Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.150 extracted from

  • Liu, J.; Zhang, Y.; Liu, W.; Zhang, Q.; Xiao, H.; Song, H.; Luo, B.
    MiR-BART1-5p targets core 2beta-1,6-acetylglucosaminyltransferase GCNT3 to inhibit cell proliferation and migration in EBV-associated gastric cancer (2020), Virology, 541, 63-74 .
    View publication on PubMed
Search for more literature for 2.4.1.150

Cloned(Commentary)

Cloned (Comment) Organism
cotransfection and expression of Epstein-Barr virus (EBV) miRNA miR-BART1-5p and GCNT3 in HEK-293T and SGC7901 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of GCNT3 using GCNT3-specific small interfering RNAs: siGCNT3-1 (GCUACUGCGAGCUGUGUAUTT), and siGCNT3-2 (GCUCAGUGCCGUGGAAAUATT). Reduction of the expression of endogenous GCNT3 by siRNA transfection in SGC7901 and BGC823 cells. Epstein-Barr virus (EBV) miRNA miR-BART1-5p specifically targets GCNT3. miR-BART1-5p suppresses GCNT3 expression, cell proliferation, and migration in EBVnGC, and the MiR-BART1-5p inhibitor increases GCNT3 expression, cell proliferation, and migration in transfected GT39 and GT38 cells. NF-kappaB can activate the expression of multiple miR-BARTs, including miR-BART1-5p Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95395
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell an EBVnGC cell line Homo sapiens
-
BGC-823 cell an EBVnGC cell line Homo sapiens
-
gastric cancer cell GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells (EBVnGC) and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. GCNT3 is closely related to the ERK signaling pathway and epithelial mesenchymal transition (EMT), regulating cell proliferation, migration, and invasion Homo sapiens
-
GT-38 cell an EBVaGC cell line Homo sapiens
-
GT-39 cell an EBVaGC cell line Homo sapiens
-
HGC-27 cell an EBVnGC cell line Homo sapiens
-
additional information GCNT3 is highly expressed in both NSCLC tissues and cell lines, and higher expression is significantly associated with advanced tumor lymph node metastasis (TNM) stage, positive lymph node metastasis, and poor overall survival. GCNT3 expression is associated with lymph node metastasis and age. But the expression level of GCNT3 is not correlated with gender, tumor location, differentiation grade, etc. Expression of GCNT3 is lower in EBVaGC cells and tissues than that in EBVnGC cells and tissues Homo sapiens
-
non-small cell lung cancer cell GCNT3 is highly expressed in both NSCLC tissues and cell lines Homo sapiens
-
SGC-7901 cell an EBVnGC cell line Homo sapiens
-
SNU-719 cell an EBVaGC cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
2beta-1,6-acetylglucosaminyltransferase
-
 Homo sapiens
C2/4GnT
-
 Homo sapiens
C24GNT
-
 Homo sapiens
C2GnT2
-
 Homo sapiens
C2GNTM
-
 Homo sapiens
core 2beta-1,6-acetylglucosaminyltransferase
-
 Homo sapiens
gcnt3
-
 Homo sapiens
GNTM
-
 Homo sapiens
More see also EC 2.4.1.102 Homo sapiens

General Information

General Information Comment Organism
malfunction miR-BART1-5p directly targets GCNT3. In addition, miR-BART1-5p mimics transfection is observed to reduce cell proliferation and migration, while miR-BART1-5p inhibitor increases cell proliferation and migration following transfection. In conclusion, both miR-BART1-5p and knockdown of GCNT3 inhibit cell proliferation and migration Homo sapiens
physiological function O-glycan synthase glucosamine (N-acetyl)transferase 3 (GCNT3) is a mucin-type responsible for catalyzing core 2 and core 4 O-glycans and forming O-linked glycosylation in protein biosynthesis. Abnormal expression of GCNT3 promotes the progression of several human cancers. GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. EBV may regulate GCNT3 by affecting the NF-kappaB signaling pathway. Patients with EBV-associated gastric cancer (EBVaGC) have a good survival rate. EBV potentially regulates GCNT3 by affecting the NF-kappaB signaling pathway Homo sapiens