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Information on EC 3.4.17.23 - angiotensin-converting enzyme 2

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IUBMB Comments

A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates . Catalytic efficiency is 400-fold higher with angiotensin II (1-8) as a substrate than with angiotensin I (1-10). Angiotensin-converting enzyme 2 also efficiently hydrolyzes des-Arg9-bradykinin, but it does not hydrolyze bradykinin . In peptidase family M2.

The enzyme appears in viruses and cellular organisms

Synonyms
angiotensin-converting enzyme 2, tmprss2, ace-2, angiotensin converting enzyme 2, hace2, angiotensin converting enzyme-2, sace2, ace 2, angiotensin converting enzyme ii, angiotensin-converting enzyme type 2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine
show the reaction diagram