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Literature summary for 2.1.1.1 extracted from

  • Sartini, D.; Seta, R.; Pozzi, V.; Morganti, S.; Rubini, C.; Zizzi, A.; Tomasetti, M.; Santarelli, L.; Emanuelli, M.
    Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity (2015), Biol. Chem., 396, 225-234.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme might be a good molecular target for lung cancer therapy Homo sapiens
pharmacology the enzyme might be a good molecular target for lung cancer therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
lung cancer cell
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Homo sapiens
-
additional information quantitative real-time PCR enzyme expression analysis Homo sapiens
-
non-small cell lung cancer cell the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue Homo sapiens
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Synonyms

Synonyms Comment Organism
NNMT
-
Homo sapiens

General Information

General Information Comment Organism
malfunction shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells Homo sapiens
physiological function role of nicotinamide N-methyltransferase in non-small cell lung cancer Homo sapiens