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Literature summary for 1.4.4.2 extracted from

  • Dominy, J.; Vazquez, F.; Puigserver, P.
    Glycine decarboxylase cleaves a malignant metabolic path to promote tumor initiation (2012), Cancer Cell, 21, 143-145.
    View publication on PubMed
Search for more literature for 1.4.4.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + H-protein-lipoyllysine Mus musculus
-
 H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
 Mus musculus
-
non-small cell lung cancer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + H-protein-lipoyllysine
-
 Mus musculus H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GLDC
-
 Mus musculus
P-protein
-
 Mus musculus

General Information

General Information Comment Organism
physiological function enzyme overexpression promotes glycolysis, serine/glycine metabolism, and the accumulation of pyrimidine nucleotides. Enzyme overexpression alone is able to transform NIH 3T3 cells in vitro and drive tumor formation in vivo Mus musculus