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Information on EC 2.7.1.21 - thymidine kinase

for references in articles please use BRENDA:EC2.7.1.21

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IUBMB Comments

Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP—thymidine kinase), EC 2.7.1.118 (ADP—thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).

The enzyme appears in viruses and cellular organisms
Reaction Schemes

Synonyms
thymidine kinase, hsv1-tk, calmodulin-binding protein, thymidine kinase 1, thymidylate kinase, type 1 thymidine kinase, hsv-1 tk, thymidine kinase 2, mitochondrial thymidine kinase, cam-binding protein, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + thymidine = ADP + dTMP
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
pyrimidine deoxyribonucleosides salvage