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Methionyl tRNA synthetase
Methionyl-transfer ribonucleate synthetase
Methionyl-transfer ribonucleic acid synthetase
Methionyl-transfer RNA synthetase
methionyl-tRNA synthetase
methionyl-tRNA synthetase1
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methionyl-tRNA-synthetase
Synthetase, methionyl-transfer ribonucleate
let-65
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mars-1
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Methionine translase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionine--tRNA ligase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl tRNA synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleate synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer ribonucleic acid synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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Methionyl-transfer RNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA synthetase
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methionyl-tRNA-synthetase
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methionyl-tRNA-synthetase
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MetRS
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MetRS
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649084, 650114, 650559, 650560, 651240, 651818, 652807, 652850, 671332, 672606, 676885, 701744, 704223, 714269, 728695
MRS
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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Synthetase, methionyl-transfer ribonucleate
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additional information
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the enzyme is a class I aminoacyl-tRNA synthetase
additional information
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the enzyme belongs to the class I aminoacyl-tRNA synthetases
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
active site structure and reaction mechanism involving Tyr15 and Thr10, Tyr94 is involved in maintaining the native enzyme conformation
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
amino acid residues D138, R139, and F135 are important for activity
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
amino acid residues involved in tRNA binding are K30, N66, S78, and M81
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
mechanism, catalytic domain is formed by amino acid residues A215-K823
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
reaction mechanism, Lys261, Lys295, and Lys301 are located in the catalytic crevice of the enzyme
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
substrate binding and mechanism
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
substrate recognition and structure
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
substrate recognition and structure
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
substrate recognition, editing, binding and reaction mechanism
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
the amino acid acceptor arm of tRNAMet binds to the plant enzyme
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
the anticodon sequence is important for tRNA substrate specificity
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
two-step reaction process via anenzyme-L-Met-AMP intermediate
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
the aminoacylation reaction is a two-step mechanism: in the first step, the synthetase recognizes the appropriate amino acid and activates it with ATP to form the activated intermediate, an aminoacyl-adenylate, aa-AMP, the second step transfers the aminoacyl moiety onto the 3'-hydroxyl of the CCA end of the tRNA, the methionine-binding pocket is composed of residues Ala12, Leu13, Tyr15, Trp253, Ala256, Pro257, Tyr260, Ile297, His301, and Trp305
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ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
the anticodon sequence is important for tRNA substrate specificity
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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AMP + diphosphate + L-methionyl-tRNAMet
ATP + L-methionine + tRNAMet
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r
ATP + (S)-2-aminohex-5-enoic acid + tRNAMet
AMP + diphosphate + (S)-2-aminohex-5-enoyl-tRNAMet
ATP + (S)-2-aminohex-5-ynoic acid + tRNAMet
AMP + diphosphate + 2(S)-aminohex-5-ynoyl-tRNAMet
500fold reduced activity compared to L-methionine
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ATP + azidonorleucine + tRNAMet
AMP + diphosphate + azidonorleucinyl-tRNAMet
MetRS SLL-mutant
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ATP + azidonorleucine + tRNAMet
AMP + diphosphate + azidonorleucyl-tRNAMet
activity of mutant L13G, overview
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ATP + L-homocysteine + tRNAMet
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edition and aminoacylation by cytoplasmic and mitochondrial isozyme
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ATP + L-methionine + tRNA fraction from Saccharomyces cerevisiae
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ATP + L-methionine + tRNAArg(CCU)
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tRNA mismethionylation
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ATP + L-methionine + tRNAAsp
AMP + diphosphate + L-methionyl-tRNAAsp
only the wild-type enzyme, not the C-terminally deleted enzyme mutant
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
ATP + L-methionine + tRNAThr(CGU)
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tRNA mismethionylation
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?
ATP + L-norleucine + tRNAMet
AMP + diphosphate + L-norleucyl-tRNAMet
ATP + L-trans-alpha-crotylglycine + tRNAMet
AMP + diphosphate + L-trans-alpha-crotylglycyl-tRNAMet
4700fold reduced activity compared to L-methionine
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ATP + L-valine + tRNAMetG34C36
AMP + diphosphate + L-valyl-tRNAMetG34C36
ATP + methionine + hydroxylamine
methionine hydroxamate + AMP + diphosphate
ATP + selenomethionine + tRNAMet
AMP + diphosphate + selenomethionyl-tRNAMet
CoA + L-methionine
Met-S-CoA
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additional information
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ATP + (S)-2-aminohex-5-enoic acid + tRNAMet
AMP + diphosphate + (S)-2-aminohex-5-enoyl-tRNAMet
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ATP + (S)-2-aminohex-5-enoic acid + tRNAMet
AMP + diphosphate + (S)-2-aminohex-5-enoyl-tRNAMet
1850fold reduced activity compared to L-methionine
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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the MetRS specificity for methionine and conformity with the identity rules for tRNAMet for archea/eukarya, anticodon binding site, overview
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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functional idiosyncrasies of the viral MetRS, activity with Escherichia coli native tRNAMet and initiator tRNAMet, and Saccharomyces cerevisiae native tRNAMet and initiator tRNAMet, overview, the MetRS specificity for methionine and recognition of the tRNAMet acceptor stem show conformity with the identity rules for tRNAMet for archea/eukarya, overview
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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structural basis for anticodon recognition by the enzyme, catalytic Rossmann fold domain
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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essentiality of the metS1, nonessentiality of the metS2 for vegetative growth
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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MetRS specifically binds tRNAMet and catalyzes the synthesis of methionyl-tRNAMet. The C-terminal appended domain causes a slow release of aminoacyl-tRNA and establishes a limiting step in the global aminoacylation reaction
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
also utilizes both subtypes of Escherichia coli tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
active site analysis and docking study, overview. Key residues are His53, Asp51 and Lys56 consistently forming H-bonding interactions with the carboxylic acid moiety of methionine. Ile12 forms a hydrogen bond with this moiety in different dockings and the residues Ile224, Val226 and Ala230 form a hydrophobic pocket
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
active site analysis and docking study, overview. Key residues are His53, Asp51 and Lys56 consistently forming H-bonding interactions with the carboxylic acid moiety of methionine. Ile12 forms a hydrogen bond with this moiety in different dockings and the residues Ile224, Val226 and Ala230 form a hydrophobic pocket
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
6.1.1.10 methionine-tRNA ligase
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