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Literature summary for 3.6.5.1 extracted from

  • Avasarala, S.; Bikkavilli, R.K.; Van Scoyk, M.; Zhang, W.; Lapite, A.; Hostetter, L.; Byers, J.T.; Heasley, L.E.; Sohn, J.W.; Winn, R.A.
    Heterotrimeric G-protein, Galpha16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer (2013), PLoS ONE, 8, e76895.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.1

Application

Application Comment Organism
medicine the enzyme is important as a potential therapeutic target for the treatment of non small cell lung cancer Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q212L site-directed mutagenesis,GTPase-deficient inactive mutant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30679
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-

Source Tissue

Source Tissue Comment Organism Textmining
BEAS-2B cell
-
 Homo sapiens
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additional information no enzyme expression in H-2122 , A-549, H-661, and H-1299 cancer cells, quantitaative enzyme expression analysis, overview Homo sapiens
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NCI-H157 cell
-
 Homo sapiens
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non-small cell lung cancer cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
heterotrimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
Galpha16
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function G-protein, Galpha16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer, Wnt7a-stimulated ERK5 activation is Galpha16-dependent. Importance of Wnt7a signaling via its cognate receptor Frizzled9, a G-protein-coupled receptor, in inhibition of cell proliferation, anchorage-independent growth, and reversal of transformed phenotype in non small cell lung cancer primarily through activation of the tumor suppressor, PPARgamma. Galpha16 is a regulator of non small cell lung cancer cell proliferation and anchorage-independent cell growth. Galpha16 and Galphaq are important mediators of PPARgamma and E-cadherin expression in non small cell lung cancer cell lines Homo sapiens