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cdc2/CDC28-like protein kinase
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dual specificity protein kinase
dual specificity protein kinase TTK
dual specificity tyrosine phosphorylated and regulated kinase 1B
dual specificity tyrosine phosphorylation regulated kinase 1A
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dual specificity tyrosine phosphorylation regulated kinase 2
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dual specificity tyrosine phosphorylation-regulated kinase
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dual specificity tyrosine phosphorylation-regulated kinase 3
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dual specificity tyrosine phosphorylation-regulated kinase 4
dual specificity tyrosine-phosphorylated and regulated kinase 1A
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dual specificity tyrosine-phosphorylation-regulated kinase 1A
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dual specificity tyrosine-phosphorylation-regulated kinase 1A Dyrk1A
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dual specificity tyrosine-phosphorylation-regulated kinase 1B
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dual specificity tyrosine-phosphorylation-regulated kinase 2
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dual specificity tyrosine-phosphorylation-regulated kinase 3
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dual specificity tyrosine-phosphorylation-regulated kinase-1A
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dual-specificity protein kinase
dual-specificity Tyr phosphorylation-regulated kinase
dual-specificity tyrosine phosphorylation-regulated kinase
dual-specificity tyrosine phosphorylation-regulated kinase 1A
dual-specificity tyrosine phosphorylation-regulated kinase 1A Dyrk1A
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dual-specificity tyrosine phosphorylation-regulated kinase 1B
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dual-specificity tyrosine-phosphorylation regulated kinase 1A
dual-specificity tyrosine-phosphorylation regulated kinase 1B
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dual-specificity tyrosine-phosphorylation regulated kinase 2
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dual-specificity tyrosine-phosphorylation regulated kinase 3
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dual-specificity tyrosine-phosphorylation-regulated kinase
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dual-specificity tyrosine-phosphorylation-regulated kinase 2
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dual-specificity tyrosine-regulated kinase
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dual-specificity tyrosine-regulated kinase 1A
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EC 2.7.1.37
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formerly, part transferred
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leucine-rich repeat-receptor-like protein kinase
minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A
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mycetozoa protein kinase-like
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non-receptor tyrosine kinase spore lysis A
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protein kinase gene DYRK3
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protein tyrosine kinase 2
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receptor serine/threonine/tyrosine kinase 1
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serine/threonine protein kinase minibrain
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serine/threonine protein kinase MPS1
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serine/threonine/tyrosine kinase
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serine/threonine/tyrosine protein kinase
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triacylglycerol accumulation regulator1
additional information
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the enzyme belongs to the insulin receptor substrate family
AtYak1
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AtYak1 kinase
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biliverdin reductase
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biliverdin reductase
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human biliverdin reductase is a dual-specificity kinase (Ser/Thr and Tyr)
dual specificity kinase
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dual specificity kinase
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dual specificity protein kinase
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dual specificity protein kinase
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dual specificity protein kinase
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dual specificity protein kinase
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dual specificity protein kinase TTK
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dual specificity protein kinase TTK
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dual specificity tyrosine phosphorylated and regulated kinase 1B
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dual specificity tyrosine phosphorylated and regulated kinase 1B
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dual specificity tyrosine phosphorylation-regulated kinase 4
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dual specificity tyrosine phosphorylation-regulated kinase 4
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dual-specificity protein kinase
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dual-specificity protein kinase
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dual-specificity protein kinase
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dual-specificity Tyr phosphorylation-regulated kinase
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dual-specificity Tyr phosphorylation-regulated kinase
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dual-specificity tyrosine phosphorylation-regulated kinase
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dual-specificity tyrosine phosphorylation-regulated kinase
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dual-specificity tyrosine phosphorylation-regulated kinase
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dual-specificity tyrosine phosphorylation-regulated kinase 1A
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dual-specificity tyrosine phosphorylation-regulated kinase 1A
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dual-specificity tyrosine-phosphorylation regulated kinase 1A
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dual-specificity tyrosine-phosphorylation regulated kinase 1A
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dual-specificity tyrosine-phosphorylation regulated kinase 1A
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dual-specificity tyrosine-phosphorylation regulated kinase 1A
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DYRK
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DYRK1A
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DYRK1B
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DYRK2
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DYRK3
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DYRK4
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GCRFno11_b05
locus name
GCRFno11_b05
locus name
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leucine-rich repeat-receptor-like protein kinase
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leucine-rich repeat-receptor-like protein kinase
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protein kinase CLK1
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protein kinase CLK2
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protein kinase CLK3
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Ser/Thr/Tyr kinase
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Ser/Thr/Tyr kinase
Thermospora curvatum
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STYK
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STYK
Thermospora curvatum
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TAR1
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triacylglycerol accumulation regulator1
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triacylglycerol accumulation regulator1
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Yak1 protein
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ATP + a protein
ADP + a phosphoprotein
ATP + adaptor protein SH2 domain-containing leukocyte protein
ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein]
ATP + amphiphysin I
ADP + phosphorylated amphiphysin I
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Substrates: -
Products: -
?
ATP + annexin 1
ADP + phospho-annexin 1
ATP + annexin 2
ADP + phospho-annexin 2
ATP + annexin 4
ADP + phospho-annexin 4
ATP + biotin-Ttds-TPGSRSRTPSLPT
ADP + phosphorylated biotin-Ttds-TPGSRSRTPSLPT
ATP + biotin-Ttds-VGLLKLASPELER
ADP + phosphorylated biotin-Ttds-VGLLKLASPELER
ATP + casein
ADP + phosphorylated casein
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Substrates: -
Products: -
?
ATP + caspase-9
ADP + phosphorylated caspase-9
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Substrates: -
Products: -
?
ATP + CREB
ADP + phosphorylated CREB
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Substrates: -
Products: -
?
ATP + cyclin L2
ADP + phosphorylated cyclin L2
ATP + dynamin 1
ADP + phosphorylated dynamin 1
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Substrates: -
Products: -
?
ATP + dynamin I
ADP + phosphorylated dynamin I
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Substrates: -
Products: -
?
ATP + eIF2Bepsilon
ADP + phosphorylated eIF2Bepsilon
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Substrates: -
Products: -
?
ATP + extracellular MAP kinase kinase
ADP + phospho-[MAP kinase kinase]
Substrates: -
Products: -
?
ATP + extracellular signal-regulated kinase
ADP + phospho-[extracellular signal-regulated kinase]
Substrates: -
Products: -
?
ATP + Gli1 protein
ADP + phosphorylated Gli1 protein
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Substrates: -
Products: -
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
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Substrates: -
Products: -
?
ATP + histone
ADP + phosphorylated histone
Substrates: recombinant glutathione S-transferase-Dyrk/fusion protein catalyzes histone phosphorylation on tyrosine and Ser/Thr residues
Products: -
?
ATP + histone H1
ADP + phosphorylated histone H1
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Substrates: -
Products: -
?
ATP + immunglobulin-alpha
ADP + phospho-[immunglobulin-alpha]
ATP + insulin receptor kinase substrate 1
ADP + phosphorylated insulin receptor kinase substrate 1
ATP + microtubule associated protein 1B
ADP + phosphorylated microtubule associated protein 1B
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Substrates: DYRK1A phosphorylates the S1392 site on microtubule associated protein 1B
Products: -
?
ATP + myelin basic protein
ADP + phospho-[myelin basic protein]
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Substrates: the substrate is phosphorylated on Ser, Thr, and Tyr residues by PrkG
Products: -
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
ATP + neurodegeneration-related septin 4
ADP + phosphorylated neurodegeneration-related septin 4
Substrates: SEPT4, also known as Pnutl2/CDCrel-2
Products: -
?
ATP + NFAT
ADP + phosphorylated NFAT
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Substrates: -
Products: -
?
ATP + Notch protein
ADP + phosphorylated Notch protein
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Substrates: -
Products: -
?
ATP + Notch-IC
ADP + phosphorylated Notch-IC
Substrates: -
Products: -
?
ATP + p27
ADP + phospho-p27
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Substrates: p27 phosphorylation at Ser10 and Thr198
Products: -
?
ATP + peptide DYRKtide
ADP + phosphorylated peptide DYRKtide
ATP + poly-(Tyr-Glu)
ADP + phospho-poly-(Tyr-Glu)
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Substrates: tyrosine kinase substrate
Products: -
?
ATP + Pop2p
ADP + phosphorylated Pop2p
Substrates: -
Products: -
?
ATP + PRAS40
ADP + phospho-PRAS40
Substrates: phosphorylation at Thr246
Products: -
?
ATP + PRAS40
ADP + phosphorylated PRAS40
Substrates: i.e. proline rich Akt substrate 40
Products: -
?
ATP + protein
ADP + phosphoprotein
ATP + protein tyrosine
ADP + protein tyrosine phosphate
Substrates: autophosphorylated on Ser and Thr residues
Products: -
?
ATP + pyruvate kinase
ADP + phospho-[pyruvate kinase]
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Substrates: phosphorylated by PrkD on Ser and Thr residues
Products: -
?
ATP + RNA binding family protein
ADP + phospho-RNA binding family protein
ATP + RRARKLTATPTPLGG
ADP + RRARKLTApTPTPLGG
ATP + RRRFRPASPLRGPPK
ADP + RRRFRPApSPLRGPPK
ATP + S6K1
ADP + phospho-S6K1
Substrates: phosphorylation at Thr389
Products: -
?
ATP + Ser/Arg-rich splicing factors
ADP + phosphorylated Ser/Arg-rich splicing factor
Substrates: -
Products: -
?
ATP + serine/arginine-rich protein 55
ADP + phospho-serine/arginine-rich protein 55
ATP + SF3B1 protein-L-Thr434
ADP + [SF3B1 protein]-L-Thr434 phosphate
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Substrates: -
Products: -
?
ATP + splicing factor 2
ADP + phosphorylated splicing factor 2
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Substrates: -
Products: -
?
ATP + splicing factor 3
ADP + phosphorylated splicing factor 3
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Substrates: -
Products: -
?
ATP + splicing factor 3B1
ADP + phosphorylated splicing factor 3B1
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Substrates: splicing factor 3B1 is poshorylated at Thr434
Products: -
?
ATP + SR protein
ADP + hyperphosphorylated SR protein
Substrates: i.e. serine-rich and arginine-rich proteins
Products: -
?
ATP + STAT3
ADP + phosphorylated STAT3
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Substrates: -
Products: -
?
ATP + synaptojanin I
ADP + phosphorylated synaptojanin I
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Substrates: -
Products: -
?
ATP + tau protein-L-Thr434
ADP + [tau protein]-L-Thr434 phosphate
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Substrates: -
Products: -
?
ATP + transcription factor FKHR
ADP + phosphorylated transcription factor FKHR
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Substrates: -
Products: -
?
ATP + VSNGSPSLER
ADP + VSNGpSPSLER
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Substrates: a p27-derived peptide, residues 6-15
Products: -
?
biliverdin + ?
bilirubin + ?
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Substrates: -
Products: -
?
additional information
?
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ATP + a protein
ADP + a phosphoprotein
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Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
-
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: enzyme Syk phosphoryles serine and tyrosine residues
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
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Substrates: -
Products: -
?
ATP + adaptor protein SH2 domain-containing leukocyte protein
ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein]
Substrates: -
Products: -
?
ATP + adaptor protein SH2 domain-containing leukocyte protein
ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein]
Substrates: phosphorylation of SLP-65 on several tyrosines
Products: -
?
ATP + annexin 1
ADP + phospho-annexin 1
Substrates: phosphorylation at tyrosine and serine/threonine residues
Products: -
?
ATP + annexin 1
ADP + phospho-annexin 1
Substrates: phosphorylation at tyrosine and serine/threonine residues
Products: -
?
ATP + annexin 2
ADP + phospho-annexin 2
Substrates: phosphorylation at tyrosine and serine/threonine residues
Products: -
?
ATP + annexin 2
ADP + phospho-annexin 2
Substrates: phosphorylation at tyrosine and serine/threonine residues
Products: -
?
ATP + annexin 4
ADP + phospho-annexin 4
Substrates: phosphorylation at tyrosine residues
Products: -
?
ATP + annexin 4
ADP + phospho-annexin 4
Substrates: phosphorylation at tyrosine residues
Products: -
?
ATP + biotin-Ttds-TPGSRSRTPSLPT
ADP + phosphorylated biotin-Ttds-TPGSRSRTPSLPT
Substrates: i.e. peptide PEP3
Products: -
?
ATP + biotin-Ttds-TPGSRSRTPSLPT
ADP + phosphorylated biotin-Ttds-TPGSRSRTPSLPT
Substrates: i.e. peptide PEP3
Products: -
?
ATP + biotin-Ttds-VGLLKLASPELER
ADP + phosphorylated biotin-Ttds-VGLLKLASPELER
Substrates: i.e. peptide PEP285
Products: -
?
ATP + biotin-Ttds-VGLLKLASPELER
ADP + phosphorylated biotin-Ttds-VGLLKLASPELER
Substrates: i.e. peptide PEP285
Products: -
?
ATP + cyclin L2
ADP + phosphorylated cyclin L2
Substrates: -
Products: -
?
ATP + cyclin L2
ADP + phosphorylated cyclin L2
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Substrates: -
Products: -
?
ATP + immunglobulin-alpha
ADP + phospho-[immunglobulin-alpha]
Substrates: the inhibitory residue of Ig-alpha S197 is phosphorylated in activated B cells by Syk
Products: -
?
ATP + immunglobulin-alpha
ADP + phospho-[immunglobulin-alpha]
Substrates: phosphorylation of tyrosines of Ig-alpha and Ig-beta and on Ser197, immunohistochemic determination of phosphorylation site Ser197
Products: -
?
ATP + insulin receptor kinase substrate 1
ADP + phosphorylated insulin receptor kinase substrate 1
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Substrates: phosphorylation at serine residues, overview, the enzyme is involved in the insulin signaling pathway
Products: -
?
ATP + insulin receptor kinase substrate 1
ADP + phosphorylated insulin receptor kinase substrate 1
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Substrates: phosphorylation at serine residues leading to blockage of insulin action, overview
Products: -
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
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Substrates: -
Products: -
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
Substrates: phosphorylation on serine, threonine, and tyrosine residues
Products: -
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
Substrates: phosphorylation on a C-terminal Ser residue
Products: -
?
ATP + peptide DYRKtide
ADP + phosphorylated peptide DYRKtide
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Substrates: synthetic peptide substrate
Products: -
?
ATP + peptide DYRKtide
ADP + phosphorylated peptide DYRKtide
Substrates: synthetic peptide substrate
Products: -
?
ATP + protein
ADP + phosphoprotein
Substrates: autophosphorylation
Products: -
?
ATP + protein
ADP + phosphoprotein
Substrates: autophosphorylates on Ser/Thr and Tyr residues
Products: -
?
ATP + protein
ADP + phosphoprotein
Substrates: autophosphorylation
Products: -
?
ATP + protein
ADP + phosphoprotein
Substrates: autophosphorylates on Ser/Thr and Tyr residues
Products: -
?
ATP + protein
ADP + phosphoprotein
Substrates: when expressed in E. coli the enzyme catalyzes autophosphorylation on Tyr residues
Products: -
?
ATP + protein
ADP + phosphoprotein