Application | Comment | Organism |
---|---|---|
medicine | chemical enzyme PFKFB3 inhibition synergizes with erlotinib in increasing erlotinib s antiproliferative activity in NSCLC cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16875 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung cancer cell | - |
Homo sapiens | - |
NCI-H522 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
PC-9 cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PFKFB3 | bifunctional enzyme with 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase activities | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme PFKFB3 is an essential target of epidermal growth factor receptor signaling. PFKFB3 activation is required for glycolysis stimulation upon epidermal growth factor receptor activation. PFKFB3 has a key role in mediating glucose metabolism and survival of NSCLC cells in response to epidermal growth factor receptor signaling | Homo sapiens |