Application | Comment | Organism |
---|---|---|
pharmacology | ErbB family receptor kinases are targets for anticancer drugs, e.g. gefitinib or erlotinib in the treatment of non-small lung cancer or colorectal cancer, treatment with therapeutic antibodies in case of breast cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genes encoding ErbB receptor protein-tyrosine kinase 1-4 are located on different chromosomes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | null mutations of any of the ErbB family enzymes result in embryonic lethality | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
OSI-774 | i.e. erlotinib, inhibits EGF receptor protein tyrosine kinase, binding to EGF receptor kinase, structure overview, anticancer drug | Homo sapiens | |
ZD1839 | i.e. gefitinib, reversible inhibition of ErbB1, competitive to ATP, binding to EGF receptor kinase, structure overview, anticancer drug | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane protein | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | MgATP- | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
additional information | Homo sapiens | ErbB family enzymes are absolutely required for viability of embryos | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
several isozymes of both ErbB receptor protein-tyrosine kinase and HER receptor protein-tyrosine kinase | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | ErbB family proteins are N-glycosylated to about 20% of their mass, deglycosylation causes loss of 70% protein tyrosine kinase activity | Homo sapiens |
phosphoprotein | phosphorylation at tyrosine residues, autophosphorylation of the ErbB receptor dimer | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | high expression level of ErbB1 receptor | Homo sapiens | - |
breast | high expression level of ErbB1 receptor | Homo sapiens | - |
kidney | high expression level of ErbB1 receptor | Homo sapiens | - |
non-small cell lung cancer cell | high expression level of ErbB1 receptor | Homo sapiens | - |
prostate cancer cell | high expression level of ErbB1 receptor | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview | Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
additional information | ErbB family enzymes are absolutely required for viability of embryos | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | dimerization of ErbB receptor results in activation, trans-autophosphorylation, and initiation of signaling occurs | Homo sapiens |
More | the ErbB family enzymes possess a single transmembrane segment, a growth-factor-binding ectodomain, an intracellular protein-tyrosine kinase catalytic domain, and a tyrosine-containing cytoplasmic tail, domain structure overview, enzyme activation involves major rotation of the ectodomain | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
EGF receptor protein-tyrosine kinase | - |
Homo sapiens |
Egfr | - |
Homo sapiens |
epidermal growth factor receptor | - |
Homo sapiens |
ErbB receptor protein-tyrosine kinase | - |
Homo sapiens |
HER receptor protein-tyrosine kinase | - |
Homo sapiens |
More | WebB and HER receptor protein-tyrosine kinase, as well as epidermal growth factor receptor belong to the ErbB family, overview | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | MgATP- | Homo sapiens |