaminergic dendrites.
Effects of chronic treatment with adrenocorticotropin on adenylate cyclase activity in the adrenal cortex.
Effects of fasting on aldosterone secretion in ovariectomized rats.
Effects of protease inhibitors on adenylate cyclase activation and aldosterone production in rat adrenal zona glomerulosa cells.
Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland.
Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida.
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat.
Inhibitory effects of bromocriptine on corticosterone secretion in male rats.
Mouse sperm adenylyl cyclase: general properties and regulation by the zona pellucida.
Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth.
Stimulation of steroidogenesis by forskolin in rat adrenal zona glomerulosa cell preparations.
Studies on cyclic nucleotides in the adrenal gland. VIII. Effects of angiotensin on adenosine 3',5'-monophosphate and steroidogenesis in the adrenal cortex.
Studies on cyclic nucleotides in the adrenal gland. X. Effects of adrenocorticotropin and prostaglandin on adenylate cyclase activity in the adrenal cortex.
Studies on cyclic nucleotides in the adrenal gland. XI. Adrenergic regulation of adenylate cyclase activity in the adrenal cortex.
HIV Infections
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
Huntington Disease
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Hutchinson's Melanotic Freckle
Expression of Soluble Adenylyl Cyclase in Lentigo Maligna.
Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins.
Investigation of cAMP microdomains as a path to novel cancer diagnostics.
Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin.
Soluble Adenylyl Cyclase Antibody (R21) as a Diagnostic Adjunct in the Evaluation of Lentigo Maligna Margins During Slow Mohs Surgery.
Hydatidiform Mole
Thyrotropic action of human chorionic gonadotropin.
Hyperalgesia
Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin.
Adenylate cyclase inhibition attenuates neuropathic pain but lacks pre-emptive effects in rats.
Allosteric interactions between ? and ? opioid receptors in peripheral sensory neurons.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways.
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Is there more than one prostaglandin E receptor subtype mediating hyperalgesia in the rat hindpaw?
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Migraine-provoking substances evoke periorbital allodynia in mice.
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
Nitric oxide signaling in pain and nociceptor sensitization in the rat.
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.
Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.
Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.
Regulation of ?-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo.
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.
Role of protein kinase A in the maintenance of inflammatory pain.
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway.
Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain.
Hypercalcemia
Comparison of postreceptor effects of 1-34 human hypercalcemia factor and 1-34 human parathyroid hormone in rat osteosarcoma cells.
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.
Lithiumogenic disorders of the thyroid and parathyroid glands as surgical disease.
Parathyroid hormone metabolism and its potential as a uremic toxin.
Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity.
Pathogenesis of humoral hypercalcemia of malignancy.
Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.
Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.
Sulfur-free parathyroid hormone analogues containing D-amino acids: biological properties in vitro and in vivo.
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
Hypercholesterolemia
Effects of PGI2 on platelet aggregation and adenylate cyclase activity in human type IIa hypercholesterolemia.
Hypercholesterolemia is associated with a reduced response of smooth muscle guanylyl cyclase to nitrovasodilators.
Hyperemia
KATP channels mediate adenosine-induced hyperemia in retina.
Hyperglycemia
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice.
Bordetella pertussis does not induce beta-adrenergic blockade.
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
Effects of alpha- and beta-adrenergic blockers on chlorpromazine-induced elevation of plasma glucose and cyclic AMP in fed mice.
Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia.
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.
Glycogenolytic activity of pituitary adenylate cyclase activating polypeptide (PACAP) in vivo and in vitro.
Modulation of G-protein expression and adenylyl cyclase signaling by high glucose in vascular smooth muscle.
Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5-generated cyclic adenosine monophosphate.
Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels.
The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase.
Variations in functional activity of the hormone-sensitive adenylate cyclase system in tissues of gastropod mollusks with streptozotocin-induced diabetes.
Hyperhidrosis
Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing ?2-adrenoceptor/cAMP signaling pathway.
Hyperinsulinism
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice.
An impaired response of adenylate cyclase to stimulation by epinephrine in adipocyte plasma membranes from genetically obese mice (ob/ob).
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects.
The response of adenylate cyclase to ACTH in adipocyte membranes of lean and obese mice.
Hyperkinesis
ADCY5-Related Dyskinesia: Improving Clinical Detection of an Evolving Disorder.
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
Deep brain stimulation reduces (nocturnal) dyskinetic exacerbations in patients with ADCY5 mutation: a case series.
Protein kinase A signalling in Schistosoma mansoni cercariae and schistosomules.
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Hyperlipoproteinemias
Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia.
Hyperparathyroidism
Altered adenylate cyclase kinetics in hyperfunctioning human parathyroid glands.
Effects of dietary-induced hyperparathyroidism on the parathyroid hormone-receptor-adenylate cyclase system of canine kidney. Evidence for postreceptor mechanism of desensitization.
Lithiumogenic disorders of the thyroid and parathyroid glands as surgical disease.
Peripheral metabolism of parathyroid hormone in patients with primary hyperparathyroidism as judged by immunological and biological studies.
Hyperparathyroidism, Primary
Adenylate cyclase activity in human parathyroid tissues: reduced sensitivity to suppression by calcium in parathyroid adenomas as compared with normal glands form normocalcemic subjects or noninvolved glands from hyperparathyroid subjects.
Peripheral metabolism of parathyroid hormone in patients with primary hyperparathyroidism as judged by immunological and biological studies.
The effect of parathyroid hormone (PTH) and 24,25-dihydroxy-vitamin D3 on adenylyl cyclase of iliac crest biopsies: diagnostic and prognostic tool for evaluation and treatment of uremic patients.
Hyperparathyroidism, Secondary
Abnormal skeletal response to parathyroid hormone in dogs with chronic uremia.
Activation of renal adenylate cyclase by forskolin: assessment of enzymatic activity in animal models of the secondary hyperparathyroid state.
An adenylate cyclase bioassay for parathyroid hormone: some clinical experiences.
Impaired parathyroid hormone-stimulated adenosine 3',5'-monophosphate release by isolated perfused bones obtained from vitamin D-deficient rats.
Influence of the amino-terminus on in vitro and in vivo biological activity of synthetic parathyroid hormone-like peptides of malignancy.
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Hyperphosphatemia
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Hyperprolactinemia
Regulation of testosterone secretion by prolactin in male rats.
Hypersensitivity
Absence of metabotropic glutamate receptor homolog(s) accelerates acetylcholine neurotransmission in Caenorhabditis elegans.
Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children.
beta-Adrenoceptor regulation in rat heart, lung and skin after chronic treatment with (--)-tertatolol or (--)-propranolol.
Catecholamine hypersensitivity of adenylate cyclase after chemical denervation in rat heart.
Differential effect of repeated treatment with L-dopa on dopamine-D1 or -D2 receptors.
Dopamine receptor changes in response to prolonged treatment with L-dopa.
Effect of epinephrine on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in control and antigen-sensitized guinea pig lungs.
Effect of long-term and short-term diabetes on the parathyroid hormone sensitive rat renal adenylate cyclase: correlation with vitamin D metabolism.
Hypersensitivity of Gi protein mediated muscarinic receptor adenylyl cyclase in chronic ischaemic heart failure in the rat.
Hypersensitivity to histamine in the guinea-pig brain: microiontophoretic and biochemical studies.
Hypersensitivity to isoproterenol in rabbit heart decreases guanine nucleotide effect on adenylate cyclase.
In vivo partial inactivation of dopamine D1 receptors induces hypersensitivity of cortical dopamine-sensitive adenylate cyclase: permissive role of alpha 1-adrenergic receptors.
In vivo Response of X-linked hypophosphatemic mice to calcitonin.
L-3,4-dihydroxyphenylalanine-induced hypersensitivity simulating features of denervation.
Levels of stimulatory G protein are increased in the rat striatum after neonatal lesion of dopamine neurons.
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
Neuropeptide Y tonically inhibits an NMDAR?AC1?TRPA1/TRPV1 mechanism of the affective dimension of chronic neuropathic pain.
Non-DA prefronto-cortical efferents modulate D1 receptors in the nucleus accumbens.
Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor alpha in rat cardiomyocytes.
Role of opiates in striatal D-1 dopamine receptor supersensitivity induced by chronic L-dopa treatment.
The antiglucocorticoid RU38486 is a potent accelerator of adipose conversion of 3T3-F442A cells.
[Comparison of fenoterol (Berotec) with the antiallergic benzopyrene compound PR-D 92 and a placebo in regard to the cutaneous immediate reaction in allergic patients (author's transl)]
[Development of cardiac adenylate cyclase hypersensitivity to isoproterenol in the chronic action of propranolol on rats]
[Development of desensitization and hypersensitivity of the adenyl cyclase system of the heart to the action of hormones]
[Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]
Hypersensitivity, Immediate
Forskolin inhibits the release of histamine from human basophils and mast cells.
Inhibition of IgE-mediated histamine release from human basophils and mast cells by fenoterol.
Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin.
Hypertension
A renal dopamine-1 receptor defect in two genetic models of hypertension.
Aberrant adenylyl cyclase/cAMP signal transduction and G protein levels in platelets from hypertensive patients improve with antihypertensive drug therapy.
Abnormalities of platelet function in hypertension and diabetes.
Adaptive myocardial hypertrophy in the renal ablation model.
Adenylate cyclase activity during development and reversal of cardiac hypertrophy.
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension.
Altered coronary dilation in deoxycorticosterone acetate-salt hypertension.
Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.
Atrial natriuretic peptide-C receptor and membrane signalling in hypertension.
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
Beta-andrenoceptors in the hearts of diabetic-hypertensive rats: radioligand binding and functional experiments.
Calcium-dependent proteolytic stimulation of adenylate cyclase in platelets from spontaneously hypertensive rats.
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Cardiac function and dysfunction in hypertension.
Comparative effects of alpha-methyldopa, propranolol and hydralazine therapy on cardiac adenylate cyclase activity in normal and spontaneously hypertensive rats.
Cross-talk between cardiac kappa-opioid and beta-adrenergic receptors in developing hypertensive rats.
Defective ANF-R2/ANP-C receptor-mediated signalling in hypertension.
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Differential regulation of ANF-R2 receptors coupled to adenylyl cyclase in cardiovascular tissues in hypertension.
DOCA-salt hypertensive rat hearts exhibit altered expression of G-proteins.
Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension.
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
Effects of forskolin on inotropic performance and phospholamban phosphorylation in exercise-trained hypertensive myocardium.
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.
Forskolin-stimulated adenylyl cyclase activity is decreased but beta 2-adrenoceptor function is unchanged in primary hypertension.
G protein alterations in hypertension and aging.
G-protein-coupled receptor kinase expression in hypertension.
G-proteins and adenylyl cyclase signalling in hypertension.
Glandular adenylate cyclase system in genetic hypertension: age-dependent response to catecholamines.
Guanine nucleotide regulatory protein levels and function in spontaneously hypertensive rat vascular smooth-muscle cells.
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.
Hormonal modulation of intracellular free calcium in platelets from normotensive and hypertensive subjects.
Identification and quantification of 2',3'-cAMP release by the kidney.
Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension.
Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension.
Isoform-targeted regulation of cardiac adenylyl cyclase.
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Low-dose angiotensin II reduces urinary cyclic AMP excretion in spontaneously hypertensive, but not normotensive, rats: independence from hypertension and renal hemodynamic effects of angiotensin.
Modulation by angiotensin II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats.
Myocardial adrenergic receptors and adenylate cyclase in the developing spontaneously hypertensive rat.
Nephron specificity of dopamine receptor-adenylyl cyclase defect in spontaneous hypertension.
Nitric oxide synthase inhibition by N(omega)-nitro-L-arginine methyl ester modulates G-protein expression and adenylyl cyclase activity in rat heart.
Ontogenetic development of isoproterenol subsensitivity of myocardial adenylate cyclase and beta-adrenergic receptors in spontaneously hypertensive rats.
Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase.
PACAP causes PAC1/VPAC2 receptor mediated hypertension and sympathoexcitation in normal and hypertensive rat.
Peripheral adrenergic receptors in hypertension.
Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta.
Plasma cyclic adenosine 3':5'-monophosphate response to isoproterenol and glucagon in hyperkinetic borderline (labile) hypertension.
Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat.
Receptor-cyclase coupling protein in erythrocytes of patients with essential hypertension.
Receptor-independent sensitization of the adenylyl cylase after chronic treatment with cyclosporine A.
Regulation of the lymphocyte adenylate cyclase system by prostaglandin E2 infusions in resistant hypertensive subjects.
Regulation of vasopressin receptors in deoxycorticosterone acetate-salt hypertension.
Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.
Secretin and VIP-stimulated adenylate cyclase from rat heart. II. Impairment in spontaneous hypertension.
Supersensitivity of beta-adrenoceptor coupled adenylate cyclase in pulmonary tissue of the spontaneously hypertensive rat.
The activity of adenylate cyclase and phosphodiesterase in the isoproterenol-damaged cardiac muscle of spontaneously hypertensive rats.
The cardiac and brain microvessel adenylate cyclase system in deoxycorticosterone acetate-hypertensive rats.
The role of renal catecholamines in hypertension.
Vascular beta-adrenergic receptor adenylyl cyclase system from renin-transgenic hypertensive rats.
[ACTH-adenylate cyclase in adipose cell "ghosts" of rats with spontaneous hypertension (effect of adrenalectomy)]
[Anomalies of the adenylate cyclase system in platelets of the SHR rat]
[Decrease in adenylate cyclase sensitivity to sodium ions in lymphocytes of patients with arterial hypertension]
[Effect of isoproterenol on adenylate cyclase activity in the adipocytes of rats with spontaneous genetic hypertension]
[Regulation of the adenylate cyclase system of lymphocytes in patients with therapy-resistant arterial hypertension and during PGE2 administration]
[Status of the adrenergic beta 2 receptor-dependent adenylate cyclase system of lymphocytes in patients with hypertension and left-ventricular hypertrophy of different degree of severity]
[The effect of a submaximal physical load on the beta 2-adrenoreceptor-dependent adenylate cyclase system of the lymphocytes in hypertension]
[The effect of obzidan and visken on the regulation of the lymphocyte beta 2-adrenoreceptor adenylate cyclase system during physical loading in hypertension patients]
[The effect of obzidan monotherapy on the beta 2-adrenoreceptors of the lymphocyte adenylate cyclase system in hypertension patients]
Hypertension, Pulmonary
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Changes in the receptor-G protein-adenylyl cyclase system in heart failure from various types of heart muscle disease.
Expression of Vasoactive Intestinal Peptide and Related Receptors in Overcirculation-Induced Pulmonary Hypertension in Piglets.
Hypoxia Inhibits Adenylyl Cyclase Catalytic Activity in a Porcine Model of Persistent Pulmonary Hypertension of the Newborn.
Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat.
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry.
Hypertension, Renal
Altered hormone sensitivity of adenylate cyclase in myocardial sarcolemma of renal hypertensive rats.
Preserved cardiac beta-adrenergic sensitivity in early renovascular hypertension.
[Properties of adenylate cyclase system in heart muscle and aorta of rats with experimental renal hypertension]
Hypertension, Renovascular
Preserved cardiac beta-adrenergic sensitivity in early renovascular hypertension.
[Properties of adenylate cyclase system in heart muscle and aorta of rats with experimental renal hypertension]
Hyperthyroidism
Adrenergic binding sites and enzyme activities in the heart of hyperthyroid rats.
Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients.
Alterations of cardiac NaK-ATPase by the thyroid state in the rat.
Altered thyroid status regulates the adipocyte A1 adenosine receptor-adenylate cyclase system.
Beta-adrenoceptor-agonist and insulin actions on glucose metabolism in rat skeletal muscle in different thyroid states.
Catecholamine, vasoactive intestinal peptide and thyrotrophin-dependent cAMP levels display a different sensitivity to iodothyronines in both normal and pathological human thyroid cells in culture.
Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes.
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Human thyroid cells transfected with SV40 DNA retain the TSH receptor.
In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine.
Influence of exogenous ATP on blood sugar, serum insulin and serum free fatty acids in short-term experimental hyperthyroid dogs and in euthyroid controls.
Influence of hyperthyroidism on the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state.
Influence of thyroid state on the specific binding of noradrenaline to a cardiac particulate fraction and on catecholamine-sensitive cardiac adenylate cyclase activity.
Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody.
Normal myocardial adenyl cyclase activity in hyperthyroid cats.
Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.
Pregnancy-associated changes in the thyroid-stimulating antibody of Graves' disease and the relationship to neonatal hyperthyroidism.
Severe but not mild alterations of thyroid function modulate the density of thyroid-stimulating hormone receptors in the rat thyroid gland.
Short-term hyperthyroidism modulates adenosine receptors and catalytic activity of adenylate cyclase in adipocytes.
Simple and sensitive method for estimation of antithyroid plasma membrane antibodies in the serum of patients with autoimmune thyroid diseases; comparison with other assays.
Species differences in myocardial beta-adrenergic receptor regulation in response to hyperthyroidism.
Thyroid hormone differentially regulates development of beta-adrenergic receptors, adenylate cyclase and ornithine decarboxylase in rat heart and kidney.
Thyroid-stimulating hormone (TSH) receptor antibodies and antibodies stimulating adenyl cyclase in relatives from two families with a high prevalence of Graves' hyperthyroidism: a ten-year follow-up study.
[The posttranslational modification of thyrotropin receptor and thyroid diseases]
Hypertrophy, Left Ventricular
Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.
Alteration of beta-adrenoceptor function in hypertensive patients with different degrees of left ventricular hypertrophy.
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
Cardiac function and dysfunction in hypertension.
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Functional activity and expression of the myocardial postreceptor adenylyl cyclase system in pressure overload hypertrophy in rat.
Myocardial hypertrophy, cardiac beta-adrenoceptors and adenylate cyclase activity during sinoaortic denervation in dogs.
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Relationship between adenylate cyclase activity and regional myocardial energetics in experimental left ventricular hypertrophy.
[Beta adrenergic receptors and experimental left ventricular hypertrophy]
Hypertrophy, Right Ventricular
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Intraventricular changes in the beta-adrenoceptor-adenylate cyclase system of the rat heart with the progress of monocrotaline-induced right ventricular hypertrophy.
Hypocalcemia
Acute dystonic reaction to methotrimeprazine in hypoparathyroidism.
Demonstration of a lack of change in serum 1 alpha,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism.
Impaired parathyroid hormone-stimulated adenosine 3',5'-monophosphate release by isolated perfused bones obtained from vitamin D-deficient rats.
Pre-menstrual syndrome--are gonadotropins the cause of the condition?
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Hypoglycemia
Alterations of G-protein and adenylate cyclase signaling in rat liver during the progression of sepsis.
Anomalous adenosine cyclic 3':5'-monophosphate responses to glucagon in patients with hepatocellular carcinoma.
Development of glucagon sensitivity in neonatal rat liver.
Enhanced hepatic adenylate cyclase activity in rats with portacaval shunt.
Enhanced reactivity of the adrenal medulla in response to pituitary adenylate cyclase activating polypeptide1-27 (PACAP) during insulin-induced hypoglycemia in anesthetized dogs.
Hypogonadism
Regulation of testosterone secretion by prolactin in male rats.
The role of testicular adenylate cyclase in the hypogonadism of renal insufficiency.
Hypokalemia
Defective leukocyte adenylate cyclase function in hypokalemia.
Hypokinesia
Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram.
[Catecholamine concentration and adenyl cyclase and phosphodiesterase activities of the sarcolemma of myocardial cells during hypokinesia and in experimental information neuroses]
[The aspects of adenylate cyclase activity regulation in myocardium cell membranes during hypokinesia]
Hyponatremia
Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.
Hypoparathyroidism
An adenylate cyclase bioassay for parathyroid hormone: some clinical experiences.
Hypoparathyroidism.
Hypophosphatemia, Familial
Mechanism of phosphaturia elicited by administration of phosphonoformate in vivo.
Parathyroid hormone metabolism and its potential as a uremic toxin.
Hypotension
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.
Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Pericardial disease in renal patients.
Peripheral adrenoceptors in hypotension of hemodialyzed uremic patients.
Specific decrease of secretin/VIP-stimulated adenylate cyclase in the heart from the Lyon strain of hypertensive rats.
Hypotension, Orthostatic
Plasma catecholamines and alpha- and beta-adrenoceptors in circulating blood cells in patients on continuous ambulatory peritoneal dialysis.
Hypothyroidism
Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients.
Alterations of cardiac NaK-ATPase by the thyroid state in the rat.
Beta-adrenergic receptors, adenylate cyclase activation, and myofibril enzyme activity in hypothyroid rats.
Beta-adrenoceptor-agonist and insulin actions on glucose metabolism in rat skeletal muscle in different thyroid states.
Coupling defect of thyrotropin receptor and adenylate cyclase in a pseudohypoparathyroid patient.
Cyclic AMP responses to parathyroid hormone and glucagon during lithium treatment.
Decreased binding of vasoactive intestinal peptide to intestinal epithelial cells from hypothyroid rats.
Decreased myocardial adenyl cyclase activity in hypothyroidism.
Effect of hypothyroidism on adenylyl cyclase activity and subtype gene expression in brown adipose tissue.
Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes.
Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity.
Effects of thyroid deficiency on the vasopressin receptors in the kidney of developing and adult rats. A comparative study of hormonal binding and adenylate cyclase activation.
Endocrinological Disorders Related to the Medical Use of Lithium. A Narrative Review.
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.
Hypothyroidism alters the effect of GTP on adenylyl cyclase in forebrain and hindbrain synaptosomal membranes from 15-day-old rats.
Hypothyroidism lowers blood pressure, adenylate cyclase and Na+, K+- and K+, Ca++-ATPase activities in normotensive and spontaneously hypertensive rats.
Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.
Influence of thyroid state on the specific binding of noradrenaline to a cardiac particulate fraction and on catecholamine-sensitive cardiac adenylate cyclase activity.
Inhibition of adenylate cyclase in rat brain synaptosomal membranes by GTP and phenylisopropyladenosine is enhanced in hypothyroidism.
Lithiumogenic disorders of the thyroid and parathyroid glands as surgical disease.
Steady-state levels of G-proteins and beta-adrenergic receptors in rat fat cells. Permissive effects of thyroid hormones.
Thyroid function and urine-concentrating ability during lithium treatment.
Thyroid hormone regulates ontogeny of beta adrenergic receptors and adenylate cyclase in rat heart and kidney: effects of propylthiouracil-induced perinatal hypothyroidism.
Thyroid status affects the rat cardiac beta-adrenoceptor system transiently and time-dependently.
hypoxanthine phosphoribosyltransferase deficiency
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.
Impotence, Vasculogenic
Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy.
Inappropriate ADH Syndrome
Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.
Infarction, Middle Cerebral Artery
Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat.
Multimodal Neuroprotection Induced by PACAP38 in Oxygen-Glucose Deprivation and Middle Cerebral Artery Occlusion Stroke Models.
Infections
Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice.
Adenylate Cyclase AcyA Regulates Development, Aflatoxin Biosynthesis and Fungal Virulence in Aspergillus flavus.
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice.
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.
Alteration of the pattern of beta-adrenergic desensitization in cultured L6E9 muscle cells infected with Trypanosoma cruzi.
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection.
Anthrax Edema Factor Toxicity Is Strongly Mediated by the N-end Rule.
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.
Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination.
Bacillus anthracis edema toxin inhibits hypoxic pulmonary vasoconstriction via edema factor and cAMP-mediated mechanisms in isolated perfused rat lungs.
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein.
Bordetella pertussis adenylate cyclase activity in nasopharyngeal aspirates for rapid diagnosis of whooping cough in relation to culture and serology.
Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.
Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.
Burn wound infection-induced myeloid suppression: the role of prostaglandin E2, elevated adenylate cyclase, and cyclic adenosine monophosphate.
cAMP and Vfr Control Exolysin Expression and Cytotoxicity of Pseudomonas aeruginosa Taxonomic Outliers.
Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease.
Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins.
Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size.
Cloning and characterization of genes specifically expressed during infection stages in the rice blast fungus.
Comparison of commercially available immunoblot assays measuring IgG and IgA antibodies to Bordetella pertussis antigens.
Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication.
Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain.
Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation.
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Determination of serum antibody to Bordetella pertussis adenylate cyclase toxin in vaccinated and unvaccinated children and in children and adults with pertussis.
Distinct characteristics of the basal activities of adenylyl cyclases 2 and 6.
Effects of anthrax toxin components on human neutrophils.
EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin.
Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice.
Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pseudomonas aeruginosa Pneumonia in Critically Ill Patients: An Exploratory Study.
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax.
Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells.
Filamin A is a phosphorylation target of plasma membrane but not cytosolic adenylyl cyclase activity.
Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis.
Infection of L6E9 myoblasts with Trypanosoma cruzi alters adenylate cyclase activity and guanine nucleotide binding proteins.
Inhibition of anthrax protective antigen outside and inside the cell.
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.
Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.
Lethal infection by Bordetella pertussis mutants in the infant mouse model.
Lymphocyte and macrophage adenyl cyclase activity in animals with enhanced cell-mediated resistance to infection and tumors.
Measles virus modulates human T-cell somatostatin receptors and their coupling to adenylyl cyclase.
Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region.
Mouse monoclonal antibodies to anthrax edema factor protect against infection.
Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.
Mutation at different sites in the Nostoc punctiforme cyaC gene, encoding the multiple-domain enzyme adenylate cyclase, results in different levels of infection of the host plant Blasia pusilla.
Myocardial adenylate cyclase activity in acute murine Chagas' disease.
Myocardial beta-adrenergic adenylate cyclase complex in a canine model of chagasic cardiomyopathy.
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.
Non-canonical effects of anthrax toxins on hem atop oiesis: implications for vaccine development.
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism.
Oxidant activated soluble adenylate cyclase of Leishmania donovani regulates the cAMP-PKA signaling axis for its intra-macrophage survival during infection.
Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract.
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.
Phosphoenolpyruvate Phosphotransferase System Components Modulate Gene Transcription and Virulence of Borrelia burgdorferi.
Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.
Protective activity of Bordetella adenylate cyclase-hemolysin against bacterial colonization.
Quantifying Adenylate Cyclase Toxin of Bordetella pertussis in vitro and During Respiratory Infection.
Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair.
Respiratory syncytial virus induces ?2-adrenergic receptor dysfunction in human airway smooth muscle cells.
Revealing how an adenylate cyclase toxin uses bait and switch tactics in its activation.
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Role of neutrophils in response to Bordetella pertussis infection in mice.
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
Small Molecule Inhibitors of Bacillus anthracis Protective Antigen Proteolytic Activation and Oligomerization.
Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection.
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
Susceptibility of primary human airway epithelial cells to Bordetella pertussis adenylate cyclase toxin in two- and three-dimensional culture conditions.
Testing the efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens using in vitro and in vivo models of infection.
The adenylate cyclase (BAC) in Botrytis cinerea is required for full pathogenicity.
The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG.
The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse.
The Borrelia burgdorferi Adenylate Cyclase, CyaB, Is Important for Virulence Factor Production and Mammalian Infection.
The Coxiella burnetii Cryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates.
The Cyclase-Associated Protein Cap1 Is Important for Proper Regulation of Infection-Related Morphogenesis in Magnaporthe oryzae.
The interaction of signal transduction pathways in FRTL5 thyroid follicular cells: studies with stable expression of beta 2-adrenergic receptors.
The multi-talented bacterial adenylate cyclases.
The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.
Trypanosoma cruzi: alteration of cAMP metabolism following infection of human endothelial cells.
Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.
Verapamil ameliorates clinical, pathologic and biochemical manifestations of experimental chagasic cardiomyopathy in mice.
Vibrio cholerae Infection of Drosophilamelanogaster Mimics the Human Disease Cholera.
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection.
[Adenylate cyclase. A possible factor in the pathogenicity of Yersinia pestis]
[Expression of ATR-Fc fusion protein in CHO cells]
[Role of histamine receptors of mouse and guinea pig peritoneal leukocytes in the pathogenetic effect of Yersinia pestis adenylate cyclase]
[Ultracytochemical localization of intracellular adenylate cyclase activity in gonococcal infection]
[Ultracytochemistry of phosphohydrolase of the microorganisms and phagocytes in gonococcal infection]
Infertility
Adenylyl cyclase and protein carboxyl methylase in human spermatozoa.
Involvement of Moc1 in sexual development and survival of Schizosaccharomyces pombe.
Infertility, Male
Correlation between the sperm motility and the adenylate cyclase activity in infertile men.
Influenza, Human
Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin.
Induction of neutralizing antibody responses to anthrax protective antigen by using influenza virus vectors: implications for disparate immune system priming pathways.
Interaction of plasma membranes with influenza virus. VI. The possible role of the adenylate cyclase system.
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Insulin Resistance
Acute glucagon induces postprandial peripheral insulin resistance.
Adenylyl cyclase 3 haploinsufficiency confers susceptibility to diet-induced obesity and insulin resistance in mice.
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Common genetic variants in ADCY5 and gestational glycemic traits.
Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity.
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity.
Obesity-induced p53 activation in insulin-dependent and independent tissues is inhibited by beta-adrenergic agonist in diet-induced obese rats.
Regulation of cyclic AMP synthesis and degradation is modified in rat liver at late gestation.
Selective alteration of secretin-stimulated cardiac adenylate cyclase activity in streptozotocin-diabetic rats.
[Effects of supplemented taohe chengqi decoction in treating insulin resistance in rats with non-insulin dependent diabetes mellitus]
Insulinoma
A novel insulin secretagogue is a phosphodiesterase inhibitor.
Adenylate cyclase responsiveness of human insulinomas.
Characterization of specific calcitonin gene-related peptide receptors present in hamster pancreatic beta cells.
Development of PACAP38 Analogue with Improved Stability: Physicochemical and In Vitro/In Vivo Pharmacological Characterization.
Effect of estradiol on insulin secreting INS-1 cells overexpressing estrogen receptors.
Evidence of functional gastric inhibitory polypeptide (GIP) receptors in human insulinoma. Binding of synthetic human GIP 1-31 and activation of adenylate cyclase.
Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma.
Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate.
Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3.
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Intellectual Disability
Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability.
Ischemic Attack, Transient
Post- and presynaptic lesions in the CA1 region of hippocampus: effect on [3H]forskolin and [3H]phorboldibutyrate ester binding.
Joint Dislocations
Evaluation of the Clavicle Hook Plate for Treatment of Acromioclavicular Joint Dislocation: A Cadaveric Study.
High Early-onset acromioclavicular secondary pathologies after acute arthroscopic joint reduction: a cohort study.
Open capsular and ligament reconstruction with semitendinosus hamstring autograft successfully controls superior and posterior translation for type V acromioclavicular joint dislocation.
Surgical treatment of acute type V acromioclavicular joint dislocations in professional athletes: an anatomic ligament reconstruction with synthetic implant augmentation.
Transacromial extra-articular Knowles pin fixation treatment of acute type V acromioclavicular joint injuries.
Kidney Calculi
Update on the genetics of nephrolithiasis.
Kidney Failure, Chronic
Adenylate cyclase of gastric mucosa in patients with chronic renal failure.
Parathyroid hormone metabolism and its potential as a uremic toxin.
Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment.
PTH activity as determined by canine renal cortical adenylate cyclase assay in chronic renal failure.
Unchanged hormone sensitivity of rat fat cell adenylate cyclase in uremia.
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Leiomyoma
Changes in beta(2)-adrenoceptor expression and in adenylyl cyclase and phosphodiesterase activity in human uterine leiomyomas.
Impairment of adenylate cyclase activity and G-proteins in human uterine leiomyoma.
Leishmaniasis
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Lesch-Nyhan Syndrome
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.
Leukemia
Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
Beta-adrenergic influences on doxorubicin-sensitive or -resistant P388 leukemia cells.
Combined action of stem cell factor, leukemia inhibitory factor, and cAMP on in vitro proliferation of mouse primordial germ cells.
Effect of high doses of somatostatin on adenylate cyclase activity in peripheral mononuclear leukocytes from normal subjects and from acute leukemia patients.
Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells.
Glycerophosphoinositols as potential markers of ras-induced transformation and novel second messengers.
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Physicochemical characterization of substituted chromeno[4,3-b][1,5]benzodiazepine stereoisomers designed as cell membrane active antitumor agents.
Physiochemical characterization of substituted chromeno[4,3-b][1,5]benzodiazepine stereoisomers designed as cell membrane active antitumor agents.
Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.
Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase.
Somatostatin analog SMS 201995 inhibits proliferation in human leukemia T-cell line: relevance of the adenylyl cyclase stimulation.
Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin.
Tetrahydrocannabinol inhibits adenyl cyclase in human leukemia cells.
[Activation of adenylate cyclase influences the sensitivity of acute promyelocytic leukemia cell lines to ATRA.]
Leukemia, Erythroblastic, Acute
A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.
Adenylate cyclase coupled beta adrenergic receptors of Rauscher erythroleukemia cells.
Alpha 2-adrenergic receptor stimulation mobilizes intracellular Ca2+ in human erythroleukemia cells.
Chronic ethanol treatment reduces adenylyl cyclase activity in human erythroleukemia cells.
Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells.
Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.
Coupling of receptors in brain membranes by fusion to the adenylate cyclase system of a foreign effector cell.
Influence of the beta-adrenergic receptor concentration on functional coupling to the adenylate cyclase system.
Interaction between alpha 2-adrenergic and NPY receptor pathways in human erythroleukemia cells.
Interactions among prostaglandin receptors.
Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16.
Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells.
Pharmacological characterization of adenosine A2B receptors: studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes.
The beta-adrenergic receptor adenylate cyclase complex of Rauscher murine erythroleukemia cells and its response to erythropoietin-induced differentiation.
Leukemia, Lymphocytic, Chronic, B-Cell
Adenylate cyclase and guanylate cyclase activity in normal and leukemic human lymphocytes.
Adenylate cyclase in thymus-derived and bone marrow-derived lymphocytes from normal donors and patients with chronic lymphocytic leukemia.
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation.
Vasoactive intestinal polypeptide modulation of lymphocyte adenylate cyclase.
Leukemia, Lymphoid
Vasoactive intestinal peptide receptor expression on human lymphoblasts.
Leukemia, Myeloid
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase.
To the mechanism of spermine-FBS cytotoxicity toward K562 human myelogenous leukemia cells.
Leukemia, Myeloid, Acute
Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia.
Suppression of the delayed rectifier type of voltage gated K+ outward current in megakaryocytes from patients with myelogenous leukemias.
Leukemia, Promyelocytic, Acute
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
[Activation of adenylate cyclase influences the sensitivity of acute promyelocytic leukemia cell lines to ATRA.]
Leukemia, T-Cell
Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin.
Leydig Cell Tumor
A transplantable rat Leydig cell tumor--2. Adenylyl cyclase activation by prostaglandin E1, isoproterenol and glucagon.
A transplantable rat Leydig cell tumor--3. Isoproterenol and prostaglandin E1 (PGE1) responsive adenylyl cyclase (AC). Regulatory effects of nucleotides and magnesium.
A transplantable rat Leydig cell tumor--5. Cellular localization of beta-adrenergic and prostaglandin receptors and their effects on testosterone production.
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Guanine nucleotide mediated desensitization of adenylate cyclase in cell free preparations from a Leydig cell tumour.
Isolation and characterization of plasma membranes containing LH sensitive adenylate cyclase from a Leydig cell tumour.
Lipoma
Adenylate cyclase of multiple lipomata. Regional differences in adrenaline-responsiveness.
Are the metabolic characteristics of congenital intraspinal lipoma cells identical to, or different from normal adipocytes?
Lipomatosis
Adenylate cyclase of multiple lipomata. Regional differences in adrenaline-responsiveness.
Adipocyte adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis.
Lipomatosis, Multiple Symmetrical
Adenylate cyclase of multiple lipomata. Regional differences in adrenaline-responsiveness.
Adipocyte adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis.
Liver Cirrhosis
Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis.
Dopamine-sensitive adenylate cyclase activity in the caudate nucleus and adrenal medulla in Parkinson's disease and in liver cirrhosis.
Liver Cirrhosis, Biliary
Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.
The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis.
Vasodilatory responses of isolated arteries of cirrhotic rats.
Liver Diseases
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Liver Failure, Acute
Lack of evidence for impaired dopamine receptor function in experimental hepatic coma in the rabbit.
Liver Neoplasms, Experimental
Comparative adenylate cyclase activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc (h).
Hormonal changes and adenylate cyclase system in rat bearing 7800 Morris hepatoma.
Lordosis
Factors elevating cAMP attenuate the effects of 8-OH-DPAT on lordosis behavior.
In the ventral tegmental area, cyclic AMP mediates the actions of progesterone at dopamine type 1 receptors for lordosis of rats and hamsters.
Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.
Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area.
Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review.
Two thalidomide analogs induce persistent estrous behavior and inhibit uterus contractility in rats: The central role of cAMP.
Lung Diseases
Cyclic adenosine monophosphate in acute ischemic stroke: some to update, more to explore.
Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects.
Lung Injury
Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor.
The Pseudomonas aeruginosa exoenzyme Y impairs endothelial cell proliferation and vascular repair following lung injury.
Lung Neoplasms
Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro.
Independent down-regulation of insulin and calcitonin receptors on a human tumour cell line.
Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer.
PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.
PACAP-27 tyrosine phosphorylates mitogen activated protein kinase and increases VEGF mRNAs in human lung cancer cells.
Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells.
Pituitary adenylate cyclase activating polypeptide causes tyrosine phosphorylation on the EGF receptor in lung cancer cells.
Pituitary adenylate cyclase activating polypeptide receptors are present on small cell lung cancer cells.
Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line.
Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells.
PYK-2 is Tyrosine Phosphorylated after Activation of Pituitary Adenylate Cyclase Activating Polypeptide Receptors in Lung Cancer Cells.
The cAMP signaling system inhibits the repair of ?-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells.
The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3.
VIP and PACAP receptors coupled to adenylyl cyclase in human lung cancer: a study in biopsy specimens.
Lymphatic Metastasis
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Lymphocytic Choriomeningitis
Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus.
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying multiple copies of a viral CD8(+) T-cell epitope.
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.
Lymphoma
2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.
3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.
A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G proteins of adenylate cyclase.
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase.
A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells.
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs.
Activated Gs alpha but not Gi alpha prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells.
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.
Activation of adenylate cyclase during swelling of S49 cells in hypotonic medium is not involved in subsequent volume regulation.
Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.
Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc- variants are prevented by islet-activating protein.
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
Agonist regulation of beta-adrenergic receptor mRNA. Analysis in S49 mouse lymphoma mutants.
Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.
ATP enhances cyclic AMP accumulation by intact P388 mouse lymphoma cells.
Beta-adrenergic activity of (+/-)-hydroxybenzylisoproterenol in isolated rat fat cells and hepatocytes.
beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.
Bioassay of hormones.
Bordetella extracytoplasmic adenylate cyclase: actions as a bacterial toxin.
Cell cycle arrest by prostaglandin A1 at the G1/S phase interface with up-regulation of oncogenes in S-49 cyc- cells.
Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.
Characterization of mammalian Gs-alpha proteins expressed in yeast.
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Clonal variation of adenylyl cyclase activity in a rat tumor cell line caused by change in G protein-catalytic unit interaction.
Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.
Cytosol activator protein from rat reticulocytes requires the stimulatory guanine nucleotide-binding protein for its actions on adenylate cyclase.
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Desensitization and recovery of prostaglandin-stimulated adenylate cyclase activity in a murine virus-induced T lymphoma cell line BL/VL3.
Desensitization of the beta-adrenergic receptor of the S49 murine lymphoma cell: mechanism of receptor loss and recovery.
Differences in the forskolin activation of adenylate cyclases in wild-type and variant lymphoma cells.
Differential effects of fluoride on adenylate cyclase activity and guanine nucleotide regulation of agonist high-affinity receptor binding.
Direct evidence for the role of the coupling proteins in forskolin activation of adenylate cyclase.
Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.
Discrimination between intact cell desensitization and agonist affinity changes.
Divergent regulation of beta 2-adrenoceptors and adenylate cyclase in the Cyc- mouse T lymphoma cell line TL2-9.
Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction.
Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system.
Effects of N-ethylmaleimide on gonadotropin and beta-adrenergic receptor function coupled to rabbit luteal adenylyl cyclase.
Enhancement of adenylate cyclase activity in S49 lymphoma cell membranes by the toxin thionin from Pyrularia pubera.
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction.
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.
Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells.
Evidence for a rabbit luteal ADP-ribosyltransferase activity which appears to be capable of activating adenylyl cyclase.
Evidence for guanosine triphosphate--binding proteins in Trypanosoma cruzi.
Evidence for the role of epinephrine binding frequency in activation of adenylate cyclase.
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. beta-Adrenergic and PGE1 receptors in parental and hybrid cells.
Fat cell beta-adrenergic receptor in the hypothyroid rat. Impaired interaction with the stimulatory regulatory component of adenylate cyclase.
Growth and protein phosphorylation in the Nb2 lymphoma: effect of prolactin, cAMP, and agents that activate adenylate cyclase.
Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.
Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni.
Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment.
Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma.
Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides.
Human chorionic gonadotropin-induced heterologous desensitization of adenylyl cyclase from highly luteinized rat ovaries: attenuation of regulatory N component activity.
Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.
Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation.
Identification of receptor contact site involved in receptor-G protein coupling.
Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma.
Inhibition of adenylate cyclase by p-bromophenacyl bromide.
Inhibition of hormonally regulated adenylate cyclase by the beta gamma subunit of transducin.
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Interactions between cyclic AMP- and phorbol ester-dependent phosphorylation systems in S49 mouse lymphoma cells.
Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase.
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Ischemic preconditioning is associated with a delay in ischemia-induced reduction of beta-adrenergic signal transduction in rabbit hearts.
Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase.
Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation.
Magnesium but not calcium accumulation is inhibited by beta-adrenergic stimulation in S49 lymphoma cells.
Manganous chloride stimulation of adenylate cyclase responsiveness in ocular ciliary process membranes.
Mechanism of action of glycopeptide hormones and cholera toxin: what is the role of ADP-ribosylation?
Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.
Mechanisms of downregulation of beta-adrenergic receptors: perspective on the role of beta-adrenergic receptors in congestive heart failure.
Membrane association of soluble protein activators of rat liver adenylate cyclase. Evidence for distinctness from the guanine nucleotide-binding stimulating protein (Ns).
Modulation of catecholamine activation of adenylate cyclase by the number of active beta-adrenergic receptors: theoretical considerations on the role of receptor diffusion in the cell membrane.
Modulation of Gs activity by phorbol myristate acetate in rat hepatocytes.
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
Multiple effects of phorbol esters on hormone-sensitive adenylate cyclase activity in S49 lymphoma cells.
Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C.
Multiple sites of action of ethanol on adenylate cyclase.
Mutants of PC12 cells with altered cyclic AMP responses.
Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase.
Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase.
Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
Occurrence of a hormone-sensitive inhibitory coupling component of the adenylate cyclase in S49 lymphoma cyc- variants.
Occurrence of an inhibitory guanine nucleotide-binding regulatory component of the adenylate cyclase system in cyc- variants of S49 lymphoma cells.
Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.
Overexpression of G(s)alpha in NG108-15, neuroblastomaXglioma cells: effects on receptor regulation of the stimulatory adenylyl cyclase cascade.
Phorbol ester treatment impairs hormone- but not stable GTP analog-induced inhibition of adenylate cyclase.
Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.
Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells.
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase.
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Purification of the regulatory component of adenylate cyclase.
Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Recovery of VIP/helodermin- and prostaglandin E1-stimulated adenylate cyclase activities in desensitized SUP-T1 human lymphoblasts.
Reduced responsiveness of adenylate cyclase to forskolin in human lymphoma cells.
Regulation of cyclic AMP accumulation in lymphoid cells.
Regulation of the catalytic component of adenylate cyclase. Potentiative interaction of stimulatory ligands and 2',5'-dideoxyadenosine.
Relationship between alcohol consumption and the activity of GTP-binding regulatory proteins in human erythrocyte membranes.
Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.
Resolution of some components of adenylate cyclase necessary for catalytic activity.
Role of protein synthesis on ethanol regulation of adenylyl cyclase activity in wild-type S49 murine lymphoma cells.
S49 lymphoma wild type and variant clones contain normal calcium dependent regulator.
Selection of a variant lymphoma cell deficient in adenylate cyclase.
Selective effects of organic mercurials on the GTP-regulatory proteins of adenylate cyclase systems.
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Serum-stimulated cyclic-AMP production in S49 lymphoma cells grown in serum-free medium.
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants.
Specific muscarinic-cholinergic desensitization in the neuroblastoma-glioma hybrid NG108-15.
Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.
Temperature-dependent changes in binding to beta-adrenergic receptors of intact S49 lymphoma cells. Implications for the state of the receptor that activates adenylate cyclase under physiological conditions.
The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.
The guanine nucleotide-binding regulatory component of adenylate cyclase in human erythrocytes.
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.
The inverse relationship between drug affinity and effectiveness: prediction under rate theory, paradox under occupancy theory.
The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.
The thermal lability of adenylate cyclase: mechanisms of stabilization.
Three adenylate cyclase phenotypes in S49 lymphoma cells produced by mutations of one gene.
Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion.
Tumorigenicity of the cyc- variant of the S49 murine lymphoma deficient in the Gs-alpha subunit of adenylate cyclase.
Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride.
Variable stimulation of adenylate cyclase activity by vasoactive intestinal-like peptides and beta-adrenergic agonists in murine T cell lymphomas of immature, helper, and cytotoxic types.
VIP receptors in human SUP-T1 lymphoblasts.
Lymphoma, B-Cell
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.
Lymphoma, Non-Hodgkin
Selection of a variant lymphoma cell deficient in adenylate cyclase.
Lymphoma, T-Cell
Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.
Lymphopenia
Leukocyte adenyl cyclase activity in human bronchial asthma.
Magnesium Deficiency
Alteration of prostanoid metabolism in rats with magnesium deficiency.
Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency.
Thalasselis' syndrome and other theories on keratoconus.
Malaria
Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins.
Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid.
Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-Lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria.
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum.
Malnutrition
Activity of cAMP-dependent protein kinase is reduced in protein-energy malnourished rats.
Adenylyl cyclase deficient cr-1 (Crisp) mutant of Neurospora crassa: cyclic AMP-dependent nutritional deficiencies.
Effect of undernutrition on GMP-PNP binding and adenylate cyclase activity from rat brain.
Effects of malnutrition on rat myocardial beta-adrenergic and muscarinic receptors.
Effects of undernutrition during suckling and early post-weaning on the inhibition by met-enkephalin of striatal adenylate cyclase activity in adult rats.
Stimulation of intestinal adenylate cyclase by cholera toxin in malnourished rats.
Mania
Clinical implications of research on the mechanism of action of lithium.
Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesising defects beyond first messenger receptors.
Mechanisms of action of anticonvulsants in affective disorders: comparisons with lithium.
Marfan Syndrome
The new bone biology: pathologic, molecular, and clinical correlates.
Mastocytoma
Altered binding properties of beta-adrenergic receptors and lack of coupling to adenylate cyclase in P815 mastocytoma cells.
Effect of adenosine 3',5'-monophosphate on growth and several functions of cultured mastocytoma P-815 cells.
Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells.
Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype.
Prostacyclin (PGI) receptor binding and cyclic AMP synthesis activities of PGI1 analogues, SM-10906 and its methyl ester, SM-10902, in mastocytoma P-815 cells.
TEI-9063, a stable and highly specific prostacyclin analogue for the prostacyclin receptor in mastocytoma P-815 cells.
[Cooperation of two subtypes of PGE2 receptor, Gi coupled EP3 and Gs coupled EP2 or EP4 subtype]
Measles
Effect of antibody-induced modulation of measles (SSPE) virus membrane proteins on beta-adrenergic receptor-mediated adenylate cyclase activity.
Measles virus modulates human T-cell somatostatin receptors and their coupling to adenylyl cyclase.
Medulloblastoma
Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA.
Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.
Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.
Melanoma
4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.
A synthetic analog of the calmodulin-binding domain of myosin light chain kinase inhibits melanotropin receptor function and activation of adenylate cyclase.
Activation of ?2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.
Adenosine and divalent cation effects on S-91 melanoma adenylate cyclase.
Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata).
Adenylate cyclase activity in homogenates of human melanoma cells. Effect of alpha-MSH and isoprenaline.
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells.
Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor.
Anti-melanogenic property of geoditin a in murine b16 melanoma cells.
Beta-carotene induces morphological differentiation and decreases adenylate cyclase activity in melanoma cells in culture.
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
Biological actions of melanocyte-stimulating hormone.
Comparative biological activities of potent active-site analogues of alpha-melanotropin. Effect of tyrosine substitution at position-4.
Cyclic melanotropins. 5. Importance of the C-terminal tripeptide (Lys-Pro-Val).
Decreased adenylate cyclase activation by helodermin and PGE1 in the lectin-resistant variant Wa4 of the mouse melanoma cell line B16.
Demonstration of histamine H2 receptors on human melanoma cells.
Dual regulation of beta-melanotropin receptor function and adenylate cyclase by calcium and guanosine nucleotides in the M2R melanoma cell line.
Effect of vitamin E and indomethacin treatment on adenylate cyclase activity, PGE2 and cAMP levels in murine melanoma cells.
Effects of latanoprost on tyrosinase activity and mitotic index of cultured melanoma lines.
Effects of tumor promoters on adenylate cyclase activity in melanoma cells in culture.
EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP.
Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones.
Expression of soluble adenylyl cyclase in acral melanomas.
Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells.
Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase.
Homologous regulation of the MSH receptor in melanoma cells.
Hormonal activation of adenylate cyclase in mouse melanoma metastatic variants.
Hormonal control of melanocytes: MSH-sensitive adenyl cyclase in the Cloudman melanoma.
Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2.
Inhibition by melittin and fluphenazine of melanotropin receptor function and adenylate cyclase in M2R melanoma cell membranes.
Investigation of cAMP microdomains as a path to novel cancer diagnostics.
Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin.
MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways.
MSH stimulates adenylate cyclase and tyrosinase in cultivated melanoma cells in the presence of cytochalasin B.
Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment.
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
PHrmonal specificity of the melanotropin-sensitive adenylate cyclase of mouse melanoma and effect of cyclic AMP on the tyrosinase activity of mouse melanoma cells, in vitro.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted alpha-melanotropins.
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes.
Regulation of adenylate cyclase by beta-melanotropin in the M2R melanoma cell line.
Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins.
Stimulation of the adenylate cyclase of A B16 melanoma cell line by pro-opiocortin-related peptides--a structure-activity study.
Synthesis and structure-function studies of melanocyte stimulating hormone analogues modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclase.
The role of adenylate cyclase, cAMP and PGE2 in the in vitro growth regulation of murine melanoma cells by vitamin E.
[half-Cys4,half-Cys10]-alpha-Melanocyte-stimulating hormone: a cyclic alpha-melanotropin exhibiting superagonist biological activity.
[Regulatory role of DOPA and components of the cyclic adenosine-3',5'-monophosphate system]
Melanoma, Experimental
Acetoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase.
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
Calmodulin activation of adenylate cyclase in the mouse B16 melanoma.
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Regulation of adenylate cyclase by beta-melanotropin in the M2R melanoma cell line.
Stimulation of the adenylate cyclase of A B16 melanoma cell line by pro-opiocortin-related peptides--a structure-activity study.
Whitening activity of luteolin related to the inhibition of cAMP pathway in alpha-MSH-stimulated B16 melanoma cells.
Memory Disorders
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.
Distribution of 5-HT(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study.
Domoic acid-induced neurodegeneration resulting in memory loss is mediated by Ca2+ overload and inhibition of Ca2+ + calmodulin-stimulated adenylate cyclase in rat brain (review).
Spatiotemporal rescue of memory dysfunction in Drosophila.
Synapsin is selectively required for anesthesia-sensitive memory.
Meniere Disease
Adenylate cyclase modulation of ion permeability in the guinea pig cochlea: a possible mechanism for the formation of endolymphatic hydrops.
Meningioma
In vitro detection of somatostatin receptors in human tumors.
Relationship between cAMP induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6.
Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth.
Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications.
Mesothelioma, Malignant
Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro.
Metabolic Syndrome
Association analysis of genetic variants with metabolic syndrome components in the Moroccan population.
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice.
Methemoglobinemia
Methylene Blue in the Treatment of Vasoplegia Following Severe Burns.
Migraine Disorders
5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs.
Biochemical Modulation and Pathophysiology of Migraine.
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38.
Effect of the H1-antihistamine clemastine on PACAP38 induced migraine.
Improvement of the closed cranial window model in rats by intracarotid infusion of signalling molecules implicated in migraine.
Investigation of carbachol and PACAP38 in a human model of migraine.
No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine.
PACAP and its receptors in cranial arteries and mast cells.
PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma.
PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor.
Pituitary adenylate cyclase activating polypeptide and migraine.
Serum CGRP, VIP, and PACAP usefulness in migraine: a case-control study in chronic migraine patients in real clinical practice.
The role of mast cells in migraine pathophysiology.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the circulation after sumatriptan.
What have we learnt from triggering migraine?
Mitral Valve Prolapse
Abnormal Gs function in mitral valve prolapse dysautonomia is not associated with abnormal alpha S cDNA sequence.
Mitral Valve Stenosis
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
Effects of the H2-receptor agonist impromidine in human myocardium from patients with heart failure due to mitral and aortic valve disease.
[Beta-adrenergic receptivity and left ventricular hypertrophy caused by pressure overload in man]
Movement Disorders
A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.
ADCY5 mutations are another cause of benign hereditary chorea.
ADCY5-Related Dyskinesia: Improving Clinical Detection of an Evolving Disorder.
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
Clinical exome sequencing in early-onset generalized dystonia and large-scale resequencing follow-up.
Deep brain stimulation reduces (nocturnal) dyskinetic exacerbations in patients with ADCY5 mutation: a case series.
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability.
Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.
Paroxysmal movement disorders - practical update on diagnosis and management.
Paroxysmal movement disorders: An update.
PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology.
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
[ADCY5-associated dyskinesia in young children: a case report of a family and an updated review].
Multiple Myeloma
[Analysis of the regulation of HLA class II genes by forskolin]
Multiple Sclerosis
The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.
[Cannabinoids--signal transduction and mode of action]
Multiple System Atrophy
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Muscle Hypotonia
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Muscle Spasticity
The genetic etiology in cerebral palsy mimics: The results from a Greek tertiary care center.
Muscular Diseases
High skeletal muscle adenylate cyclase in malignant hyperthermia.
Membrane alteration in failing hearts of cardiomyopathic hamsters.
[Cyclic 3',5'-AMP metabolism in progressive muscular dystrophy patients]
[Pathogenesis of several forms of progressive muscular dystrophy]
[Use of adenylate cyclase inhibitors for treating myopathies]
Muscular Dystrophies
Adenyl cyclase and cyclic nucleotide phosphodiesterase activities in murine muscular dystrophy.
Adenyl cyclase in the pectoral muscle of normal chickens and chickens with hereditary muscular dystrophy.
Adenylate cyclase in Duchenne and Fukuyama type muscular dystrophy.
Adenylate cyclase in muscular dystrophy.
The enzymes of the red blood cell plasma membrane.
[Creatine biosynthesis in mice with hereditary muscular dystrophy: possible defect in liver plasma membrane adenyl cyclase]
Muscular Dystrophy, Duchenne
Adenyl cyclase abnormality in Duchenne muscular dystrophy: muscle cells in culture.
Adenylate cyclase and ATPase activities in red cell membranes of patients and genetic carriers of Duchenne muscular dystrophy.
Erythrocyte membrane protein kinase and adenylate cyclase in Duchenne muscular dystrophy.
Protein kinase and adenylate cyclase of erythrocyte membrane from patients with Duchenne muscular dystrophy.
Myeloproliferative Disorders
Alpha 2-adrenoceptor coupling to adenylate cyclase in adrenaline insensitive human platelets.
Myocardial Infarction
A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion.
Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction.
Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats.
Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion.
Decreased type VI adenylyl cyclase mRNA concentration and Mg(2+)-dependent adenylyl cyclase activities and unchanged type V adenylyl cyclase mRNA concentration and Mn(2+)-dependent adenylyl cyclase activities in the left ventricle of rats with myocardial infarction and longstanding heart failure.
Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmural myocardial infarction.
Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure.
Effects of beta-adrenergic blockade on papillary muscle function and the beta-adrenergic receptor system in noninfarcted myocardium in compensated ischemic left ventricular dysfunction.
Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction.
Influence of cardiac dysfunction on fast sodium current regulation by Forskolin.
Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta.
Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction.
Regional beta-adrenergic receptors and adenylate cyclase activity after healing of myocardial infarction in cats.
Sensitization of the beta-adrenergic system in acute myocardial ischaemia by a protein kinase C-dependent mechanism.
Studies on adenyl cyclase system in myocardium (Part II). Adenyl cyclase system in myocardial infarction of dogs.
Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.
[Systems for regulating the level of Ca2+, cyclic nucleotides, and reverse absorption of neurotransmitters in isolated nerve endings of the rat brain during development of myocardial infarct]
[The molecular cellular aspects in predicting the course of an acute myocardial infarct]
Myocardial Ischemia
Adrenergic receptors and sensitization of adenylyl cyclase in acute myocardial ischemia.
Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system.
Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion.
Beta-receptors and adenylate cyclase: comparison of nonischemic, ischemic, and postmortem tissue.
Dual sensitization of the adrenergic system in early myocardial ischemia: independent regulation of the beta-adrenergic receptors and the adenylyl cyclase.
Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure.
Expression, function, and regulation of E-type prostaglandin receptors (EP3) in the nonischemic and ischemic pig heart.
Externalization of beta-adrenergic receptors promoted by myocardial ischemia.
Impaired adenylate cyclase signaling in acute myocardial ischemia: Impact on effectiveness of P2Y12 receptor antagonists.
Modification of beta-adrenoceptors and adenylyl cyclase in hearts perfused with hypochlorous acid.
One hour of myocardial ischemia decreases the activity of the stimulatory guanine-nucleotide regulatory protein Gs.
One hour of myocardial ischemia in conscious dogs increases beta-adrenergic receptors, but decreases adenylate cyclase activity.
Preserved beta-adrenoceptor-mediated adenylyl cyclase activity despite receptor and postreceptor dysfunction in acute myocardial ischemia.
Supersensitivity of the adenylyl cyclase system in acute myocardial ischemia: evaluation of three independent mechanisms.
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
The guanine nucleotide-binding regulatory proteins (G proteins) in myocardium with ischemia.
[Adenyl cyclase activity in the thrombocytes of patients with ischemic heart disease]
[Proceedings: Myocardial adenyl cyclase (5). Effects of propranolol on the ventricular fibrillation threshold in acute myocardial ischemia and the myocardial adenyl cyclase system]
Myocardial Stunning
Beta-adrenergic receptor signalling in stunned myocardium of conscious pigs.
Oxygen free radical injury and Gs mediated signal transduction in the stunned porcine myocardium.
The guanine nucleotide-binding regulatory proteins (G proteins) in myocardium with ischemia.
Myocarditis
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection.
[Interaction of antibodies with cardiac neurotransmitter receptors]
Myoclonus
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Myokymia
Facial twitches in ADCY5-associated disease - Myokymia or myoclonus? An electromyography study.
Myositis Ossificans
Heterotopic ossification.
The new bone biology: pathologic, molecular, and clinical correlates.
Myxedema
Inhibition of thyrotropin-induced adenosine 3'5'-monophosphate increase by immunoglobulins from patients with primary myxedema.
Inhibition of thyrotropin-stimulated adenylate cyclase activation and growth of rat thyroid cells, FRTL-5, by immunoglobulin G from patients with primary myxedema: comparison with activities of thyrotropin-binding inhibitor immunoglobulins.
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase.
Thyroid autoantigens and their relevance in the pathogenesis of thyroid autoimmunity.
Nasal Polyps
Enzyme-ultracytochemical study of adenylate and guanylate cyclases in normal and pathologic human nasal mucosa.
[Adenylate cyclase activity in human nasal polyps under conditions of stimulation of serotonin biosynthesis (in vitro)]
Neoplasm Metastasis
Carcinoma of the breast associated with hypercalcemia and the presence of parathyroid hormone-like substances in the tumor.
Molecular pathways: Beta-adrenergic signaling in cancer.
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Neoplasms
3',5'-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1.
A 68 000 dalton protein genetically associated with corticotropin-sensitive adenylate cyclase activity. Purification and preliminary characterization using a specific antiserum.
A mu-opiate receptor in 7315c tumor tissue mediates inhibition of immunoreactive prolactin release and adenylate cyclase activity.
A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.
A Pan-Cancer Analysis of the Prognostic Value and Expression of Adenylate Cyclase 7 (ADCY7) in Human Tumors.
A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis.
A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - therapeutic implications.
A study of cyclic nucleotide metabolism and the histology of rat liver during 3'-methyl-4-dimethylamino-azobenzene carcinogenesis. II. Cyclic AMP metabolism.
A transplantable rat Leydig cell tumor--2. Adenylyl cyclase activation by prostaglandin E1, isoproterenol and glucagon.
A transplantable rat Leydig cell tumor--3. Isoproterenol and prostaglandin E1 (PGE1) responsive adenylyl cyclase (AC). Regulatory effects of nucleotides and magnesium.
A transplantable rat Leydig cell tumor--5. Cellular localization of beta-adrenergic and prostaglandin receptors and their effects on testosterone production.
A unifying model of the cell proliferation emphasizing plasma membrane fluxes.
Aberrant REST-mediated transcriptional regulation in major depressive disorder.
Absence of G(s)alpha gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia.
Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas.
ACTH and prostaglandin receptors in human adrenocortical tumors. Apparent modification of a specific component of the ACTH-binding site.
ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.
Activated 3',5'-cyclic AMP-dependent protein kinase is sufficient to induce neuroendocrine-like differentiation of the LNCaP prostate tumor cell line.
Activation of steroidogenesis and adenylate cyclase by adenosine in adrenal and Leydig tumor cells.
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Activity and hormone responsiveness of adenyl cyclase during induction of tumors in rat liver with 3'-methyl-4-dimethylaminoazobenzene.
Adenosine potentiates lutropin-stimulated cyclic AMP production and inhibits lutropin-induced desensitization of adenylate cyclase in rat Leydig tumour cells.
Adenyl cyclase and phosphodiesterase in human cerebral tumors.
Adenyl cyclase hormone responses of certain human endocrine tumors.
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
Adenylate cyclase activity and steroidogenesis in phenotypic revertants of an ACTH-insensitive adrenal tumour cell line.
Adenylate cyclase activity as a predictor of thyroid tumor aggressiveness.
Adenylate cyclase activity in adrenocorticotropic hormone-sensitive and mutant adrenocortical tumor cell lines.
Adenylate cyclase activity in Y1 mouse adrenocortical tumor cells: some properties of the enzyme associated with purified plasma membrane fractions.
Adenylate cyclase in human ovarian cancers: sensitivity to gonadotropins and nonhormonal activators.
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Adenylate cyclase responsiveness of human insulinomas.
Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
Adenylyl cyclase from a prolactin producing tumor cell: the effect of phenothiazines.
Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.
Agonist-induced desensitization of adenylyl cyclase in Y1 adrenocortical tumor cells.
Alteration in the transmission of TSH-message to thyroid target in a transplantable rat thyroid tumor.
Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma.
Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.
Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
Altered subcellular distribution of protein kinase C (a phorbol ester receptor). Possible role in tumor promotion and the regulation of cell growth: relationship to changes in adenylate cyclase activity.
Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells.
Analysis of the proliferative response to lysophosphatidic acid in primary cultures of mammary epithelium: differences between normal and tumor cells.
Anti-microtubular agents as inhibitors of desensitization to catecholamine stimulation of adenylate cyclase in Ehrlich ascites tumor cells.
Antibodies against human chorionic gonadotropin convert the deglycosylated hormone from an antagonist to an agonist.
Antibody binding to the beta-subunit of deglycosylated chorionic gonadotropin converts the antagonist to an agonist.
Arrest of mammary tumor growth in vivo by L-arginine: stimulation of NAD-dependent activation of adenylate cyclase.
Association of a 68,000-dalton protein with adrenocorticotropin-sensitive adenylate cyclase activity in Y1 adrenocortical tumor cells.
Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.
Bacteria and their toxins tamed for immunotherapy.
beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.
Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma.
Beta-adrenergic signalling in neoplastic lung type 2 cells: glucocorticoid-dependent and -independent defects.
Beta-adrenoceptor distribution in murine lymphoid cell lines.
Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors.
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
Bone and kidney adenylate cyclase-stimulating activity produced by a hypercalcemic canine adenocarcinoma line (CAC-8) maintained in nude mice.
Ca+2 is an inhibitor of adenylate cyclase in MA-10 Leydig tumor cells.
Calcitonin gene-related peptide (CGRP) acts independently of calcitonin on cyclic AMP formation in clonal osteogenic sarcoma cells (UMR 106-01).
Calcitonin-responsive adenylate cyclase in a calcitonin-producing human cancer cell line.
cAMP-mediated regulation of CYP enzymes and its application in chemotherapy.
Catabolism of adipose tissue by a tumour-produced lipid-mobilising factor.
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Cationized serum albumin enhances basal and stimulated adenylate cyclase activity in canine renal membranes.
Cerebral tumours induced by ENU; changes of adenylate cyclase activity in the tumour latency time.
Changes in the cellular phenotype and extracellular matrix during progression of estrogen-induced mesenchymal kidney tumors in Syrian hamsters.
Characteristics of an adenylate cyclase coupled beta 2-adrenergic receptor in a smooth muscle tumor cell line.
Characterization of beta-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16).
Characterization of the glucagon receptor in a pheochromocytoma.
Characterization of the homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase.
Cholera toxin activation of adenylate cyclase in cancer cell membrane fragments.
Choleragen stimulates steroidogenesis and adenylate cyclase in cells lacking functional hormone receptors.
Clinical implications of genetic defects in G proteins: oncogenic mutations in G alpha s as the molecular basis for the McCune-Albright syndrome.
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
Clonal variation in adrenocorticotropin-induced desensitization of adenylate cyclase in Y1 adrenocortical tumor cells. Association with a 68,000-dalton protein.
Clonal variation of adenylyl cyclase activity in a rat tumor cell line caused by change in G protein-catalytic unit interaction.
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Co-purification of bone resorbing activity and adenylate cyclase stimulating activity from human tumours associated with the humoral hypercalcaemia of malignancy.
Co-purification of calcium transport-stimulating and DNA synthesis-stimulating agents with parathormone-like activity isolated from the hypercalcaemic strain of the Walker 256 tumour.
Comparative adenylate cyclase activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc (h).
Comparison between vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide levels in neuroblastoma tumour tissues.
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme.
Concurrent changes in growth-related biochemical parameters during regression of hormone-dependent rat mammary tumors.
Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.
Coupling between membrane hormone receptors and adenylate cyclase in tumour cells.
Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells.
Cushing syndrome with food-dependent periodic hormonogenesis.
Cyclic AMP and adenyl cyclase in brain tumors.
Cyclic AMP regulation of mammary tumor virus production.
Cyclic AMP-binding proteins: inverse relationship with estrogen-receptors in hormone-dependent mammary tumor regression.
Cyclic nucleotide metabolism in differentiated and undifferentiated epithelial thyroid cells in culture.
Cytochemical localization of adenyl cyclase in isoproterenol stimulated hepatoma ascites cells.
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
D2 dopaminergic receptors: normal and abnormal transduction mechanisms.
Decreased adenylyl cyclase and cAMP-dependent protein kinase activities inhibit the cytotoxic function of human natural killer cells.
Decreased stathmin expression does not affect the actions of human choriogonadotropin or epidermal growth factor in Leydig tumor cells.
Development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor.
Diazepam inhibits forskolin-stimulated adenylyl cyclase activity in human tumour cells.
Difference between magnesium and manganese ions in modification of effect of catecholamine on adenylate cyclase system in Ehrlich ascites tumor cells.
Differences in adenylate cyclase activities in murine normal cells and bladder tumor cells in tissue culture.
Different effects of selenium on cyclic AMP metabolism in hepatoma cells and normal liver cells.
Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type I by its own trans-activator and cyclic AMP.
Differential cyclic AMP responses to calcitonin among human ovarian carcinoma cell lines: a calcitonin-responsive line derived from a rare tumor type.
Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.
Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas.
Diminished binding of thyroid-stimulating hormone in a transplantable rat thyroid tumor as a possible cause of hormone unresponsiveness.
Divergent effects of phenothiazines on Leydig tumor cell steroidogenesis and adenylate cyclase activity.
Dopamine decreases 7315a tumor cell prolactin release induced by calcium mobilization.
Down-regulation of gonadotropin receptors in a murine Leydig tumor cell line.
Dual effect of pituitary adenylate cyclase activating polypeptide on prostate tumor LNCaP cells: short- and long-term exposure affect proliferation and neuroendocrine differentiation.
Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome.
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
Ectopic beta-adrenergic receptors coupled to adenylate cyclase in human adrenocortical carcinomas.
Effect of histamine on growth and differentiation of the rat mammary gland.
Effect of prostaglandins on adenylate cyclase activities in membranes from liver and transplantable hepatomas.
Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro.
Effect of suramin on adenylate cyclase and protein kinase C.
Effect of the H1-antihistamine clemastine on PACAP38 induced migraine.
Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.
Effects of catecholamines and monovalent cations on adenylate cyclase activity in cultured glial tumor cells.
Effects of forskolin on Kupffer cell production of interleukin-10 and tumor necrosis factor alpha differ from those of endogenous adenylyl cyclase activators: possible role for adenylyl cyclase 9.
Effects of ketoconazole on progesterone and cAMP production in MA-10 mouse Leydig tumor cells.
Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C.
Effects of tumor promoters on adenylate cyclase activity in melanoma cells in culture.
EGFR may couple moderate alcohol consumption to increased breast cancer risk.
Elevation of intracellular cyclic adenosine 3',5'-monophosphate levels in macrophages activated with lipopolysaccharide for tumor cell killing.
Endocannabinoids in endocrine and related tumours.
Endotoxic lipopolysaccharides stimulate steroidogenesis and adenylate cyclase in adrenal tumor cells.
Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.
EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP.
Epidermal growth factor desensitizes the gonadotropin-responsive adenylyl cyclase in membranes isolated from MA-10 Leydig tumor cells and luteinized rat ovaries.
Epigenetic identification of ADCY4 as a biomarker for breast cancer: an integrated analysis of adenylate cyclases.
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system.
Evaluation of Cytotoxicity and Hypoxic Effect of Nitroimidazole Embedded Nanoparticles.
Evaluation of receptor function in ACTH-responsive and ACTH-insensitive adrenal tumor cells.
Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones.
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in human glial cell tumors.
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Expression of vasoactive intestinal peptide and functional VIP receptors in human prostate cancer: antagonistic action of a growth-hormone-releasing hormone analog.
Extracellular cAMP formation from host cell ATP by Bordetella pertussis adenylate cyclase.
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy.
Forskolin and a tumor promoter are able to induce c-fos and c-myc expression in normal, but not in a v-ras-transformed rat thyroid cell line.
Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.
Forskolin-resistant Y1 mutants harbor defects associated with the guanyl nucleotide-binding regulatory protein, Gs.
Functional Non-Nucleoside Adenylyl Cyclase Inhibitors.
Functional receptors for VIP, GIP, glucagon-29 and -37 in the HGT-1 human gastric cancer cell line.
GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation.
GNAS1 (G?s) Gene T393C Polymorphism and Renal Cell Carcinoma Risk in a North Indian Population: A Case-Control Study.
Gonadotropin receptors in experimentally induced ovarian tumors in mice.
Gonadotropin-mediated desensitization in a murine Leydig tumor cell line does not alter the regulatory and catalytic components of adenylate cyclase.
Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumor.
gsp mutations in human thyroid tumours.
Guanine nucleotide mediated desensitization of adenylate cyclase in cell free preparations from a Leydig cell tumour.
Guanosine triphosphate-sensitive adenylate cyclase of adrenocorticotrophic hormone- and prostaglandin-resistant human adrenocortical tumors.
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Heterogeneous forms of thyroid-stimulating hormone in mouse thyrotropic tumor and serum: differences in receptor-binding and adenylate cyclase-stimulating activity.
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells.
Higher TNF? responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression.
Hormonal modulation of plasminogen activator: an approach to prediction of human breast tumor responsiveness.
Hormonal regulation of adenylate cyclase activity in circulating lymphocytes and its interrelationship with hormone sensitivity of tumor tissue in colorectal cancer patients.
Hormone receptors and cyclic nucleotide metabolism in cancer cells.
Human pancreatic tumor growth hormone-releasing factor stimulates anterior pituitary adenylate cyclase activity, adenosine 3',5'-monophosphate accumulation, and growth hormone release in a calmodulin-dependent manner.
Humoral hypercalcaemia in a patient with renal-cell carcinoma.
Humoral hypercalcaemia of malignancy: report of two further patients with biochemical studies on tumour extracts.
Hydrodynamic properties of the gonadotropin receptor from a murine Leydig tumor cell line are altered by desensitization.
Identification of a Leydig tumor cell protein that is phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor.
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones.
Indications for selective coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition by endogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor cell lines.
Influence of lithium ions on epinephrine-stimulated adenylate cyclase activity in cultured glial tumor cells.
Inhibition of cell migration via G protein-coupled receptors to opioid peptides and angiotensin.
Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.
Inhibition of hCG-stimulated steroidogenesis in cultured mouse Leydig tumor cells by bisphenol A and octylphenols.
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.
Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects.
Inhibitory guanine nucleotide binding protein in pig epidermis: regulation of epidermal adenylate cyclase.
Interaction of cholera enterotoxin with cultured adrenal tumor cells.
Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA.
Investigation of cAMP microdomains as a path to novel cancer diagnostics.
Isolation and characterization of plasma membranes containing LH sensitive adenylate cyclase from a Leydig cell tumour.
Isolation and characterization of the plasma membrane from Yoshida hepatoma cells.
Isolation of forskolin-resistant adrenal cells defective in the adenylate cyclase system.
Lack of immunological analogy between the beta-subunits of cholera toxin and human choriogonadotropin.
Leydig tumor cell protein phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor is identified as stathmin.
Loss of prostaglandin E receptors during progression of rat mammary tumors from hormonal dependence to autonomy.
Low expression of Galpha protein subunits in human prostate cancer.
Low temperature blocks the stimulatory effect of human chorionic gonadotropin on steroidogenic acute regulatory protein mRNA and testosterone production but not cyclic adenosine monophosphate in mouse Leydig tumor cells.
Lymphocyte and macrophage adenyl cyclase activity in animals with enhanced cell-mediated resistance to infection and tumors.
Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism.
Mechanism of action of glycopeptide hormones and cholera toxin: what is the role of ADP-ribosylation?
Mechanism of depletion of liver glycogen in cancer cachexia.
Mechanisms of calcitonin induction of prolonged activation of adenylate cyclase in human cancer cells.
Medroxyprogesterone acetate (MPA) stimulates adenylate cyclase activity in rat mammary tumours.
Metabolic regulation and relationship of endogenous protein kinase activity and steroidogenesis in isolated adrenocortical carcinoma cells of the rat.
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Modulation of the beta-adrenergic receptor-coupled adenylate cyclase by chemical inducers of differentiation: effects on beta receptors and the inhibitory regulatory protein Gi.
Molecular mechanisms of corticotropin-releasing factor stimulation of calcium mobilization and adrenocorticotropin release from anterior pituitary tumor cells.
Molecular pathways: Beta-adrenergic signaling in cancer.
Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumors.
Naturally occurring forms of thyrotropin with low bioactivity and altered carbohydrate content act as competitive antagonists to more bioactive forms.
PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation.
PACAP38 and PACAP6-38 Exert Cytotoxic Activity Against Human Retinoblastoma Y79 Cells.
Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia.
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
Partial dopamine D2 receptor agonists antagonize prolactin-regulating D2 receptors in a transfected clonal cell line (GH4ZR7).
Pathogenesis of humoral hypercalcemia of malignancy.
Peculiarities of hormonal regulation of adenylate cyclase and lipid composition in colonic and rectal tumors.
Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities.
Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists.
Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.
Pharmacological profile of adenosine A2 receptor in PC12 cells.
Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes.
Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes.
Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line.
Phorbol ester induces loss of VIP stimulation of adenylate cyclase and VIP-binding sites in HT29 cells.
Phorbol esters do not influence the maturation and the beta-adrenergic responsiveness of differentiated adipose precursor cells, cultured in a charcoal-treated serum medium.
Pituitary adenylate cyclase activating peptide and its receptors are expressed in human neuroblastomas.
Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
Pituitary adenylate cyclase-activating polypeptide directly stimulates LH and FSH secretion by human pituitary gonadotrophinomas.
Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes are differently expressed in rat transplanted pituitary tumours (SMtTW) and in the normal gland.
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced group II phospholipase A2 expression in rat renal mesangial cells.
Positive cardiac inotropic effect of albumin infusion in rats with cirrhosis and ascites: Molecular mechanisms.
Predictors of thyroid tumor aggressiveness.
Presence of ectopic beta-adrenergic receptors on human adrenocortical cortisol-producing adenomas.
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara.
Proceedings: Alterations in liver adenylate cyclase responsiveness during induction of tumours in rat liver with 3'-methyl-4-dimethylaminoazobenzene.
Production of recombinant lethal factor of Bacillus anthracis in Bacillus subtilis.
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line.
Properties of AT1a and AT1b angiotensin receptors expressed in adrenocortical Y-1 cells.
Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. But hCG-induced desensitization does not involve protein kinase C activation.
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways.
Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.
Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with hypercalcemia.
Pyrrolidine dithiocarbamate differentially affects cytokine- and cAMP-induced expression of group II phospholipase A2 in rat renal mesangial cells.
Radiation induced osteogenic sarcoma in the rat as a model of hormone-responsive differentiated cancer.
Rapid localization of parathyroid tumors by selective venous catheterization and parathyroid hormone bioassay.
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.
Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells.
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Reduced Malignancy as a Mechanism for Longevity in Mice with Adenylyl Cyclase Type 5 (AC5) Disruption.
Regulation of adenylate cyclase activity in GH1 cells by chlorpromazine and a heat-stable factor.
Regulation of adenylate cyclase from glial tumor cells by calcium and a calcium-binding protein.
Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.
Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor alpha in rat cardiomyocytes.
Regulation of cyclic adenosine 3',5'-monophosphate in relation to growth of dimethylbenz[a]anthracene-induced mammary tumors in rats.
Regulation of growth hormone secretion and messenger ribonucleic acid accumulation in human somatotropinoma cells in vitro.
Regulation of in vitro insulin release from a transplantable Syrian hamster insulinoma.
Regulation of the adenylate cyclase system in transplantable hepatomas.
Regulation of thyrotropin (TSH) release and production in monolayer cultures of transplantable TSH-producing mouse tumors.
Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas.
Resensitization of lutropin-desensitized tumour Leydig-cell adenylate cyclase with human erythrocyte membranes.
Resistance to bromocriptine in prolactinomas.
Resistance to somatostatin (SRIH) analog therapy in acromegaly. Re-evaluation of the correlation between the SRIH receptor status of the pituitary tumor and the in vivo inhibition of GH secretion in response to SRIH analog.
Role of cyclic AMP and protein kinase on the steroidogenic action of ACTH, prostaglandin E1 and dibutyryl cyclic AMP in normal adrenal cells and adrenal tumor cells from humans.
Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin.
Signaling pathways in adrenocortical cancer.
Similarities and differences in phorbol ester- and luteinizing-hormone-induced desensitization of rat tumour Leydig-cell adenylate cyclase.
Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.
Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions.
Somatostatin receptors, adenylate cyclase activity, and growth hormone (GH) response to octreotide in GH-secreting adenomas.
Some properties of adenyl cyclase from Ehrlich tumor cells.
Squamous carcinoma model of humoral hypercalcemia of malignancy.
Striatal dopamine-stimulated adenylate cyclase activity reflects susceptibility of rats to 7,12-dimethylbenz[a]anthracene-induced mammary tumor development.
Structure-guided cancer blockade between bioactive bursehernin and proteins: Molecular docking and molecular dynamics study.
Stu8es on an ACTH-activated adenyl cyclase from a mouse adrenal tumor.
Studies on cyclic nucleotides in cancer. I. Adenylate guanylate cyclase and protein kinases in the prostatic sarcoma tissue.
Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.
Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents.
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
Temperature effects on the modulation of adenylate cyclases from rat liver and Morris hepatomas.
Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis.
The adenylate cyclase activator forskolin partially protects L929 cells against tumour necrosis factor-alpha-mediated cytotoxicity via a cAMP-independent mechanism.
The biochemical mechanisms of the stimulating action of estradiol on the growth of mammary tumours.
The content and metabolism of cyclic adenosine 3', 5'-monophosphate and cyclic guanosine 3', 5'-monophosphate in adenocarcinoma of the human colon.
The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse.
The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.
The glycerophosphoinositols: cellular metabolism and biological functions.
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
The relation between cell proliferation and adenylate cyclase activity in grafts of 3-methylcholanthrene induced mouse uterine cervical tumors.
The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg).
Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope.
Thrombin- and histamine-induced signal transduction in human endothelial cells. Stimulation and agonist-dependent desensitization of protein phosphorylation.
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Thyrotropin (TSH) receptor and adenylate cyclase activity in human thyroid tumors: absence of high affinity receptor and loss of TSH responsiveness in undifferentiated thyroid carcinoma.
Thyrotropin binding and adenylate cyclase stimulation in thyroid neoplasms.
Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas from Brazil.
Thyrotropin receptor-adenylate cyclase function in human thyroid neoplasms.
Thyrotropin stimulation of the ADP-ribosyltransferase activity of bovine thyroid membranes.
Transmembrane signalling systems.
Transplantable ductal adenocarcinoma of the Syrian hamster pancreas.
Tumor necrosis factor alpha stimulates adenylyl cyclase activity in human myometrial cells.
Tumor necrosis factor alpha up-regulates Gi alpha and G beta proteins and adenylyl cyclase responsiveness in rat cardiomyocytes.
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Tumour promoter uncouples beta-adrenergic receptor from adenyl cyclase in mouse epidermis.
Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy.
Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation.
Vasoactive intestinal peptide (VIP) increases vascular endothelial growth factor (VEGF) expression and secretion in human breast cancer cells.
Vasoactive intestinal peptide- and adrenocorticotropin-stimulated adenyl cyclase in cultured adrenal tumor cells: evidence for a specific vasoactive intestinal peptide receptor.
Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer.
Vasoactive intestinal peptide: autocrine growth factor in neuroblastoma.
Vidarabine is neither a potent nor a selective AC5 inhibitor.
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Vitamin E and cancer prevention: recent advances and future potentials.
Watery diarrhea syndrome in an adult with ganglioneuroma-pheochromocytoma: identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity.
[Adenylate cyclase activity and cyclic nucleotide content in human adrenal tumors under Icenko-Cushing syndrome]
[Adenylate cyclase complex, lipids and the regulation of the hormonal sensitivity of tumor tissue]
[adenylate cyclase system in Ehrlich ascites tumor cells sensitive and resistant to 5-fluorouracil]
[Age-related changes in adenylate cyclase activity, lipid composition and lipid peroxidation in rat intestinal mucosa: comparison with the frequency of spontaneous tumors]
[Amplification of the heterologous response of adenylate cyclase in colonic tumors: relation to tissue lipid composition]
[Biochemical differences in the tumor cells of 5-fluorouracil-sensitive and -resistant strains of Ehrlich ascitic carcinoma]
[Cancerostatically active 6,6a,7,8,13,13a-hexahydro-1-benzopyrano[4,3-b]-1,5-benzodiazepine diastereoisomers (author's transl)]
[Comparative study on activity of adenylate cyclase in normal human ovary with ovarian tumors]
[Concentration and metabolism of cyclic AMP during the early stages of hepatoma 22a growth]
[Concentration of cyclic nucleotides, activity of adenylate cyclase, 3',5'-AMP phosphodiesterase and guanylate cyclase in plasma membranes from liver and hepatomas of different degrees of malignancy]
[Effect of hypolipidemic preparations on basal and stimulated adenylate cyclase activity in tumor cells]
[Effect of somatocrinin 1-40 (hpGRF-40) on human prolactinoma]
[Expression of proto-oncogenes myc and ras and hormonal regulation of adenylate cyclase in human colon tumor cells]
[Interaction of sarcolysine with beta-adrenoreceptors in tumor cells]
[Membrane receptors and coupling proteins in adenohypophyseal cells]
[Participation of the adenyl cyclase system in estradiol-activated growth of tumors in rat mammary glands]
[Proceedings: Experimental transplantable cancer and cyclic nucleotides. I. Adenyl cyclase activity and protein phosphorylating enzymes in transplantable prostatic cancer]
[Some features of cyclic adenosine monophosphate metabolism in mouse liver and hepatoma 22]
[Studies on the thyrotropin receptor and adenylate cyclase activity in various thyroid diseases: II. The properties of TSH receptor and adenylate cyclase in human thyroid tumors (author's transl)]
[The assessment of the hormonal sensitivity of tumors of the large intestine in the adenylate cyclase test]
[The effect of estradiol on the activity of cAMP-dependent protein kinase in cells of estradiol-dependent tumors of the rat mammary gland. The role of a thermally stable protein inhibitor of cAMP-dependent protein kinase]
[The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine]
[The role of protein kinase C in the adenylate cyclase activation by estradiol in the plasma membranes of estradiol-dependent tumors]
Nephrocalcinosis
Hypercalciuria revisited: one or many conditions?
Nephrolithiasis
Erratum: Use of whole-exome sequencing to identify a novel ADCY10 mutation in a patient with nephrolithiasis.
Update on primary hypercalciuria from a genetic perspective.
Use of whole-exome sequencing to identify a novel ADCY10 mutation in a patient with nephrolithiasis.
Nephrosis
cAMP Signaling Prevents Podocyte Apoptosis via Activation of Protein Kinase A and Mitochondrial Fusion.
Nervous System Diseases
Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications.
Neuralgia
Adenylate cyclase inhibition attenuates neuropathic pain but lacks pre-emptive effects in rats.
Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model.
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.
Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.
Targeting pain where it resides ... In the brain.
The 5-HT6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain.
Neurilemmoma
SAG: a Schwann cell membrane glycoprotein.
Neuroblastoma
38-Amino acid form of pituitary adenylate cyclase activating peptide induces process outgrowth in human neuroblastoma cells.
5'-Deoxy-5'-methylthioadenosine: a nucleoside which differentiates between adenosine receptor types.
A neuroblastoma clone which has dopamine-sensitive adenylate cyclase but which lacks stereospecific binding sites for the neuroleptic [3H]spiperone.
Activation of dopamine receptors does not affect phosphoinositide turnover in NCB-20 cells.
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: modulation during cell differentiation.
Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids.
Adenylate cyclase from synchronized neuroblastoma cells: responsiveness to prostaglandin E1, adenosine, and dopamine during the cell cycle.
Adenylyl cyclase in SH-SY5Y human neuroblastoma cells is regulated by intra- and extracellular calcium.
Adenylyl cyclase supersensitivity in opioid-withdrawn NG108-15 hybrid cells requires Gs but is not mediated by the Gsalpha subunit.
Adenylyl cyclase, a coincidence detector for nitric oxide.
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity.
Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor.
Agonist-induced desensitization of D1-dopamine receptors linked to adenylyl cyclase activity in cultured NS20Y neuroblastoma cells.
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Alpha 2-adrenergic receptors in neuroblastoma x glioma hybrid cells. Characterization with agonist and antagonist radioligands and relationship to adenylate cyclase.
Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy mu-opioids.
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes.
Attenuation of enkephalin activity in neuroblastoma X glioma NG108-15 hybrid cells by phospholipases.
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Barbiturates are selective antagonists at A1 adenosine receptors.
Beta-adrenoceptor, vasoactive intestinal polypeptide (VIP) and neuropeptide tyrosine (NPY) receptors functionally coupled to adenylate cyclase in the human neuroblastoma SK-N-MC cell line.
Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells.
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells.
Calmodulin inhibits entry of Bordetella pertussis adenylate cyclase into animal cells.
cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes.
Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes.
Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes.
Cannabinoid inhibition of adenylate cyclase: relative activity of constituents and metabolites of marihuana.
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides.
CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.
Cell-free desensitization of opioid inhibition of adenylate cyclase in neuroblastoma X glioma NG108-15 hybrid cell membranes.
Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase.
Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line.
Characterization of muscarinic receptors: type M2 (subtype B) on neuro-2A neuroblastoma cells.
Cholera toxin activation of neuroblastoma adenylate cyclase.
Cholera toxin covalently linked with horseradish peroxidase does not activate the adenylate cyclase of neuroblastoma cells.
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Comparison between vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide levels in neuroblastoma tumour tissues.
Comparison of binding affinities and adenylate cyclase inhibition for the determination of efficacy at mu-opioid receptors in a neuroblastoma cell line.
Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines.
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.
Control of opiate receptor-adenylate cyclase interactions by calcium ions and guanosine-5'-triphosphate.
Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System.
Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells.
Cyclic AMP-mediated desensitization of D1 dopamine receptor-coupled adenylyl cyclase in NS20Y neuroblastoma cells.
D1 dopamine receptors of NS20Y neuroblastoma cells are functionally similar to rat striatal D1 receptors.
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Decreased GTP-stimulated adenylyl cyclase activity in HPRT-deficient human and mouse fibroblast and rat B103 neuroblastoma cell membranes.
Degradation of choleragen bound to cultured human fibroblasts and mouse neuroblastoma cells.
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Demonstration of acetylcholine-sensitive adenyl cyclase in malignant neuroblastoma cells in culutre.
Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells.
Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and beta 2-adrenoceptor-expressing NG108-15 cells.
Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid.
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture.
Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture.
Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture.
Effect of lysolecithin of guanylate and adenylate cyclase activities in neuroblastoma cells in culture.
Effect of neurotransmitters, Guanosine triphosphate, and divalent ions on the regulation of adenylate cyclase activity in malignant and adenosine cyclic 3':5'-monophosphate-induced "differentiated" neuroblastoma cells.
Effect of phospholipases on chronic opiate action in neuroblastoma X glioma NG108-15 hybrid cells.
Effects of adenosine analogues on basal, prostaglandin E1- and forskolin-stimulated cyclic AMP formation in intact neuroblastoma cells.
Effects of amino and ammonio derivatives of adenosine on smooth muscle preparations and mouse neuroblastoma adenylate cyclase.
Effects of chronic exposure to ethanol on the prostaglandin E1 receptor-mediated response and binding in a murine neuroblastoma clone (N1E-115).
Effects of nitric oxide on adenylyl cyclase stimulation in N18TG2 neuroblastoma cells.
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Efficacy and tolerance of narcotic analgesics at the mu opioid receptor in differentiated human neuroblastoma cells.
Efficacy of inverse agonists in cells overexpressing a constitutively active beta2-adrenoceptor and type II adenylyl cyclase.
Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization.
Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.
Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells.
Enkephalin inhibition of adenylate cyclase activity in neuroblastoma N18TG2 cells: effect of sulfatide incorporation.
Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells.
Evidence for [D-Ala2,D-Leu5]enkephalin-induced supersensitivity to 5-hydroxytryptamine in a neurotumor x brain hybrid cell line (NCB-20).
Factors affecting prostacyclin receptor agonist efficacy in different cell types.
Functional vasoactive intestinal polypeptide (VIP) receptors in human neuroblastoma subclones that contain VIP precursor mRNA and release VIP-like substances.
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells.
Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Guanine nucleotide-independent inhibition of adenylate cyclase by a stimulatory hormone.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
High-affinity calmodulin binding is required for the rapid entry of Bordetella pertussis adenylyl cyclase into neuroblastoma cells.
Human A-type ANP receptor upregulation by PACAP and carbachol in neuroblastoma cells.
Identification and characterization of functional D1 dopamine receptors in a human neuroblastoma cell line.
Identification of a domain in Bordetella pertussis adenylyl cyclase important for subunit interactions and cell invasion activity.
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.
Increased expression of ubiquitin during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in culture.
Independent regulation of receptor-mediated cell depolarization and adenylate cyclase by 5-hydroxytryptamine (serotonin) in neuroblastoma hybrid cells [proceedings]
Induction of adenylate cyclase sensitive dopamine D2-receptors in retinoic acid induced differentiated human neuroblastoma SHSY-5Y cells.
Induction of catecholamine-responsive adenylate cyclase in HeLa cells by sodium butyrate. Evidence for a more efficient stimulatory regulatory component.
Inhibition by ethanol of forskolin-stimulated adenylate cyclase in a murine neuroblastoma clone (N1E-115).
Inhibition by lithium of PGE1-sensitive adenylate cyclase in neuroblastoma X glioma hybrid cells: approach to the attenuation of the opiate withdrawal syndrome.
Inhibition by methylmercuric chloride of prostaglandin E1-sensitive adenylate cyclase activity in glioma but not in neuroblastoma cells in culture.
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment.
Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds.
Inhibition of phospholipase C-epsilon by Gi-coupled receptors.
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells.
Interaction of 2',3'-di-O-nitro-5'-(N-ethylcarboxamido)adenosine with adenosine receptors in intestinal smooth muscle.
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins.
Interaction of manganese with NB41A neuroblastoma adenylate cyclase.
Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Isolation of a protein fraction from Bordetella pertussis that facilitates entry of the calmodulin-sensitive adenylate cyclase into animal cells.
Lipid requirement for long-lived morphine-dependent activations of adenylate cyclase of neuroblastoma X glioma hybrid cells.
Long-term morphine treatment enhances proteasome-dependent degradation of G beta in human neuroblastoma SH-SY5Y cells: correlation with onset of adenylate cyclase sensitization.
Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.
Manganese inhibits adenylate cyclase activity and stimulates phosphodiesterase activity in neuroblastoma cells: its possible implication in manganese-poisoning.
Maxadilan interacts with receptors for pituitary adenylyl cyclase activating peptide in human SH-SY5Y and SK-N-MC neuroblastoma cells.
Mechanism of action of cholera toxin on intact cells. Generation of A1 peptide and activation of adenylate cyclase.
Mechanism of action of cholera toxin: studies on the lag period.
Membrane fatty acids, lipid peroxidation and adenylate cyclase activity in cultured neural cells.
Modification of neuroblastoma x glioma hybrid NG108-15 adenylate cyclase by vanadium ions.
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
Modulation of adenylate cyclase activity by a cytosolic factor following chronic opiate exposure in neuroblastoma x glioma NG108-15 hybrid cells.
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.
Morphine dependence in human neuroblastoma SH-SY5Y cells is associated with adaptive changes in both the quantity and functional interaction of PGE1 receptors and stimulatory G proteins.
Morphine receptors as regulators of adenylate cyclase activity.
Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity.
Mouse neuroblastoma cell adenylate cyclase: regulation by 2-chloroadenosine, prostaglandin E1 and the cations Mg2+, Ca2+ and Mn2+.
Mu and delta opiate receptors coupled negatively to adenylate cyclase on embryonic neurons from the mouse striatum in primary cultures.
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation.
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Muscarinic pharmacology of the inhibition of adenylate cyclase in N18TG2 neuroblastoma cells.
Muscarinic receptor binding is inhibited by quinacrine.
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Neuroblastoma adenylate cyclase. Role of 2-chloroadenosine, prostaglandin E1, and guanine nucleotides in regulation of activity.
Neuroblastoma cell adenylate cyclase: direct activation by adenosine and prostaglandins.
Neuroblastoma X glioma NG108-15 hybrid cells cultured in a serum-free chemically defined medium: effects on acute and chronic opiate regulation of adenylate cyclase activity.
Neuroprotective Effect of PACAP on Translational Control Alteration and Cognitive Decline in MPTP Parkinsonian Mice.
Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase.
Ni-coupled receptors in cultured neural hybrid cells: cell specificity for dibutyryl cyclic AMP-induced down-regulation but not morphological differentiation.
Nitric oxide selectively inhibits adenylyl cyclase isoforms 5 and 6.
Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.
NPY-stimulated Ca2+ mobilization in SK-N-MC cells is enhanced after isoproterenol treatment.
Opiate-dependent modulation of adenylate cyclase.
Opioid activities and structures of alpha-casein-derived exorphins.
Opioid peptides derived from food proteins. The exorphins.
Opioid signal transduction in intact and fragmented SH-SY5Y neural cells.
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities.
Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor.
Pituitary adenylate cyclase activating peptide and its receptors are expressed in human neuroblastomas.
Pituitary adenylate cyclase activating peptide and vasoactive intestinal polypeptide: differentiation effects on human neuroblastoma NB-OK-1 cells.
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in ganglioneuroblastoma and neuroblastoma.
Potentiation of opiate action in neuroblastoma N18TG2 cells by lipid incorporation.
Production of immunoreactive pituitary adenylate cyclase activating polypeptide (PACAP) by human neuroblastoma cells, IMR-32: detection and characterization with monoclonal and polyclonal antibodies against different epitopes of PACAP.
Prolonged exposure of human neuroblastoma SH-SY5Y cell line to morphine and oxotremorine modulates signal transduction in adenylate cyclase system.
Prostaglandin D2, a neuromodulator.
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via ?-catenin stabilization.
Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists.
Protein kinase C regulates adenosine A2a receptor mRNA expression in SH-SY5Y cells.
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells.
Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies.
Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs.
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. II. Long lived increase of adenylate cyclase activity mediated by alpha receptors.
Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.
Regulation of cellular Gs alpha levels and basal adenylyl cyclase activity by expression of the beta 2-adrenoceptor in neuroblastoma cell lines.
Regulation of Gi by the CB1 cannabinoid receptor C-terminal juxtamembrane region: structural requirements determined by peptide analysis.
Regulation of stimulatory adenylyl cyclase signaling during forskolin-induced differentiation of mouse neuroblastoma x rat glioma (NG108-15) cells.
Relationship between desensitization and sequestration of muscarinic cholinergic receptors in two neuronal cell lines.
Remifentanil produces cross-desensitization and tolerance with morphine on the mu-opioid receptor.
Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines.
Retinoic acid-induced regulation of neuropeptide Y receptor expression and function in the neuroepithelioma line SK-N-MC.
Role of phosphodiesterase II in cross talk between cGMP and cAMP in human neuroblastoma NB-OK-1 cells.
Role of receptor regulation in opioid tolerance mechanisms.
Secretin receptors on neuroblastoma cell membranes: characterization of 125I-labeled secretin binding and association with adenylate cyclase.
Segregation of discrete GS alpha-mediated responses that accompany homologous or heterologous desensitization in two related somatic hybrids.
Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation.
Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor.
Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells.
SK-N-BE: a human neuroblastoma cell line containing two subtypes of delta-opioid receptors.
Specific receptor-mediated inhibition of cyclic AMP synthesis by dopamine in a neuroblastoma X brain hybrid cell line NCB-20.
Specificity of interactions of receptors and effectors with GTP-binding proteins in native membranes.
Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?
Stimulation of adenylyl cyclase mediated by phospholipase C-linked M3 muscarinic receptor in human neuroblastoma SK-N-BE (2) C cells.
Stimulation of neuroblastoma adenylate cyclase by arachidonic acid metabolites.
Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes.
Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist.
Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma.
Studies on synapse formation and opiate dependence.
Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells.
The coupling of muscarinic receptors to hydrolysis of inositol lipids in human neuroblastoma SH-SY5Y cells.
The delta-opioid receptor in SK-N-BE human neuroblastoma cell line undergoes heterologous desensitization.
The effects of exposure to unsaturated fatty acids on opiate receptors, prostaglandin E1 receptors, and adenylate cyclase activity of neuroblastoma x glioma hybrid cells.
The expression of a novel Ca2+/CaM stimulated adenylyl cyclase activity in the neuroblastoma cell line Lan-1 is regulated by cell density.
The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.
The interaction of Ca2+ with the calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK.
The role and specificity of guanine nucleotide binding proteins in receptor-effector coupling.
Thyroid effects on adenosine 3',5'-monophosphate levels and adenylate cyclase in cultured neuroblastoma cells.
Tolerance and dependence evoked by an endogenous opiate peptide.
Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion.
Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells.
Up-regulation of a constitutively active form of the beta2-adrenoceptor by sustained treatment with inverse agonists but not antagonists.
Up-regulation of angiotensin II receptors by in vitro differentiation of murine N1E-115 neuroblastoma cells.
Vasoactive intestinal peptide: autocrine growth factor in neuroblastoma.
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
[Adenylate cyclase in synchronized neuroblastoma cells: enzyme response during the cell cycle]
[Change in adenyl cyclase activity in the differentiation of neuroblastoma cells]
Neurodegenerative Diseases
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders.
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.
Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration.
Neurodegenerative disease: Pituitary adenylate cyclase activator ameliorates SBMA.
Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects.
Pituitary Adenylyl Cyclase Activating Polypeptide (PACAP) Signaling and the Cell Cycle Machinery in Neurodegenerative Diseases.
Protective role of endogenous PACAP in inflammation-induced retinal degeneration.
The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration.
Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury.
Neuroectodermal Tumors, Primitive
Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Neuroendocrine Tumors
Peptide receptors in neuroendocrine tumors of the lung as potential tools for radionuclide diagnosis and therapy.
Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines.
Neurofibromatoses
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways.
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.
Neurofibromatosis 1
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways.
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.
Gamma neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila.
Neurofibrosarcoma
Aberrant cAMP Metabolism in NF1 Malignant Peripheral Nerve Sheath Tumor Cells.
Neurogenic Inflammation
Effect of pituitary adenylate cyclase activating polypeptide-38 on sensory neuropeptide release and neurogenic inflammation in rats and mice.
Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat.
Protective effects of PACAP in ischemia.
Neuroinflammatory Diseases
Implications of VIP and PACAP in Parkinson's disease: what do we know so far?
Neuromuscular Diseases
The metabolism of cyclic-3'-5'-adenosine monophosphate (cAMP) in diseased muscle.
Obesity
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.
A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Adenylate cyclase activity in brown adipose tissue of the genetically obese (ob/ob) mouse.
Adenylyl cyclase 3 haploinsufficiency confers susceptibility to diet-induced obesity and insulin resistance in mice.
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
Adult type 3 adenylyl cyclase-deficient mice are obese.
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice.
Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans.
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Application of agents active at the alpha 2-adrenoceptor of fat cells to the treatment of obesity--a critical appraisal.
Beta 3-adrenergic activation of adenylyl cyclase in mouse white adipocytes: modulation by GTP and effect of obesity.
Beta-adrenergic responsiveness of adenylate cyclase in human adipocyte plasma membranes in obesity and after massive weight reduction.
beta-Adrenoceptor density and adenylyl cyclase activity in obese rabbit hearts.
Control mechanisms in brown adipose tissue plasma membrane.
Defective stimulation of adipocyte adenylate cyclase, blunted lipolysis, and obesity in pseudohypoparathyroidism 1a.
Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity.
Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes.
Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway.
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Experimental basis of obesity.
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.
Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity.
Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study.
Insulin downregulates M(2)-muscarinic receptors in adult rat atrial cardiomyocytes: a link between obesity and cardiovascular complications.
Liraglutide reduces body weight by upregulation of adenylate cyclase 3.
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating.
Quantitation of inhibitory G-proteins in fat cells of obese and normal-weight human subjects.
Regulation of cardiac adenylate cyclase activity in rodent models of obesity.
Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial ?-adrenergic system and does not compromise cardiac function.
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
[Attenuation of inhibitory influence of hormones on adenylyl cyclase systems in the myocardium and brain of rats with obesity and type 2 diabetes mellitus and effect of intranasal insulin on it].
[BETA-ADRENERGIC REGULATION OF THE ADENYLYL CYCLASE SIGNALING SYSTEM IN MYOCARDIUM AND BRAIN OF RATS WITH OBESITY AND TYPES 2 DIABETES MELLITUS AND THE EFFECT OF LONG-TERM INTRANASAL INSULIN TREATMENT].
[THE EFFECTS OF LONG-TERM METFORMIN TREATMENT ON THE ACTIVITY OF ADENYLYL CYCLASE SYSTEM AND NO-SYNTHASES IN THE BRAIN AND THE MYOCARDIUM OF RATS WITH OBESITY].
Obstetric Labor, Premature
Adenosine 3',5'-monophosphate analogs and beta-adrenergic agonists induce the synthesis of the major surfactant apoprotein in human fetal lung in vitro.
Ocular Hypotension
Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions.
Ocular Motility Disorders
Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease.
Optic Nerve Injuries
Effects of PACAP on Intracellular Signaling Pathways in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress.
Osteogenesis Imperfecta
The new bone biology: pathologic, molecular, and clinical correlates.
Osteolysis
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Osteomalacia
Humoral hypercalcaemia of malignancy: report of two further patients with biochemical studies on tumour extracts.
Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia.
Osteopetrosis
The new bone biology: pathologic, molecular, and clinical correlates.
Osteoporosis
By inhibiting ADCY5, miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture.
Cortisone-induced osteoporosis: effects on bone adenylate cyclase.
The new bone biology: pathologic, molecular, and clinical correlates.
Osteosarcoma
1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line.
1,25-dihydroxyvitamin D-3 and 24,25-dihydroxyvitamin D-3 affect parathormone (PTH) -sensitive adenylate cyclase activity and alkaline phosphatase secretion of osteoblastic cells through different mechanisms of action.
Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.
Adenylate cyclase enhancing factor from rat osteosarcoma cytosol.
Adenylate cyclase in plasma membranes purified from rat osteogenic sarcoma.
Adenylate cyclase of osteoblast-like cells from rat osteosarcoma is stimulated by calcitonin as well as parathyroid hormone.
Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture.
An adenylate cyclase activating factor in cytosol of rat osteogenic sarcoma [proceedings]
Analogues of human parathyroid hormone (1-31)NH(2): further evaluation of the effect of conformational constraint on biological activity.
Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: cyclic lactams of the receptor binding region.
Bone and kidney adenylate cyclase-stimulating activity produced by a hypercalcemic canine adenocarcinoma line (CAC-8) maintained in nude mice.
Calcitonin gene-related peptide (CGRP) acts independently of calcitonin on cyclic AMP formation in clonal osteogenic sarcoma cells (UMR 106-01).
Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4).
Characteristics of prostate-derived growth factors for cells of the osteoblast phenotype.
Characterization of an osteoblast-like clonal cell line which responds to both parathyroid hormone and calcitonin.
Comparison of bone and osteosarcoma adenylate cyclase. Effects of Mg2+, Ca2+, ATP4- and HATP3- in the assay mixture.
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme.
Comparison of renal and osseous binding of parathyroid hormone and hormonal fragments.
Dexamethasone increases G alpha q-11 expression and hormone-stimulated phospholipase C activity in UMR-106-01 cells.
Differential effects of parathyroid hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured rat osteoblast-like cells.
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation.
Effect of 1,25-dihydroxyvitamin D3 on cyclic AMP responses to hormones in clonal osteogenic sarcoma cells.
Effects of beta-adrenergic blockade in an osteoblast-like cell line.
Effects of retinoic acid on alkaline phosphatase messenger ribonucleic acid, catecholamine receptors, and G proteins in ROS 17/2.8 cells.
Estimation of biologically active intact parathyroid hormone in normal and hyperparathyroid sera by sequential N-terminal immunoextraction and midregion radioimmunoassay.
Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy.
Expression and characterization of a recombinant human parathyroid hormone secreted by Escherichia coli employing the staphylococcal protein A promoter and signal sequence.
Expression of human parathyroid hormone in Escherichia coli.
Formycin 5'-triphosphate, a fluorescent analog of ATP, as a substrate for adenylate cyclase.
Glucocorticoid and 1,25-dihydroxyvitamin D modulate the degree of adenosine 3',5'-monophosphate-dependent protein kinase isoenzyme I and II activation by parathyroid hormone in rat osteosarcoma cells.
Gold(III) inhibits activated human osteosarcoma adenylate cyclase by an action at or near the catalytic component.
High-yield expression of fully bioactive N-terminal parathyroid hormone analog in Escherichia coli.
HMGB1 expression and release by bone cells.
Humoral hypercalcaemia of malignancy: report of two further patients with biochemical studies on tumour extracts.
Humoral hypercalcemia of malignancy.
Influence of the amino-terminus on in vitro and in vivo biological activity of synthetic parathyroid hormone-like peptides of malignancy.
Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
Inorganic Phosphate as A Signaling Molecule: A Potential Strategy in Osteosarcoma Treatment.
Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway.
Insulin sensitizes a cultured rat osteogenic sarcoma cell line to hormones which activate adenylate cyclase.
Interactive regulation of signalling pathways in bone cells: possible modulation of PGE2-stimulated adenylyl cyclase activity by protein kinase C.
Interleukin-1 beta induces the synthesis of adenylyl cyclase in Swiss 3T3 fibroblasts and MG-63 osteosarcoma cells.
Lactam formation increases receptor binding, adenylyl cyclase stimulation and bone growth stimulation by human parathyroid hormone (hPTH)(1-28)NH2.
Large scale preparation of recombinant human parathyroid hormone 1-84 from Escherichia coli.
Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106.
Membranes from a transplantable osteogenic sarcoma responsive to parathyroid hormone and prostaglandins: regulation of adenylate cyclase and of hormone metabolism.
NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.
Osteosarcoma cytosol factor promotes parathyroid hormone stimulation of adenylate cyclase independent of GTP.
Oxidation of recombinant human parathyroid hormone: effect of oxidized position on the biological activity.
Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells. Hormone competition and site heterogeneity.
Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells.
Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase.
Parathyroid hormone stimulation of the Na+/K+ pump in rat clonal osteosarcoma cells.
Parathyroid hormone-related protein of malignancy: active synthetic fragments.
Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma.
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
Proceedings: hormone-responsive adenylate cyclase in a transplantable osteogenic sarcoma in the rat.
Production and characterisation of immunoreactive calcitonin gene-related peptide (CGRP) from a CGRP receptor-positive cloned osteosarcoma cell line (UMR 106.01).
Properties of a factor in cytosol that enhances hormones-stimulated adenylate cyclase activity.
Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells.
Protein kinase C-activating domains of parathyroid hormone-related protein.
Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with hypercalcemia.
Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2).
Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity.
Receptor activator of NF-kappaB ligand protein expression in UMR-106 cells is differentially regulated by parathyroid hormone and calcitriol.
Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide.
Skeletal alkaline phosphatase specific activity is an index of the osteoblastic phenotype in subpopulations of the human osteosarcoma cell line SaOS-2.
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2).
Stimulation of membrane-associated protein kinase-C activity in spleen lymphocytes by hPTH-(1-31)NH2, its lactam derivative, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, and hPTH-(1-30)NH2.
Synthesis of a gene encoding parathyroid hormone-like protein-(1-141): purification and biological characterization of the expressed protein.
Synthesis of human parathyroid-hormone-related protein(1-141) in Saccharomyces cerevisiae. A correct amino-terminal processing vital for the hormone's biological activity is obtained by an ubiquitin fusion protein approach.
Synthetic parathyroid hormone-like protein-(1-74): biochemical and physiological characterization.
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
The biological properties of bovine parathyroid hormone (1-41), a fragment generated from the native hormone by human leukocytes.
The bovine renal parathyroid hormone (PTH) receptor has equal affinity for two different amino acid sequences: the receptor binding domains of PTH and PTH-related protein are located within the 14-34 region.
The effect of 1,25-dihydroxyvitamin D3 on human osteoblast-like osteosarcoma cell: modification of response to PTH.
The inhibitory guanine nucleotide regulatory protein modulates agonist-stimulated cAMP production in rat osteosarcoma cells.
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.
The role of Mg2+ in hormone stimulation of rat osteosarcoma adenylate cyclase.
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists.
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy.
Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1-34).
Ovarian Neoplasms
Adenylate cyclase in human ovarian cancers: sensitivity to gonadotropins and nonhormonal activators.
Pituitary adenylate cyclase activating polypeptide (PACAP) in human ovarian cancers.
Pancreatic Neoplasms
Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells.
cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition.
Forskolin and phorbol ester have opposite effects on the expression of mucin-associated sialyl-Lewis(a) in pancreatic cancer cells.
Genome-wide pathway analysis in pancreatic cancer.
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.
Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.
Secretion of MUC5AC mucin from pancreatic cancer cells in response to forskolin and VIP.
Pancreatitis
Adenyl cyclase and cyclic AMP (cAMP) in acute experimental pancreatitis.
Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats.
[Effects of analogs of pituitary adenylate cyclase activating polypeptide on acute pancreatitis in rats]
[On PACAP-aggravated experimental acute pancreatitis]
Pancreatitis, Acute Hemorrhagic
Adenyl cyclase and cyclic AMP (cAMP) in acute experimental pancreatitis.
Papilloma
Phorbol myristate acetate uncouples the relationship between beta-adrenergic receptors and adenyl cyclase in mouse epidermis: a phenotypic trait in papillomas.
Paralysis
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Interaction of lipopolysaccharide endotoxin produced from Escherichia coli with D-tubocurarine at the nicotinic2 receptor and adenosine 3':5' cyclic monophosphate during physiological contraction in skeletal muscle.
Paraparesis, Spastic
Child Neurology: Spastic paraparesis and dystonia with a novel ADCY5 mutation.
Parathyroid Neoplasms
Adenylate cyclase activity in human parathyroid tissues: reduced sensitivity to suppression by calcium in parathyroid adenomas as compared with normal glands form normocalcemic subjects or noninvolved glands from hyperparathyroid subjects.
Hormone receptors and cyclic nucleotide metabolism in cancer cells.
Human parathyroid adenoma adenylate cyclase: stimulation by histamine that is blocked by cimetidine.
Parkinson Disease
Antagonism of striatal muscarinic receptors inhibiting dopamine D1 receptor-stimulated adenylyl cyclase activity by cholinoceptor antagonist used to treat Parkinson's disease.
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Dopamine-sensitive adenylate cyclase activity in the caudate nucleus and adrenal medulla in Parkinson's disease and in liver cirrhosis.
Dopamine-sensitive adenylate cyclase activity in the striatum in Parkinson's disease.
Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications.
Effects of pituitary adenylate cyclase activating polypeptide and its fragments on retinal degeneration induced by neonatal monosodium glutamate treatment.
Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats.
Impaired ?-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.
Implications of VIP and PACAP in Parkinson's disease: what do we know so far?
Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease.
Opposing effects of dopaminergic to cholinergic compounds on a cerebral dopamine-activated adenylate cyclase.
Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells.
Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease.
Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats.
Sensitization of dopamine-stimulated adenylyl cyclase in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys and patients with idiopathic Parkinson's disease.
SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?
The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors.
The differential behavioural effects of benzazepine D1 dopamine agonists with varying efficacies, co-administered with quinpirole in primate and rodent models of Parkinson's disease.
[Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]
Parkinsonian Disorders
Dopamine-stimulated adenylate cyclase activity in the human brain: changes in Parkinsonism.
Peptic Ulcer
Human gastric mucosal adenylate cyclase: activation by histamine-H2-receptor stimulation and inhibition by cimetidine in vitro and in peptic ulcer patients.
Peptic ulcer disease: absence of antibodies stimulating the histamine sensitive adenylate cyclase of gastric mucosal cells.
Pericarditis
Pericardial disease in renal patients.
Perinephritis
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension.
Periodontitis
Enhancement of carbachol-induced amylase secretion in parotid glands from rats with experimental periodontitis.
[Adenylate cyclase and guanylate cyclase in the saliva of healthy persons and in periodontitis]
Peripheral Nerve Injuries
Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration.
Injury-associated PACAP expression in rat sensory and motor neurons is induced by endogenous BDNF.
Pituitary adenylate cyclase activating peptide expression in the rat dorsal root ganglia: up-regulation after peripheral nerve injury.
Peritonitis
Effects of isoproterenol on diaphragmatic contractility in septic peritonitis.
Persistent Infection
Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.
Pheochromocytoma
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.
7-Deaza-9-phenyladenines. A new class of adenosine receptor antagonists.
A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.
A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase.
Adrenal pheochromocytoma PC12h cells respond to pituitary adenylate cyclase activating polypeptide.
Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors.
Basis of false-positive glucagon tests for pheochromocytoma.
C-type natriuretic peptide neuromodulates via "clearance" receptors.
Characterization of the glucagon receptor in a pheochromocytoma.
Cooperative regulation of neurotensin content in PC12 pheochromocytoma cell cultures: effects of nerve growth factor, dexamethasone, and activators of adenylate cyclase.
Definition of subclasses of adenosine receptors associated with adenylate cyclase: interaction of adenosine analogs with inhibitory A1 receptors and stimulatory A2 receptors.
Differential response of adenylate cyclase and ATPase activities after chronic ethanol exposure of PC12 cells.
Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells.
Effect of ethanol on cyclic AMP levels in intact PC12 cells.
Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.
Enhancement of depolarization-dependent neurosecretion from PC12 cells by forskolin-induced elevation of cyclic AMP.
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner.
Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells.
Hypertrophy of pheochromocytoma cells treated with nerve growth factor and activators of adenylate cyclase.
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Lithium dramatically potentiates neurotensin/neuromedin N gene expression.
Molecular and pharmacological characterization of somatostatin receptor subtypes in adrenal, extraadrenal, and malignant pheochromocytomas.
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.
Pharmacological profile of adenosine A2 receptor in PC12 cells.
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in pheochromocytomas.
Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response.
Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway.
Regulation of adenylyl cyclase type VI activity during desensitization of the A2a adenosine receptor-mediated cyclic AMP response: role for protein phosphatase 2A.
Regulation of differentiation of PC12 cells by nerve growth factor.
Regulation of neurotensin content in adrenal medullary cells: comparison of PC12 cells to normal rat chromaffin cells in vitro.
Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors.
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.
The action of adenosine analogs on PC12 cells.
The influence of nerve growth factor on the activities of adenylate cyclase and high-affinity GTPase in pheochromocytoma PC12 cell.
Tyrosine hydroxylase is activated and phosphorylated on different sites in rat pheochromocytoma PC12 cells treated with phorbol ester and forskolin.
Pick Disease of the Brain
Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex.
Pinealoma
Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.
Pituitary ACTH Hypersecretion
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas.
Pituitary Neoplasms
'Cross-talk' between phospholipase C and adenylyl cyclase involves regulation of G-protein levels in GH3 rat pituitary cells.
7-OH-DPAT antagonizes dopamine D2 receptor-inhibited adenylyl cyclase activity.
A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.
A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity.
A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents.
Activation of Na+ channels in GH3 cells and human pituitary adenoma cells by PACAP.
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Adenylyl cyclase and cyclic nucleotide phosphodiesterases in GH-Strains of rat pituitary cells.
Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.
Calcium-dependent adenylate cyclase of pituitary tumor cells.
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
Corticotropin releasing factor stimulates cAMP formation in pituitary corticotropic tumor cells.
Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro.
Effects of long term treatment with corticotropin releasing factor on corticotropic tumor cells in vitro.
Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals.
Effects of vasoactive intestinal polypeptide (VIP) in human prolactin (PRL) secreting pituitary adenomas. Stimulation of PRL release and activation of adenylate cyclase.
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation.
Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells.
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Forskolin stimulates adenylate cyclase activity, cyclic AMP accumulation, and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.
G protein mutations in pituitary tumors: a study on Turkish patients.
Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein.
Growth factors and the anterior pituitary.
Growth hormone releasing hormone-sensitive adenylate cyclase activity in growth hormone-producing pituitary adenoma: correlation to the response of plasma growth hormone to growth hormone releasing hormone in patients with acromegaly.
GS protein mutations and pituitary tumors: functional correlates and possible therapeutic implications.
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.
GTPase-inhibiting mutations activate the alpha-chain of Gs in human tumours.
Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.
Hormone-sensitive adenylate cyclase of prolactin-producing rat pituitary adenoma (GH4C1) cells: molecular organization.
Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins.
Hypothalamic hormones modulate G protein levels and second messenger responsiveness in GH3 rat pituitary tumour cells.
Hypothalamic peptides modulate cytosolic free Ca2+ levels and adenylyl cyclase activity in human nonfunctioning pituitary adenomas.
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine.
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element.
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas.
Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin.
Muscarinic cholinergic ligand binding to intact mouse pituitary tumor cells (AtT-20/D16-16) coupling with two biochemical effectors: adenylate cyclase and phosphatidylinositol turnover.
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells).
Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.
Resistance to somatostatin (SRIH) analog therapy in acromegaly. Re-evaluation of the correlation between the SRIH receptor status of the pituitary tumor and the in vivo inhibition of GH secretion in response to SRIH analog.
Somatostatin pretreatment desensitizes somatostatin receptors linked to adenylate cyclase and facilitates the stimulation of cyclic adenosine 3':5'-monophosphate accumulation in anterior pituitary tumor cells.
Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions.
Spontaneous Intracellular Calcium Oscillations and G(s) ? Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells.
Stimulation of adrenocorticotropin secretion from AtT-20 cells by the calcium channel activator, BAY-K-8644, and its inhibition by somatostatin and carbachol.
The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells.
The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by the use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein.
Thyroliberin receptor binding and adenylyl cyclase activation in cultured prolactin-producing rat pituitary tumor cells (GH cells).
Vasoactive intestinal peptide effects on GH3 pituitary tumor cells: high affinity binding, affinity labeling, and adenylate cyclase stimulation. Comparison with peptide histidine isoleucine and growth hormone-releasing factor.
[Vasoactive intestinal peptide (VIP): specific receptors and adenylate cyclase activation in a human prolactin-secreting pituitary tumor]
Plague
[Adenylate cyclase of the causative agent of plague: its purification and properties]
[Adenylate cyclase. A possible factor in the pathogenicity of Yersinia pestis]
[Evaluation of the modulating action of Yersinia pestis adenylate cyclase on guinea pig peritoneal leukocytes using chemiluminescence]
[Role of histamine receptors of mouse and guinea pig peritoneal leukocytes in the pathogenetic effect of Yersinia pestis adenylate cyclase]
Plasmacytoma
Stimulation by tubulin of an adenylate cyclase from murine plasmacytoma.
Stimulation of chelators of the membrane bound adenylate cyclase in plasmacytoma cells.
Pneumonia, Viral
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Polycystic Kidney Diseases
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Generation and phenotypic characterization of Pde1a mutant mice.
Polycystic Kidney, Autosomal Dominant
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells.
Generation and phenotypic characterization of Pde1a mutant mice.
KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease.
The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro.
The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Recessive
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells.
Polycythemia Vera
[Thrombocyte adenylate cyclase activity in polycythemia vera]
Polyuria
"Lithium" A Versatile Tool to Understand Renal Physiology"
Adenyl cyclase activity in kidneys of rats with lithium-induced polyuria.
Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats.
Correction of polyuria by activation of adenylate cyclase in Brattleboro rats.
Lithium-induced polyuria: effect of lithium on adenylate cyclase and adenosine 3',5'-monophosphate phosphodiesterase in medullary ascending limb of Henle's loop and in medullary collecting tubules.
The relation between vasopressin stimulation of renal adenyl cyclase and lithium-induced polyuria in rats.
Pre-Eclampsia
Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Adenylate cyclase and guanylate cyclase activity in normal and leukemic human lymphocytes.
Premature Birth
EBF1 Gene mRNA Levels in Maternal Blood and Spontaneous Preterm Birth.
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.
Primary Dysautonomias
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs.
Prolactinoma
Combined effects of vasoactive intestinal peptide and dopamine on adenylate cyclase in prolactin-secreting cells.
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas.
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
In vitro studies on prolactin release and adenylate cyclase activity in human prolactin-secreting pituitary adenomas. Different sensitivity of macro- and microadenomas to dopamine and vasoactive intestinal polypeptide.
Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.
Resistance to bromocriptine in prolactinomas.
[Effect of somatocrinin 1-40 (hpGRF-40) on human prolactinoma]
Propionic Acidemia
Effects of methylmalonate and propionate on [3H]glutamate binding, adenylate cyclase activity and lipid synthesis in rat cerebral cortex.
Prostatic Neoplasms
?-arrestin2 mediates ?-2 adrenergic receptor signaling inducing prostate cancer cell progression.
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity.
Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action.
Distribution of Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-activated adenylyl cyclase in normal and neoplastic tissue with special reference to the prostate.
Inhibition of soluble adenylyl cyclase increases the radiosensitivity of prostate cancer cells.
Low expression of Galpha protein subunits in human prostate cancer.
Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+ -dependent adenylyl cyclase(s).
PACAP(6-38) inhibits the growth of prostate cancer cells.
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells.
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide stimulate interleukin-6 production in prostate cancer cells and prostatic epithelial cells.
[Proceedings: Experimental transplantable cancer and cyclic nucleotides. I. Adenyl cyclase activity and protein phosphorylating enzymes in transplantable prostatic cancer]
Proteinuria
Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria.
Pruritus
G protein-mediated signal transduction is affected in primary biliary cirrhosis.
[Cannabinoids--signal transduction and mode of action]
Pseudohypoparathyroidism
A case of Albright's hereditary osteodystrophy-like syndrome complicated by several endocrinopathies: normal Gs alpha gene and chromosome 2q37.
A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds.
Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism.
Characterization of Albright hereditary osteodystrophy and related disorders.
Clinical investigation of olfactory and auditory function in type I pseudohypoparathyroidism: participation of adenylate cyclase system.
Coupling defect of thyrotropin receptor and adenylate cyclase in a pseudohypoparathyroid patient.
Defective stimulation of adipocyte adenylate cyclase, blunted lipolysis, and obesity in pseudohypoparathyroidism 1a.
Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism.
Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I.
Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.
Father to son transmission of decreased Ns activity in pseudohypoparathyroidism type Ia.
Fibroblast defect in pseudohypoparathyroidism, type I: reduced activity of receptor-cyclase coupling protein.
Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy.
Heterogeneous mutations in the gene encoding the alpha-subunit of the stimulatory G protein of adenylyl cyclase in Albright hereditary osteodystrophy.
Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese family.
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis.
New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase.
Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency.
On the lipolytic action of parathyroid hormone in man.
Parathyroid hormone and vitamin D receptors.
Parathyroid hormone-sensitive adenyl cyclase from the renal cortex of a patient with pseudohypoparathyroidism.
Partial gonadotrophin-resistance in pseudohypoparathyroidism.
Prevalence of three mutations in the Gs alpha gene among 24 families with pseudohypoparathyroidism type Ia.
Pseudohypoparathyroidism with normal serum calcium level.
Pseudohypoparathyroidism, a novel mutation in the betagamma-contact region of Gsalpha impairs receptor stimulation.
Pseudohypoparathyroidism: an inherited disorder of adenylate cyclase.
Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.
Pseudohypoparathyroidism: mutation affecting adenylate cyclase.
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Selective resistance to parathyroid hormone caused by a novel uncoupling mutation in the carboxyl terminus of G alpha(s). A cause of pseudohypoparathyroidism type Ib.
Targeted disruption of Gnas in embryonic stem cells.
The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism.
The new bone biology: pathologic, molecular, and clinical correlates.
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
[Cutaneous osteoma and Albright's hereditary osteodystrophy]
[Pseudohypoparathyroidism and the concept of hormonal resistance. Types Ia and Ic and pseudohypoparathyroidism]
[Pseudohypoparathyroidism and the concept of hormonal resistance. Types Ib and II]
[Pseudohypoparathyroidism: a generalized and multiple disorder in the adenyl cyclase system]
[Pseudohypoparathyroidism: mutation of adenylate cyclase]
[The usefulness of the teriparatide acetate (Parathar) infusion test in the diagnosis of pseudohypoparathyroidism]
Pseudopseudohypoparathyroidism
Cutaneous ossification in Albright's hereditary osteodystrophy.
Psoriasis
Abnormalities in adenyl cyclase in psoriasis, a hyperproliferative skin disease.
Cyclosporin A induced augmentation of the beta-adrenergic adenylate cyclase response of pig epidermis.
Decreased epidermal aryl hydrocarbon hydroxylase and localized pustular psoriasis.
Electron microscopic cytochemical demonstration of adenyl cyclase activity in psoriatic epidermis.
Further studies on adenyl cyclase in psoriasis.
Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis.
Inhibition of T cell cAMP formation by cyclosporin A and FK506.
Neurotransmitters, neuropeptides and their receptors interact with immune response in healthy and psoriatic skin.
Ultrastructural localization and differentiation of membrane-bound ATP utilizing enzymes including adenyl cyclase in normal and psoriatic epidermis.
[Lack of beta-adrenergic stimulation of membrane bound adenyl cyclase in psoriasis as compared to normal epidermis (author's transl)]
Puberty, Precocious
Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function.
Pulmonary Disease, Chronic Obstructive
Identification of hub genes and functional modules in colon adenocarcinoma based on public databases by bioinformatics analysis.
Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats.
Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and beta-sympathicomimetics.
The role of adenylyl cyclase isoform 6 in ?-adrenoceptor signalling in murine airways.
Pulmonary Fibrosis
Impairment in coupled beta-adrenergic receptor and adenylate cyclase system during bleomycin-induced lung fibrosis in hamsters.
Pyoderma
Adenylate cyclase activity of cultural strains of Neisseria gonorrhoeae and Staphylococcus aureus.
Rabies
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Rectal Neoplasms
Peculiarities of hormonal regulation of adenylate cyclase and lipid composition in colonic and rectal tumors.
Reflex, Abnormal
A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI).
Renal Insufficiency
Abnormality of adenylate cyclase regulation in human platelet membranes in renal insufficiency.
Adenylate cyclase activity and cAMP content of human platelets in uraemia.
Inhibition of renal adenylate cyclase by plasma from uremic patients.
Regulation of thrombocyte adenylate cyclase activity in terminal renal failure.
Surgically induced uremia in rats. II: Osseous PTH-susceptible signaling systems as predictors of bone resorption.
The role of testicular adenylate cyclase in the hypogonadism of renal insufficiency.
Renal Insufficiency, Chronic
Effects of dopamine on kidney function and on the adenyl cyclase phosphodiesterase system in man.
Reperfusion Injury
Elevated cyclic adenosine monophosphate ameliorates ischemia-reperfusion injury in rat cardiac allografts.
Role of cyclic nucleotides in ischemia and reperfusion injury of canine livers.
Role of H2O2 in changing beta-adrenoceptor and adenylyl cyclase in ischemia-reperfused hearts.
Respiratory Distress Syndrome
Adenosine 3',5'-monophosphate analogs and beta-adrenergic agonists induce the synthesis of the major surfactant apoprotein in human fetal lung in vitro.
Respiratory Insufficiency
cAMP-dependent reversal of opioid- and prostaglandin-mediated depression of the isolated respiratory network in newborn rats.
Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression.
Reversal by phosphodiesterase-4 blockers of in vitro apnea in the isolated brainstem-spinal cord preparation from newborn rats.
ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression.
Respiratory Tract Infections
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Retinal Degeneration
Degree of damage compensation by various PACAP treatments in monosodium glutamate-induced retinal degeneration.
Effects of pituitary adenylate cyclase activating polypeptide and its fragments on retinal degeneration induced by neonatal monosodium glutamate treatment.
Effects of pituitary adenylate cyclase activating polypeptide in retinal degeneration induced by monosodium-glutamate.
Neuroprotective Potential of Pituitary Adenylate Cyclase Activating Polypeptide in Retinal Degenerations of Metabolic Origin.
Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.
Protective role of endogenous PACAP in inflammation-induced retinal degeneration.
Retinal Neovascularization
Beta-adrenoreceptor (?-AR) agonism influences retinal responses to hypoxia in a mouse model of retinopathy of prematurity.
Retinoblastoma
Coupling of corticotropin-releasing hormone receptors to adenylyl cyclase in human Y-79 retinoblastoma cells.
Human Y-79 retinoblastoma cells express functional corticotropin-releasing hormone receptors.
Novel high-affinity photoactivatable antagonists of corticotropin-releasing factor (CRF) photoaffinity labeling studies on CRF receptor, type 1 (CRFR1).
On the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field.
Rheumatic Diseases
Effect of gold compounds on the activity of adenylyl cyclase in human lymphocyte membranes.
Rhinitis, Allergic
[Experimental studies for botulinum toxin type A to antagonist the VIP/PACAP expression on nasal mucosa in allergic rhinitis rat].
Rhinitis, Allergic, Seasonal
[Comparison of fenoterol (Berotec) with the antiallergic benzopyrene compound PR-D 92 and a placebo in regard to the cutaneous immediate reaction in allergic patients (author's transl)]
Rhinitis, Atrophic
Adenylate cyclase activity of a 68,000-molecular-weight protein isolated from the outer membrane of Bordetella bronchiseptica.
Rickets
Parathyroid function in different stages of vitamin D deficiency rickets.
Parathyroid hormone and vitamin D receptors.
Rubinstein-Taybi Syndrome
Interstitial 16p13.3 microduplication: case report and critical review of genotype-phenotype correlation.
Sarcoma
Adenylate cyclase activity in fibroblasts transformed by Kirsten or Moloney sarcoma viruses. Decreased activity and loss of response to prostaglandin E1.
beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation.
Increased adenylate cyclase activity in rat thyroid epithelial cells expressing viral ras genes.
Interaction of Vibrio cholerae toxin with sarcoma 180 cell membranes.
Isolation and characterization of two biologically active O-glycosylated forms of human parathyroid hormone produced in Saccharomyces cerevisiae. Identification of a new motif for O-glycosylation.
Modulation of adenylate cyclase by guanine nucleotides and Kirsten sarcoma virus mediated transformation.
Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma.
Partial reversal of doxorubicin resistance by forskolin and 1,9-dideoxyforskolin in murine sarcoma S180 variants.
ras oncogene-induced transformation of a rat seminal vesicle epithelial cell line produces a marked increase of adenylate cyclase and protein kinase C activities.
Receptor-associated changes of the catecholamine-sensitive adenylate cyclase in glioma cells doubly transformed with Moloney sarcoma virus.
Triiodothyronine stimulates steroid and VEGF production in murine Leydig cells via cAMP-PKA pathway.
Sarcoma 180
Interaction of Vibrio cholerae toxin with sarcoma 180 cell membranes.
Small fragments from the A subunit of cholera toxin capable of activating adenylate cyclase.
Sarcoma, Avian
A comparison between adenylate cyclase solubilized from normal and Rous sarcoma virus-transformed chicken embryo fibroblasts.
Adenylate cyclase activity and membrane polypeptides of chick embryo fibroblasts transformed with avian sarcoma viruses.
Adenylate cyclase activity and the cAMP level are not directly correlated with transformation by avian sarcoma viruses.
Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild type and temperature sensitive Schmidt-Ruppin Rous sarcoma virus.
Adenylate cyclase and cyclic AMP phosphodiesterase of normal and Rous sarcoma virus transformed chicken embryo fibroblasts.
Alterations in components of adenylate cyclase associated with transformation of chicken embryo fibroblasts by Rous sarcoma virus.
Effect of membrane phospholipid composition changes on adenylate cyclase activity in normal and rous-sarcoma-transformed chicken embryo fibroblasts.
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Strain specificity of changes in adenylate cyclase activity in cells transformed by avian sarcoma viruses.
The increase in hormone-stimulated adenylate cyclase activity following Rous sarcoma virus transformation.
Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity.
Sarcoma, Ewing
Neuropeptide Y inhibits vasoactive intestinal peptide- and dopamine-induced cyclic AMP formation in human Ewing's sarcoma WE-68 cells.
Schistosomiasis
Granulomas in murine schistosomiasis mansoni contain vasoactive intestinal peptide-responsive lymphocytes.
Seizures
Biochemical aspects of pentylenetetrazole induced seizure.
Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.
Early-life hyperthermic seizures upregulate adenosine A2A receptors in the cortex and promote depressive-like behavior in adult rats.
Effect of interleukin-1beta on the variation of adenylyl cyclase expression in rats with seizures induced by L-glutamate.
Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat.
Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions.
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats.
Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP.
Microglia PACAP and glutamate: Friends or foes in seizure-induced autonomic dysfunction and SUDEP?
Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila.
Pharmacological inhibition of forskolin-stimulated adenylate cyclase activity in rat brain by melatonin, its analogs, and diazepam.
Seizure Suppression by High Temperature via cAMP Modulation in Drosophila.
Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats.
Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins.
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography.
Sepsis
Alterations of G-protein and adenylate cyclase signaling in rat liver during the progression of sepsis.
Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans.
Cecal Ligation and Puncture Sepsis is Associated With Attenuated Expression of Adenylyl Cyclase 9 and Increased miR-142-3p.
G protein and adenylate cyclase complex-mediated signal transduction in the rat heart during sepsis.
Impairment of beta-adrenergic signaling in healthy peripheral blood mononuclear cells exposed to serum from patients with septic shock: involvement of the inhibitory pathway of adenylyl cyclase stimulation.
Impairment of cardiac beta-adrenoceptor cellular signaling by decreased expression of G(s alpha) in septic rabbits.
Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat.
[A study on the mechanism of the cardiac adenylyl cyclase activity alteration in septic rats]
Shock, Septic
Anti-shock effect of pituitary adenylate cyclase activating polypeptide (PACAP) on experimental endotoxin shock in dogs.
Desensitization of rat cardiomyocyte adenylyl cyclase stimulation by plasma of noradrenaline-treated patients with septic shock.
Impairment of beta-adrenergic signaling in healthy peripheral blood mononuclear cells exposed to serum from patients with septic shock: involvement of the inhibitory pathway of adenylyl cyclase stimulation.
Myocardial beta adrenergic receptor coupling to adenylate cyclase during developing septic shock.
Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock.
Unexpected hyperactivity of myocardial adenylate cyclase system in endotoxic male rats.
Skin Diseases
Abnormalities in adenyl cyclase in psoriasis, a hyperproliferative skin disease.
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.
[Contemporary views of role played by neuro-humoral and adenylate cyclase systems in occupational allergic skin diseases (review of literature)]
Skin Neoplasms
Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer.
Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors.
Sleep Deprivation
Sleep deprivation increases dopamine D1 receptor antagonist [3H]SCH 23390 binding and dopamine-stimulated adenylate cyclase in the rat limbic system.
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Small Cell Lung Carcinoma
Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells.
Pituitary adenylate cyclase activating polypeptide receptors are present on small cell lung cancer cells.
Smooth Muscle Tumor
Characteristics of an adenylate cyclase coupled beta 2-adrenergic receptor in a smooth muscle tumor cell line.
Spastic Paraplegia, Hereditary
The genetic etiology in cerebral palsy mimics: The results from a Greek tertiary care center.
Spinal Cord Injuries
(284) Persistent electrical activity in primary nociceptors after spinal cord injury is maintained by scaffolded adenylyl cyclase and protein kinase A and is associated with altered adenylyl cyclase regulation.
A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI).
Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injury.
Effects of intrathecal administration of pituitary adenylate cyclase activating polypeptide on lower urinary tract functions in rats with intact or transected spinal cords.
Lack of adenylate cyclase 1 (AC1): consequences on corticospinal tract development and on locomotor recovery after spinal cord injury.
Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats.
Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury.
Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.
Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects.
Starvation
A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression.
A possible involvement of cya gene in the synthesis of cyclic guanosine 3':5'-monophosphate in E. coli.
Adenylate cyclase and phosphodiesterase in the rat gastric mucosa after starvation, feeding and pentagastrin.
amiB, a novel gene required for the growth/differentiation transition in Dictyostelium.
Changed sensitivity of adenylate cyclase signaling system to biogenic amines and peptide hormones in tissues of starving rats.
Desynchronization of cells on the developmental path triggers the formation of spiral waves of cAMP during Dictyostelium aggregation.
Developmentally regulated compartmentalization of adenylate cyclase in Dictyostelium discoideum.
Dictyostelium TRFA homologous to yeast Ssn6 is required for normal growth and early development.
Effect of nutritional status on swine adipose tissue lipolytic activities.
Effects of starvation, refeeding, and fat feeding on adipocyte ghost adenyl cyclase activity.
Genetic regulation of differentiation towards meiosis in the yeast Saccharomyces cerevisiae.
In vitro metacyclogenesis of Trypanosoma cruzi induced by starvation correlates with a transient adenylyl cyclase stimulation as well as with a constitutive upregulation of adenylyl cyclase expression.
Increased sensitivity to epinephrine stimulated lipolysis during starvation: tighter coupling of the adenylate cyclase complex.
Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A.
Modulation of expression of the stress-inducible p118 of Saccharomyces cerevisiae by cAMP. II. A study of p118 expression in mutants of the cAMP cascade.
Phosphate starvation enhances the pathogenesis of Bacillus anthracis.
Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity.
Regulation of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium.
Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium development upon starvation.
Starvation-induced increase in the parathyroid hormone/PTH-related protein receptor mRNA of bone and kidney in sham-operated and thyroparathyroidectomized rats.
The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.
[Reactivity of the adenylyl cyclase system in rat tissues to biogenic amines and peptide hormones under starvation condition]
Status Asthmaticus
[Bronchial spasm or edema, factor in the asthmatic crisis.]
Stomach Neoplasms
Desensitization by histamine of H2 receptor-mediated adenylate cyclase activation in the human gastric cancer cell line HGT-1.
Protein kinase C alpha is the isoform responsible for inhibition of histamine H2 receptor mediated stimulation of adenylate cyclase in the human gastric cancer cell line HGT-1.
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
The alpha isoform of protein kinase C inhibits histamine-stimulated adenylate cyclase activity in a particulate fraction of the human gastric cancer cell line HGT-1.
Stomach Ulcer
[The effect of laser therapy on the mechanisms for generating healing in long-term nonhealing stomach ulcers]
Stroke
Cyclic nucleotides in stroke and related cerebrovascular disorders.
Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier.
Modulation of ischemic-induced damage to cerebral adenylate cyclase in gerbils by calcium channel blockers.
Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.
Multimodal Neuroprotection Induced by PACAP38 in Oxygen-Glucose Deprivation and Middle Cerebral Artery Occlusion Stroke Models.
Regional cyclic AMP systems during secondary ischemia in gerbils: influence of anesthetic agents.
Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death.
Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.
Subarachnoid Hemorrhage
The effect of subarachnoid hemorrhage on mechanisms of vasodilation mediated by cyclic adenosine monophosphate.
Sunburn
Effects of UVB irradiation on epidermal adenylate cyclase responses in vitro: its relation to sunburn cell formation.
Supranuclear Palsy, Progressive
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Syncope
Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients.
Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients.
Synovitis
The adenylate cyclase of rheumatoid synovial fluid macrophages is more sensitive for dl-5E, 19,14-di dehydro-carbo-prostacyclin, a stable prostacyclin analogue, than for prostaglandin E2.
Tachycardia
Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptide.
Influence of a phosphodiesterase inhibitor on the chronotropic effects of glucagon and norepinephrine in fetal mouse hearts.
Milrinone inhibits sympathetic-mediated tachycardia by a postjunctional action independent of cyclic AMP.
Reduced adenylyl cyclase inhibition by carbachol and GTP during acute myocardial ischaemia.
Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects.
Specific M2-receptor activation: an alternative to treatment with beta-receptor blockers?
The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathy.
Tachycardia, Supraventricular
Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia.
Tardive Dyskinesia
Effects of ceruletide on perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine.
Rolipram, a selective c-AMP phosphodiesterase inhibitor suppresses oro-facial dyskinetic movements in rats.
Tauopathies
Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.
Teratocarcinoma
Different expression of adenylyl cyclase isoforms after retinoic acid induction of P19 teratocarcinoma cells.
Differentiation of F9 teratocarcinoma stem cells to primitive endoderm is regulated by the Gialpha2/Gsalpha axis via phospholipase C and not adenylylcyclase.
Tetanus
Bacterial toxins: potential weapons against HIV infection.
Structural Biology and Molecular Modeling to Analyze the Entry of Bacterial Toxins and Virulence Factors into Host Cells.
Synthetic peptides with antigenic specificity for bacterial toxins.
Thrombasthenia
[Adenyl cyclase activity of human blood platelets in various blood diseases]
Thrombosis
Diminished platelet adenylate cyclase activation by prostaglandin D2 in acute thrombosis.
Shear-dependent suppression of platelet thrombus formation by phosphodiesterase 3 inhibition requires low levels of concomitant Gs-coupled receptor stimulation.
Thymoma
Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity.
Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling.
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
Thyroid Cancer, Papillary
Growth suppression of thyroid cancer cells by adenylcyclase activator.
Thyroid Carcinoma, Anaplastic
Growth suppression of thyroid cancer cells by adenylcyclase activator.
Thyroid Diseases
Graves' IgG stimulation of iodide uptake in FRTL-5 rat thyroid cells: a clinical assay complementing FRTL-5 assays measuring adenylate cyclase and growth-stimulating antibodies in autoimmune thyroid disease.
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Thyroid adenylate cyclase stimulating immunoglobulins in thyroid diseases.
[Studies on the thyrotropin receptor and adenylate cyclase activity in various thyroid diseases: I. The properties of TSH receptor and adenylate cyclase in Graves' thyroid and retro-orbital adipose tissues (author's transl)]
[Studies on the thyrotropin receptor and adenylate cyclase activity in various thyroid diseases: II. The properties of TSH receptor and adenylate cyclase in human thyroid tumors (author's transl)]
Thyroid Neoplasms
Activating mutations of the TSH receptor in differentiated thyroid carcinomas.
Adenyl cyclase activity in human thyroid plasma membranes from normal human thyroid tissue and thyroid adenomas.
Adenyl cyclase activity in thyroid carcinomas.
Adenylate cyclase of a human medullary thyroid carcinoma.
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Dissociation in the response of the adenylate cyclase system to thyrotropin and prostaglandin E2 in human thyroid carcinoma tissue.
Effects of sorafenib and an adenylyl cyclase activator on in vitro growth of well-differentiated thyroid cancer cells.
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Growth inhibition of new human thyroid carcinoma cell lines by activation of adenylate cyclase through the beta-adrenergic receptor.
Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity.
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
T.S.H. receptor and adenylate cyclase in undifferentiated thyroid carcinoma.
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue.
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Thyrotropin (TSH) receptor and adenylate cyclase activity in human thyroid tumors: absence of high affinity receptor and loss of TSH responsiveness in undifferentiated thyroid carcinoma.
Thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue: lack of effect of thyroglobulin.
Thyrotropin binding and adenylate cyclase stimulation in thyroid neoplasms.
Thyrotropin receptor-adenylate cyclase function in human thyroid neoplasms.
Thyrotropin receptor: a role for thyroid tumourigenesis?
Thyrotropin regulation of adenylate cyclase activity in human thyroid neoplasms.
TSH binding correlates with TSH-stimulated thyroid adenylate cyclase activity in human thyroid tissues.
[Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction]
[Hormonal therapy in differentiated carcinoma of the thyroid gland]
[Stimulation of adenyl cyclase and fixation of iodine in human cancerous thyroid cells in culture]
[Transmembrane controls in cultured human thyroid carcinoma]
Thyroid Nodule
Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of "cold" thyroid nodules and normal human thyroid tissue.
Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules.
G protein and thyrotropin receptor mutations in thyroid neoplasia.
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Secretion and adenylate cyclase in thyroid nodules.
[Comparison of the effect of TSH and fluoride on the adenylate cyclase activity of cold thyroid nodules (author's transl)]
Thyroiditis
Prostacyclin stimulation of adenylate cyclase activity in human thyroid membranes.
Thyroid-stimulating immunoglobulins in Hashimoto's thyroiditis measured by radioreceptor assay and adenylate cyclase stimulation and their relationship to HLA-D alleles.
Thyroiditis, Autoimmune
Hyperthyroidism following hypothyroidism.
Thyroiditis, Subacute
Nature of thyrotropin displacement activity in subacute thyroiditis.
Tics
Regulation of testosterone secretion by prolactin in male rats.
Tonsillitis
[Enzyme histochemical characteristics of prostaglandin synthetase, adenylate cyclase and cAMP in a focus of inflammation in chronic tonsillitis]
Toxemia
Synthesis of ?-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.
Tremor
Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma.
Protein interaction studies for understanding the tremor pathway in Parkinson's disease.
Tuberculosis
A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis.
Adenylyl cyclase inMycobacterium tuberculosis H37Rv-A possible virulence factor.
Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection.
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain.
Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases.
An adenylyl cyclase pseudogene in Mycobacterium tuberculosis has a functional ortholog in Mycobacterium avium.
Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase.
BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice.
cAMP signaling in Mycobacterium tuberculosis.
Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.
Characterization of phylogenetically distant members of the adenylate cyclase family from mycobacteria: Rv1647 from Mycobacterium tuberculosis and its orthologue ML1399 from M. leprae.
Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling.
Comparison of the in vivo & in vitro activities of adenylate cyclase from Mycobacterium tuberculosis H37Ra (NCTC 7417).
Cyclic AMP in mycobacteria: characterization and functional role of the Rv1647 ortholog in Mycobacterium smegmatis.
Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase.
Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids.
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
Eukaryotic-like adenylyl cyclases in Mycobacterium tuberculosis H37Rv: cloning and characterization.
Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv.
Functional chimeras between the catalytic domains of the mycobacterial adenylyl cyclase Rv1625c and a Paramecium guanylyl cyclase.
Induction of cytotoxic T lymphocyte response against Mycobacterial antigen using domain I of anthrax edema factor as antigen delivery system.
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.
Interaction of RvErp protein of Mycobacterium tuberculosis with Rv2212 enhances intracellular survival of Mycobacterium smegmatis.
Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization.
New structural forms of a mycobacterial adenylyl cyclase Rv1625c.
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.
Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice.
Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases.
Purification, crystallization and preliminary X-ray diffraction analysis of the catalytic domain of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis.
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis.
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid.
Transmembrane receptor chimeras to probe HAMP domain function.
Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases.
[Changes in the properties of adenylate cyclase from guinea pig lungs in tuberculosis]
Tuberculosis, Bovine
Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis.
Tyrosinemias
[In vitro study of hepatic adenyl cyclase in cases of hereditary tyrosinemia]
Uremia
Abnormal skeletal response to parathyroid hormone in dogs with chronic uremia.
Adenylate cyclase of gastric mucosa in patients with chronic renal failure.
Cardiac beta-adrenoceptors in chronic uremia: studies in humans and rats.
Effects of uremia, acetate and bicarbonate dialysis on beta-adrenergic responsiveness as assessed by epinephrine-stimulated adenylate cyclase.
Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration.
The regulation of skeletal muscle alanine and glutamine formation and release in experimental chronic uremia in the rat: subsensitivity of adenylate cyclase and amino acid release to epinephrine and serotonin.
Unchanged hormone sensitivity of rat fat cell adenylate cyclase in uremia.
Urinary Bladder Neoplasms
Differences in adenylate cyclase activities in murine normal cells and bladder tumor cells in tissue culture.
Urinary Incontinence
Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse.
Uterine Cervical Neoplasms
Different effects of adenylyl cyclase activators and phosphodiesterases inhibitors on cervical cancer (HeLa) and breast cancer (MCF-7) cells proliferation.
GTL001 and bivalent CyaA-based therapeutic vaccine strategies against human papillomavirus and other tumor-associated antigens induce effector and memory T-cell responses that inhibit tumor growth.
miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells.
The role of ADCYAP1, adenylate cyclase activating polypeptide 1, as a methylation biomarker for the early detection of cervical cancer.
Vaccinia
Functional characterization of the human dopamine D4.2 receptor using vaccinia virus as an expression system.
Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara.
Vascular Diseases
Thyrotropin regulation of cyclic adenosine monophosphate production in human coronary artery smooth muscle cells.
Vasoplegia
Methylene Blue in the Treatment of Vasoplegia Following Severe Burns.
Ventricular Dysfunction
Pharmacokinetics and a simulation model of colforsin daropate, new forskolin derivative inotropic vasodilator, in patients undergoing coronary artery bypass grafting.
Ventricular Dysfunction, Left
Functional activity and expression of the myocardial postreceptor adenylyl cyclase system in pressure overload hypertrophy in rat.
Ventricular Fibrillation
Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion.
Contrasting effects of cyclic AMP increase caused by beta-adrenergic stimulation or by adenylate cyclase activation on ventricular fibrillation threshold of isolated rat heart.
Effect of interventions that increase cyclic AMP levels on susceptibility to ventricular fibrillation in unanesthetized dogs.
Inhibition by simulated ischemia or hypoxia of delayed afterdepolarizations provoked by cyclic AMP: significance for ischemic and reperfusion arrhythmias.
[Proceedings: Myocardial adenyl cyclase (5). Effects of propranolol on the ventricular fibrillation threshold in acute myocardial ischemia and the myocardial adenyl cyclase system]
Vesicular Stomatitis
Cyclic AMP modulates the rate of 'constitutive' exocytosis of apical membrane proteins in Madin-Darby canine kidney cells.
Virus Diseases
Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs.
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Vitamin A Deficiency
A vitamin A-free diet results in impairment of the rat hippocampal somatostatinergic system.
Vitamin B 12 Deficiency
Impairment of adenylyl cyclase signal transduction in mecobalamin-deficient rats.
Vitamin B12 deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver.
Vitamin D Deficiency
Impaired production and decreased urinary excretion of adenosine 3',5'-monophosphate in primary hyperparathyroidism with vitamin D deficiency.
Parathyroid function in different stages of vitamin D deficiency rickets.
Vitamin E Deficiency
Vitamin E deficiency impairs the somatostatinergic receptor-effector system and leads to phosphotyrosine phosphatase overactivation and cell death in the rat hippocampus.
Werner Syndrome
Reduced sensitivity to catecholamine in Werner's syndrome fibroblasts.
Whooping Cough
26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas.
5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms.
5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus.
5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus.
5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.
A 23-kilodalton protein, distinct from BvgA, expressed by virulent Bordetella pertussis binds to the promoter region of vir-regulated toxin genes.
A Bacterial Adenylate Cyclase-Based Two-Hybrid System Compatible with Gateway® Cloning.
A bacterial two-hybrid system based on a reconstituted signal transduction pathway.
A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor.
A Bordetella pertussis acellular vaccine candidate: antigenic characterization and antibody induction.
A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells.
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
A direct pyrophosphatase-coupled assay provides new insights into the activation of the secreted adenylate cyclase from Bordetella pertussis by calmodulin.
A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates.
A fortunate journey on uneven grounds.
A Gateway(®) -compatible bacterial adenylate cyclase-based two-hybrid system.
A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line.
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
A kinase-mediated regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): disparate response sensitivities of distinct IGFBP species.
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
A monoclonal antibody directed against the catalytic site of Bacillus anthracis adenylyl cyclase identifies a novel mammalian brain catalytic subunit.
A neuroactive steroid inhibits guinea pig airway sensory nerves via Maxi-K channel activation.
A new assay for the invasive adenylate cyclase toxin of Bordetella pertussis based on its morphological effects on the fibronectin-stimulated spreading of BHK21 cells.
A novel hypothalamic peptide, pituitary adenylate cyclase activating peptide, modulates Sertoli cell function in vitro.
A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: crossover from G protein-coupled inhibition to stimulation.
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.
A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression.
A protein activator for the adenylate cyclase of Bordetella pertussis.
A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers.
A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.
A simple method for the assay of Bordetella pertussis adenylate cyclase employing 31P nuclear magnetic resonance spectroscopy.
A two-dimensional model of cell movement. Well differentiated human rectal adenocarcinoma cells move as coherent sheets upon TPA stimulation.
A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C.
A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig.
A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation.
Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms.
Acceleration of desipramine-induced changes on the dopamine receptor-coupled adenylate cyclase system by pertussis toxin.
Accounting for ligand-bound metal ions in docking small molecules on adenylyl cyclase toxins.
Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon.
Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis.
Actions of pertussis toxin on the inhibitory effects of dopamine and somatostatin on prolactin and growth hormone release from ovine anterior pituitary cells.
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein).
Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis.
Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout.
Activation of Bordetella pertussis adenylate cyclase by the carboxyl-terminal tryptic fragment of calmodulin.
Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation.
Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop.
Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation.
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis.
Activation of opioid and muscarinic receptors stimulates basal adenylyl cyclase but inhibits Ca2+/calmodulin- and forskolin-stimulated enzyme activities in rat olfactory bulb.
Activation of protein kinase C by oxytocin inhibits the biological activity of the human myometrial corticotropin-releasing hormone receptor at term.
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.
Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins.
Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells.
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
Acylation of lysine 983 is sufficient for toxin activity of Bordetella pertussis adenylate cyclase. Substitutions of alanine 140 modulate acylation site selectivity of the toxin acyltransferase CyaC.
Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins.
Adaptations of myocardial beta-adrenergic receptor complex in hibernating marmots.
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.
Adenosine 3':5'-cyclic monophosphate (cAMP) is not the mediator of kappa opiate effect on human placental lactogen release.
Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.
Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells.
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface.
Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.
Adenyl cyclase in Bordetella pertussis vaccines.
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.
Adenylate cyclase activity during phenotypic variation of Bordetella pertussis.
Adenylate cyclase activity of Bordetella organisms. I. Its production in liquid medium.
Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells.
Adenylate cyclase influences filamentous haemagglutinin-mediated attachment of Bordetella pertussis to epithelial alveolar cells.
Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.
Adenylate cyclase toxin (CyaA) of Bordetella pertussis. Evidence for the formation of small ion-permeable channels and comparison with HlyA of Escherichia coli.
Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro.
Adenylate cyclase toxin from Bordetella pertussis produces ion conductance across artificial lipid bilayers in a calcium- and polarity-dependent manner.
Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.
Adenylate cyclase toxin from Bordetella pertussis. Conformational change associated with toxin activity.
Adenylate cyclase toxin from Bordetella pertussis. Identification and purification of the holotoxin molecule.
Adenylate cyclase toxin from Bordetella pertussis. The relationship between induction of cAMP and hemolysis.
Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions.
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice.
Adenylate cyclase toxin of Bordetella pertussis: production, purification, and partial characterization.
Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells.
Adenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacity.
Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation.
Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines.
Adenylate cyclase toxin-mediated delivery of the S1 subunit of pertussis toxin into mammalian cells.
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.
Adenylyl cyclase and G-proteins in Phytomonas.
Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs.
Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.
Adjuvant and protective properties of native and recombinant Bordetella pertussis adenylate cyclase toxin preparations in mice.
Adjuvant effects of adenylate cyclase toxin of Bordetella pertussis after intranasal immunisation of mice.
Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigens.
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D(2L) cells.
Adrenergic control of cAMP generation in rat inner medullary collecting tubule cells.
Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation.
Adrenoceptor-activation of oxygen consumption in rat parotid acini.
Affinity-based chromatography utilizing genetically engineered proteins. Interaction of Bordetella pertussis adenylate cyclase with calmodulin.
Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.
Age-related alterations in adenylyl cyclase system of rat hearts.
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation.
Agonist-induced desensitization of D2 dopamine receptors in human Y-79 retinoblastoma cells.
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Agonist-specific coupling of a cloned Drosophila melanogaster D1-like dopamine receptor to multiple second messenger pathways by synthetic agonists.
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.
All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase.
Allosteric Activation of Bordetella pertussis Adenylyl Cyclase by Calmodulin: MOLECULAR DYNAMICS AND MUTAGENESIS STUDIES.
Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin.
Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells.
Alpha 1-adrenoceptor-mediated inhibition of cellular cAMP accumulation in neonatal rat ventricular myocytes.
Alpha 2-adrenergic receptors activate phospholipase C in renal epithelial cells.
Alpha 2-adrenergic receptors in brown adipose tissue of infant rats--II. Studies on function and regulation.
Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.
Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig.
Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase.
Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons.
Alteration of intracellular cAMP levels and beating rates of cultured chick cardiac cells by Bordetella pertussis adenylate cyclase.
Alterations in cardiac membrane beta-adrenoceptors and adenylyl cyclase due to hypochlorous acid.
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit.
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma.
Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.
Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages.
Amphiphile-mediated activation of soluble adenylate cyclase of Bordetella pertussis.
Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.
Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.
Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system.
An amphipathic alpha-helix including glutamates 509 and 516 is crucial for membrane translocation of adenylate cyclase toxin and modulates formation and cation selectivity of its membrane channels.
An Escherichia coli insertion element (IS2) provides a functional promoter in Bordetella pertussis.
An evaluation of serious neurological disorders following immunization: a comparison of whole-cell pertussis and acellular pertussis vaccines.
An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis.
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis.
An intact N terminus of the gamma subunit is required for the Gbetagamma stimulation of rhodopsin phosphorylation by human beta-adrenergic receptor kinase-1 but not for kinase binding.
An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins.
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
Analysis of Bordetella pertussis cya operon regulation by use of cya-lac fusions.
Analysis of Membrane Protein Interactions with a Bacterial Adenylate Cyclase-Based Two-Hybrid (BACTH) Technique.
Analysis of the chromosomal location of two copies of a Bordetella pertussis insertion sequence.
Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase.
Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.
Angiopeptin (BIM23014C) inhibits vascular smooth muscle cell migration in vitro through a G-protein-mediated pathway and is associated with inhibition of adenylyl cyclase and cyclic AMP accumulation.
Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion.
Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins.
Angiotensin II receptor recognized by DuP753 regulates two distinct guanine nucleotide-binding protein signaling pathways.
Angiotensin II receptors and inhibitory actions in Leydig cells.
Angiotensin II stimulates the synthesis of angiotensinogen in hepatocytes by inhibiting adenylylcyclase activity and stabilizing angiotensinogen mRNA.
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus.
Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination.
Antibodies to Bordetella pertussis adenylate cyclase toxin in neonatal and maternal sera.
Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes.
Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming.
Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.
Antineoplastic effects of Bordetella pertussis adenylate cyclase.
Apical and basolateral effects of PTH in OK cells: transport inhibition, messenger production, effects of pertussis toxin, and interaction with a PTH analog.
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Assay of calmodulin with Bordetella pertussis adenylate cyclase.
Assay of pertussis vaccine reactivity factors by measurement of the paw swelling response, endotoxin and histamine-sensitizing factor.
Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.
ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells.
ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells.
Atrial natriuretic factor reduces cyclic adenosine monophosphate content of human fibroblasts by enhancing phosphodiesterase activity.
Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles.
Attenuation of chick heart adenylate cyclase by muscarinic receptors after pertussis toxin treatment.
Attenuation of parasite cAMP levels in T. cruzi-host cell membrane interactions in vitro.
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner.
B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP.
Bacteria and their toxins tamed for immunotherapy.
Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.
Bacterial toxins: potential weapons against HIV infection.
Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex.
Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels.
Bimodal regulation of cyclic AMP by muscarinic receptors. Involvement of multiple G proteins and different forms of adenylyl cyclase.
Binding of 3'-anthraniloyl-2'-deoxy-ATP to calmodulin-activated adenylate cyclase from Bordetella pertussis and Bacillus anthracis.
Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.
Biochemical and physical analyses of newly synthesized muscarinic acetylcholine receptors in cultured embryonic chicken cardiac cells.
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy.
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes.
Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Biomimetic tethered lipid membranes designed for membrane-protein interaction studies.
Biphasic alterations in cardiac beta-adrenoceptor signal transduction mechanism due to oxyradicals.
Biphasic effect of sodium fluoride and guanyl nucleotides on binding to prostaglandin E2 receptors in rat epididymal adipocyte membranes.
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications.
Bordatella pertussis adenylate cyclase: a toxin with multiple talents.
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein.
Bordetella adenylate cyclase toxin induces a cascade of morphological changes of sheep erythrocytes and localizes into clusters in erythrocyte membranes.
Bordetella Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells.
Bordetella adenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formation in vitro.
Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3.
Bordetella adenylate cyclase toxin promotes calcium entry into both CD11b+ and CD11b- cells through cAMP-dependent L-type-like calcium channels.
Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.
Bordetella adenylate cyclase toxin: entry of bacterial adenylate cyclase into mammalian cells.
Bordetella adenylate cyclase: host toxicity and diagnostic utility.
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.
Bordetella pertussis adenylate cyclase activity in nasopharyngeal aspirates for rapid diagnosis of whooping cough in relation to culture and serology.
Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo.
Bordetella pertussis adenylate cyclase inactivation by the host cell.
Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1).
Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation.
Bordetella pertussis adenylate cyclase toxin as a tool to analyze molecular interactions in a bacterial two-hybrid system.
Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase.
Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.
Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death.
Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer.
Bordetella pertussis adenylate cyclase toxin. Structural and functional independence of the catalytic and hemolytic activities.
Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.
Bordetella pertussis adenylate cyclase toxin: a versatile screening tool.
Bordetella pertussis adenylate cyclase toxin: intoxication of host cells by bacterial invasion.
Bordetella pertussis adenylate cyclase toxin: proCyaA and CyaC proteins synthesised separately in Escherichia coli produce active toxin in vitro.
Bordetella pertussis adenylate cyclase. Identification of multiple forms of the enzyme by antibodies.
Bordetella pertussis adenylate cyclase. Penetration into host cells.
Bordetella pertussis adenylate cyclase. Purification, characterization, and radioimmunoassay.
Bordetella pertussis adenylate cyclase: a toxin with multiple talents.
Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions.
Bordetella pertussis adenylate cyclase: isolation and purification by calmodulin-sepharose 4B chromatography.
Bordetella pertussis adenylate cyclase: purification and characterization of the toxic form of the enzyme.
Bordetella pertussis adenylate cyclase: the gene and the protein.
Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways.
Bordetella pertussis does not induce beta-adrenergic blockade.
Bordetella pertussis infection of human monocytes inhibits antigen-dependent CD4 T cell proliferation.
Bordetella pertussis infection: pathogenesis, diagnosis, management, and the role of protective immunity.
Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.
Bordetella pertussis invasive adenylate cyclase. Partial resolution and properties of its cellular penetration.
Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A.
Bordetella pertussis modulates human macrophage defense gene expression.
Bordetella pertussis tracheal cytotoxin.
Bordetella pertussis virulence factors affect phagocytosis by human neutrophils.
Bordetella pertussis: new concepts in pathogenesis and treatment.
Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.
Both pertussis toxin-sensitive and insensitive g-proteins link melatonin receptor to inhibition of adenylate cyclase in the ovine pars tuberalis.
Botulinum C2 toxin ADP-ribosylates actin.
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Bradykinin inhibits adenylate cyclase activity in guinea pig ileum membranes via a separate high-affinity bradykinin B2 receptor.
Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.
Bromocriptine, a dopamine D2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium.
C-type natriuretic peptide neuromodulates via "clearance" receptors.
Calcium inhibition of cardiac adenylyl cyclase. Evidence for two distinct sites of inhibition.
Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form.
Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
Calcium-Driven Folding of RTX Domain ?-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts.
Calcium-independent activation of adenylate cyclase by calmodulin.
Calcium-independent stimulation of Bordetella pertussis adenylate cyclase by calmodulin.
Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin.
Calcium-induced folding of a beta roll motif requires C-terminal entropic stabilization.
Calcium-induced folding of intrinsically disordered Repeat-in-Toxin (RTX) motifs via changes of protein charges and oligomerization states.
Calmodulin activates prokaryotic adenylate cyclase.
Calmodulin binding of a peptide derived from the regulatory domain of Bordetella pertussis adenylate cyclase.
Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.
Calmodulin inhibits entry of Bordetella pertussis adenylate cyclase into animal cells.
Calmodulin-activated bacterial adenylate cyclases as virulence factors.
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.
Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain.
cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation.
cAMP regulates G-protein alpha i-2 subunit gene transcription in polarized LLC-PK1 cells by induction of a CCAAT box nuclear binding factor.
cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.
Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells.
Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2.
Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures.
Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process.
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides.
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Cardiac swelling-induced chloride current is enhanced by endothelin.
Catecholamine-induced heterologous desensitization of rabbit luteal adenylyl cyclase: loss of luteinizing hormone responsiveness is associated with impaired G-protein function.
CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.
CCK and gastrin inhibit adenylate cyclase activity through a pertussis toxin-sensitive mechanism in the tumoral rat pancreatic acinar cell line AR 4-2J.
Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis.
Cell signalling pathway involved in PACAP-induced AR4-2J cell proliferation.
Cell-invasive activity of epitope-tagged adenylate cyclase of Bordetella pertussis allows in vitro presentation of a foreign epitope to CD8+ cytotoxic T cells.
Changes in expression of a functional Gi protein in cultured rat heart cells.
Channel Formation by LktA of Mannheimia (Pasteurella) haemolytica in Lipid Bilayer Membranes and Comparison of Channel Properties with Other RTX-Cytolysins.
Channel formation by RTX-toxins of pathogenic bacteria: Basis of their biological activity.
Channel formation in model membranes by the adenylate cyclase toxin of Bordetella pertussis: effect of calcium.
Characterisation of the fish sst3 receptor, a member of the SRIF1 receptor family: atypical pharmacological features.
Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase.
Characterization of a chimeric human dopamine D3/D2 receptor functionally coupled to adenylyl cyclase in Chinese hamster ovary cells.
Characterization of a Membrane-Active Peptide from the Bordetella pertussis CyaA Toxin.
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Characterization of a synthetic calmodulin-binding peptide derived from Bacillus anthracis adenylate cyclase.
Characterization of adenosine A1 receptor in a cell line (28A) derived from rabbit collecting tubule.
Characterization of adenosine A1 receptors in human proximal tubule epithelial (HK-2) cells.
Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.
Characterization of alpha 2A-adrenergic receptors in GT1 neurosecretory cells.
Characterization of beta-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for beta1-, beta2- and beta3-adrenoceptors in rat ileum.
Characterization of binding of adenylate cyclase toxin to target cells by flow cytometry.
Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line.
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins.
Characterization of mutant Bordetella pertussis adenylate cyclase toxins with reduced affinity for calmodulin. Implications for the mechanism of toxin entry into target cells.
Characterization of recombinant Bordetella pertussis adenylate cyclase toxins carrying passenger proteins.
Characterization of somatostatin receptor subtypes.
Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
Characterization of the adenosine receptor in cultured embryonic chick atrial myocytes: coupling to modulation of contractility and adenylate cyclase activity and identification by direct radioligand binding.
Characterization of the bacterial cell associated calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
Characterization of the C-terminal domain essential for toxic activity of adenylate cyclase toxin.
Characterization of the calmodulin-binding and of the catalytic domains of Bordetella pertussis adenylate cyclase.
Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin.
Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3.
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin.
Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway.
Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: implication for the in vivo delivery of CD8(+) T cell epitopes into antigen-presenting cells.
Chemical fatty acylation confers hemolytic and toxic activities to adenylate cyclase protoxin of Bordetella pertussis.
Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins.
Cholera toxin effects on body temperature changes induced by morphine.
Cholinergic inhibition of cAMP accumulation in Sertoli cells cultured from immature hamsters.
Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins.
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Chronic muscarinic cholinoceptor stimulation increases adenylyl cyclase responsiveness in rat cardiomyocytes by a decrease in the level of inhibitory G-protein alpha-subunits.
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia.
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
Clonidine inhibits fluid absorption in the rabbit proximal convoluted renal tubule.
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.
Cloning and expression of mouse-brain calmodulin as an activator of Bordetella pertussis adenylate cyclase in Escherichia coli.
Cloning and expression of the calmodulin-sensitive Bacillus anthracis adenylate cyclase in Escherichia coli.
Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
Cloning of the adenylate cyclase genetic determinant of Bordetella pertussis and its expression in Escherichia coli and B. pertussis.
Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.
Co-expression of a Ca2+-inhibitable adenylyl cyclase and of a Ca2+-sensing receptor in the cortical thick ascending limb cell of the rat kidney. Inhibition of hormone-dependent cAMP accumulation by extracellular Ca2+.
Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation.
Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes.
Complementation of mutations in Escherichia coli and Bordetella pertussis by B. pertussis DNA cloned in a broad-host-range cosmid vector.
Components of purified sarcolemma from porcine skeletal muscle.
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?
Conformational transitions within the calmodulin-binding site of Bordetella pertussis adenylate cyclase studied by time-resolved fluorescence of Trp242 and circular dichroism.
Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.
Construction of mini-Tn5cyaA' and its utilization for the identification of genes encoding surface-exposed and secreted proteins in Bordetella bronchiseptica.
Continuous Assembly of ?-Roll Structures Is Implicated in the Type I-Dependent Secretion of Large Repeat-in-Toxins (RTX) Proteins.
Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation.
Contributions of the Hydrophobic Helix 2 of the Bordetella pertussis CyaA-hemolysin to Membrane Permeabilization.
Control of cyclic adenosine 3',5'-monophosphate production in osteoclasts: calcitonin-induced persistent activation and homologous desensitization of adenylate cyclase.
Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin.
Corticotropin-releasing factor receptors and actions in rat Leydig cells.
Coupling mechanisms of alpha 2-adrenoceptors.
Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion.
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.
Coupling of an endogenous 5-HT1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells.
Coupling of hepatic prostaglandin receptors to adenylate cyclase through a pertussis toxin sensitive guanine nucleotide regulatory protein.
Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells.
Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.
Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein.
Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals.
Crosstalk between thrombin and adenylyl cyclase-stimulating agonists in proliferating human erythroid progenitor cells.
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin.
Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.
Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells.
Cytoplasmic domain of natriuretic peptide receptor C constitutes Gi activator sequences that inhibit adenylyl cyclase activity.
Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein.
D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase.
D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway.
Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization.
Deletions affecting hemolytic and toxin activities of Bordetella pertussis adenylate cyclase.
Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase.
Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.
Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.
Delivery of multiple epitopes by recombinant detoxified adenylate cyclase of Bordetella pertussis induces protective antiviral immunity.
Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates.
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells.
Dermonecrotic toxin and tracheal cytotoxin, putative virulence factors of Bordetella avium.
Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.
Detection of antibodies against fimbria type 3 (Fim3) is useful diagnostic assay for pertussis.
Detection of Bordetella pertussis by determination of adenylate cyclase activity.
Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Determination of serum antibody to Bordetella pertussis adenylate cyclase toxin in vaccinated and unvaccinated children and in children and adults with pertussis.
Detrusor contraction--Focus on muscarinic receptors.
Development and validation of a robust multiplex serological assay to quantify antibodies specific to pertussis antigens.
Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system.
Development of a targeted nanoLC-MS/MS method for quantitation of residual toxins from Bordetella pertussis.
Development of an approach for the laboratory toxicological evaluation of Bordetella pertussis adenylate cyclase genetic toxoid constructs as multipurpose vaccines.
Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat.
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
Dexras1 inhibits adenylyl cyclase.
Differences in Purinergic Amplification of Osmotic Cell Lysis by the Pore-Forming RTX Toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: The Role of Pore Size.
Different modes of membrane permeabilization by two RTX toxins: HlyA from Escherichia coli and CyaA from Bordetella pertussis.
Different sites of action of arachidonic acid on steroidogenesis in rat Leydig cells.
Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells.
Differential agonist regulation of the human kappa-opioid receptor.
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes.
Differential coupling of the extreme C-terminus of G protein alpha subunits to the G protein-coupled melatonin receptors.
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein.
Differential coupling with pertussis toxin-sensitive G proteins of dopamine and somatostatin receptors involved in regulation of adenohypophyseal secretion.
Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.
Differential mechanisms for calcium-dependent protein/membrane association as evidenced from SPR-binding studies on supported biomimetic membranes.
Differential opioid agonist regulation of the mouse mu opioid receptor.
Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin.
Differential regulation of Bordetella pertussis virulence factors.
Differential regulation of cAMP-mediated gene transcription by m1 and m4 muscarinic acetylcholine receptors. Preferential coupling of m4 receptors to Gi alpha-2.
Differential role of calmodulin and calcium ions in the stabilization of the catalytic domain of adenyl cyclase CyaA from Bordetella pertussis.
Differential sensitivity of alpha o and alpha i to ADP-ribosylation by pertussis toxin in the intact cultured embryonic chick ventricular myocyte. Relationship to the role of G proteins in the coupling of muscarinic cholinergic receptors to inhibition of adenylate cyclase activity.
Differentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside.
Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters.
Direct action of pertussis toxin in isolated hamster fat cells.
Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells.
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.
Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms.
Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism.
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.
Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion.
Disparate effects of neuropeptide Y and clonidine on the excretion of sodium and water in the rat.
Dissociation between muscarinic receptor-mediated inhibition of adenylate cyclase and autoreceptor inhibition of [3H] acetylcholine release in rat hippocampus.
Dissociation of catalytic and invasive activities of Bordetella pertussis adenylate cyclase.
Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin.
Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.
Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes. Translocation of the toxin across the membrane.
Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells.
Divalent cations suppress 3',5'-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells.
Does the guanine nucleotide regulatory protein Ni mediate progesterone inhibition of Xenopus oocyte adenylate cyclase?
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines.
Dopamine receptor signaling.
Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells.
Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium.
Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling.
Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s).
Dual effects of calcitonin and calcitonin gene-related peptide on intracellular cyclic 3',5'-monophosphate in a human breast cancer cell line.
Dual effects of DAMGO [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on adenylyl cyclase activity: implications for mu-opioid receptor Gs coupling.
Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor.
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties.
Dual regulation of human syncytial adenylyl cyclase.
Dual regulation of neutrophil adenylate cyclase by fluoride and its relationship to cellular activation.
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.
Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog.
Effect of bacterial toxins on spermine-induced inhibition of adenylate cyclase activity of cultured heart cells.
Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets.
Effect of calcitonin gene-related peptide on skeletal muscle via specific binding site and G protein.
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine model.
Effect of different levels of intracellular cAMP on the in vitro maturation of cattle oocytes and their subsequent development following in vitro fertilization.
Effect of GHRH and peptides from the vasoactive intestinal peptide family on cAMP production of human cancer cell lines in vitro.
Effect of glucocorticoid on prostaglandin E1 mediated cyclic AMP formation by vascular smooth muscle cells.
Effect of islet-activating pertussis toxin on the binding characteristics of Ca2+-mobilizing hormones and on agonist activation of phosphorylase in hepatocytes.
Effect of methyl-cyclodextrin on adenylate cyclase activity of Bordetella pertussis.
Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.
Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists.
Effect of pertussis toxin on hormonal responsiveness of rat hepatocytes.
Effect of pertussis toxin on the hormonal regulation of cyclic AMP levels in hamster fat cells.
Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells.
Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.
Effect of PT-treatment on ANP-mediated inhibition of adenylate cyclase and amylase release in rat parotid gland.
Effect of somatostatin on adenylate cyclase activity in normal and neoplastic thyroid tissue.
Effect of substance P and neurokinin A on rat parietal cell function.
Effect of sulpiride on somatostatin receptors, somatostatin-like immunoreactivity and modulation of adenylyl cyclase activity in the rat brain.
Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase.
Effector coupling of somatostatin receptor subtypes on human endocrine tumors.
Effector coupling of stably transfected human A3 adenosine receptors in CHO cells.
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus.
Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.
Effects of calcium-antagonists on dopamine release in the central nervous system--possible interactions with D2-autoreceptors and guanosine triphosphate-binding proteins.
Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin.
Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence.
Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.
Effects of insulin, adenosine, and prostaglandin on alpha-adrenergic-stimulated respiration in brown adipocytes.
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits.
Effects of pertussis toxin on vasodilation and cyclic GMP in bovine mesenteric arteries and demonstration of a 40 kD soluble protein ribosylation substrate for pertussis toxin.
Effects of pertussis toxin treatment of rats on estradiol-induced adenohypophyseal growth reaction and on adrenergic lipolysis.
Effects of pertussis toxin treatment on metabolism in hamster brown adipocytes.
Effects of pertussis toxin treatment on the metabolism of rat adipocytes.
Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides.
Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids.
Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.
Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.
Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes.
Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization.
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.
Endothelins inhibit adenylate cyclase in brain capillary endothelial cells.
Engineered calcium-precipitable restriction enzyme.
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.
Enhancement of differentiation of cultured adipogenic cells (TA1) by pertussis toxin.
Enhancement of parathyroid hormone-responsive renal cortical adenylate cyclase activity by a cytosol protein activator from rat reticulocytes.
Enzymatic activity of adenylate cyclase toxin from Bordetella pertussis is not required for hemolysis.
Enzymatic synthesis of the cAMP antagonist (Rp)-adenosine 3',5'-monophosphorothioate on a preparative scale.
Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein.
Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system.
Essential role of methionine residues in calmodulin binding to Bordetella pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases.
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing.
Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice.
Evaluation of the toxicity of recombinant Bordetella pertussis adenylate cyclase toxin preparations.
Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body.
Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida.
Evidence for two GTPases activated by thrombin in membranes of human platelets.
Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.
Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons.
Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems.
Evidence that muscarinic receptors in islet cells are not coupled functionally to adenylate cyclase through the inhibitory guanine nucleotide binding protein (Ni).
Evidence that the adenylate cyclase secreted from Bordetella pertussis does not enter animal cells by receptor-mediated endocytosis.
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation.
Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells.
Expression and modulation of 5-hydroxytryptamine1A receptors in P11 cells.
Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes.
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.
Expression of bacterial cytotoxin genes in mammalian target cells.
Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs.
Expression of functionally active cannabinoid receptor CB1 in the human prostate gland.
Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.
Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase.
Extracellular cAMP formation from host cell ATP by Bordetella pertussis adenylate cyclase.
Extracytoplasmic adenylate cyclase of Bordetella pertussis.
Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells.
Facilitatory effects of diltiazem on dopamine release in the central nervous system. Focus on interactions with D2 autoreceptors and guanosine triphosphate binding proteins.
Fatal Bordetella pertussis infection: report of two cases with novel pathologic findings.
Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts.
Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin.
Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells.
Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase.
Formation and biological action of inositol 1,4,5-trisphosphate.
Formulation of the adenylate cyclase toxin of Bordetella pertussis as protein-coated microcrystals.
Functional analysis of a human A(1) adenosine receptor/green fluorescent protein/G(i1)alpha fusion protein following stable expression in CHO cells.
Functional analysis of the cya promoter of Bordetella pertussis.
Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
Functional and structural studies on different forms of the adenylate cyclase toxin of Bordetella pertussis.
Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B.
Functional characterization of the human dopamine D4.2 receptor using vaccinia virus as an expression system.
Functional consequences of single amino acid substitutions in calmodulin-activated adenylate cyclase of Bordetella pertussis.
Functional coupling of cerebral ?-aminobutyric acid (GABA)(B) receptor with adenylate cyclase system: effect of phaclofen.
Functional coupling of the alpha 2-adrenergic receptor-adenylate cyclase complex in the pregnant human myometrium.
Functional expression of GABAB receptors in airway epithelium.
Functional expression of the P2Y14 receptor in murine T-lymphocytes.
Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding.
Functional lysophosphatidic acid receptor in bovine luteal cells.
Functional maturation of somatostatin neurons and somatostatin receptors during development of mouse hypothalamus in vivo and in vitro.
Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
Functional somatostatin receptors on a rat pancreatic acinar cell line.
Functional uncoupling of muscarinic receptors from adenylate cyclase in rat cardiac membranes by the active component of islet-activating protein, pertussis toxin.
G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb.
G protein alterations in hypertension and aging.
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland.
G(z) can mediate the acute actions of mu- and kappa-opioids but is not involved in opioid-induced adenylyl cyclase supersensitization.
G-protein level quantification in platelets and leukocytes from patients with panic disorder.
G-proteins and adenylyl cyclase in ovarian granulosa cells of amago salmon (Oncorhynchus rhodurus).
G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate.
G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions.
GABAB and adenosine receptors mediate enhancement of the K+ current, IAHP, by reducing adenylyl cyclase activity in rat CA3 hippocampal neurons.
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein.
Gbetagamma signaling promotes breast cancer cell migration and invasion.
Gene isolation by direct in situ cAMP binding.
Generation and use of site-directed chromosomal cyaA' translational fusions in Salmonella enterica.
Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir.
Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling.
Genetic studies of the molecular basis of whooping cough.
Genomics of Bordetella pertussis toxins.
Gentamicin nucleotidyltransferase. Stereochemical inversion at phosphorus in enzymatic 2'-deoxyadenylyl transfer to tobramycin.
Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells.
Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.
Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.
Growth factor-like action of lysophosphatidic acid: mitogenic signalling mediated by G proteins.
Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes.
GTL001 and bivalent CyaA-based therapeutic vaccine strategies against human papillomavirus and other tumor-associated antigens induce effector and memory T-cell responses that inhibit tumor growth.
GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T cell responses leading to tumor regression.
GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica.
GTP-binding proteins associated with the human placental syncytiotrophoblast plasma membrane.
Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts.
Guanine nucleotide binding proteins in the dual regulation of lacrimal function.
Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.
Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni.
Haemolytic assay for the detection of adenylate cyclase toxin of Bordetella pertussis.
Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle.
Halothane interaction with guanine nucleotide binding proteins in mouse heart.
Halothane myocardial depression: interactions with the adenylate cyclase system.
Heart contains two substrates (Mr = 40,000 and 41,000) for pertussis toxin-catalyzed ADP-ribosylation that co-purify with Ns.
Hemolytic activity of adenylate cyclase toxin from Bordetella pertussis.
Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli.
Heparin inhibits melatonin binding and signal transduction in chick brain.
Heteromeric association creates a P2Y-like adenosine receptor.
Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.
High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection.
High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2.
HIGH GLUCOSE-INDUCED INHIBITION OF 2-DEOXYGLUCOSE UPTAKE IS MEDIATED BY cAMP, PROTEIN KINASE C, OXIDATIVE STRESS AND MITOGEN-ACTIVATED PROTEIN KINASES IN MOUSE EMBRYONIC STEM CELLS.
High level expression of transfected G protein alpha i3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts.
High level of soluble expression in Escherichia coli and characterisation of the CyaA pore-forming fragment from a Bordetella pertussis Thai clinical isolate.
High-affinity calmodulin binding is required for the rapid entry of Bordetella pertussis adenylyl cyclase into neuroblastoma cells.
High-level synthesis of active adenylate cyclase toxin of Bordetella pertussis in a reconstructed Escherichia coli system.
Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells.
Homologous and heterologous beta-adrenergic desensitization in hepatocytes. Additivity and effect of pertussis toxin.
Homologous sensitisation of embryonic chick atrial myocytes to adenosine: mediation by adenosine A1 receptor and guanine nucleotide binding protein.
Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
Human serologic response to envelope-associated proteins and adenylate cyclase toxin of Bordetella pertussis.
Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.
Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels.
Identification and characterization of guanine nucleotide-sensitive melatonin receptors in chicken brain.
Identification and Characterization of Putative Translocated Effector Proteins of the Edwardsiella ictaluri Type III Secretion System.
Identification and regulation of cold-inducible factors of Bordetella bronchiseptica.
Identification and type III-dependent secretion of the Yersinia pestis insecticidal-like proteins.
Identification by in vitro complementation of regions required for cell-invasive activity of Bordetella pertussis adenylate cyclase toxin.
Identification of a common domain in calmodulin-activated eukaryotic and bacterial adenylate cyclases.
Identification of a domain in Bordetella pertussis adenylyl cyclase important for subunit interactions and cell invasion activity.
Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin.
Identification of Bordetella pertussis in nasopharyngeal swabs by PCR amplification of a region of the adenylate cyclase gene.
Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system.
Identification of new secreted effectors in Salmonella enterica serovar Typhimurium.
Identification of novel type III secretion effectors in Xanthomonas oryzae pv. oryzae.
Identification of residues essential for catalysis and binding of calmodulin in Bordetella pertussis adenylate cyclase by site-directed mutagenesis.
Identification of the predominant substrate for ADP-ribosylation by islet activating protein.
Identification, characterization, and biological activity of somatostatin receptors in human neuroblastoma cell lines.
Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid-induced adenylyl cyclase supersensitivity.
Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-Lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria.
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate.
Immunoelectron microscopy of antigens of Bordetella pertussis using monoclonal antibodies to agglutinogens 2 and 3, filamentous haemagglutinin, pertussis toxin, pertactin and adenylate cyclase toxin.
Immunological relatedness between Bordetella pertussis and rat brain adenylyl cyclases.
Impaired cardiac muscarinic receptor function in dogs with heart failure.
Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism.
Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats.
Improving administration regimens of CyaA-based vaccines using TRAP assays to detect antigen-specific CD8(+) T cells directly ex vivo.
In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase.
In vitro effects of 17 beta-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary culture.
In vitro selection for enzymatic activity: a model study using adenylate cyclase.
In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus.
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying multiple copies of a viral CD8(+) T-cell epitope.
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.
In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.
Independence of, and interactions between, cannabinoid and opioid signal transduction pathways in N18TG2 cells.
Induction of a polarized Th1 response by insertion of multiple copies of a viral T-cell epitope into adenylate cyclase of Bordetella pertussis.
Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis.
Infection of L6E9 myoblasts with Trypanosoma cruzi alters adenylate cyclase activity and guanine nucleotide binding proteins.
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathy.
Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils.
Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland.
Influence of pertussis toxin on the effects of guanine nucleotide on adenylate cyclase in rat striatal membranes.
Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity.
Influences of pertussis toxin, guanine nucleotides and forskolin on adenylate cyclase in striatal membranes of infant, adult and senescent rats.
Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein.
Inhibition of adenylate cyclase activity in the goldfish melanophore is mediated by alpha2-adrenoceptors and a pertussis toxin-sensitive GTP-binding protein.
Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor.
Inhibition of adenylate cyclase in bovine ciliary process and rabbit iris ciliary body to alpha 2-adrenergic agonists.
Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine receptors: selective blockade by antisera directed against Gi1 and/or Gi2.
Inhibition of bovine rod outer segment GTPase by Bordetella pertussis toxin.
Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes.
Inhibition of fetal rat pancreatic beta-cell replication by interleukin-1 beta in vitro is not mediated through pertussis toxin-sensitive G-proteins, a decrease in cyclic AMP, or protease activation.
Inhibition of formation of cyclic AMP and cyclic GMP by vasopressin in smooth-muscle cells is insensitive to pertussis toxin.
Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures.
Inhibition of hepatic adenylate cyclase by NADH.
Inhibition of immunological and nonimmunological histamine release from human basophils by adenosine analogues that act at P-sites.
Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin.
Inhibition of noradrenaline release by neuropeptide Y in mouse atria does not involve inhibition of adenylate cyclase or a pertussis toxin-susceptible G protein.
Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
Inhibition of protein kinase A and cyclic AMP response element (CRE)-specific transcription factor binding by delta9-tetrahydrocannabinol (delta9-THC): a putative mechanism of cannabinoid-induced immune modulation.
Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC).
Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway.
Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.
Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds.
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.
Inhibitory action of forskolin on adenylate cyclase activity and cyclic AMP generation.
Inhibitory and stimulatory effects of neuropeptide Y(17-36) on rat cardiac adenylate cyclase activity. Structure-function studies.
Inhibitory effects of pertussis toxin on a depolarization-evoked Ca2+ influx in NG108-15 cells.
Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes.
Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes.
Inhibitory pathway of cardiac PKA-dependent Cl- conductance via pertussis toxin-sensitive G proteins.
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Insertional mutagenesis of Bordetella pertussis adenylate cyclase.
Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments.
Insulin secretion and action.
Interaction between prostacyclin and cortisol in fetal lung cells: effects on cAMP production.
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding.
Interaction of Bordetella pertussis adenylate cyclase with calmodulin. Identification of two separated calmodulin-binding domains.
Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.
Interaction of Bordetella pertussis virulence components with neutrophils: effect on chemiluminescence induced by a chemotactic peptide and by intact bacteria.
Interaction of calcium with Bordetella pertussis adenylate cyclase toxin. Characterization of multiple calcium-binding sites and calcium-induced conformational changes.
Interaction of halothane with inhibitory G-proteins in the human myocardium.
Interaction of somatostatin receptors with G proteins and cellular effector systems.
Interactions between inhibitory and excitatory modulatory signals in single submucosal neurons.
Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.
Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: Comparison with membranous adenylyl cyclase I.
Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis.
Internalization of cloned pancreatic polypeptide receptors is accelerated by all types of Y4 agonists.
International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides.
Intracellular cross-talk between thyrotropin receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes.
Intrinsic fluorescence of a truncated Bordetella pertussis adenylate cyclase expressed in Escherichia coli.
Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.
Invasive adenylate cyclase toxin of Bordetella pertussis.
Invasive adenylyl cyclase of Bordetella pertussis. Physical, catalytic, and toxic properties.
Inventory and functional analysis of the large Hrp regulon in Ralstonia solanacearum: identification of novel effector proteins translocated to plant host cells through the type III secretion system.
Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Involvement of Ni protein in the functional coupling of the atrial natriuretic factor (ANF) receptor to adenylate cyclase in rat lung plasma membranes.
Involvement of protein kinase-C in the effect of angiotensin-II on adenosine 3',5'-monophosphate production in lactotroph cells.
Ionotropic histamine receptors and H2 receptors modulate supraoptic oxytocin neuronal excitability and dye coupling.
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.
Islet-activating protein, pertussis toxin: a specific uncoupler of receptor-mediated inhibition of adenylate cyclase.
Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.
Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.
Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase.
Isolation and characterization of natural human IgG with a morphine-like activity.
Isolation of a protein fraction from Bordetella pertussis that facilitates entry of the calmodulin-sensitive adenylate cyclase into animal cells.
Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.
K+ channel and adenylate cyclase involvement in regulation of Ca2+-evoked release of [3H]dopamine from synaptosomes.
Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling.
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells.
Kinase cascades and ligand-directed signaling at the kappa opioid receptor.
Lethal infection by Bordetella pertussis mutants in the infant mouse model.
LH release is facilitated by agents that alter cyclic AMP-generating system.
Lidocaine enhances Galphai protein function.
Linkage between somatostatin and acid secretion: evidence from use of pertussis toxin.
Long-term neuroleptic treatments counteract dopamine D2 agonist inhibition of adenylate cyclase but do not affect pertussis toxin ADP-ribosylation in the rat brain.
Loss of activation of Gs but not Gi following expression of an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.
Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system.
LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.
Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.
Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells.
Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
Maintenance of bovine oocytes in prophase of meiosis I by high [cAMP]i.
Maintenance of meiotic arrest in isolated rat oocytes by the invasive adenylate cyclase of Bordetella pertussis.
Mapping structural determinants within 3rd intracellular loop that direct signalling specificity of type 1 corticotropin releasing hormone receptor.
Mass spectrometric analysis of recombinant adenylate cyclase toxin from Bordetella pertussis strain 18323/pHSP9.
Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome.
Mechanism of action of peptide YY to inhibit gastric motility.
Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction.
Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.
Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: toxin increases bradykinin-stimulated prostaglandin formation.
Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase.
Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.
Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid.
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C.
Mechanism of Li inhibition of vasopressin-sensitive adenylate cyclase in cultured renal epithelial cells.
Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein.
Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits.
Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.
Mechanism of retinoic acid induced attenuation of PTH action in UMR 106-01 cells.
Mechanism underlying histamine-induced desensitization of amylase secretion in rat parotid glands.
Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.
Mechanisms of action of angiotensin II on mammalian sperm function.
Mechanisms of action of antisecretory drugs. Studies on isolated canine fundic mucosal cells.
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells.
Mechanisms of opioid delta (delta) and kappa ( kappa) receptors' cardioprotection in ischaemic preconditioning in a rat model of myocardial infarction.
Mediation by G protein betagamma subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb.
Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT.
Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.
Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone.
Melatonin promotes osteoblast differentiation and bone formation.
Melatonin receptors in the spinal cord.
Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
Melatonin-induced organelle movement in melanophores is coupled to tyrosine phosphorylation of a high molecular weight protein.
Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors.
Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes.
Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin.
Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells.
Membrane Permeabilization by Bordetella Adenylate Cyclase Toxin Involves Pores of Tunable Size.
Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins.
Membrane restructuring by Bordetella pertussis adenylate cyclase toxin, a member of the RTX toxin family.
Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans.
Mitogenic effects of fibroblast growth factors in cultured fibroblasts. Interaction with the G-protein-mediated signaling pathways.
Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes.
Mode of inhibition of renin release by angiotensin II.
Modification of cardiac beta-adrenoceptor mechanisms by H2O2.
Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation.
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin.
Modulation of adenylate cyclase in human keratinocytes by protein kinase C.
Modulation of adenylate cyclase toxin production as Bordetella pertussis enters human macrophages.
Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists.
Modulation of invasiveness and catalytic activity of Bordetella pertussis adenylate cyclase by polycations.
Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina.
Modulation of norepinephrine release by galanin in rat medulla oblongata.
Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis.
Modulation of responsiveness of the adenylate cyclase system in avian chondroprogenitor cells by pertussis toxin, PTH, and PGE2.
Modulation of sympathetic actions on the heart by opioid receptor stimulation.
Molecular analysis of CCR-3 events in eosinophilic cells.
Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides.
Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis.
Molecular aspects of Bordetella pertussis pathogenesis.
Molecular biology of somatostatin receptor subtypes.
Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis.
Molecular mechanisms of adenylyl cyclase desensitization in pregnant rat myometrium following in vivo administration of the beta-adrenergic agonist, isoproterenol.
Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling.
Monitoring the conformational changes of an intrinsically disordered peptide using a quartz crystal microbalance.
Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.
Mr 40,000 and Mr 39,000 pertussis toxin substrates are increased in surgically denervated dog ventricular myocardium.
mt(1) Receptor-mediated antiproliferative effects of melatonin on the rat uterine antimesometrial stromal cells.
Mu type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to G-protein-mediated inhibition of adenylyl cyclase.
mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein.
Mu-opioid-receptor-mediated inhibition of the N-type calcium-channel current.
Multiple approaches to a complete inventory of Pseudomonas syringae pv. tomato DC3000 type III secretion system effector proteins.
Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
Multiple effector coupling of somatostatin receptor subtype SSTR1.
Multiple pertussis toxin substrates as candidates for regulatory G proteins of adenylate cyclase coupled to the somatostatin receptor in primary rat astrocytes.
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin.
Muscarine receptors regulating electrically evoked release of acetylcholine in hippocampus are linked to pertussis toxin-sensitive G proteins but not to adenylate cyclase.
Muscarinic cholinergic inhibition of cyclic AMP accumulation in airway smooth muscle. Role of a pertussis toxin-sensitive protein.
Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma.
Muscarinic M2 receptors directly activate Gq/11 and Gs G-proteins.
Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics.
Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.
Muscarinic receptors in MDCK cells are coupled to multiple messenger systems.
Muscarinic receptors in the failing human heart.
Muscarinic regulation of cyclic AMP in bovine trachealis cells.
Muscarinic stimulation of gallbladder epithelium. III. Antagonism of cAMP-mediated effects.
Mutants in the ptlA-H genes of Bordetella pertussis are deficient for pertussis toxin secretion.
Mutation in the ?-hairpin of the Bordetella pertussis adenylate cyclase toxin modulates N-lobe conformation in calmodulin.
NaF and guanine nucleotides modulate adenylate cyclase activity in NG108-15 cells by interacting with both Gs and Gi.
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors.
Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin.
Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
Neurochemical and behavioural evidence that dopamine D-2 receptors in striatum couple to the Ni regulatory protein and inhibition of cyclic AMP accumulation.
Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase.
Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells.
Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein.
Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process.
Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism.
Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells.
Neuropeptide Y reduces macromolecule permeability of coronary endothelial monolayers.
Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.
Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis.
Ni-mediated inhibition of human platelet adenylate cyclase by thrombin.
Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase.
NMR and circular dichroic studies on the solution conformation of a synthetic peptide derived from the calmodulin-binding domain of Bordetella pertussis adenylate cyclase.
Non-steady state kinetic analysis of the regulation of adenylate cyclase by GTP-binding proteins.
Norepinephrine, acting via adenylate cyclase, inhibits melatonin output but does not phase-shift the pacemaker in cultured chick pineal cells.
Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cepsilon.
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase.
Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor.
Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution.
On the selectivity of the G?q inhibitor UBO-QIC: A comparison with the G?i inhibitor pertussis toxin.
Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development.
Ontogeny of beta-adrenergic receptor-mediated cyclic AMP generating system in primary cultured neurons.
Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin.
Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain.
Opioid inhibition of adenylyl cyclase in membranes from pertussis toxin-treated NG108-15 cells.
Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G(i1) and G(i3).
Oxytocin Downregulates the CaV1.2 L-Type Ca2+ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes.
Palmitoylation of human endothelinB. Its critical role in G protein coupling and a differential requirement for the cytoplasmic tail by G protein subtypes.
Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes.
PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.
Paradoxical antagonism of PACAP receptor signaling by VIP in Xenopus oocytes via the type-C natriuretic peptide receptor.
Peptide YY receptors in the proximal tubule PKSV-PCT cell line derived from transgenic mice. Relation with cell growth.
Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus.
Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP.
Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract.
Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway.
Pertussis toxin attenuates 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.
Pertussis toxin attenuates angiotensin II-induced vasoconstriction and inhibition of renin release.
Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.
Pertussis toxin attenuates D2 inhibition and enhances D1 stimulation of adenylate cyclase by dopamine in rat striatum.
Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.
Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra.
Pertussis toxin blocks melatonin-induced inhibition of forskolin-stimulated adenylate cyclase activity in the chick brain.
Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists.
Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.
Pertussis toxin blocks the outward currents evoked by opiate and alpha 2-agonists in locus coeruleus neurons.
Pertussis toxin blocks the somatostatin-induced inhibition of growth hormone release and adenosine 3',5'-monophosphate accumulation.
Pertussis toxin can distinguish the augmentary effect elicited by epidermal growth factor from that of phorbol ester on luteal adenylate cyclase activity.
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.
Pertussis toxin distinguishes between muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells.
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization.
Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.
Pertussis toxin enhances proenkephalin synthesis in bovine chromaffin cells.
Pertussis toxin enhances the beta-adrenergic and blocks the alpha 2-adrenergic regulation of renin secretion in renal cortical slices.
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.
Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum.
Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells.
Pertussis toxin inhibits negative inotropic and negative chronotropic muscarinic cholinergic effects on the heart.
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
Pertussis toxin lesioning of the nucleus caudate-putamen attenuates adenylate cyclase inhibition and alters neuronal electrophysiological activity.
Pertussis toxin mediates ADP-ribosylation of pituitary membrane proteins.
Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91.
Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.
Pertussis toxin prevents homologous desensitization of adenylate cyclase in cultured renal epithelial cells.
Pertussis toxin reversal of the antilipolytic action of insulin in rat adipocytes in the presence of forskolin does not involve cyclic AMP.
Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices.
Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase.
Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production.
Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells.
Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells.
Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.
Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells.
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.
Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium.
Pertussis toxin treatment in vivo is associated with a decline in G-protein beta-subunits.
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
Pertussis toxin treatment modifies opiate action in the rat brain striatum.
Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
Pertussis toxin uncouples dopamine agonist inhibition of prolactin release.
Pertussis toxin-catalyzed ADP-ribosylation of adenylate cyclase. Effects of guanyl nucleotides and rhodopsin.
Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system.
Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase.
Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells.
Pertussis toxin-sensitive melatonin receptors negatively coupled to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells.
Pertussis toxin-treated dog: a whole animal model of impaired inhibitory regulation of adenylate cyclase.
Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase.
Pertussis toxin: a tool for studying the regulation of adenylate cyclase.
Pertussis whole cell vaccine: relation between intracerebral protection in mice and antibody response to pertussis toxin, filamentous hemagglutinin and adenylate cyclase.
Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Pharmacological characterization of the "silent" 5-hydroxytryptamine1B-like receptors of rabbit ear artery.
Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes.
Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system.
Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells.
Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action.
Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.
Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.
Phorbol ester-induced inhibition of the beta-adrenergic system in pulmonary endothelium: role of a pertussis toxin-sensitive protein.
Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain.
Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium.
Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells.
Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis.
Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells.
PKC modulation of inhibitory coupling of angiotensin II receptors with adenylate cyclase in lactotroph cells.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells.
Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: role of voltage and pH.
Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8(+) and CD4(+) T cells.
Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes.
Positive inotropism induced by androgens in isolated left atrium of rat: evidence for a cAMP-dependent transcriptional mechanism.
Positive vs. negative inotropic effects of carbachol in avian atrial muscle: role of Ni-like protein.
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
Possible involvement of pertussis toxin substrates (Gi, Go) in desipramine-induced refractoriness of adenylate cyclase in cerebral cortices of rats.
Possible involvement of pertussis toxin-sensitive G proteins and D2 dopamine receptors in the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.
Possible mechanism of CCL2-induced Akt activation in prostate cancer cells.
Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
Potent and cooperative feedback inhibition of adenylate cyclase activity by calcium in pituitary-derived GH3 cells.
Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors.
Prejunctional alpha 2-adrenoceptors and adenylyl cyclase regulation in the rabbit iris-ciliary body.
Presence of a functional inhibitory GTP-binding regulatory component, Gi, linked to adenylate cyclase in adipocytes of ob/ob mice.
Prevention of alpha 2-adrenergic inhibition on ADH action by pertussis toxin in rabbit CCT.
Progesterone inhibition of Xenopus oocyte adenylate cyclase is not mediated via the Bordetella pertussis toxin substrate.
Progress in the pursuit of therapeutic adenosine receptor antagonists.
Prokaryotic adenylate cyclase toxin stimulates anterior pituitary cells in culture.
Prolactin inhibits hCG-stimulated steroidogenesis and cAMP accumulation, possibly by increasing phosphodiesterase activity, in rat granulosa cell cultures.
Properties of delta opioid receptor in neuroblastoma NS20Y: receptor activation and neuroblastoma proliferation.
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner.
Prostaglandin E receptors in myometrial cells.
Prostaglandin E2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein.
Prostaglandin F2 alpha and alpha-adrenergic agonists regulate parathyroid cell function via the inhibitory guanine nucleotide regulatory protein.
Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C.
Prostaglandin-concentration-dependent desensitization of adenylate cyclase in human erythroleukaemia (HEL) cells is abolished by pertussis toxin and enhanced by induction by dimethyl sulphoxide.
Prostaglandin-sensitive adenylyl cyclase of cultured preadipocytes and mature adipocytes of the rat: probable role of Gi in determination of stimulatory or inhibitory action.
Prostaglandins and the urinary concentrating defect in potassium-depleted rabbits.
Prostaglandins inhibit proliferation of the murine P815 mastocytoma by decreasing cytoplasmic free calcium levels [( Ca+2]i).
Prostanoid inhibition of canine parietal cells: mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase.
Protective activity of Bordetella adenylate cyclase-hemolysin against bacterial colonization.
Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate.
Protein intrinsic viscosity determination with the Viscosizer TD instrument: reaching beyond the initially expected applications.
Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.
Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.
Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells.
Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium.
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle.
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently.
Protein-protein interaction between Bacillus stearothermophilus tyrosyl-tRNA synthetase subdomains revealed by a bacterial two-hybrid system.
Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins which involves regulation of bacterial virulence traits.
PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line.
Purification and assay of cell-invasive form of calmodulin-sensitive adenylyl cyclase from Bordetella pertussis.
Purification and characterization of a calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
Purification and characterization of the heat-labile toxin of Bordetella pertussis.
Purification and properties of calmodulin from adrenal cortex.
Purinergic receptors on insulin-secreting cells.
Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea.
Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin.
Quantifying Adenylate Cyclase Toxin of Bordetella pertussis in vitro and During Respiratory Infection.
Quantitation of adenylate cyclase of Bordetella pertussis by enzyme linked immunosorbent assay.
Quantitative mass spectrometry for bacterial protein toxins - a sensitive, specific, high-throughput tool for detection and diagnosis.
Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells.
RANTES modulates the release of glutamate in human neocortex.
Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium.
Rapid diagnosis of pertussis.
Receptor and G protein-mediated responses to thrombin in HEL cells.
Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.
Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.
Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis.
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes.
Reconstitution of muscarinic cholinergic inhibition of adenylate cyclase activity in homogenates of embryonic chick hearts by membranes of adult chick hearts.
Rediscovering Pertussis.
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.
Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor.
Regulation of Bordetella pertussis extracytoplasmic adenylate cyclase.
Regulation of calcitonin secretion in vitro.
Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.
Regulation of Xenopus oocyte meiosis arrest by G protein betagamma subunits.
Relationship between the self-incompatibility and cAMP level in Lilium longiflorum.
Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.
Repeat sequences in the Bordetella pertussis adenylate cyclase toxin can be recognized as alternative carboxy-proximal secretion signals by the Escherichia coli alpha-haemolysin translocator.
Requirement for both choleragen and pertussis toxin to obtain maximal activation of adenylate cyclase in cultured cells.
Reticulocyte cytosol activator protein: effects on the stimulatory and inhibitory regulatory proteins of adenylate cyclase.
Reticulocyte cytosol activator protein: its actions upon the beta adrenergic receptor and the N-proteins of adenylate cyclase.
Rhodopsin expressed in Chinese hamster ovary cells regulates adenylyl cyclase activity.
Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system.
Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production.
Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells.
Role of adenosine 3',5'-monophosphate and the Ri-receptor Gi-coupled adenylate cyclase inhibitory pathway in the mechanism whereby adrenalectomy increases the adenosine antilipolytic effect in rat fat cells.
Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line.
Role of Bordetella pertussis RseA in the cell envelope stress response and adenylate cyclase toxin release.
Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis.
Role of dopamine and indolamine derivatives in the regulation of the sea urchin adenylate cyclase.
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines.
Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye.
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance.
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Role of neutrophils in response to Bordetella pertussis infection in mice.
Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.
Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
Role of PKC-? in NADPH oxidase-PKC?-Gi? axis dependent inhibition of ?-adrenergic response by U46619 in pulmonary artery smooth muscle cells.
Role of PKC?-p38 MAPK-Gi? axis in peroxynitrite-mediated inhibition of ?-adrenergic response in pulmonary artery smooth muscle cells.
Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors.
Role of two different guanine nucleotide-binding proteins in the antagonistic modulation of the S-type K+ channel by cAMP and arachidonic acid metabolites in Aplysia sensory neurons.
Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms.
RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion.
RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides.
Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms.
Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.
Secretion of the Bordetella pertussis adenylate cyclase from Escherichia coli containing the hemolysin operon.
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Selective blockage by islet-activating protein, pertussis toxin, of negative signal transduction from receptors to adenylate cyclase.
Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor.
Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
Sensitive genetic screen for protease activity based on a cyclic AMP signaling cascade in Escherichia coli.
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors.
Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK.
Sequential activation and environmental regulation of virulence genes in Bordetella pertussis.
Serum resistance in bvg-regulated mutants of Bordetella pertussis.
Shapes of cells spreading on fibronectin: measurement of the stellation of BHK21 cells induced by raising cyclic AMP, and of its reversal by serum and lysophosphatidic acid.
Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells.
Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.
Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine.
Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells.
Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein.
Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Signal-transducing GTP-binding proteins of mammalian heart and lungs.
Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression.
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis.
Site I Inactivation Impacts Calmodulin Calcium Binding and Activation of Bordetella pertussis Adenylate Cyclase Toxin.
Site of pertussis toxin-induced ADP-ribosylation on Gi is critical for receptor modulation of GDP interaction with Gi.
Site-directed mutagenesis of lysine 58 in a putative ATP-binding domain of the calmodulin-sensitive adenylate cyclase from Bordetella pertussis abolishes catalytic activity.
Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain.
Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells.
Solubilization and immunopurification of a somatostatin receptor from the human gastric tumoral cell line HGT-1.
Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterization.
Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP.
Somatostatin inhibition of adenylate cyclase activity in different brain areas.
Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats.
Somatostatin inhibits follicle-stimulating hormone-induced adenylyl cyclase activity and proliferation in immature porcine Sertoli cell via sst2 receptor.
Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase.
Somatostatin inhibits stem cell factor messenger RNA expression by Sertoli cells and stem cell factor-induced DNA synthesis in isolated seminiferous tubules.
Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat.
Somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase.
Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.
Specific inhibition of FSH-stimulated cAMP accumulation by delta 9-tetrahydrocannabinol in cultures of rat Sertoli cells.
Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.
Spurious protein activators of Bordetella pertussis adenylate cyclase.
SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist.
SR144528 as inverse agonist of CB2 cannabinoid receptor.
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.
Stable inhibition of adenylate cyclase by muscarinic agonist in rat parotid gland: effects of neomycin and pertussis toxin.
Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins.
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins.
Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin.
Stimulation of Bordetella pertussis adenylate cyclase toxin intoxication by its hemolysin domain.
Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide.
Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors.
Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins.
Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin.
Structural and functional properties of a 69-kilodalton outer membrane protein of Bordetella pertussis.
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes.
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Structural characterization by nuclear magnetic resonance spectroscopy of a genetically engineered high-affinity calmodulin-binding peptide derived from Bordetella pertussis adenylate cyclase.
Structural consequences of divalent metal binding by the adenylyl cyclase toxin of Bordetella pertussis.
Structural flexibility of the calmodulin-binding locus in Bordetella pertussis adenylate cyclase. Reconstitution of catalytically active species from fragments or inactive forms of the enzyme.
Structural homology between virulence-associated bacterial adenylate cyclases.
Structure and function of A1 adenosine receptors.
Structure of a cannabinoid receptor and functional expression of the cloned cDNA.
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.
Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
Structure-function studies of the adenylate cyclase toxin of Bordetella pertussis and the leukotoxin of Pasteurella haemolytica by heterologous C protein activation and construction of hybrid proteins.
Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells.
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy.
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
Suppression of leukotriene synthesis in human leukocytes by a urea extract of Bordetella pertussis: evidence for mediation by adenylate cyclase toxin.
Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin.
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.
Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism.
Surface proteins of Bordetella pertussis.
Susceptibility of primary human airway epithelial cells to Bordetella pertussis adenylate cyclase toxin in two- and three-dimensional culture conditions.
Synergistic interaction of muscarinic and opioid receptors with GS-linked neurotransmitter receptors to stimulate adenylyl cyclase activity of rat olfactory bulb.
Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells.
Synthesis and characterization of fluorescently labeled bovine brain G protein subunits.
Synthesis and characterization of tethered lipid assemblies for membrane protein reconstitution (Review).
Synthesis and secretion of Bordetella pertussis adenylate cyclase as a 200-kilodalton protein.
Synthesis of ?-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.
Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.
Synthetic peptides corresponding to human follicle-stimulating hormone (hFSH)-beta-(1-15) and hFSH-beta-(51-65) induce uptake of 45Ca++ by liposomes: evidence for calcium-conducting transmembrane channel formation.
Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence.
Temperature Accelerated Molecular Dynamics with Soft-Ratcheting Criterion Orients Enhanced Sampling by Low-Resolution Information.
Temperature-accelerated molecular dynamics gives insights into globular conformations sampled in the free state of the AC catalytic domain.
The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor.
The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
The action of pertussis toxin on heart adenylate cyclase and lipolysis in the parametrial adipose tissue of the rat.
The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies.
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.
The adenylate cyclase of Bordetella pertussis: a vector to target antigen presenting cells.
The adenylate cyclase toxin contributes to the survival of Bordetella pertussis within human macrophages.
The adenylate cyclase toxin from Bordetella pertussis--a novel promising vehicle for antigen delivery to dendritic cells.
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).
The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.
The adenylate cyclase toxins.
The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity.
The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse.
The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.
The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col.
The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli.
The Campylobacter jejuni CiaC virulence protein is secreted from the flagellum and delivered to the cytosol of host cells.
The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells.
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status.
The coupling of pertussis toxin-sensitive G proteins to phospholipase A2 and adenylyl cyclase in CHO cells expressing bovine rhodopsin.
The cox-2-specific inhibitor celecoxib inhibits adenylyl cyclase.
The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.
The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells.
The effect of growth conditions on adenylate cyclase activity and virulence-related properties of Bordetella pertussis.
The effect of streptozotocin diabetes on the vasoactive intestinal peptide receptor/effector system in membranes from rat ventral prostate.
The effects of endothelin-1 on the PKA-dependent Cl- current in the heart.
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
The H-L subgroup of guinea-pig cardiac M2 receptors (M2 beta) regulates inositol phosphate formation.
The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.
The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.
The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells.
The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteins.
The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha.
The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells.
The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism.
The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase.
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.
The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells.
The interaction of Ca2+ with the calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.
The invasive adenylate cyclase of Bordetella pertussis. Intracellular localization and kinetics of penetration into various cells.
The invasive adenylate cyclase of Bordetella pertussis. Properties and penetration kinetics.
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases.
The morphological changes in cultured cells caused by Bordetella pertussis adenylate cyclase toxin.
The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte.
The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1.
The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi.
The P2Y14 receptor activity in glioma C6 cells.
The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling.
The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. Coupling to adenylate cyclase/cyclic AMP signal-transduction system.
The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes.
The relationship between 3',5'-cyclic adenosine monophosphate and calcium in mediating follicle-stimulating hormone signal transduction in Sertoli cells.
The RNA Chaperone Hfq is Required for Virulence of Bordetella pertussis.
The role of histidine 63 in the catalytic mechanism of Bordetella pertussis adenylate cyclase.
The somatostatin receptor family.
The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways.
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein.
The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response.
Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope.
Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C.
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.
Tn5-induced mutations affecting virulence factors of Bordetella pertussis.
Tonic inhibition of adenylate cyclase in cultured hamster Sertoli cells.
Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis.
Toxicity tests on native and recombinant Bordetella pertussis adenylate cyclase toxin preparations.
Toxins which activate adenylate cyclase.
Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.
Transcriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis.
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Transforming growth factor-beta 1 regulation of signal transduction in two renal epithelial cell lines.
Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.
Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells.
Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis.
Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.
Transmembrane signalling pathways initiating cell growth in fibroblasts.
Treatment in hypertensive cardiac hypertrophy, II. Postreceptor events.
Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms.
Treatment with pertussis toxin does not prevent central effects of eel calcitonin.
Tricyclic antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal cord neurons.
tTGase/G alpha h protein expression inhibits adenylate cyclase activity in Balb-C 3T3 fibroblasts membranes.
Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein.
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells.
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes.
Up-regulation of beta 2-adrenergic receptors in previously transplanted, denervated nonfailing human hearts.
Uptake and intracellular survival of Bordetella pertussis in human macrophages.
Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.
Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.
Use of pertussis toxin to investigate the mechanism of action of prostaglandin F2 alpha on the corpus luteum in sheep.
Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule. Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate.
Virulence dependent and independent regulation of the Bordetella pertussis cya operon.
Virulence factor secretion and translocation by Bordetella species.
Virulence of a Bordetella pertussis strain expressing a mutant adenylyl cyclase with decreased calmodulin affinity.
WAY208466 inhibits glutamate release at hippocampal nerve terminals.
Whooping Cough in Adults: A Series of Severe Cases.
[A polyvalent complex of Bordetella pertussis antigens as the basis for an acellular pertussis vaccine]
[Development and optimization of an in-house PCR method for molecular diagnosis of pertussis].
[Evaluation of G(i/o) protein signal transduction pathway in cardioprotection of hypoxic preconditioning]
[Intracellular messengers in the regulation of renin secretion]
[Localization of segments in the Gs protein interacting with adenylate cyclase using a Gs/G0-chimera]
[Pertussis toxin stimulates brain adenyl cyclase and induces ADP ribosylation of a 40,000 dalton membrane protein]
[Regulation by cations of adenylate cyclase activity in chicken tissues]
[Structural organization of a segment of chromosome, containing the vir gene of Bordetella pertussis]
[The discovery of neuromedin U and its pivotal role in the central regulation of energy homeostasis].
Wolfram Syndrome
RETRACTION: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
Xeroderma Pigmentosum
Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism.
Yersinia Infections
[Prostaglandins and cyclic nucleotides in the gastrointestinal form of yersiniosis]
Zika Virus Infection
Variations in maternal adenylate cyclase genes are associated with congenital Zika syndrome in a cohort from Northeast, Brazil.