Literature summary for 6.4.1.1 extracted from

Sellers, K.; Fox, M.P.; Bousamra, M.; Slone, S.P.; Higashi, R.M.; Miller, D.M.; Wang, Y.; Yan, J.; Yuneva, M.O.; Deshpande, R.; Lane, A.N.; Fan, T.W.
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation (2015), J. Clin. Invest., 125, 687-698 .

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Application

Application	Comment	Organism
medicine	cancerous tissues of patients with early-stage non-small-cell lung cancer display enhanced pyruvate carboxylase activity. Pyruvate carboxylase overexpression is found in cancer cells rather than in stromal cells of tumor tissues. Pyruvate carboxylase knockdown induces multinucleation, decreases cell proliferation and colony formation in human non-small-cell lung cancer cells, and reduces tumor growth in a mouse xenograft model	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11498	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
non-small cell lung cancer cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)