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Literature summary for 2.7.11.30 extracted from

  • Bueno, L.; de Alwis, D.P.; Pitou, C.; Yingling, J.; Lahn, M.; Glatt, S.; Troconiz, I.F.
    Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice (2008), Eur. J. Cancer, 44, 142-150.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
LY2157299 inhibits Smad3 and Smad3 phosphorylation and antagonizes TGF-beta receptor I kinase activity in vivo in human cancer cells implanted into nude mice, pharmacokinetic model, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [TGF-beta receptor I] Homo sapiens
-
 ADP + [TGF-beta receptor I] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell
-
 Homo sapiens
-
Calu-6 cell anaplastic carcinoma lung cell Homo sapiens
-
MX-1 cell carcinoma breast cell Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [TGF-beta receptor I]
-
 Homo sapiens ADP + [TGF-beta receptor I] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
type I receptor TGF-beta kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens