Application | Comment | Organism |
---|---|---|
diagnostics | OAT may be a potential biomarker for the diagnosis and therapeutic outcome monitoring of non-small cell lung cancer (NSCLC). Relationship between OAT mRNA expression and clinicopathological features in patients with NSCLC, overview | Homo sapiens |
medicine | inhibition of OAT may represent a therapeutic strategy in treatment of non-small cell lung cancer (NSCLC) | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of OAT promoting the growth and metastasis of A549 cells. OAT knockdown in H-1299 cells transfected with OAT siRNA results in a lower expression level of OAT mRNA and protein than in the control group. Knockdown of OAT suppresses cell proliferation, decreases the number of colonies, invades cells, and migrates cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine + 2-oxoglutarate | Homo sapiens | - |
L-glutamate 5-semialdehyde + L-glutamate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04181 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
NCI-H226 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | NSCLC cell. Upregulation of OAT in NSCLC tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine + 2-oxoglutarate | - |
Homo sapiens | L-glutamate 5-semialdehyde + L-glutamate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
OAT | - |
Homo sapiens |
ornithine aminotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | PLP, dependent on | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is upregulated in non-small cell lung cancer cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of OAT promotes the growth and metastasis of A-549 lung cancer cells, and overexpression of OAT also promotes the epithelial-mesenchymal transition (EMT) of OAT-overexpressing A549 cells. Knockdown of OAT inhibits the proliferation and metastasis of H-1299 cells | Homo sapiens |
physiological function | ornithine aminotransferase (OAT) promotes the proliferation, invasion, and migration, inhibits the apoptosis, and alters cell cycle of non-small cell lung cancer cells (NSCLC cells). Also the involvement of OAT-miR-21-glycogen synthase kinase-3beta signaling in the functional role of OAT in NSCLC is revealed. Glycogen synthase kinase-3beta (GSK-3beta) is a direct target of miR-21 in NSCLC | Homo sapiens |