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Literature summary for 4.6.1.2 extracted from

  • Punathil, T.; Katiyar, S.K.
    Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2 (2008), Mol. Carcinog., 48, 232-242.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
nitric oxide
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1one
-
 Homo sapiens
1H-[1,2,4]oxadiazolo[4.3a]quinoxalin-1-one inhibition of the enzyme is blocked by 8-bromo-cGMP or L-arginine Homo sapiens
additional information inhibition of the enzyme is involved in inhibition of tumor cell migration in lung Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens the enzyme and cGMP-pathway are involved in NO-mediated cell migration 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Homo sapiens
-
 3',5'-cyclic-GMP + diphosphate
-
 ?
additional information Homo sapiens inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
adenocarcinoma cell
-
 Homo sapiens
-
large cell lung cancer cell line
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP the enzyme and cGMP-pathway are involved in NO-mediated cell migration Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP
-
 Homo sapiens 3',5'-cyclic-GMP + diphosphate
-
 ?
additional information inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2, overview Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function guanylate cyclase plays a role in migration of A-549 cells Homo sapiens