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Information on EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase

for references in articles please use BRENDA:EC2.7.11.2
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IUBMB Comments
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
pyruvate dehydrogenase kinase, pdh kinase, pyruvate dehydrogenase kinase 4, pyruvate dehydrogenase kinase 1, pdhk2, pdhk4, pyruvate dehydrogenase kinase-4, pdhk1, pdk-4, pdk-2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
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ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)]phosphate
show the reaction diagram