Information on EC 2.7.11.30 - receptor protein serine/threonine kinase

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EC Tree 2 Transferases 2.7 Transferring phosphorus-containing groups 2.7.11 Protein-serine/threonine kinases 2.7.11.30 receptor protein serine/threonine kinase

IUBMB Comments

The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].

The enzyme appears in viruses and cellular organisms