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Information on EC 2.8.2.4 - estrone sulfotransferase
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EC Tree
2.8.2.4 estrone sulfotransferaseSpecify your search results
Word Map
- 2.8.2.4
- steroid
-
sulfotransferases
- hydroxysteroid
- medicine
-
sulfatase
- 3'-phosphoadenosine
- pharmacology
- analysis
- synthesis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
hsult1e1, oestrogen sulphotransferase, estrogen sulphotransferase, estrone sulfotransferase, sulfotransferase 1e1, oestrogen sulfotransferase, estrogen sult, estradiol sulfotransferase, rest-6, sult1e, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase
-
-
-
-
3'-phosphoadenylyl sulfate:oestrone sulfotransferase
-
-
-
-
cytosolic sulfotransferase
EST
estrogen sulfotransferase
estrogen sulphotransferase
-
-
-
-
oestrogen sulphotransferase
rSULT1E1
steroid sulfotransferase
sulfotransferase 1E1
SULT
SULT1A1
SULT1E
SULT1E1
EST
-
-
estrogen sulfotransferase
-
-
-
-
estrogen sulfotransferase
-
-
estrogen sulfotransferase
-
oestrogen sulphotransferase
-
-
-
-
SULT1E1
-
-
SULT1E1
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
a reaction transition state with substantial S-O bond fission and partial charge neutralization of the leaving group
-
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
random bi-bi mechanism catalytic mechanism of SULTs, many family members have distinct, but overlapping substrate specificities, the enzymes have a sequential catalytic mechanism that is susceptible to substrate inhibition
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
the proposed reaction mechanism: upon binding of PAPS, Ser137 forms an H-bond with Lys47, thus prevents its interaction with the bridging oxygenin PAPS and its further hydrolysis; His107 attracts a proton from the substrate hydroxyl (i.e. of E2 or DHEA), and enables nucleophilic attack at the sulfur atom in PAPS. In the next step, Lys47 interacts with the 5' phosphate of PAPS, which helps in dissociation of the sulfuryl group and in its transfer to the substrate. Finally, the reaction products, PAP and E1-S, are released, which completes the catalytic cycle
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
sulfate group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase
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CAS REGISTRY NUMBER
COMMENTARY
9026-06-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
17beta-estradiol + 3'-phosphoadenylyl sulfate
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phopshoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate
-
i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview
three different sulfate products, product identification by NMR, overview
-
?
3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
3'-phosphoadenylyl sulfate + 1H-indol-6-ol
adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 3-cyano-7-hydroxycoumaryl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
3'-phosphoadenylyl sulfate + 6-hydroxy-4-methylbenzo[d]thiazole-2-carbonitrile
adenosine 3',5'-bisphosphate + ?
i.e. proluciferin substrate UGT-Glo substrate A, GSA
-
-
?
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + ethinyl estradiol
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
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a synthetic oral contraceptive, low activity
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,16alpha,17beta-triol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien-16alpha,17beta-diol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17alpha-diol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 17alpha-ol-3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoacetate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoglucosiduronate
adenosine 3',5'-bisphosphate + ?
-
very low sulfation rate
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monovalerinate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3-ol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 11-hydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 16-epiestriol
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
3'-phosphoadenylylsulfate + 17-deoxyestrone
adenosine 3',5'-bisphosphate + 17-deoxyestrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17-epiestriol
adenosine 3',5'-bisphosphate + 17-epiestriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol
adenosine 3',5'-bisphosphate + ?
-
isoform SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 17alpha-ethynyl-1,3,5(10)-estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + 17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,2',4'-trichlorodiphenyl ether
adenosine 3',5'-bisphosphate + 2-OH-4,2',4'-trichlorodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,5,3',2',3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 2-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-6,7,8-trichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-6,7,8-trichlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,16alpha-dihydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + 16-alpha-hydroxy-1,3,5(10)-estratrien-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10),9-estratetraen-12-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10)-estratrien-6-one
adenosine 3',5'-bisphosphate + ?
-
high sulfation rate
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrachloro-4,4'-isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'- tetrachloro-4,4'-isopropylidendiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6,8-estrapentaen-17-one
adenosine 3',5'-bisphosphate + 1,3,5(10),6,8-estrapentaen-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6-estratetraen-17-one
adenosine 3',5'-bisphosphate + 1,3,5(10),6-estratetraen-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),7-estratetraen-17-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),9-estratetraen-12,17-dione
adenosine 3',5'-bisphosphate + 1,3,5(10),9-estratetraen-12,17-dione 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10)-estratrien-16-one
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratriene-16-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-4,5,3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 3-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitro-1,3,5(10)estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-2',4',6'-tribromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-2',4',6'-tribromodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',2',4',6'-tetrabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',2',4',6'-tetrabromodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',5,2',4',6'-pentabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',5,2',4',6'- pentabromodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3,3',4'-trichlorated biphenyl
adenosine 3',5'-bisphosphate + 4-OH-3,3',4'-trichlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 7alpha-methyl-1,3,5(10)-estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + 7alpha-methyl-1,3,5(10)-estratrien 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 7alpha-methyl-3-hydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + androstenediol
adenosine 3',5'-bisphosphate + androstenediol sulfate
-
wild-type EST exhibits little ability to sulfate AD
-
r
3'-phosphoadenylylsulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + butylated hydroxyanisole sulfate
-
-
r
3'-phosphoadenylylsulfate + catechin hydrate
adenosine 3',5'-bisphosphate + catechin hydrate sulfate
-
-
r
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein sulfate
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylylsulfate + epicatechin
adenosine 3',5'-bisphosphate + epicatechin sulfate
-
-
r
3'-phosphoadenylylsulfate + epigallocatechin gallate
adenosine 3',5'-bisphosphate + epigallocatechin gallate sulfate
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
-
r
3'-phosphoadenylylsulfate + hexestrol
adenosine 3',5'-bisphosphate + hexestrol 4-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + kaempferol
adenosine 3',5'-bisphosphate + kaempferol sulfate
-
-
r
3'-phosphoadenylylsulfate + myricetin
adenosine 3',5'-bisphosphate + myricetin sulfate
-
-
r
3'-phosphoadenylylsulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + n-propyl gallate sulfate
-
-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
3'-phosphoadenylylsulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol sulfate
-
-
-
r
3'-phosphoadenylylsulfate + stilbestrol
adenosine 3',5'-bisphosphate + stilbestrol 4-sulfate
-
-
-
r
8-bromoadenosine 3'-phosphate 5'-phosphosulfate + estrone
8-bromoadenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
adenosine 3'-phosphate 5'-phosphosulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
formycin 3'-phosphate 5'-phosphosulfate + estrone
formycin 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
tubercidin 3'-phosphate 5'-phosphosulfate + estrone
tubercidin 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
best substrate
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
SULT1E1 has a high affinity and catalytic efficiency for estradiol as substrate
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
inactivation
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
inactivation, increased 17beta-estradiol sulfation affects the GH signaling pathway and E2-regulated gene expression, enhanced SULT1E1 activity plays a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of 17beta-estradiol, regulation, overview
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
reaction of phenol sulfonyltransferase, EC 2.8.2.1, determination of reaction equilibrium in the forward direction at 70% of conversion of 4-nitrophenol
-
-
r
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate