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Information on EC 2.8.2.30 - [heparan sulfate]-glucosamine 3-sulfotransferase 3

for references in articles please use BRENDA:EC2.8.2.30
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IUBMB Comments
Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN*-> and -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN6S*-> (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells . There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes . The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)].
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
hs3st3b1, isoform 3a, 3-ost-3a, hs6st3, 3-ost-3, 3-ost3a, heparan sulfate 3-o-sulfotransferase, hs3st3a1, 3-ost-3b, hs3st3b, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
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Two major substrates contain the tetrasaccharides: undetermined 2-sulfo-uronic acid-GlcN2S-IdoA2S-GlcN*- and undetermined 2-sulfo-uronic acid-GlcN2S-IdoA2S-GlcN6S with modification of the N-unsubstituted glucosamine residue. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells. There are two isoenzymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes. The specificity of this enzyme differs from that of other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of antithrombin binding site, in contrast to EC 2.8.2.23, [heparan sulfate]-glucosamine 3-sulfotransferase 1, and it does not modify glucosamine preceded by GlcA2S, unlike EC 2.8.2.29, [heparan sulfate]-glucosamine 3-sulfotransferase 2
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