EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
non-small cell lung cancer cell |
- |
685958, 689069 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
non-small cell lung cancer cell |
NSCLC cell, much lower expression of 15-hydroxyprostaglandin dehydrogenase in all NSCLC histologic groups compared with healthy lung cell. Treatment with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib increases the expression of the enzyme in a subset of NSCLC lines |
685947 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
non-small cell lung cancer cell |
reduced expression of 15-PGDH occurrs in tumor cells and is paralleled by decreased 15-PGDH activity in tumors |
697090 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
non-small cell lung cancer cell |
the amount of 15-PGDH is frequently decreased in NSCLC cells compared with adjacent normal lung |
697090 |
1.1.1.184 | carbonyl reductase (NADPH) |
non-small cell lung cancer cell |
enzyme expression analysis, 59 different samples |
668135 |
1.11.1.27 | glutathione-dependent peroxiredoxin |
non-small cell lung cancer cell |
- |
765749 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
non-small cell lung cancer cell |
- |
744224 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
non-small cell lung cancer cell |
increased expression of PTGS2 |
728294 |
1.3.1.20 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
non-small cell lung cancer cell |
- |
687141 |
1.3.1.91 | tRNA-dihydrouridine20 synthase [NAD(P)+] |
non-small cell lung cancer cell |
elevated hDus2 mRNA and protein levels |
743940 |
1.4.4.2 | glycine dehydrogenase (aminomethyl-transferring) |
non-small cell lung cancer cell |
- |
724693 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
non-small cell lung cancer cell |
H1299 |
674464 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
non-small cell lung cancer cell |
overexpression |
724356 |
2.1.1.1 | nicotinamide N-methyltransferase |
non-small cell lung cancer cell |
the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue |
733449, 733618 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
non-small cell lung cancer cell |
- |
757010 |
2.3.1.48 | histone acetyltransferase |
non-small cell lung cancer cell |
- |
756850 |
2.3.1.48 | histone acetyltransferase |
non-small cell lung cancer cell |
high GCN5 expression level which correlates with tumor size |
736413 |
2.3.1.50 | serine C-palmitoyltransferase |
non-small cell lung cancer cell |
- |
755965 |
2.3.1.57 | diamine N-acetyltransferase |
non-small cell lung cancer cell |
A549 and H157. TNFalpha can lead to the induction of NFkappaB signaling with a concomitant increase in spermidine/spermine N1-acetyltransferase expression |
674623 |
2.3.1.B43 | protein-lysine desuccinylase (NAD+) |
non-small cell lung cancer cell |
SIRT5 is overexpressed in human non-small cell lung cancer cells, high expression of SIRT5 predicts poor survival |
731010 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
non-small cell lung cancer cell |
GCNT3 is highly expressed in both NSCLC tissues and cell lines |
760226 |
2.4.1.149 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase |
non-small cell lung cancer cell |
NSCLC, quantitative real-time PCR enzyme expression analysis |
759552 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
non-small cell lung cancer cell |
GCNT3 is highly expressed in both NSCLC tissues and cell lines |
760226 |
2.4.2.10 | orotate phosphoribosyltransferase |
non-small cell lung cancer cell |
- |
759774 |
2.4.2.4 | thymidine phosphorylase |
non-small cell lung cancer cell |
- |
735645 |
2.4.2.4 | thymidine phosphorylase |
non-small cell lung cancer cell |
similar distribution of thymidine phosphorylase and thymidine kinase, EC 2.7.1.21, immunohistochemical analysis, overview |
704933 |
2.4.2.4 | thymidine phosphorylase |
non-small cell lung cancer cell |
the mean thymidine phosphorylase concentration in non-small cell lung cancer tissue is statistically higher than that of normal lung tissue |
676268 |
2.5.1.59 | protein geranylgeranyltransferase type I |
non-small cell lung cancer cell |
- |
705670, 739426 |
2.6.1.13 | ornithine aminotransferase |
non-small cell lung cancer cell |
NSCLC cell. Upregulation of OAT in NSCLC tissues |
759545 |
2.7.1.105 | 6-phosphofructo-2-kinase |
non-small cell lung cancer cell |
- |
761491 |
2.7.1.171 | protein-fructosamine 3-kinase |
non-small cell lung cancer cell |
- |
760823 |
2.7.1.30 | glycerol kinase |
non-small cell lung cancer cell |
- |
761627 |
2.7.1.74 | deoxycytidine kinase |
non-small cell lung cancer cell |
- |
704900 |
2.7.10.1 | receptor protein-tyrosine kinase |
non-small cell lung cancer cell |
- |
661551, 737831 |
2.7.10.1 | receptor protein-tyrosine kinase |
non-small cell lung cancer cell |
high expression level of ErbB1 receptor |
660873 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
non-small cell lung cancer cell |
i.e. NSCLC, reduced PDK/PDH activity, PDK1 and PDH expression patterns |
662948 |
2.7.11.30 | receptor protein serine/threonine kinase |
non-small cell lung cancer cell |
- |
692159 |
2.7.12.1 | dual-specificity kinase |
non-small cell lung cancer cell |
- |
741257 |
2.7.7.1 | nicotinamide-nucleotide adenylyltransferase |
non-small cell lung cancer cell |
- |
737990 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
non-small cell lung cancer cell |
- |
739489 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
non-small cell lung cancer cell |
- |
761220 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
non-small cell lung cancer cell |
HS3ST3B1 is significantly upregulated in NSCLC tissues compared with matched normal tissues. Its expression is also upregulated in mesenchymal phenotype of non-small cell lung cancer cell (NSCLC) lines compared with epithelial phenotype. When TGF-beta is applied to induce the epithelial phenotype to mesenchymal phenotype, HS3ST3B1 is upregulated compared with previous epithelial cell lines. When HS3ST3B1 is knocked down by specific small interfering RNA in the mesenchymal phenotype, mesenchymal phenotype is transformed to epithelial phenotype. HS3ST3B1 can be targeted by miR-218 in non-small cell lung cancer cells (NSCLC) |
761577 |
2.8.2.B6 | [heparan sulfate]-iuronate 2-sulfotransferase |
non-small cell lung cancer cell |
- |
761220 |
3.1.3.1 | alkaline phosphatase |
non-small cell lung cancer cell |
- |
679113 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
non-small cell lung cancer cell |
- |
696397 |
3.4.17.23 | angiotensin-converting enzyme 2 |
non-small cell lung cancer cell |
decreased ACE2 expression, expression profile in relation to clinicopathological factors, e.g. smoking, overview |
710171 |
3.4.21.119 | kallikrein 13 |
non-small cell lung cancer cell |
- |
732966 |
3.4.21.B41 | kallikrein 10 |
non-small cell lung cancer cell |
KLK10 is significantly downregulated as compared to non-cancer samples. CpG island hypermethylation of KLK10 is detected in 46.2% of non-small cell lung cancer tissues |
707999 |
3.4.21.B42 | hippostasin |
non-small cell lung cancer cell |
patients with a high enzyme activity have a longer longer overall survival and progression free survival, expression analysis in 138 cancer samples and 40 healthy controls |
732964 |
3.4.21.B45 | kallikrein 14 |
non-small cell lung cancer cell |
KLK13 and KLK14 cannot be considered as specific markers for non-small-cell lung cancer |
691155 |
3.4.22.56 | caspase-3 |
non-small cell lung cancer cell |
- |
699643 |
3.4.22.61 | caspase-8 |
non-small cell lung cancer cell |
- |
697284, 699643 |
3.4.24.22 | stromelysin 2 |
non-small cell lung cancer cell |
MMP-10 protein levels are higher in the tumor tissues than in the adjacent normal tissues |
684472 |
3.4.24.23 | matrilysin |
non-small cell lung cancer cell |
MMP-7 expression analysis of 106 different samples, higher enzyme levels in squamous compared to adenocarcinomas, MMP-7 expression increases the cell proliferation and is correlated to Wnt1 expression,overview |
683843 |
3.4.24.86 | ADAM 17 endopeptidase |
non-small cell lung cancer cell |
- |
719210 |
3.4.24.B7 | matrix metalloproteinase-26 |
non-small cell lung cancer cell |
high expression rate of MMP-26 |
710795 |
3.5.4.5 | cytidine deaminase |
non-small cell lung cancer cell |
- |
753114 |
3.6.4.13 | RNA helicase |
non-small cell lung cancer cell |
- |
756284 |
3.6.5.1 | heterotrimeric G-protein GTPase |
non-small cell lung cancer cell |
- |
735104 |
4.1.1.17 | ornithine decarboxylase |
non-small cell lung cancer cell |
- |
708200 |
4.2.1.1 | carbonic anhydrase |
non-small cell lung cancer cell |
- |
699957 |
4.6.1.2 | guanylate cyclase |
non-small cell lung cancer cell |
- |
694121 |
5.3.99.5 | thromboxane-A synthase |
non-small cell lung cancer cell |
- |
702474, 703584 |
5.3.99.5 | thromboxane-A synthase |
non-small cell lung cancer cell |
adenocarcinomas and squamous cell carcinomas, enzyme expression profile, overview. Enzyme expression is higher in adenocarcinoma and female patients |
728292 |
5.6.2.1 | DNA topoisomerase |
non-small cell lung cancer cell |
- |
714760 |
6.1.1.10 | methionine-tRNA ligase |
non-small cell lung cancer cell |
high expression |
744596 |
6.3.4.5 | argininosuccinate synthase |
non-small cell lung cancer cell |
increased co-expression of AS and TNF-a mRNA is observed in non-small cell lung and stomach cancer, compared with normal corresponding tissues |
674048 |
6.4.1.1 | pyruvate carboxylase |
non-small cell lung cancer cell |
- |
745446 |
7.1.1.1 | proton-translocating NAD(P)+ transhydrogenase |
non-small cell lung cancer cell |
- |
765163 |
7.1.2.2 | H+-transporting two-sector ATPase |
non-small cell lung cancer cell |
- |
748800 |