Information on EC 2.8.2.4 - estrone sulfotransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.8.2.4
-
RECOMMENDED NAME
GeneOntology No.
estrone sulfotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Steroid hormone biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-06-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Hartley
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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estrogen sulfotransferase SULT1E1 regulates inflammatory response and lipid metabolism of human endothelial cells via proliferator-activated receptor gamma
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
17beta-estradiol + 3'-phosphoadenylyl sulfate
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phopshoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate
show the reaction diagram
-
i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview
three different sulfate products, product identification by NMR, overview
-
?
3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 1H-indol-6-ol
adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 3-cyano-7-hydroxycoumaryl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + ethinyl estradiol
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
show the reaction diagram
-
a synthetic oral contraceptive, low activity
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,16alpha,17beta-triol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien-16alpha,17beta-diol 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17alpha-diol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 17alpha-ol-3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoacetate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoglucosiduronate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
very low sulfation rate
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monovalerinate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3-ol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 11-hydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 16-epiestriol
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 17-deoxyestrone
adenosine 3',5'-bisphosphate + 17-deoxyestrone 3-sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 17-epiestriol
adenosine 3',5'-bisphosphate + 17-epiestriol 3-sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 17alpha-ethynyl-1,3,5(10)-estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + 17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,2',4'-trichlorodiphenyl ether
adenosine 3',5'-bisphosphate + 2-OH-4,2',4'-trichlorodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,5,3',2',3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 2-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-6,7,8-trichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-6,7,8-trichlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,16alpha-dihydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + 16-alpha-hydroxy-1,3,5(10)-estratrien-17-one 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10),9-estratetraen-12-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10)-estratrien-6-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
high sulfation rate
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrabromo-4,4'isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'-tetrabromo-4,4'isopropylidendiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrachloro-4,4'isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'- tetrachloro-4,4'isopropylidendiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6,8-estrapentaen-17-one
adenosine 3',5'-bisphosphate + 1,3,5(10),6,8-estrapentaen-17-one 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6-estratetraen-17-one
adenosine 3',5'-bisphosphate + 1,3,5(10),6-estratetraen-17-one 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),7-estratetraen-17-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),9-estratetraen-12,17-dione
adenosine 3',5'-bisphosphate + 1,3,5(10),9-estratetraen-12,17-dione 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10)-estratrien-16-one
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratriene-16-one 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8- etrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-4,5,3',2',3',4'- tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 3-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitro-1,3,5(10)estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-2',4',6'-tribromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-2',4',6'-tribromodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',2',4',6'-tetrabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',2',4',6'-tetrabromodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',5,2',4',6'-pentabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',5,2',4',6'- pentabromodiphenyl ethyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3,3',4'-trichlorated biphenyl
adenosine 3',5'-bisphosphate + 4-OH-3,3',4'-trichlorated biphenyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 7alpha-methyl-1,3,5(10)-estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + 7alpha-methyl-1,3,5(10)-estratrien 3-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + 7alpha-methyl-3-hydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + androstenediol
adenosine 3',5'-bisphosphate + androstenediol sulfate
show the reaction diagram
-
wild-type EST exhibits little ability to sulfate AD
-
r
3'-phosphoadenylylsulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + butylated hydroxyanisole sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + catechin hydrate
adenosine 3',5'-bisphosphate + catechin hydrate sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + epicatechin
adenosine 3',5'-bisphosphate + epicatechin sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + epigallocatechin gallate
adenosine 3',5'-bisphosphate + epigallocatechin gallate sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + hexestrol
adenosine 3',5'-bisphosphate + hexestrol 3-sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + kaempferol
adenosine 3',5'-bisphosphate + kaempferol sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + myricetin
adenosine 3',5'-bisphosphate + myricetin sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + n-propyl gallate sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + quercetin sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + stilbestrol
adenosine 3',5'-bisphosphate + stilbestrol 4-sulfate
show the reaction diagram
-
-
-
r
8-bromoadenosine 3'-phosphate 5'-phosphosulfate + estrone
8-bromoadenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
r
adenosine 3'-phosphate 5'-phosphosulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
r
formycin 3'-phosphate 5'-phosphosulfate + estrone
formycin 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
r
tubercidin 3'-phosphate 5'-phosphosulfate + estrone
tubercidin 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
r
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 1H-indol-6-ol
adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NaCl
-
activates
Zn2+
-
weakly stimulatory at 2.5 mM ZnCl2
additional information
-
varying the Mg2+ concentration from 0-10 mM in the beta-estradiol sulfation reaction does not affect the sulfation activity of isoform rEST-6
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
-
-
(+)-hispanone
-
-
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
-
-
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
-
1,3,5(10)estatriene-17beta-ol
-
-
1,3,5(10)estatriene-3,16alpha,17beta-triol
-
-
1,3,5(10)estatriene-3,16alpha-diol
-
-
1,3,5(10)estatriene-3,16beta,17beta-triol
-
-
1,3,5(10)estatriene-3,17beta-diol
-
-
1,3,5(10)estatriene-3,17beta-diol 17beta-phosphate
-
-
1,3,5(10)estatriene-3,17beta-diol 17beta-sulfate
-
-
1,3,5(10)estatriene-3,17beta-diol 3,17beta-diphosphate
-
-
1,3,5(10)estatriene-3,17beta-diol 3-phosphate
-
-
1,3,5(10)estatriene-3,17beta-diol-3-acetate
-
-
1,3,5(10)estatriene-3,17beta-diol-3-benzoate
-
-
1,3,5(10)estatriene-3-ol
-
-
1,3,5(10)estatriene-3-ol 17-one 3-sulfate
-
-
1-[2-(p-[3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl]phenoxy)ethyl]-pyrrolidine hydrochloride
-
-
16alpha-hydroxyestrone
-
maximum inhibition at 100 nM
17beta-estradiol
17beta-hydroxy-5alpha-androstane-3-one
-
-
17beta-hydroxy-5beta-androstane-3-one
-
-
2,4,6-tribromophenol
-
-
2,4,6-Trichlorophenol
-
-
2,4,6-triiodophenol
-
-
2,4-dibromo-1,3,5(10)estatriene-3,17beta-diol
-
-
2,4-dinitro-1,3,5(10)estatriene-3,17beta-diol
-
-
2,6-Dichloro-4-nitrophenol
2-amino-1,3,5(10)estatriene-3,17beta-diol
-
-
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
-
2-hydroxy-3,4,2',3',4'-pentachlorobiphenyl
-
-
2-hydroxy-3,4,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
-
2-hydroxy-7,8-dichlorodibenzofuran
-
-
2-nitro-1,3,5(10)estatriene-3,17beta-diol
-
-
2-OH-3,2'-dibromobiphenyl
-
-
-
3',4',7-trihydroxyisoflavone
-
-
3'-phosphoadenylylsulfate
3,17beta-dihydroxy-1,3,5(10)estatriene-6-one
-
-
-
3,3',5,5'-tetrachlorobisphenol A
-
-
3,3'-(hydroxy)2-4,4'-dichlorobiphenyl
-
-
-
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide
-
DBHM
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide
-
DBHD
3-hydroxy-1,3,5(10)estatriene-17-one
-
-
-
3-hydroxy-2,'4',5',2',3',4',5'-heptachlorobiphenyl
-
-
-
3-hydroxy-2,4,5,3',4'-pentachlorobiphenyl
-
-
-
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
-
-
3-hydroxy-2,4,7,8-tetrachlorodibenzofuran
-
-
-
3-hydroxy-4,5,2',3',4'-pentachlorobiphenyl
-
-
-
3-hydroxy-4,5,3',4',5'-pentachlorobiphenyl
-
-
-
3-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
-
3-methoxy-1,3,5(10)estatriene-17beta-ol
-
-
-
3-methoxy-4-nitro-1,3,5(10)estatriene-17-one
-
-
-
3-OH-2,2'-dibromobiphenyl
-
-
-
3-OH-4,4'-dibromobiphenyl
-
-
-
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-hydroxy-5beta-androstane-17-one
-
-
3beta-hydroxy-androst-5-ene-17-one
-
-
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl
-
-
4,4'-isopropyl idenediphenol-3,3',5,5'-tetrachlorobisphenol
-
-
4,4'-isopropylidenediphenol
-
-
4-amino-1,3,5(10)estatriene-3,17beta-diol
-
-
4-ene tibolone
-
inhibits at high concentrations of 0.05 mM by 59%
4-hydroxy-2',3',4',5'-tetrachlorobiphenyl
-
-
4-hydroxy-2',4',6'-trichlorobiphenyl
-
-
4-hydroxy-2,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
-
4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',3',4'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
-
4-hydroxy-2,3,5,6,2',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-3,3',4'-trichlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4'-tetrachlorobiphenyl
-
-
4-hydroxy-3,5,3',5'-tetrachlorobiphenyl
-
-
4-hydroxybenzoate esters
-
i.e.parabens, structure-activity relationship, overview
4-hydroxybenzoic acid
-
-
4-nitro-1,3,5(10)estatriene-3,17beta-diol
-
-
4-nonyl phenol
4-OH-2,2'-dibromobiphenyl
-
-
-
4-OH-3,4'-dibromobiphenyl
-
-
-
4-OH-4'-monobromobiphenyl
-
-
-
5,7-dichlorokynurenic acid
-
-
5-androstene-3beta,17beta-diol
-
-
5alpha-Androstane-3beta,17beta-diol
-
-
6-OH-2,2'-dibromobiphenyl
-
-
-
7-deazadenosine
-
tubercidin
8-bromoadenosine 3',5'-diphosphate
-
-
8-bromoadenosine 3'-phosphate 5'-phosphosulfate
-
-
Acetylsalicylate
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
adenosine 2',5'-diphosphate
-
noncompetitive inhibition
adenosine 3',5'-diphosphate
-
-
adenosine 3'-diphosphate 5'-phosphate
-
-
adenosine 3'-phosphate 5'-diphosphate
-
-
adenosine 5'-(beta,gamma-imido) triphosphate
-
i.e. AMP-PNP, a non-hydrolysable ATP analogue
adenosine 5'-phosphosulfate
-
-
adenosine 5'-sulfate
-
-
adenosine N1-oxide 3,5'-diphosphate
-
-
AMP
-
-
androst-5-ene-3beta-ol
-
-
ATP
-
mixed-type inhibition
buthionine sulfoxamine
-
a GSH depletor, decreases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
butylparaben
-
50% inhibition at 0.021 mM, complete inhibition at 1 mM; strong inhibition, which is threefold higher in vivo than in vitro
cetyltriammonium bromide
-
-
-
Chloroform
-
excess chloroform inactivates
Co2+
-
strong inhibition
daidzein
-
-
daidzein 4,7-bisulfate
-
IC50: 0.01 mM
-
diclofenac
-
-
diethylstilbestrol
-
-
dithiothreitol
-
inhibition above 0.005 mM
equol
-
potent mixed type inhibitor
estrone
ethylparaben
-
; 50% inhibition at 0.080 mM
fatty acid
-
unsaturated fatty acid of chain length C11-C14
formononetin
-
-
formycin 3'-phosphate 5'-phosphosulfate
-
-
gavestinel
-
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
genistein
-
potent mixed type inhibitor
GSSG
-
oxidized glutathione, inactivation and kinetics, adenosine 3'-phosphate 5'-phosphosulfate protects
guanosine 2',3'-cyclic phosphate 5'-phosphate
-
-
hydroxylated polychlorated biphenyls
-
-
-
Ibuprofen
-
-
ICI 182,720
-
produces a marked decrease (over 50%) of EST activity with respect to untreated control cell cultures at 24 h
indomethacin
-
-
inosine 3',5'-diphosphate
-
-
iodoacetamide
-
-
iodoacetate
-
-
Kynurenic acid
-
-
L689,560
-
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
-
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
leosibiric acid A
-
most potent inhibition
leosibiric acid B
-
-
meclofenamate
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
Meclofenamic acid
-
-
medrogestone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
Mefenamic acid
-
-
methylparaben
-
; 50% inhibition at 0.330 mM
myristate
-
inhibition is non-competitive with respect to the substrate estrone
N-ethylmaleimide
-
-
N6-dimethylaminoadenosine 3',5'-diphosphate
-
-
naproxen
-
-
nebularine 3',5'-diphosphate
-
-
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
-
Ni2+
-
strong inhibition
nimesulide
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
o-Iodosobenzoate
-
sensitive above 10 mM
OrgOD14
-
active substance in Livial (r), above 0.05 mM decreases significantly biosynthesis of estrone by 50-60%, no effect in MDA-MB-231 cells
p-chloromercuribenzoate
-
sensitive above 1 mM
p-hydroxymercuribenzoate
-
-
Pentachlorophenol
-
-
piroxicam
-
-
Promegestone
-
activates SULT1E1 by 26% at low concentrations of 500 nM, inhibits at 0.05 mM by 41%, leads to increased and decreased expression levels, respetively; biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
propylparaben
-
; 50% inhibition at 0.030 mM
pyridoxal 5'-phosphate
-
a competitive inhibitor for sulfotransferases
quercetin
resveratrol
retinoic acid
-
-
salicylate
-
-
salicylic acid
-
-
Sodium dodecyl sulfate
-
-
sulindac
-
-
tamoxifen
-
weak inhibition
tibolone
-
activates SULT1E1 in MCF-7 cells by 63% and 44% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 64%
trans-resveratrol
-
0.1 mM resveratrol significantly decreases the SULT1E1-mediated beta-estradiol sulfation
tributyltin
-
a common androgenic marine pollutant
triclosan
Triphenyltin
tubercidin 2',5'-diphosphate
tubercidin 3',5'-bisphosphate
-
-
tubercidin 3'-phosphate 5'-phosphosulfate
-
-
Zn2+
-
strong inhibition
ZnCl2
-
inhibition of liver isoenzyme at 15 mM
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17-hydroxy-19-nor-7-methyl-17-pregn-5(10)-en-20-yn-3-one
2-mercaptoethanol
-
activation
3alpha-hydroxy-tibolone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-hydroxy-tibolone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview
3beta-hydroxytibolone
-
102% stimulation of activity at 0.0005 mM
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4-ene-tibolone
-
-
cAMP
-
enzyme activity is induced by
celecoxib
-
-
cysteine
-
-
dithiothreitol
-
activation up to 0.005 mM
medrogestone
Melatonin
-
the level of EST mRNA steady-state of cells treated with melatonin is three times higher than that in control cells
monothiolglycerol
N-acetylcysteine
-
a GSH inducer, increases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
NaCl
-
activity of liver EST transiently expressed in COS-1 cells increases 86% in presence of 150 mM
nomegestrol acetate
progesterone
-
specific induction by 0.01 mM, 7fold increase in sulfation of beta-estradiol, Ishikawa endometrial adenocarcinoma cells
Promegestone
quercetin
-
-
resveratrol
-
-
tibolone
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.014
16-epiestriol
-
pH 8.6, 37C
0.014
17-deoxyestrone
-
pH 8.6, 37C
0.008
17-epiestriol
-
pH 8.6, 37C
0.000005 - 0.014
17beta-estradiol
0.00211
2-(4-aminophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00025
2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00142
2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00056
2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00052
2-(4-iodophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.0009
2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.001
2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00077
2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00142
2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00132
2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00236
2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00012
2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00591
2-naphthol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00099
2-phenyl-1,3-benzothiazol-6-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.00043
2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
-
in 50 mM Tris-HCl, pH 7.4, at 37C
0.000005
3'-phosphoadenylyl sulfate
-
pH and temperature not specified in the publication
0.000059 - 0.037
3'-phosphoadenylylsulfate
0.00018
3alpha-tibolone
-
pH 6.5, 37C, recombinant SULT1E1
0.00048
3beta-tibolone
-
pH 6.5, 37C, recombinant SULT1E1
0.15
4-nitrophenol
-
pH 6.1, 25C
0.018
8-bromoadenosine 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C
0.000038 - 0.07
adenosine 3',5'-bisphosphate
0.044
adenosine 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C
0.000868 - 0.003224
androstenediol
0.0053
apigenin
-
pH 6.5, 37C, recombinant SULT1E1; pH 6.5, 37C, SULT1E1
0.00033
beta-estradiol
-
isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0045
chrysin
-
pH 6.5, 37C, recombinant SULT1E1; pH 6.5, 37C, SULT1E1
0.00005 - 0.0607
dehydroepiandrosterone
0.2407 - 79.35
dopamine
0.962
epicatechin
-
pH 6.5, 37C, recombinant SULT1E1; pH 6.5, 37C, SULT1E1
0.000004 - 0.00125
estradiol
0.00004 - 0.005
estriol
0.00006 - 0.0166
estrone
0.000007
ethinyl estradiol
-
pH 7.4, SULT1E1
0.13
formycin 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C
0.0766 - 0.9372
p-nitrophenol
0.00032 - 0.002
quercetin
0.00058 - 0.0069
resveratrol
0.021
tubercidin 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00267 - 0.0217
17beta-estradiol
0.52
4-nitrophenol
-
pH 6.1, 25C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00011 - 0.694
3-cyano-7-hydroxycoumarin
0.0009 - 0.151
4-nitrophenol
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.043
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3,5''-diphosphate
-
pH 7.5, 37C
0.016
1,3,5(10)estatriene-17beta-ol
-
pH 8.1, 37C
0.0082
1,3,5(10)estatriene-3,16alpha,17beta-triol
-
pH 8.1, 37C
0.0013
1,3,5(10)estatriene-3,16alpha-diol
-
pH 8.1, 37C
0.0055
1,3,5(10)estatriene-3,16beta,17beta-triol
-
pH 8.1, 37C
0.0061
1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.021
1,3,5(10)estatriene-3,17beta-diol 17beta-phosphate
-
pH 8.1, 37C
0.047
1,3,5(10)estatriene-3,17beta-diol 17beta-sulfate
-
pH 8.1, 37C
0.333
1,3,5(10)estatriene-3,17beta-diol 3,17beta-diphosphate
-
pH 8.1, 37C
0.024
1,3,5(10)estatriene-3,17beta-diol 3-phosphate
-
pH 8.1, 37C
0.017
1,3,5(10)estatriene-3,17beta-diol-3-acetate
-
pH 8.1, 37C
0.09
1,3,5(10)estatriene-3,17beta-diol-3-benzoate
-
pH 8.1, 37C
0.0035
1,3,5(10)estatriene-3-ol
-
pH 8.1, 37C
0.128
1,3,5(10)estatriene-3-ol-17-one 3-sulfate
-
pH 8.1, 37C
0.074
1-[2-(p-[3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl]phenoxy)ethyl]-pyrrolidine hydrochloride
-
pH 8.1, 37C
0.000013 - 0.00008
17beta-estradiol
0.038
17beta-hydroxy-5alpha-androstane-3-one
-
pH 8.1, 37C
0.074
17beta-hydroxy-5beta-androstane-3-one
-
pH 8.1, 37C
0.00011
2,4-dibromo-1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.0043
2,4-dinitro-1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.0035
2-amino-1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.00006
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
pH 7.2, 37C
0.000002
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
pH 7.2, 37C
0.00027
2-hydroxy-7,8-dichlorodibenzofuran
-
pH 7.2, 37C
0.0024
2-nitro-1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.002
3',4',7-trihydroxyisoflavone
-
-
1.9 - 5
3'-AMP
0.000155 - 0.056
3'-phosphoadenylylsulfate
0.0055
3,17beta-dihydroxy-1,3,5(10)estatriene-6-one
-
pH 8.1, 37C
-
0.000035
3,3',5,5'-tetrachlorobisphenol A
-
pH 7.2, 37C
0.0049
3-hydroxy-1,3,5(10)estatriene-17-one
-
pH 8.1, 37C
-
0.00000615
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
pH 7.2, 37C
-
0.0048
3-methoxy-1,3,5(10)estatriene-17beta-ol
-
pH 8.1, 37C
-
0.0043
3-methoxy-4-nitro-1,3,5(10)estatriene-17-one
-
pH 8.1, 37C
-
0.17
3beta-hydroxy-5-androstene-17-one
-
pH 8.1, 37C
0.302
3beta-hydroxy-5beta-androstane-17-one
-
pH 8.1, 37C
0.014
4,4'-isopropylidenediphenol
-
pH 7.2, 37C
0.0035
4-amino-1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.00015
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
pH 7.2, 37C
0.00015
4-nitro-1,3,5(10)estatriene-3,17beta-diol
-
pH 8.1, 37C
0.035
5-androstene-3beta,17beta-diol
-
pH 8.1, 37C
0.047
5alpha-Androstane-3beta,17beta-diol
-
pH 8.1, 37C
0.0017
8-bromoadenosine 3',5'-diphosphate
-
pH 7.5, 37C
0.0017
8-bromoadenosine 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C, competitive inhibition
12.9
adenosine 2',5'-diphosphate
-
pH 7.5, 37C, noncompetitive inhibition
0.007
adenosine 3',5'-diphosphate
-
pH 7.5, 37C
0.046
adenosine 3'-diphosphate 5'-phosphate
-
pH 7.5, 37C
0.116
adenosine 3'-phosphate 5'-diphosphate
-
pH 7.5, 37C
1.49
adenosine 5'-phosphosulfate
-
pH 7.5, 37C
5
adenosine 5'-sulfate
-
pH 7.5, 37C
0.35
adenosine N1-oxide 3,5'-diphosphate
-
pH 7.5, 37C
1.1 - 2.8
ADP
0.05
androst-5-ene-3beta-ol
-
pH 8.1, 37C
0.002
daidzein
-
-
0.12
diethylstilbestrol
-
pH 8.1, 37C
0.0004
equol
-
-
0.006
formononetin
-
-
0.043
formycin 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C, noncompetitive inhibition
0.0005
genistein
-
-
0.084
guanosine 2',3'-cyclic phosphate 5'-phosphate
-
pH 7.5, 37C
0.8
inosine 3',5'-diphosphate
-
pH 7.5, 37C
0.125
N6-dimethylaminoadenosine 3',5'-diphosphate
-
pH 7.5, 37C
0.068
nebularine 3',5'-diphosphate
-
pH 7.5, 37C
0.068
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
pH 7.5, 37C
0.00058
quercetin
-
pH 7.4, 37C
0.00036 - 0.0023
resveratrol
0.005 - 0.0053
tubercidin 2',5'-diphosphate
0.0006
tubercidin 3',5'-bisphosphate
-
pH 7.5, 37C
0.0006
tubercidin 3'-phosphate 5'-phosphosulfate
-
pH 7.5, 37C, competitive inhibition
additional information
additional information
-
inactivation kinetics with oxidized glutathione
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0313
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
Homo sapiens
-
at pH 6.0 and 37C
0.0198
(+)-hispanone
Homo sapiens
-
at pH 6.0 and 37C
0.0405
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
Homo sapiens
-
at pH 6.0 and 37C
1.5
Acetylsalicylate
Homo sapiens
-
pH 6.5, 37C, versus beta-estradiol
0.012 - 0.062
butylparaben
0.01
daidzein 4,7-bisulfate
Homo sapiens
-
IC50: 0.01 mM
-
0.14
Ibuprofen
Homo